747 research outputs found
Dark energy, non-minimal couplings and the origin of cosmic magnetic fields
In this work we consider the most general electromagnetic theory in curved
space-time leading to linear second order differential equations, including
non-minimal couplings to the space-time curvature. We assume the presence of a
temporal electromagnetic background whose energy density plays the role of dark
energy, as has been recently suggested. Imposing the consistency of the theory
in the weak-field limit, we show that it reduces to standard electromagnetism
in the presence of an effective electromagnetic current which is generated by
the momentum density of the matter/energy distribution, even for neutral
sources. This implies that in the presence of dark energy, the motion of
large-scale structures generates magnetic fields. Estimates of the present
amplitude of the generated seed fields for typical spiral galaxies could reach
G without any amplification. In the case of compact rotating objects,
the theory predicts their magnetic moments to be related to their angular
momenta in the way suggested by the so called Schuster-Blackett conjecture.Comment: 5 pages, no figure
A Class of Effective Field Theory Models of Cosmic Acceleration
We explore a class of effective field theory models of cosmic acceleration
involving a metric and a single scalar field. These models can be obtained by
starting with a set of ultralight pseudo-Nambu-Goldstone bosons whose couplings
to matter satisfy the weak equivalence principle, assuming that one boson is
lighter than all the others, and integrating out the heavier fields. The result
is a quintessence model with matter coupling, together with a series of
correction terms in the action in a covariant derivative expansion, with
specific scalings for the coefficients. After eliminating higher derivative
terms and exploiting the field redefinition freedom, we show that the resulting
theory contains nine independent free functions of the scalar field when
truncated at four derivatives. This is in contrast to the four free functions
found in similar theories of single-field inflation, where matter is not
present. We discuss several different representations of the theory that can be
obtained using the field redefinition freedom. For perturbations to the
quintessence field today on subhorizon lengthscales larger than the Compton
wavelength of the heavy fields, the theory is weakly coupled and natural in the
sense of t'Hooft. The theory admits a regime where the perturbations become
modestly nonlinear, but very strong nonlinearities lie outside its domain of
validity.Comment: 43 pages, 2 figures; Version 3 publication versio
Rules, Standards, and the Internal Point of View
Large scale structure and cosmolog
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Epithelial-to-mesenchymal stem cell transition in a human organ: Lessons from Lichen Planopilaris
YesEpithelial-to-mesenchymal transition (EMT) is critical for embryonic development and wound healing, and occurs in fibrotic disease and carcinoma. Here, we show that EMT also occurs within the bulge, the epithelial stem cell (eSC) niche of human scalp hair follicles, during the inflammatory permanent alopecia, lichen planopilaris. We show that a molecular EMT signature can be experimentally induced in healthy human eSCs in situ by antagonizing E-cadherin, combined with transforming growth factor-ÎČ1, epidermal growth factor, and IFN-Îł administration, which to our knowledge has not been reported previously. Moreover, induction of EMT within primary human eSCs can be prevented and even partially reversed ex vivo by peroxisome proliferatorâactivated receptor-Îł agonists, likely through suppression of the transforming growth factor-ÎČ signaling pathway. Furthermore, we show that peroxisome proliferatorâactivated receptor-Îł agonists also attenuates the EMT signature even in lesional lichen planopilaris hair follicles ex vivo. We introduce lichen planopilaris as a model disease for pathological EMT in human adult eSCs, report a preclinical assay for therapeutically manipulating eSC EMT within a healthy human (mini-)organ, and show that peroxisome proliferatorâactivated receptor-Îł agonists are promising agents for suppressing and partially reversing EMT in human hair follicles eSCs ex vivo, including in lichen planopilaris
Interactions Between Marine Megafauna and Plastic Pollution in Southeast Asia
Southeast (SE) Asia is a highly biodiverse region, yet it is also estimated to cumulatively contribute a third of the total global marine plastic pollution. This threat is known to have adverse impacts on marine megafauna, however, understanding of its impacts has recently been highlighted as a priority for research in the region. To address this knowledge gap, a structured literature review was conducted for species of cartilaginous fishes, marine mammals, marine reptiles, and seabirds present in SE Asia, collating cases on a global scale to allow for comparison, coupled with a regional expert elicitation to gather additional published and grey literature cases which would have been omitted during the structured literature review. Of the 380 marine megafauna species present in SE Asia, but also studied elsewhere, we found that 9.1 % and 4.5 % of all publications documenting plastic entanglement (n = 55) and ingestion (n = 291) were conducted in SE Asian countries. At the species level, published cases of entanglement from SE Asian countries were available for 10 % or less of species within each taxonomic group. Additionally, published ingestion cases were available primarily for marine mammals and were lacking entirely for seabirds in the region. The regional expert elicitation led to entanglement and ingestion cases from SE Asian countries being documented in 10 and 15 additional species respectively, highlighting the utility of a broader approach to data synthesis. While the scale of the plastic pollution in SE Asia is of particular concern for marine ecosystems, knowledge of its interactions and impacts on marine megafauna lags behind other areas of the world, even after the inclusion of a regional expert elicitation. Additional funding to help collate baseline data are critically needed to inform policy and solutions towards limiting the interactions of marine megafauna and plastic pollution in SE Asia
Improved constraints on the expansion rate of the Universe up to z~1.1 from the spectroscopic evolution of cosmic chronometers
We present new improved constraints on the Hubble parameter H(z) in the
redshift range 0.15 < z < 1.1, obtained from the differential spectroscopic
evolution of early-type galaxies as a function of redshift. We extract a large
sample of early-type galaxies (\sim11000) from several spectroscopic surveys,
spanning almost 8 billion years of cosmic lookback time (0.15 < z < 1.42). We
select the most massive, red elliptical galaxies, passively evolving and
without signature of ongoing star formation. Those galaxies can be used as
standard cosmic chronometers, as firstly proposed by Jimenez & Loeb (2002),
whose differential age evolution as a function of cosmic time directly probes
H(z). We analyze the 4000 {\AA} break (D4000) as a function of redshift, use
stellar population synthesis models to theoretically calibrate the dependence
of the differential age evolution on the differential D4000, and estimate the
Hubble parameter taking into account both statistical and systematical errors.
We provide 8 new measurements of H(z) (see Tab. 4), and determine its change in
H(z) to a precision of 5-12% mapping homogeneously the redshift range up to z
\sim 1.1; for the first time, we place a constraint on H(z) at z \neq 0 with a
precision comparable with the one achieved for the Hubble constant (about 5-6%
at z \sim 0.2), and covered a redshift range (0.5 < z < 0.8) which is crucial
to distinguish many different quintessence cosmologies. These measurements have
been tested to best match a \Lambda CDM model, clearly providing a
statistically robust indication that the Universe is undergoing an accelerated
expansion. This method shows the potentiality to open a new avenue in constrain
a variety of alternative cosmologies, especially when future surveys (e.g.
Euclid) will open the possibility to extend it up to z \sim 2.Comment: 34 pages, 15 figures, 6 tables, published in JCAP. It is a companion
to Moresco et al. (2012b, http://arxiv.org/abs/1201.6658) and Jimenez et al.
(2012, http://arxiv.org/abs/1201.3608). The H(z) data can be downloaded at
http://www.physics-astronomy.unibo.it/en/research/areas/astrophysics/cosmology-with-cosmic-chronometer
Evolution of metabolic risk factors over a two-year period in a cohort of first episodes of psychosis
Patients with a first episode of psychosis (FEP) display a broad range of metabolic risk factors related to the development of diverse medical comorbidities. Initial stages of these disorders are essential in understanding the increased vulnerability of developing cardiometabolic disturbances, associated with a reduced life expectancy. This study aimed to evaluate the metabolic profile of a cohort of patients with a FEP and its evolution during a two year follow-up, as well as the factors that influence the changes in their metabolic status. 16 participating centers from the PEPs Project recruited 335 subjects with a FEP and 253 matched healthy controls, aged 9â35 years. We investigated a set of anthropometric measures, vital signs and laboratory data obtained from each participant over two years in a prospective, naturalistic study. From the beginning of the study the FEP group showed differences in the metabolic profile compared to the control group, together with a progressive worsening in the major part of the analyzed variables during the follow-up period, with higher rates of obesity and metabolic syndrome. Certain risk factors were related to determinate clinical variables such as male gender, the presence of affective symptoms or an early onset or to treatment variables such as the use of antipsychotic polypharmacy, antidepressants or mood stabilizers. Our results highlight the extremely high risk of patients at early phases of schizophrenia and other psychotic disorders of developing cardiovascular comorbidity and the fast worsening of the metabolic profile during the first two years
Electroexcitation of the at low momentum transfer
We report on new p measurements at the
resonance at the low momentum transfer region. The mesonic
cloud dynamics is predicted to be dominant and rapidly changing in this
kinematic region offering a test bed for chiral effective field theory
calculations. The new data explore the low dependence of the resonant
quadrupole amplitudes while extending the measurements of the Coulomb
quadrupole amplitude to the lowest momentum transfer ever reached. The results
disagree with predictions of constituent quark models and are in reasonable
agreement with dynamical calculations that include pion cloud effects, chiral
effective field theory and lattice calculations. The reported measurements
suggest that improvement is required to the theoretical calculations and
provide valuable input that will allow their refinements
Light propagation in statistically homogeneous and isotropic universes with general matter content
We derive the relationship of the redshift and the angular diameter distance
to the average expansion rate for universes which are statistically homogeneous
and isotropic and where the distribution evolves slowly, but which have
otherwise arbitrary geometry and matter content. The relevant average expansion
rate is selected by the observable redshift and the assumed symmetry properties
of the spacetime. We show why light deflection and shear remain small. We write
down the evolution equations for the average expansion rate and discuss the
validity of the dust approximation.Comment: 42 pages, no figures. v2: Corrected one detail about the angular
diameter distance and two typos. No change in result
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