Scenography of the rehabilitation of architectural heritage(Opening of Rams Road as a model)

The exploitation of archaeological areas as one of the elements of scenography is not new. Attempts have continued for a long time to employ them across different countries of the world (either in concerts or musical performances ... etc., but the method of exploiting them and integrating between the live elements of theatrical performance and the filmed elements and The use of non-professional youth as a kind of active participation between the audience and the performers in the performance of parts of the ceremonies and the combination of all these elements with lighting and filming for some parts of the show and the preparation of unprepared places such as the road of rams and ancient Egyptian temples in the pursuit of achieving Communicating with the public and gaining a new audience to bring about social changes represented by drawing attention to the importance of our cultural heritage, which will remain, through the ages, an important and pivotal factor in emphasizing national belonging. Supporting a sense of national identity and a sense of pride among the new generations because of what he focused on showing the beauty and grandeur of the ancient Egyptian architectural monuments, which witnessed the greatness of the Egyptian artist through the ages. This celebration was able to stir the stagnant waters in a new experience represented in a great celebration attended by the President of the Republic, the ministers, and many ambassadors of countries and important personalities, in addition to conveying the events of this celebration to the whole world in a way that differs from what was previously presented from parties in archaeological areas that were It is prepared as a theatrical model and mechanisms have been invented based on which this heritage area has been re-exploited by holding this opening under the auspices of the state and adopting and nurturing the creative talents of the Egyptian youth who have creative energies in various fields

Designing of hydraulic lifts and their impact on the scenography of theatrical performances

The designer's ability to create theatrical scenes to impress the audience is reflected in the challenges of using and designing hydraulic lifts. It is what gives the theater audience a sense of life on this stage, in addition to integrating them with characters, backgrounds, and movements that make the scene seem animated, realistic, and magical, and around the world many theaters Using hydraulic lifts as one of the main elements of theatrical performances.The design of hydraulic lifts is based on understanding the special needs of theatrical performance through design vocabulary and thinking about its problems, and looking at it from the shape and functional point of view on the basis that it is an integrated chain that moves in a sequential or successive manner in addition to addressing all possible mechanical solutions, whether they are Simple or complex, identifying guidance systems, defining methods of control and movement, the possibility of determining their movement sequence, exploiting the interconnectedness in movement, which is pre-determined, understanding the effects of the entire system, and preparing operating systems that include the application of design standards in all its stages, this in addition to finding solutions that enable us to rearrange the design vocabulary to maintain diversity in the form of presentation through reuse in a different way or upgrade and renewal, and thus hydraulic platforms are among the most important scenographic elements that distinguish theatrical architecture, as they provide scenography with the ability to provide action and response The action through its relationship with the rest of the elements to achieve the desired scene, as the director and scenographer were able to present moving paintings on stage to take the action For scenes to necessary and impossible, allowing the ability to implement scenes that were not available before, and showing skill in achieving mechanical and electronic design requirements by creating kinetic environments that depend on creating an unexpected shock

Scenography of the Nutcracker Balle experimental view on venue and presentation

Many basic factors aim to achieve the ability of the show to evoke deep emotions for the viewers and transcend all forms of written literature from a novel to a live show to transport us to a different world of perceptions, visions, and kinetic rhythms between viewers and actors by relying on audience participation and creating interaction with a space Of a special nature through individual perceptions by reinventing aesthetic forms that do not maintain to the traditional forms for the theatrical performance by changing the way that spectators sit, movement, sound, and through the exchange of interaction between the movement of the performers and the display areas according to the experimental method developed by the new show, the entire experiments could be repeated to identify sources of variation for better effects through sequential analysis.how to transform the selected area to fit this theatrical performance, we thought about taking the advantage of natural resources, how to use it in the implementation of the design as one of the factors that help in the success of the theatrical performance, providing the design with a natural background rich in landscapes, plants, wildlife, and includes many archaeological sites of great importance to match the fictional events of the novel.Choosing the venue for the show was one of the most important elements of performing this experience, Wadi El-Gamal Reserve was characterized by calm sea day and night, no violent waves, by using marine platforms dealing with the relationship between the audience, theatrical platforms, and natural background, how can we connect them, integrate all the possibilities of platform construction using custom techniques with recycled materials transforming the show from a stationary stage to several floating platforms on the water.The charming nature of the place was exploited and combined with the vocabulary of the theatrical performance, using boats as seating places for spectators with specific locations, the five floating platforms were set up on the surface of the water.design lines ware based on the shape Derived from the dew drops formed on the tree leaf, analyzed to five floating platforms, the natural passage provided by the coastal environment was exploite

