Comparative analysis of viral shedding in pediatric and adult subjects with central nervous system-associated enterovirus infections from 2013 to 2015 in Switzerland.

Several enterovirus (EV) genotypes can result in aseptic meningitis, but their routes of access to the central nervous system remain to be elucidated and may differ between the pediatric and adult populations. To assess the pattern of viral shedding in pediatric and adult subjects with acute EV meningitis and to generate EV surveillance data for Switzerland. All pediatric and adult subjects admitted to the University Hospitals of Geneva with a diagnosis of EV meningitis between 2013 and 2015 were enrolled. A quantitative EV real-time reverse transcriptase (rRT)-PCR was performed on the cerebrospinal fluid (CSF), blood, stool, urine and respiratory specimens to assess viral shedding and provide a comparative analysis of pediatric and adult populations. EV genotyping was systematically performed. EV positivity rates differed significantly between pediatric and adult subjects; 62.5% of pediatric cases (no adult case) were EV-positive in stool and blood for subjects for whom these samples were all collected. Similarly, the EV viral load in blood was significantly higher in pediatric subjects. Blood C-reactive protein levels were lower and the number of leucocytes/mm3 in the CSF were higher in non-viremic than in viremic pediatric subjects, respectively. A greater diversity of EV genotypes was observed in pediatric cases, with a predominance of echovirus 30 in children ≥3 years old and adults. In contrast to adults, EV-disseminated infections are predominant in pediatric subjects and show different patterns of EV viral shedding. This observation may be useful for clinicians and contribute to modify current practices of patient care

Analysis of CMB polarization on an incomplete sky

The full sky cosmic microwave background polarization field can be decomposed into 'electric' and 'magnetic' components. Working in harmonic space we construct window functions that allow clean separation of the electric and magnetic modes from observations over only a portion of the sky. Our construction is exact for azimuthally symmetric patches, but should continue to perform well for arbitrary patches. From the window functions we obtain variables that allow for robust estimation of the magnetic component without risk of contamination from the probably much larger electric signal. For isotropic, uncorrelated noise the variables have a very simple diagonal noise correlation, and further analysis using them should be no harder than analysing the temperature field. For an azimuthally-symmetric patch, such as that obtained from survey missions when the galactic region is removed, the exactly-separated variables are fast to compute allowing us to estimate the magnetic signal that could be detected by the Planck satellite in the absence of non-galactic foregrounds. We also discuss the sensitivity of future experiments to tensor modes in the presence of a magnetic signal generated by weak lensing, and give lossless methods for analysing the electric polarization field in the case that the magnetic component is negligible.Comment: 27 pages, 8 figures. New appendix on weak signal detection and revised plots using a better statistic. Other changes to match version accepted by PRD. Sample source code now available at http://cosmologist.info/pola

Scale Dependence of the Halo Bias in General Local-Type Non-Gaussian Models I: Analytical Predictions and Consistency Relations

We investigate the clustering of halos in cosmological models starting with general local-type non-Gaussian primordial fluctuations. We employ multiple Gaussian fields and add local-type non-Gaussian corrections at arbitrary order to cover a class of models described by frequently-discussed f_nl, g_nl and \tau_nl parameterization. We derive a general formula for the halo power spectrum based on the peak-background split formalism. The resultant spectrum is characterized by only two parameters responsible for the scale-dependent bias at large scale arising from the primordial non-Gaussianities in addition to the Gaussian bias factor. We introduce a new inequality for testing non-Gaussianities originating from multi fields, which is directly accessible from the observed power spectrum. We show that this inequality is a generalization of the Suyama-Yamaguchi inequality between f_nl and \tau_nl to the primordial non-Gaussianities at arbitrary order. We also show that the amplitude of the scale-dependent bias is useful to distinguish the simplest quadratic non-Gaussianities (i.e., f_nl-type) from higher-order ones (g_nl and higher), if one measures it from multiple species of galaxies or clusters of galaxies. We discuss the validity and limitations of our analytic results by comparison with numerical simulations in an accompanying paper.Comment: 25 pages, 3 figures, typo corrected, Appendix C updated, submitted to JCA

The lifecycle of powerful AGN outflows

During the course of this conference, much evidence was presented that points to an intimate connection between the energetic outflows driven by AGN and the energy budget and quite possibly also the evolution of their gaseous environments. However, it is still not clear if and how the AGN activity is triggered by the cooling gas, how long the activity lasts for and how these effects give rise to the observed distribution of morphologies of the outflows. In this contribution we concentrate on the high radio luminosity end of the AGN population. While most of the heating of the environmental gas may be due to less luminous and energetic outflows, these more powerful objects have a very profound influence on their surroundings. We will describe a simple model for powerful radio galaxies and radio-loud quasars that explains the dichotomy of their large-scale radio morphologies as well as their radio luminosity function.Comment: 6 pages, contribution to 'Heating vs. coooling in galaxies and galaxy clusters', Garching 2006, proceedings to be published by Springer (ESO Astrophysics Symposia), eds. H. Boehringer, P. Schuecker, G.W. Pratt & A. Finogueno

