The Geoff Egan Memorial Lecture 2011. Artefacts, art and artifice: reconsidering iconographic sources for archaeological objects in early modern Europe

A first systematic analysis of historic domestic material culture depicted in contemporaneous Western painting and prints, c.1400-1800. Drawing on an extensive data set, the paper proposes to methodologies and hermeneutics for historical analysis and archaeological correspondence

Microarray analyses demonstrate the involvement of type i interferons in psoriasiform pathology development in D6-deficient mice

The inflammatory response is normally limited by mechanisms regulating its resolution. In the absence of resolution, inflammatory pathologies can emerge, resulting in substantial morbidity and mortality. We have been studying the D6 chemokine scavenging receptor, which played an indispensable role in the resolution phase of inflammatory responses and does so by facilitating removal of inflammatory CC chemokines. In D6-deficient mice, otherwise innocuous cutaneous inflammatory stimuli induce a grossly exaggerated inflammatory response that bears many similarities to human psoriasis. In the present study, we have used transcriptomic approaches to define the molecular make up of this response. The data presented highlight potential roles for a number of cytokines in initiating and maintaining the psoriasis-like pathology. Most compellingly, we provide data indicating a key role for the type I interferon pathway in the emergence of this pathology. Neutralizing antibodies to type I interferons are able to ameliorate the psoriasis-like pathology, confirming a role in its development. Comparison of transcriptional data generated from this mouse model with equivalent data obtained from human psoriasis further demonstrates the strong similarities between the experimental and clinical systems. As such, the transcriptional data obtained in this preclinical model provide insights into the cytokine network active in exaggerated inflammatory responses and offer an excellent tool to evaluate the efficacy of compounds designed to therapeutically interfere with inflammatory processes

An RNA-Seq Strategy to Detect the Complete Coding and Non-Coding Transcriptome Including Full-Length Imprinted Macro ncRNAs

Imprinted macro non-protein-coding (nc) RNAs are cis-repressor transcripts that silence multiple genes in at least three imprinted gene clusters in the mouse genome. Similar macro or long ncRNAs are abundant in the mammalian genome. Here we present the full coding and non-coding transcriptome of two mouse tissues: differentiated ES cells and fetal head using an optimized RNA-Seq strategy. The data produced is highly reproducible in different sequencing locations and is able to detect the full length of imprinted macro ncRNAs such as Airn and Kcnq1ot1, whose length ranges between 80–118 kb. Transcripts show a more uniform read coverage when RNA is fragmented with RNA hydrolysis compared with cDNA fragmentation by shearing. Irrespective of the fragmentation method, all coding and non-coding transcripts longer than 8 kb show a gradual loss of sequencing tags towards the 3′ end. Comparisons to published RNA-Seq datasets show that the strategy presented here is more efficient in detecting known functional imprinted macro ncRNAs and also indicate that standardization of RNA preparation protocols would increase the comparability of the transcriptome between different RNA-Seq datasets

Estimation of the XUV radiation onto close planets and their evaporation

Context: The current distribution of planet mass vs. incident stellar X-ray flux supports the idea that photoevaporation of the atmosphere may take place in close-in planets. Integrated effects have to be accounted for. A proper calculation of the mass loss rate due to photoevaporation requires to estimate the total irradiation from the whole XUV range. Aims: The purpose of this paper is to extend the analysis of the photoevaporation in planetary atmospheres from the accessible X-rays to the mostly unobserved EUV range by using the coronal models of stars to calculate the EUV contribution to the stellar spectra. The mass evolution of planets can be traced assuming that thermal losses dominate the mass loss of their atmospheres. Methods: We determine coronal models for 82 stars with exoplanets that have X-ray observations available. Then a synthetic spectrum is produced for the whole XUV range (~1-912 {\AA}). The determination of the EUV stellar flux, calibrated with real EUV data, allows us to calculate the accumulated effects of the XUV irradiation on the planet atmosphere with time, as well as the mass evolution for planets with known density. Results: We calibrate for the first time a relation of the EUV luminosity with stellar age valid for late-type stars. In a sample of 109 exoplanets, few planets with masses larger than ~1.5 Mj receive high XUV flux, suggesting that intense photoevaporation takes place in a short period of time, as previously found in X-rays. The scenario is also consistent with the observed distribution of planet masses with density. The accumulated effects of photoevaporation over time indicate that HD 209458b may have lost 0.2 Mj since an age of 20 Myr. Conclusions: Coronal radiation produces rapid photoevaporation of the atmospheres of planets close to young late-type stars. More complex models are needed to explain fully the observations.Comment: Accepted by A&A. 10 pages, 8 figures, 7 Tables (2 online). Additional online material includes 7 pages, 6 figures and 6 tables, all include

Non-parametric modeling of the intra-cluster gas using APEX-SZ bolometer imaging data

We demonstrate the usability of mm-wavelength imaging data obtained from the APEX-SZ bolometer array to derive the radial temperature profile of the hot intra-cluster gas out to radius r_500 and beyond. The goal is to study the physical properties of the intra-cluster gas by using a non-parametric de-projection method that is, aside from the assumption of spherical symmetry, free from modeling bias. We use publicly available X-ray imaging data from the XMM-Newton observatory and our Sunyaev-Zel'dovich Effect (SZE) imaging data from the APEX-SZ experiment at 150 GHz to de-project the density and temperature profiles for the relaxed cluster Abell 2204. We derive the gas density, temperature and entropy profiles assuming spherical symmetry, and obtain the total mass profile under the assumption of hydrostatic equilibrium. For comparison with X-ray spectroscopic temperature models, a re-analysis of the recent Chandra observation is done with the latest calibration updates. Using the non-parametric modeling we demonstrate a decrease of gas temperature in the cluster outskirts, and also measure the gas entropy profile. These results are obtained for the first time independently of X-ray spectroscopy, using SZE and X-ray imaging data. The contribution of the SZE systematic uncertainties in measuring T_e at large radii is shown to be small compared to the Chandra systematic spectroscopic errors. The upper limit on M_200 derived from the non-parametric method is consistent with the NFW model prediction from weak lensing analysis.Comment: Replaced with the published version; A&A 519, A29 (2010

Mass-loss rates for transiting exoplanets

Exoplanets at small orbital distances from their host stars are submitted to intense levels of energetic radiations, X-rays and extreme ultraviolet (EUV). Depending on the masses and densities of the planets and on the atmospheric heating efficiencies, the stellar energetic inputs can lead to atmospheric mass loss. These evaporation processes are observable in the ultraviolet during planetary transits. The aim of the present work is to quantify the mass-loss rates (dm/dt), heating efficiencies (eta), and lifetimes for the whole sample of transiting exoplanets, now including hot jupiters, hot neptunes, and hot super-earths. The mass-loss rates and lifetimes are estimated from an "energy diagram" for exoplanets, which compares the planet gravitational potential energy to the stellar X/EUV energy deposited in the atmosphere. We estimate the mass-loss rates of all detected transiting planets to be within 10^6 to 10^13 g/s for various conservative assumptions. High heating efficiencies would imply that hot exoplanets such the gas giants WASP-12b and WASP-17b could be completely evaporated within 1 Gyr. We further show that the heating efficiency can be constrained when dm/dt is inferred from observations and the stellar X/EUV luminosity is known. This leads us to suggest that eta ~ 100% in the atmosphere of the hot jupiter HD209458b, while it could be lower for HD189733b. Simultaneous observations of transits in the ultraviolet and X-rays are necessary to further constrain the exospheric properties of exoplanets.Comment: 10 pages, 5 figures, 2 tables. Accepted for publication in Astronomy & Astrophysic