Reliability and Cost-Benefit Efficient in a Two-Dissimilar- Unit with Warm Unit Standby Case Subject to Arbitrary Repair and Replacement

In this paper, we deal with a warm case of standby system made up of two-dissimilar-units. One of these units is a high quality unit, while the other is a low quality one and may require repairs or replacement with a different lesser device in the event of failure, so the first unit is given priority in use. Assume that an arbitrary distribution for repairing the main unit and standby unit. We also examine all transition probabilities and calculate mean sojourn time, availability, and repair time. In the end, we use all of the previous measurments to evaluate the cost-benefit of the system

Impairments in Activities of Daily Living in Older Japanese Men in Hawaii and Japan

Introduction. Hypertension and cigarette smoking are dominant risk factors for cardiovascular disease in Japan while in westernized countries, broader effects encompass obesity, diabetes, and hypercholesterolemia. This paper examines whether different associations also appear important in the manifestation of activities of daily living (ADL) in older Japanese men in Hawaii and Japan. Methods. Measures of ADL (feeding, toileting, dressing, bathing, and walking around the house) were assessed from 1995 to 1999 in 1,893 men in Hawaii and 543 men in Japan. Concomitant risk factors were measured from 1990 to 1993. Results. In Hawaii, diabetes increased the odds of ≥1 ADL impairment nearly 1.5-fold (P = .020). A similar association was absent in Japan. In contrast, the odds of an ADL impairment in Japan was increased more than 5-fold in the presence of stroke (P < .001). The association in Hawaii was significantly weaker (P = .007). In both cohorts, past alcohol use was associated with a greater likelihood of ADL impairment. Conclusion. In this comparison of genetically similar samples, findings suggest that different strengths in risk factor associations with cardiovascular disease in Japan and westernized countries may also include different strengths in associations with impaired ADL

New derivatives of sulfonylhydrazone as potential antitumor agents: Design, synthesis and cheminformatics evaluation

Phosphoinositide 3-kinase α (PI3Kα) is a propitious target for designing anticancer drugs. A series of new N\u27-(diphenylmethylene)benzenesulfonohydrazide was synthesized and characterized using FT-IR, NMR (1H and 13C), HRMS, and elemental analysis. Target compounds exhibited an antiproliferative effect against the human colon carcinoma (HCT-116) cell line. Our cheminformatics analysis indicated that the para-tailored derivatives [p-NO2 (3) and p-CF3 (7)] have better ionization potentials based on calculated Moran autocorrelations and ionization potentials. Subsequent in vitro cell proliferation assays validated our cheminformatics results by providing experimental evidence that both derivatives 3 and 7 exhibited improved antiproliferative activities against HCT-116. Hence, our results emphasized the importance of electron-withdrawing groups and hydrogen bond-acceptors in the rational design of small-molecule chemical ligands targeting PI3Kα. These results agreed with the induced-fit docking against PI3Kα, highlighting the role of p-substituted aromatic rings in guiding the ligand-PI3Kα complex formation, by targeting a hydrophobic pocket in the ligand-binding site and forming π-stacking interactions with a nearby tryptophan residue