The High Redshift Integrated Sachs-Wolfe Effect

In this paper we rely on the quasar (QSO) catalog of the Sloan Digital Sky Survey Data Release Six (SDSS DR6) of about one million photometrically selected QSOs to compute the Integrated Sachs-Wolfe (ISW) effect at high redshift, aiming at constraining the behavior of the expansion rate and thus the behaviour of dark energy at those epochs. This unique sample significantly extends previous catalogs to higher redshifts while retaining high efficiency in the selection algorithm. We compute the auto-correlation function (ACF) of QSO number density from which we extract the bias and the stellar contamination. We then calculate the cross-correlation function (CCF) between QSO number density and Cosmic Microwave Background (CMB) temperature fluctuations in different subsamples: at high z>1.5 and low z<1.5 redshifts and for two different choices of QSO in a conservative and in a more speculative analysis. We find an overall evidence for a cross-correlation different from zero at the 2.7\sigma level, while this evidence drops to 1.5\sigma at z>1.5. We focus on the capabilities of the ISW to constrain the behaviour of the dark energy component at high redshift both in the \LambdaCDM and Early Dark Energy cosmologies, when the dark energy is substantially unconstrained by observations. At present, the inclusion of the ISW data results in a poor improvement compared to the obtained constraints from other cosmological datasets. We study the capabilities of future high-redshift QSO survey and find that the ISW signal can improve the constraints on the most important cosmological parameters derived from Planck CMB data, including the high redshift dark energy abundance, by a factor \sim 1.5.Comment: 20 pages, 18 figures, and 7 table

Can induced gravity isotropize Bianchi I, V, or IX Universes?

We analyze if Bianchi I, V, and IX models in the Induced Gravity (IG) theory can evolve to a Friedmann--Roberson--Walker (FRW) expansion due to the non--minimal coupling of gravity and the scalar field. The analytical results that we found for the Brans-Dicke (BD) theory are now applied to the IG theory which has $\omega \ll 1$ ($\omega$ being the square ratio of the Higgs to Planck mass) in a cosmological era in which the IG--potential is not significant. We find that the isotropization mechanism crucially depends on the value of $\omega$. Its smallness also permits inflationary solutions. For the Bianch V model inflation due to the Higgs potential takes place afterwads, and subsequently the spontaneous symmetry breaking (SSB) ends with an effective FRW evolution. The ordinary tests of successful cosmology are well satisfied.Comment: 24 pages, 5 figures, to be published in Phys. Rev. D1

Speciation of OH reactivity above the canopy of an isoprene-dominated forest

Measurements of OH reactivity, the inverse lifetime of the OH radical, can provide a top&ndash;down estimate of the total amount of reactive carbon in an air mass. Using a comprehensive measurement suite, we examine the measured and modeled OH reactivity above an isoprene-dominated forest in the southeast United States during the 2013 Southern Oxidant and Aerosol Study (SOAS) field campaign. Measured and modeled species account for the vast majority of average daytime reactivity (80&ndash;95 %) and a smaller portion of nighttime and early morning reactivity (68&ndash;80 %). The largest contribution to total reactivity consistently comes from primary biogenic emissions, with isoprene contributing &sim;&thinsp; 60 % in the afternoon, and &sim;&thinsp; 30&ndash;40 % at night and monoterpenes contributing &sim;&thinsp; 15&ndash;25 % at night. By comparing total reactivity to the reactivity stemming from isoprene alone, we find that &sim;&thinsp; 20 % of the discrepancy is temporally related to isoprene reactivity, and an additional constant &sim;&thinsp; 1 s-1 offset accounts for the remaining portion. The model typically overestimates measured OVOC concentrations, indicating that unmeasured oxidation products are unlikely to influence measured OH reactivity. Instead, we suggest that unmeasured primary emissions may influence the OH reactivity at this site.</p

Photoproduction of mesons off nuclei

Recent results for the photoproduction of mesons off nuclei are reviewed. These experiments have been performed for two major lines of research related to the properties of the strong interaction. The investigation of nucleon resonances requires light nuclei as targets for the extraction of the isospin composition of the electromagnetic excitations. This is done with quasi-free meson photoproduction off the bound neutron and supplemented with the measurement of coherent photoproduction reactions, serving as spin and/or isospin filters. Furthermore, photoproduction from light and heavy nuclei is a very efficient tool for the study of the interactions of mesons with nuclear matter and the in-medium properties of hadrons. Experiments are currently rapidly developing due to the combination of high quality tagged (and polarized) photon beams with state-of-the-art 4pi detectors and polarized targets

Large enhancement of deuteron polarization with frequency modulated microwaves

We report a large enhancement of 1.7 in deuteron polarization up to values of 0.6 due to frequency modulation of the polarizing microwaves in a two liters polarized target using the method of dynamic nuclear polarization. This target was used during a deep inelastic polarized muon-deuteron scattering experiment at CERN. Measurements of the electron paramagnetic resonance absorption spectra show that frequency modulation gives rise to additional microwave absorption in the spectral wings. Although these results are not understood theoretically, they may provide a useful testing ground for the deeper understanding of dynamic nuclear polarization.Comment: 10 pages, including the figures coming in uuencoded compressed tar files in poltar.uu, which also brings cernart.sty and crna12.sty files neede

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes