Socio-Economic Differences in the Prevalence of Single Motherhood in North America and Europe

The study focuses on understanding the association between parental socio-economic status (SES) and the likelihood of women experiencing a first birth while single, and identifying societal factors that influence this association in 18 North American and European societies. Previous research has shown that single motherhood occurs disproportionately among those from with lower a lower parental SES. The study assesses whether this is caused by parental SES differences in the risk of single women experiencing a first conception leading to a live birth or by parental SES differences in how likely women are to enter a union during pregnancy. Additionally, an assessment is made of whether cross-national differences in these associations can be explained by a country’s access to family planning, norms regarding family formation, and economic inequality. Across countries, a negative gradient of parental SES was found on the likelihood of single women to experience a first pregnancy. The negative gradient was stronger in countries with better access to family planning. In some countries, the negative gradient of parental SES was aggravated during pregnancy because women from lower parental SES were less likely to enter a union. This was mostly found in societies with less conservative norms regarding marriage. The results suggest that certain developments in Western societies may increase socio-economic differentials in family demography

The evolutionary drivers of primate scleral coloration

The drivers of divergent scleral morphologies in primates are currently unclear, though white sclerae are often assumed to underlie human hyper-cooperative behaviours. Humans are unusual in possessing depigmented sclerae whereas many other extant primates, including the closely-related chimpanzee, possess dark scleral pigment. Here, we use phylogenetic generalized least squares (PGLS) analyses with previously generated species-level scores of proactive prosociality, social tolerance (both n = 15 primate species), and conspecific lethal aggression (n = 108 primate species) to provide the first quantitative, comparative test of three existing hypotheses. The ‘self-domestication’ and ‘cooperative eye’ explanations predict white sclerae to be associated with cooperative, rather than competitive, environments. The ‘gaze camouflage’ hypothesis predicts that dark scleral pigment functions as gaze direction camouflage in competitive social environments. Notably, the experimental evidence that non-human primates draw social information from conspecific eye movements is unclear, with the latter two hypotheses having recently been challenged. Here, we show that white sclerae in primates are associated with increased cooperative behaviours whereas dark sclerae are associated with reduced cooperative behaviours and increased conspecific lethal violence. These results are consistent with all three hypotheses of scleral evolution, suggesting that primate scleral morphologies evolve in relation to variation in social environment

Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the enhancing neuro Imaging genetics through meta analysis (ENIGMA) Consortium

BACKGROUND: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group. METHODS: The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11-78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10-87 years; 53% male) assessed with standardized methods at 39 centers worldwide. RESULTS: Compared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen's d = -0.530/-0.516) and smaller surface area (left/right hemisphere: Cohen's d = -0.251/-0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differences in cortical thickness remained significant when statistically controlling for global cortical thickness, suggesting regional specificity. In contrast, effects for cortical surface area appear global. Case-control, negative, cortical thickness effect sizes were two to three times larger in individuals receiving antipsychotic medication relative to unmedicated individuals. Negative correlations between age and bilateral temporal pole thickness were stronger in individuals with schizophrenia than in healthy volunteers. Regional cortical thickness showed significant negative correlations with normalized medication dose, symptom severity, and duration of illness and positive correlations with age at onset. CONCLUSIONS: The findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Nonmarital fertility in Europe and North-America: what is the role of parental SES and own SES?

The research in this chapter provides consistent evidence that parental SES influences partnership status at first birth in western societies. Overall, lower parental SES is related to a higher likelihood of having a first birth in cohabitation and while being single. It is possible that unequal occurrence of births in cohabitation and while being single aggravate inequalities between groups. Previous research shows that single motherhood has negative socio-economic consequences for mothers and their children (Kollmeyer 2013). Moreover, cohabiting parents are often treated differently than married parents. For example, cohabiters may be entitled to a lesser extent to tax and social security benefits. Also, after separation or death of a partner, the division of property and entitlement to inheritance may depend on the partnership status (Perelli-Harris and Gassen 2012). It is therefore important to understand if inequalities that exist at the start of parenthood could be prohibited. What may help in this regard is understanding why inequalities that are found in some western societies are not found in others. The research in this chapter suggests that the influence of parental SES on the likelihood of having a birth outside of marriage can be partly explained through the intergenerational transmission of SES. In addition, a direct – mostly negative – effect of parental SES is found. Possibly, differences in parental support in the transition to adulthood can explain these differences. In the case of single motherhood, it is also possible that parental SES influences the ability to prevent pregnancies

Having a child within a cohabiting union in Europe and North America: What is the role of parents' socio-economic status?

The link between parental socio-economic status (SES) and the likelihood of having a birth in cohabitation or in marriage varies considerably across countries. Previous studies have referred to the pattern of disadvantage perspective and the second demographic transition theory to explain this cross-national variation. Yet no study has directly tested the explanatory power of both theories in this context. In the current study, hypotheses are formulated about the influence of economic inequality and norms regarding family formation on this relationship. The hypotheses are tested in 19 European and North American countries, using data of the Generations and Gender Survey and four other datasets. The analyses show that in societies that have more traditional family formation norms, women with lower parental SES are more likely to have a birth in cohabitation whereas such differences are not found in less traditional societies. The influence of economic inequality is less clear-cut

Electronic Health Program to Empower Patients in Returning to Normal Activities After General Surgical and Gynecological Procedures: Intervention Mapping as a Useful Method for Further Development

BACKGROUND: Support for guiding and monitoring postoperative recovery and resumption of activities is usually not provided to patients after discharge from the hospital. Therefore, a perioperative electronic health (eHealth) intervention ("ikherstel" intervention or "I recover" intervention) was developed to empower gynecological patients during the perioperative period. This eHealth intervention requires a need for further development for patients who will undergo various types of general surgical and gynecological procedures. OBJECTIVE: This study aimed to further develop the "ikherstel" eHealth intervention using Intervention Mapping (IM) to fit a broader patient population. METHODS: The IM protocol was used to guide further development of the "ikherstel" intervention. First, patients' needs were identified using (1) the information of a process evaluation of the earlier performed "ikherstel" study, (2) a review of the literature, (3) a survey study, and (4) focus group discussions (FGDs) among stakeholders. Next, program outcomes and change objectives were defined. Third, behavior change theories and practical tools were selected for the intervention program. Finally, an implementation and evaluation plan was developed. RESULTS: The outcome for an eHealth intervention tool for patients recovering from abdominal general surgical and gynecological procedures was redefined as "achieving earlier recovery including return to normal activities and work." The Attitude-Social Influence-Self-Efficacy model was used as a theoretical framework to transform personal and external determinants into change objectives of personal behavior. The knowledge gathered by needs assessment and using the theoretical framework in the preparatory steps of the IM protocol resulted in additional tools. A mobile app, an activity tracker, and an electronic consultation (eConsult) will be incorporated in the further developed eHealth intervention. This intervention will be evaluated in a multicenter, single-blinded randomized controlled trial with 18 departments in 11 participating hospitals in the Netherlands. CONCLUSIONS: The intervention is extended to patients undergoing general surgical procedures and for malignant indications. New intervention tools such as a mobile app, an activity tracker, and an eConsult were developed. TRIAL REGISTRATION: Netherlands Trial Registry NTR5686; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=5686