22 research outputs found
Supplier Integration and Communication Strategies in Collaborative Platform Development
Associations of autozygosity with a broad range of human phenotypes
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (F-ROH) for >1.4 million individuals, we show that F-ROH is significantly associated (p <0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: F-ROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of F-ROH are confirmed within full-sibling pairs, where the variation in F-ROH is independent of all environmental confounding.Peer reviewe
Propofol and halothane versus sevoflurane in paediatric day-case surgery: induction and recovery characteristics†
Cervical cytology screening in a sexually transmitted diseases clinic for the first time in Sri Lanka.
The distribution over time of costs and social net benefits for pertussis immunization programs
Pertussis immunization, Cost analysis of pertussis vaccination program, Total cost and total social net benefit over time, Acellular and whole-cell pertussis vaccines, Transfer function ARIMA model, C22, I12, I18,