Assessment of serum interleukin 19 level in patients with warts

Background: Warts are viral cutaneous infections caused by human papilloma virus (HPV), presented by verrucous growth over the skin surface. The cell mediated immune response is considered to play a crucial role in HPV clearance. The viral load and number of lesions increase when there is an imbalance between the T-helper 1 and T-helper 2 immune responses. Interleukin (IL)-19 is a cytokine that belongs to interleukin 10 cytokines family and constitutes a sub-family with IL-20, IL-22 and IL-24. IL-19 is mainly produced by activated monocytes and to a lesser extent by B-cells, keratinocytes and fetal membranes. IL-19 was found to shift T-cell maturation away from the pro-inflammatory T-helper 1 cells toward the anti-inflammatory T-helper 2 cells. It induces IL-4 and IL-13 production in T cells and apoptosis in monocytes. Aim: This study aimed to measure serum level of IL-19 in patients with warts compared to healthy controls and to find out the correlation between this level and number, size and clinical types of warts. Methods: The study included 50 patients with warts and 50 control subjects. Serum concentration of IL-19 was measured by enzyme-linked immune sorbent assay. Results: Interleukin-19 serum level was significantly lower in patients with warts than in controls (P < 0.003). Moreover, there was a significant positive correlation between IL-19 serum level and the number of warts (P = 0.027). Conclusion: Serum level of IL-19 was significantly lower in patients with warts, and this low level might be crucial for an effective cell mediated immunological response to HPV

A 6-Month Open-Label Study of Vortioxetine among Cancer Patients with Major Depressive Disorder (MDD)

Objective: Vortioxetine is a monoaminergic drug with a novel multimodal mechanism of action. We investigated its efficacy on depressive symptoms, cognitive function, and quality of life among cancer patients.Methods: In this multicenter, open-label, single-arm, observational study, patients received flexible doses of Vortioxetine for a period of six months. All participants were assessed at baseline and scheduled for monitoring at weeks 2, 4, 8, 12, 16, 20, and 24. Depression severity was assessed using Montgomery-Asberg Depression Rating Scale (MADRS) and the Clinical Global Impression (CGI) scale. The Perceived Deficiency Questionnaire (PDQ-5) assessed the perceived cognitive difficulties in concentration, executive functioning, and memory. The European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC) was used to assess the patients’ quality of life. Side effects of vortioxetine were monitored using the Antidepressant Side-Effect Checklist (ASEC). Results: Patients experienced a reduction in MADRS scores from 29.89 ± 5.997 at baseline to 11.59 ± 4.629 by Week 24. The PDQ-5 scores showed significant change from Week-4, whereas the EORTC role, emotional, and cognitive functioning scores showed a significant change from Week 2 onwards. CGI-Severity scores decreased from a baseline of 4.39 ± 0.746 to 2.41 ± 1.085 by Week 24. During the 24-Weeks of therapy, around three-quarters of the patients (73.3%) had one or more adverse events reported on the ASEC. The most frequently reported TEAEs were dry mouth, insomnia, somnolence, and headache, with more than a 30% incidence rate. Conclusion: Vortioxetine seems promising in the management of depression and enhancement of cognitive function and quality of life of cancer patients with Major Depressive Disorder

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

A cross-sectional association of obesity with coronary calcium among Japanese, Koreans, Japanese-Americans, and US-Whites

[Aims] Conflicting evidence exists regarding whether obesity is independently associated with coronary artery calcium (CAC), a measure of coronary atherosclerosis. We examined an independent association of obesity with prevalent CAC among samples of multi-ethnic groups whose background populations have varying levels of obesity and coronary heart disease (CHD). [Methods and results] We analysed a population-based sample of 1212 men, aged 40–49 years free of clinical cardiovascular disease recruited in 2002–06; 310 Japanese in Japan (JJ), 294 Koreans in South Korea (KN), 300 Japanese Americans (JA), and 308 Whites in the USA (UW). We defined prevalent CAC as an Agatston score of ≥10. Prevalent CAC was calculated by tertile of the body mass index (BMI) in each ethnic group and was plotted against the corresponding median of tertile BMI. Additionally, logistic regression was conducted to examine whether an association of the BMI was independent of conventional risk factors. The median BMI and crude prevalence of CAC for JJ, KN, JA, and UW were 23.4, 24.4, 27.4, and 27.1 (kg/m2); 12, 11, 32, and 26 (%), respectively. Despite the absolute difference in levels of BMI and CAC across groups, higher BMI was generally associated with higher prevalent CAC in each group. After adjusting for age, smoking, alcohol, hypertension, lipids, and diabetes mellitus, the BMI was positively and independently associated with prevalent CAC in JJ, KN, UW, but not in JA. [Conclusion] In this multi-ethnic study, obesity was independently associated with subclinical stage of coronary atherosclerosis among men aged 40–49 years regardless of the BMI level