6 research outputs found

    A 3 year retrospective study on gestational trophoblastic disease in a government obstetrical tertiary care centre

    Get PDF
    Background: The aim of this study is to assess the post diagnostic outcome of Gestational Trophoblastic Disease, a heterogeneous group of disorders, in a government obstetrical tertiary care centre.Methods: The study was conducted in the Institute of Obstetrics & Gynecology, Madras Medical College as a retrospective study. A total of 75 cases were studied over a 3 year period from January 2012 to December 2015. The parameters which were studied included age group, antecedent pregnancy, beta hCG values, histopathological types and Treatment profile.Results: Of the 75 cases, 55 cases (73%) were in the 21-39 age group. The spectrum of disorders that were studied included 69 cases of complete mole, 2 cases of partial mole, 1 case of twin pregnancy with single live foetus and partial mole, 1 case of triplet pregnancy with two live foetuses and partial mole, 1 case of epithelioid trophoblastic tumour and 1 case of choriocarcinoma. Of the 75 cases, 16 cases underwent chemotherapy. No mortality was observed during the study period.Conclusions: Close monitoring and follow up with beta hCG values is of utmost importance in the management of Gestational trophoblastic disease. In cases of gestational trophoblastic neoplasia (GTN), WHO/FIGO scoring should be done and managed with chemotherapy according to the risk assessment

    Single tertiary care centre experience of ovarian granulosa cell tumour in Chennai, India: a retrospective analysis

    Get PDF
    Background: Granulosa cell tumours of ovary are rare sex-cord stromal tumours characterized by long natural history and favourable prognosis. The present study was done to evaluate the clinical presentation, treatment, outcome, and prognostic factors for patients diagnosed as granulosa cell tumours.Methods: A Retrospective study of Granulosa cell tumour of the ovary was done for a period of five years from January 2011 to December 2015 at a tertiary care centre, Institute of Obstetrics and Gynaecology, Madras Medical College, Chennai. The clinical data and the treatment details were retrieved from the records of medical oncology department and the data were analysed.Results: Twenty five patients were diagnosed as granulose cell tumours of ovary during the study period. The median patient age was 48 years. The most common clinical presentation at diagnosis was vaginal bleeding (76%) followed by abdominal pain (40%). Mean tumor size was 9.6cm. The majority of patients were diagnosed in FIGO stage Ia (84%, n = 21). Thirteen patients (52%) underwent complete staging laparotomy. Twenty three patients (92%) had Adult Granulosa cell tumour. Two patients (8%)had juvenile Granulosa cell tumour. After surgery, all patients were put on observation except two patients who received adjuvant chemotherapy (EP: Etoposide, Cisplatin). The median followup period was 48 months. Five patients (20%) had recurrence; The average time to relapse was 29.6 months. Patients who had tumour size more than 9.7cm had more recurrence events (Hazard Ratio(HR):1.058), but their association is not significant (P value-0.839). The association between menopausal status, torsion of tumour mass, tumour stage with recurrence rate were not significant. The estimated mean overall survival was 84.8 months. Following univariate Cox regression modeling, survival appeared to be independent of age range, post operative residual tumour and the FIGO stage.Conclusions: Granulosa cell tumours of ovary are rare, often diagnosed in early stage. Patients who had tumour size of more than 9.7cm had more recurrence events. A prolonged post therapeutic follow-up is necessary to pick up the late relapses

    A 3 year retrospective study on gestational trophoblastic disease in a government obstetrical tertiary care centre

    No full text
    Background: The aim of this study is to assess the post diagnostic outcome of Gestational Trophoblastic Disease, a heterogeneous group of disorders, in a government obstetrical tertiary care centre.Methods: The study was conducted in the Institute of Obstetrics & Gynecology, Madras Medical College as a retrospective study. A total of 75 cases were studied over a 3 year period from January 2012 to December 2015. The parameters which were studied included age group, antecedent pregnancy, beta hCG values, histopathological types and Treatment profile.Results: Of the 75 cases, 55 cases (73%) were in the 21-39 age group. The spectrum of disorders that were studied included 69 cases of complete mole, 2 cases of partial mole, 1 case of twin pregnancy with single live foetus and partial mole, 1 case of triplet pregnancy with two live foetuses and partial mole, 1 case of epithelioid trophoblastic tumour and 1 case of choriocarcinoma. Of the 75 cases, 16 cases underwent chemotherapy. No mortality was observed during the study period.Conclusions: Close monitoring and follow up with beta hCG values is of utmost importance in the management of Gestational trophoblastic disease. In cases of gestational trophoblastic neoplasia (GTN), WHO/FIGO scoring should be done and managed with chemotherapy according to the risk assessment

    Land Use Dynamics and Impact on Regional Climate Post-Tehri Dam in the Bhilangana Basin, Garhwal Himalaya

    No full text
    Land use and land cover (LULC) changes are a dynamic process determined by natural factors as well as the degree of human interaction in spatial and temporal perspectives. The present study focuses on analysing the LULC changes in the Bhilangana basin post-Tehri dam construction in the Garhwal Himalaya. Landsat series satellite images were used for three time periods to quantify spatial and temporal changes in the LULC using unsupervised classification techniques. The calculations of the areal coverage and change detection were carried out using the ArcGIS 10.3 software. The study finds that LULC changes were observed in the area surrounding the Tehri reservoir. The area under forest cover decreased by 54.71 km2, which is −5.7% of the geographical area, followed by agricultural land by 6.06 km2 (−0.4%) and scrubland and grass cover by 4.23 km2 (−0.28%) during the decade 2000 to 2010. Gradually, due to compensatory afforestation, forest cover increased by 5.65% in the period 2010–2020. A significant relationship with climatic variability is also established with LULC change in the region. The presence of a large water surface at a high altitude modified the albedo and air temperature and increased the atmospheric humidity and precipitation pattern. This study would be vital in understanding the climatic variability in the Himalayas and its impact on the community, environment and climate

    Ribonucleotide reductase, a novel drug target for gonorrhea

    No full text
    Antibiotic-resistant Neisseria gonorrhoeae (Ng) are an emerging public health threat due to increasing numbers of multidrug resistant (MDR) organisms. We identified two novel orally active inhibitors, PTC-847 and PTC-672, that exhibit a narrow spectrum of activity against Ng including MDR isolates. By selecting organisms resistant to the novel inhibitors and sequencing their genomes, we identified a new therapeutic target, the class Ia ribonucleotide reductase (RNR). Resistance mutations in Ng map to the N-terminal cone domain of the α subunit, which we show here is involved in forming an inhibited α4β4 state in the presence of the β subunit and allosteric effector dATP. Enzyme assays confirm that PTC-847 and PTC-672 inhibit Ng RNR and reveal that allosteric effector dATP potentiates the inhibitory effect. Oral administration of PTC-672 reduces Ng infection in a mouse model and may have therapeutic potential for treatment of Ng that is resistant to current drugs.</jats:p

    Moroccan antidiabetic medicinal plants: Ethnobotanical studies, phytochemical bioactive compounds, preclinical investigations, toxicological validations and clinical evidences; challenges, guidance and perspectives for future management of diabetes worldwide

    No full text
    corecore