170 research outputs found
Semiclassical evaluation of average nuclear one and two body matrix elements
Thomas-Fermi theory is developed to evaluate nuclear matrix elements averaged
on the energy shell, on the basis of independent particle Hamiltonians. One-
and two-body matrix elements are compared with the quantal results and it is
demonstrated that the semiclassical matrix elements, as function of energy,
well pass through the average of the scattered quantum values. For the one-body
matrix elements it is shown how the Thomas-Fermi approach can be projected on
good parity and also on good angular momentum. For the two-body case the
pairing matrix elements are considered explicitly.Comment: 15 pages, REVTeX, 6 ps figures; changed conten
Hadron-nucleon Total Cross Section Fluctuations from Hadron-nucleus Total Cross Sections
The extent to which information about fluctuations in hadron-nucleon total
cross sections in the frozen approximation can be extracted from very high
energy hadron-nucleus total cross section measurements for a range of heavy
nuclei is discussed. The corrections to the predictions of Glauber theory due
to these fluctuations are calculated for several models for the distribution
functions, and differences of the order of 50 mb are found for heavy nuclei.
The generating function for the moments of the hadron-nucleon cross section
distributions can be approximately determined from the derivatives of the
hadron-nucleus total cross sections with respect to the nuclear geometric cross
section. The argument of the generating function, however, it limited to the
maximum value of a dimensionless thickness function obtained at zero impact
parameter for the heaviest nuclear targets: about 1.8 for pions and 3.0 for
nucleons.Comment: 14 pages, revtex 3.0, 4 figures available upon reques
Triple-Pomeron Matrix Model for Dispersive Corrections to Nucleon-Nucleus Total Cross Section
Dispersive corrections to the total cross section for high-energy scattering
from a heavy nucleus are calculated using a matrix model, based on the
triple-Pomeron behavior of diffractive scattering from a single nucleon, for
the cross section operator connecting different states of the projectile
nucleon . Energy-dependent effects due to the decrease in longitudinal momentum
transfers and the opening of more channels with increasing energy are included.
The three leading terms in an expansion in the number of inelastic transitions
are evaluated and compared to exact results for the model in the uniform
nuclear density approximation for the the scattering of nucleons from Pb^{208}
for laboratory momenta ranging from 50 to 200 GeV/c.Comment: 16 pages, 2 figures, RevTex
Experimental and Theoretical Challenges in the Search for the Quark Gluon Plasma: The STAR Collaboration's Critical Assessment of the Evidence from RHIC Collisions
We review the most important experimental results from the first three years
of nucleus-nucleus collision studies at RHIC, with emphasis on results from the
STAR experiment, and we assess their interpretation and comparison to theory.
The theory-experiment comparison suggests that central Au+Au collisions at RHIC
produce dense, rapidly thermalizing matter characterized by: (1) initial energy
densities above the critical values predicted by lattice QCD for establishment
of a Quark-Gluon Plasma (QGP); (2) nearly ideal fluid flow, marked by
constituent interactions of very short mean free path, established most
probably at a stage preceding hadron formation; and (3) opacity to jets. Many
of the observations are consistent with models incorporating QGP formation in
the early collision stages, and have not found ready explanation in a hadronic
framework. However, the measurements themselves do not yet establish
unequivocal evidence for a transition to this new form of matter. The
theoretical treatment of the collision evolution, despite impressive successes,
invokes a suite of distinct models, degrees of freedom and assumptions of as
yet unknown quantitative consequence. We pose a set of important open
questions, and suggest additional measurements, at least some of which should
be addressed in order to establish a compelling basis to conclude definitively
that thermalized, deconfined quark-gluon matter has been produced at RHIC.Comment: 101 pages, 37 figures; revised version to Nucl. Phys.
Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis
Bacterial Cyclic Diguanylate Signaling Networks Sense Temperature
Many bacteria use the second messenger cyclic diguanylate (c-di-GMP) to control motility, biofilm production and virulence. Here, we identify a thermosensory diguanylate cyclase (TdcA) that modulates temperature-dependent motility, biofilm development and virulence in the opportunistic pathogen Pseudomonas aeruginosa. TdcA synthesizes c-di-GMP with catalytic rates that increase more than a hundred-fold over a ten-degree Celsius change. Analyses using protein chimeras indicate that heat-sensing is mediated by a thermosensitive Per-Arnt-SIM (PAS) domain. TdcA homologs are widespread in sequence databases, and a distantly related, heterologously expressed homolog from the Betaproteobacteria order Gallionellales also displayed thermosensitive diguanylate cyclase activity. We propose, therefore, that thermotransduction is a conserved function of c-di-GMP signaling networks, and that thermosensitive catalysis of a second messenger constitutes a mechanism for thermal sensing in bacteria
Identification of regulatory variants associated with genetic susceptibility to meningococcal disease
Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely
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