β2-adrenergic agonists do not improve physical performance in healthy individuals

All beta-2 agonists are prohibited by the World Anti-Doping Agency (WADA, www.wada-ama.org). However, its use may be permitted in athletes who are granted a therapeutic use exemption (TUE). [...]info:eu-repo/semantics/publishedVersio

β2-adrenergic agonists and doping: Where do we stand?

Hostrup et al1 kindly commented on our previous paper related to the enhancement of physical performance by β2-agonists.2 First, we would like to thank the authors for their review and acknowledge that our title and conclusions may have been misleading because, in fact, they only refer to endurance/aerobic-dominated performances [...]info:eu-repo/semantics/publishedVersio

Germline MUTYH (MYH) mutations in Portuguese individuals with multiple colorectal adenomas

Germinal mutations in the base excision repair (BER) gene MUTYH (MYH) have recently been described in association with predisposition to multiple colorectal adenomas and cancer. In contrast to the classic dominant condition of familial adenomatous polyposis (FAP) due to germinal mutations in the APC gene, the MYH polyposis is an autosomal recessive disease. The identification of individuals affected by MYH polyposis brings new and important implications for the diagnostic, screening, genetic counseling, follow up and therapeutic options in these patients. In this study, screening for germinal mutations in the MYH gene was performed in 53 Portuguese individuals with multiple colorectal adenomas or classic adenomatous polyposis, in whom no mutation had been identified in the APC gene. The results revealed the presence of biallelic germline MYH mutations in 21 patients. In addition, we here report 3 mutations (c.340T>C [p.Y114H]; c.503G>A [p.R168H]; and c.1186_1187insGG [p.E396fsX437]) which, to our knowledge, have not been previously describe

Genetic structure of sigmodontine rodents (Cricetidae) along an altitudinal gradient of the Atlantic Rain Forest in southern Brazil

The population genetic structure of two sympatric species of sigmodontine rodents (Oligoryzomys nigripes and Euryoryzomys russatus) was examined for mitochondrial DNA (mtDNA) sequence haplotypes of the control region. Samples were taken from three localities in the Atlantic Rain Forest in southern Brazil, along an altitudinal gradient with different types of habitat. In both species there was no genetic structure throughout their distribution, although levels of genetic variability and gene flow were high

Exposição a aditivos e contaminantes alimentares em Portugal: Avaliação de risco e dicas de mitigação

O projeto FOCACCia, desenvolvido no período de 2018-2021, avaliou na população portuguesa a exposição a aditivos alimentares e contaminantes resultantes do processamento dos alimentos e dos materiais que entram em contacto com os alimentos. Neste âmbito, a pensar no consumidor e em todos os profissionais de saúde, foram construídos dois manuais (um folheto e um e-book) que ficam agora disponíveis para consulta. No e-book encontra-se sumariada a informação obtida da literatura bem como os resultados originais do projeto FOCACCia, estimando a exposição e as principais fontes de aditivos alimentares (edulcorantes e outros aditivos), de contaminantes do processamento dos alimentos (acrilamida, aminas heterocíclicas e hidrocarbonetos aromáticos policíclicos) e de contaminantes derivados da embalagem e de outros materiais que entram em contacto com os alimentos (bisfenol A e ftalatos). No manual são apresentados resultados da avaliação do risco para a saúde da população portuguesa associado à exposição a edulcorantes, aminas heterocíclicas, acrilamida, hidrocarbonetos aromáticos policíclicos e bisfenol A. Por fim, o e-book inclui um capítulo final onde se apresentam alguns resultados relacionados com a associação entre a exposição a padrões alimentares com mais aditivos e contaminantes e aspetos de saúde cardiometabólica e cognitiva. No folheto, de uma forma mais visual, encontram-se os principais resultados deste projeto, assim como mensagens práticas para serem utilizadas no dia a dia pelos consumidores

Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE

Measurement of the t t-bar production cross section in the dilepton channel in pp collisions at sqrt(s) = 7 TeV

The t t-bar production cross section (sigma[t t-bar]) is measured in proton-proton collisions at sqrt(s) = 7 TeV in data collected by the CMS experiment, corresponding to an integrated luminosity of 2.3 inverse femtobarns. The measurement is performed in events with two leptons (electrons or muons) in the final state, at least two jets identified as jets originating from b quarks, and the presence of an imbalance in transverse momentum. The measured value of sigma[t t-bar] for a top-quark mass of 172.5 GeV is 161.9 +/- 2.5 (stat.) +5.1/-5.0 (syst.) +/- 3.6(lumi.) pb, consistent with the prediction of the standard model.Comment: Replaced with published version. Included journal reference and DO

Combined search for the quarks of a sequential fourth generation

Results are presented from a search for a fourth generation of quarks produced singly or in pairs in a data set corresponding to an integrated luminosity of 5 inverse femtobarns recorded by the CMS experiment at the LHC in 2011. A novel strategy has been developed for a combined search for quarks of the up and down type in decay channels with at least one isolated muon or electron. Limits on the mass of the fourth-generation quarks and the relevant Cabibbo-Kobayashi-Maskawa matrix elements are derived in the context of a simple extension of the standard model with a sequential fourth generation of fermions. The existence of mass-degenerate fourth-generation quarks with masses below 685 GeV is excluded at 95% confidence level for minimal off-diagonal mixing between the third- and the fourth-generation quarks. With a mass difference of 25 GeV between the quark masses, the obtained limit on the masses of the fourth-generation quarks shifts by about +/- 20 GeV. These results significantly reduce the allowed parameter space for a fourth generation of fermions.Comment: Replaced with published version. Added journal reference and DO