発達障害のある子どもを養育する親の経験について

滋賀医科大学修士（看護学）令和6年度thesi

高齢者の日常生活活動における主観的・客観的評価の乖離に関連する要因の探索的検討

滋賀医科大学修士（看護学）令和6年度thesi

Characterization of the gut phageome of Japanese patients with ulcerative colitis under endoscopic remission

滋賀医科大学博士（医学）This study aimed to analyze the gut phageome in Japanese patients with ulcerative colitis (UC) in endoscopic remission. Fecal samples were collected from 35 UC patients and 22 healthy controls. The gut microbiome was analyzed using 16S rRNA amplicon sequencing, and the phageome was profiled through shotgun metagenomic sequencing. Compared to healthy controls, UC patients showed a significant reduction in phageome richness (observed species and Chao1 index). Principal coordinate analysis revealed a significant difference in beta-diversity between UC and ‍healthy controls (p = 0.001). The abundance of temperate phages was higher in UC (15.2%) compared to healthy controls (5.9%), although this was not statistically significant (p = 0.088). Temperate phages associated with Coprococcus sp., Bacteroides sp. KFT8, and Faecalibacterium prausnitzii, as well as virulent phages associated with Ruminococcus gnavus and Lactobacillus farciminis, were increased in UC patients. Conversely, phages associated with Thermosipho affectus, Bacteroides sp. OF03-11BH, and Odoribacter splanchnicus were decreased in UC patients. Phages associated with the genera Odoribacter (p = 0.0004), Ruminococcus (p = 0.009), and Veillonella (p = 0.013) were significantly reduced in UC patients. The gut phageome of inactive UC patients exhibited notable alterations in viral composition compared to healthy controls. These results suggest that changes in the gut phageome might be involved in the pathogenesis of UC.令和6年度doctoral thesi

Moderate hypothermia circulatory arrest as a brain-protective strategy for type A aortic dissection

滋賀医科大学博士（医学）Objectives: Brain-protective strategies for acute type A aortic dissection (TAAD) remain controversial. Moderate hypothermia circulatory arrest (MHCA) without cerebral perfusion is not commonly used. However, we aimed to assess its safety and efficacy in 358 patients who underwent hemiarch replacement with MHCA for acute type A aortic dissection at our institution from August 2012 to August 2022. Methods: Clinical outcomes were compared according to circulatory arrest time [≤15 min (S group, n = 52) vs ≥16 min (L group, n = 306)]. The primary outcome was postoperative stroke. Results: The S group had more older patients (72.5 vs 68.8 years; P = 0.04), a greater incidence of carotid artery malperfusion (21% vs 11%; P = 0.043) and a lower body mass index (21.7 vs 23.6 kg/m2; P < 0.01) and hemodynamic instability (3.8% vs 16%; P = 0.02) than the L group. The incidence of postoperative stroke (7.7% vs 12%; P = 0.33) and the rate of 30-day mortality (5.8% vs 6.5%; P = 0.83) did not significantly differ between groups. After adjusting for all potential confounding factors pre- and intraoperatively, there was no significant difference in postoperative outcomes between groups. Conclusions: MHCA alone for TAAD had comparable postoperative outcomes with circulatory arrest times under and over 15 min. However, longer arrest times were associated with a higher risk of stroke.令和6年度doctoral thesi

Comfortable Seatbelts for Pregnant Women with Twins in Japan: A Cross-Sectional Observational Study on Seatbelt Usage

滋賀医科大学博士（医学）Healthcare. 2024 Aug 9;12(16):1590.令和6年度thesi

Clinical outcomes and future fertility after uterine artery embolization for postpartum and post-abortion hemorrhage

滋賀医科大学博士（医学）Acta Radiologica. 2024 Jun;65(6):670-677.令和6年度thesi

Exploratory study on quantitative assessment of skin hardness in patients with systemic sclerosis using SOFTGRAM

滋賀医科大学博士（医学）Clinical and Experimental Rheumatology. 2024 Aug;42(8):1549-1555.令和6年度thesi

Survey of vascular ultrasound examinations in dialysis facilities

近年バスキュラーアクセス管理や穿刺困難症例に対して血管超音波検査（シャントエコー）の重要性が高まり、医師や臨床検査技師だけではなく看護師や臨床工学技士が施行する施設が増えてきた。活用方法や検査頻度に決まったものは無く、各施設又は担当医の判断に委ねられている。今回、県内の透析施設とびわこ臨床透析カンファレンス参加施設における血管超音波検査の施行実態を調査するために、44施設を対象に記名式アンケートを行った。回答方法は質問紙またはQRコードを使用したWebアンケートでの回答のどちらか一方を選択してもらい、回答率は81.8％であった。その結果、8割の施設でシャントエコー検査を活用し、定期検査やシャントトラブル時に使用している事がわかった。実施頻度は、1週間に1-5件の検査を行っている施設が最も多い結果となったが、20件以上との回答もあり、施設間でばらつきがみられた。今回の結果から、シャントエコー検査実施に関する明確な基準があれば、シャントトラブルの早期発見など、よりよいシャント管理に繋がると期待する。departmental bulletin pape

Moderate hypothermia circulatory arrest as a brain-protective strategy for type A aortic dissection

滋賀医科大学博士（医学）Interdisciplinary Cardiovascular and Thoracic Surgery. 2024 Oct 8;39(4):ivae166.令和6年度thesi

滋賀医大病院ニュースTOPICS Vol.95 (2025/3)

滋賀医大病院ニュース第68号別冊 乳がんとその治療 / 冨田　香othe