Calibration and accuracy determination of airdata system for a modern fighter

An Air data system (ADS) is an essential avionics module found in modern fighter aircraft cockpits. It provides critical information about the aircraft to the pilot throughout the flight regime. Airdata system comprises of air data computer and their associated sensors. Sensors instrumented on aircraft normally measure pressures and flow angles in the local flow field using vanes and probes. However, aircraft requires the free stream parameters for flying. Therefore, forward lookup tables in Air Data Computer (ADC) are used to covert local parameters measured using airdata sensor to free stream parameters. In order to design flight controls, improved system performance, ADS should deliver accurate output. Accuracy of free stream parameters depends upon the accuracy of these tables in Air data computer. In this paper, the airdata system of a modern fighter aircraft is considered. This system carries airdata tables which are calibrated/updated using Maximum Likelihood Estimation (MLE) method. The accuracy of it needs to be determined by another independent technique. Hence an Extended Kalman Filter (EKF) is proposed to calibrate and describe the accuracy limits of airdata system. The technique is tested with flight data and the results demonstrate the strength of the technique for airdata calibration and accuracy determination

Teledentistry: A Boon in Indian Scenario

An amalgamation of telecommunication and dentistry is known as ‘Teledentistry’, which involves switch over the clinical information in remote areas for diagnosis, consultation, health education and treatment planning. The accessibility of dental care at low cost by all people has ton increased by teledentistry. It also has an immense perspective to overcome the disparities in oral healthcare between rural and urban population. Thus the aim behind to review this article is to establish the essential role of Teledentistry in Indian Scenari. The literature for this review obtained from published articles, online manuals and books

Correlation of Ultra High Energy Cosmic Rays with Compact Radio Loud Quasars

Angular correlations of ultra-high energy cosmic rays with cosmologically distant sources may provide clues to these mysterious events. We compare cosmic ray tracks with energies above $10^{20}eV$ to a compilation of radio-loud compact QSO positions. The statistical method emphasizes invariant quantities and a test of {\it statistical independence} of track and source distributions. Statistical independence is ruled out by several independent statistics at confidence levels of less that $10^{-3}$ ($99.9$.), indicating that track directions and QSO source positions are correlated at a highly significant level.Comment: 12 pages, 2 figure

Protein Profile of Human Lung Epithelial Cells (A549) Revealing Deviation in Cytoskeleton Proteins in Response to Zinc Oxide Nanoparticles Exposure

Zinc oxide nanoparticles (ZnO NPs) are widely used in biomedicine and scientific research because of their high dissolution property and bioavailability. On the contrary, this property also increases the intracellular reactivity, accessibility and cytotoxicity. These nano-bio interactions could induce undesirable changes in the proteome of the interacting cells, especially in the lung cells as these are the primary contact site. However, the potential effects of ZnO NPs exposure on proteome remain unclear. Proteomics data will substantiate the detailed mechanism of cellular interactions and modulatory effects of ZnO NPs on cells. Quantitative proteomic profiling was done using MALDI-TOF/TOF and MS/MS to identify differential protein expression on exposure to NPs among non exposed and exposed cells. Twenty-two proteins, with approximately 1.5 fold differential expression in cells exposed to ZnO NPs as compared to control cells were identified. Differentially expressed proteins were further classified using PANTHER software on the basis of functional gene ontology term: molecular function, biological process and cellular component. ToppGene suite was used to study protein-protein interaction and network was enriched with STRING. This study is a systematic analysis of protein modulation of the A549 cells exposed to ZnO NPs indicating alterations in the cytoskeleton

Early prognosis prediction in acute myeloid and acute lymphoid leukemia patients using cell-free DNA concentration ratios

Background: Cell-free DNA (cfDNA) is a promising biomarker for disease prediction in many cancers, including acute leukemia (acute myeloid leukemia [AML] and acute lymphoblastic leukemia [ALL]). This study investigated the role of cfDNA in predicting relapse or unfavorable outcomes in acute leukemia patients upon initial diagnosis.Methods: Paired peripheral blood samples of 25 patients with ALL and AML were compared at baseline and induction/follow-up and clinically correlated with clinicopathological and outcome variables according to the risk category. cfDNA was isolated using commercial cfDNA extraction kits. The probability of poor outcomes in high-risk groups and a cut-off value for risk stratification minimal residual disease (MRD) positivity and outcome prediction were derived.Results: Twenty-five patients diagnosed with AML and ALL were risk-stratified based on NCI risk stratification, and of these 25 patients, 4 patients were of standard risk (SR) and 1 patient was of intermediate risk (IR), while a majority of patients (80%) were of high risk (HR). Of these, four HR patients passed away. The ratio of cfDNA reduction at baseline and the end of induction was a strong predictor of poor outcomes in high-risk patients, regardless of the MRD status. A cfDNA ratio score of 2.6 or higher at diagnosis/remission predicted poor outcomes, with higher accuracy than conventional MRD detection by flow cytometry.Conclusion: A higher cfDNA ratio at diagnosis/remission or at baseline predicts poor outcomes in acute leukemia patients. This pilot study suggests that cfDNA ratio scoring may be a useful tool for predicting prognosis in acute leukemia patients, regardless of the MRD status

Interobserver agreement of estimating the extent of intestinal metaplasia in patients with chronic atrophic gastritis

The extent of gastric intestinal metaplasia (GIM) can be used to determine the risk of gastric cancer. Eleven international gastrointestinal expert pathologists estimated the extent of GIM on haematoxylin and eosin (H&E)- and Alcian blue-Periodic acid Schiff (AB-PAS)-stained slides of 46 antrum biopsies in 5% increments. Interobserver agreement was tested with the intraclass correlation coefficient (ICC). Correlation between standard deviation and extent of GIM was evaluated with the Spearman correlation. The interobserver agreement was very good (ICC = 0.983, 95% confidence interval (CI) 0.975–0.990). The use of AB-PAS did not increase the agreement (ICC = 0.975, 95% CI 0.961–0.985). Cases with a higher amount of metaplastic epithelium demonstrated a higher standard deviation (rs = 0.644; p < 0.01), suggesting lower diagnostic accuracy in cases with extensive GIM. In conclusion, estimating the extent of GIM on H&E-stained slides in patients with chronic atrophic gastritis can be achieved satisfactorily with high interobserver agreement, at least among international expert gastrointestinal pathologists.Open access funding provided by Medical University of Graz.https://www.springer.com/journal/428am2023Anatomical Patholog

Synthetic and mass spectral fragmentation studies on trisubstituted 2H-pyran- 2-ones and comparative EIMS behaviour of biologically active 3,5- disubstituted pyrazoles and isoxazoles

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Junction profiles of sub keV ion implantation for deep sub-quarter micron devices

Junction profiles of sub keV ion implantation for deep sub-quarter micron device

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI