Desaturation after remifentanil-propofol induced apnea

No Abstract. Southern African Journal of Anaesthesia and Analgesia Vol. 12(1) 2006: 4

Constraints on the Phase Plane of the Dark Energy Equation of State

Classification of dark energy models in the plane of w and w', where w is the dark energy equation of state and w' its time-derivative in units of the Hubble time, has been studied in the literature. We take the current SN Ia, CMB and BAO data, invoke a widely used parametrization of the dark energy equation of state, and obtain the constraints on the w -w' plane. We find that dark energy models including the cosmological constant, phantom, non-phantom barotropic fluids, and monotonic up-rolling quintessence are ruled out at the 68.3% confidence level based on the current observational data. Down-rolling quintessence, including the thawing and the freezing models, is consistent with the current observations. All the above-mentioned models are still consistent with the data at the 95.4% confidence level.Comment: 14 pages, 5 figures, "Test of the method" added in Sec. 4 in v

Can the quintessence be a complex scalar field?

In light of the recent observations of type Ia supernovae suggesting an accelerating expansion of the Universe, we wish in this paper to point out the possibility of using a complex scalar field as the quintessence to account for the acceleration. In particular, we extend the idea of Huterer and Turner in deriving the reconstruction equations for the complex quintessence, showing the feasibility of making use of a complex scalar field (instead of a real scalar field) while maintaining the uniqueness feature of the reconstruction for two possible situations, respectively. We discuss very briefly how future observations may help to distinguish the different quintessence scenarios, including the scenario with a positive cosmological constant.Comment: 9 pages, LaTeX, final versio

Teleparallel Dark Energy with Purely Non-minimal Coupling to Gravity

We propose the simplest model of teleparallel dark energy with purely a non-minimal coupling to gravity but no self-potential, a single model possessing various interesting features: simplicity, self-potential-free, the guaranteed late-time cosmic acceleration driven by the non-minimal coupling to gravity, tracker behavior of the dark energy equation of state at earlier times, a crossing of the phantom divide at a late time, and the existence of a finite-time future singularity. We find the analytic solutions of the dark-energy scalar field respectively in the radiation, matter, and dark energy dominated eras, thereby revealing the above features. We further illustrate possible cosmic evolution patterns and present the observational constraint of this model obtained by numerical analysis and data fitting.Comment: 12 pages, 3 figures, Title changed, Revised Version Accepted for publication in Phys. Lett.

Reflexive learning, socio-cognitive conflict and peer-assessment to improve the quality of feedbacks in online tests

International audienceOur previous works have introduced the Tsaap-notes platform dedicated to the semi automatic generation of multiple choice questionnaire providing feedbacks: it reuses interactive questions asked by teachers during lectures, as well as the notes taken by students after the presentation of the results as feedbacks integrated into the quizzes. In this paper, we introduce a new feature which aims at increasing the number of contributions of students in order to significantly improve the quality of the feedbacks used in the resulting quizzes. This feature splits the submission of an answer into several distinct phases to harvest explanations given by students, and then applies an algorithm to filter the best contributions to be integrated as feedbacks in the tests. Our approach has been validated by a first experimentation involving master students enrolled in a computer science course

High-throughput genomic technology in research and clinical management of breast cancer. Plasma-based proteomics in early detection and therapy

Protein-based breast cancer biomarkers are a promising resource for breast cancer detection at the earliest and most treatable stages of the disease. Plasma is well suited to proteomic-based methods of biomarker discovery because it is easily obtained, is routinely used in the diagnosis of many diseases, and has a rich proteome. However, due to the vast dynamic range in protein concentration and the often uncertain tissue and cellular origin of plasma proteins, proteomic analysis of plasma requires special consideration compared with tissue and cultured cells. This review briefly touches on the search for plasma-based protein biomarkers for the early detection and treatment of breast cancer

Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases

Aims: Cells have developed quality control systems for protection against proteotoxicity. Misfolded and aggregation-prone proteins, which are behind the initiation and progression of many neurodegenerative diseases (ND), are known to challenge the proteostasis network of the cells. We aimed to explore the role of DNJ-27/ERdj5, an endoplasmic reticulum (ER)-resident thioredoxin protein required as a disulfide reductase for the degradation of misfolded proteins, in well-established Caenorhabditis elegans models of Alzheimer, Parkinson and Huntington diseases. Results: We demonstrate that DNJ-27 is an ER luminal protein and that its expression is induced upon ER stress via IRE-1/XBP-1. When dnj-27 expression is downregulated by RNA interference we find an increase in the aggregation and associated pathological phenotypes (paralysis and motility impairment) caused by human β-amyloid peptide (Aβ), α-synuclein (α-syn) and polyglutamine (polyQ) proteins. In turn, DNJ-27 overexpression ameliorates these deleterious phenotypes. Surprisingly, despite being an ER-resident protein, we show that dnj-27 downregulation alters cytoplasmic protein homeostasis and causes mitochondrial fragmentation. We further demonstrate that DNJ-27 overexpression substantially protects against the mitochondrial fragmentation caused by human Aβ and α-syn peptides in these worm models. Innovation: We identify C. elegans dnj-27 as a novel protective gene for the toxicity associated with the expression of human Aβ, α-syn and polyQ proteins, implying a protective role of ERdj5 in Alzheimer, Parkinson and Huntington diseases. Conclusion: Our data support a scenario where the levels of DNJ-27/ERdj5 in the ER impact cytoplasmic protein homeostasis and the integrity of the mitochondrial network which might underlie its protective effects in models of proteotoxicity associated to human ND

Awe and Wonder in Scientific Practice: Implications for the Relationship Between Science and Religion

This paper examines the role of awe and wonder in scientific practice. Drawing on evidence from psychological research and the writings of scientists and science communicators, I argue that awe and wonder play a crucial role in scientific discovery. They focus our attention on the natural world, encourage open-mindedness, diminish the self (particularly feelings of self-importance), help to accord value to the objects that are being studied, and provide a mode of understanding in the absence of full knowledge. I will flesh out implications of the role of awe and wonder in scientific discovery for debates on the relationship between science and religion. Abraham Heschel argued that awe and wonder are religious emotions because they reduce our feelings of self-importance, and thereby help to cultivate the proper reverent attitude towards God. Yet metaphysical naturalists such as Richard Dawkins insist that awe and wonder need not lead to any theistic commitments for scientists. The awe some scientists experience can be regarded as a form of non-theistic spirituality, which is neither a reductive naturalism nor theism. I will attempt to resolve the tension between these views by identifying some common ground

Problems with Time-Varying Extra Dimensions or "Cardassian Expansion" as Alternatives to Dark Energy

It has recently been proposed that the Universe might be accelerating as a consequence of extra dimensions with time varying size. We show that although these scenarios can lead to acceleration, they run into serious difficulty when taking into account limits on the time variation of the four dimensional Newton's constant. On the other hand, models of ``Cardassian'' expansion based on extra dimensions which have been constructed so far violate the weak energy condition for the bulk stress energy, for parameters that give an accelerating universe.Comment: 8 pages, minor changes. To appear in Physical Review

Tetraspanin (TSP-17) Protects Dopaminergic Neurons against 6-OHDA-Induced Neurodegeneration in <i>C. elegans</i>

Parkinson's disease (PD), the second most prevalent neurodegenerative disease after Alzheimer's disease, is linked to the gradual loss of dopaminergic neurons in the substantia nigra. Disease loci causing hereditary forms of PD are known, but most cases are attributable to a combination of genetic and environmental risk factors. Increased incidence of PD is associated with rural living and pesticide exposure, and dopaminergic neurodegeneration can be triggered by neurotoxins such as 6-hydroxydopamine (6-OHDA). In C. elegans, this drug is taken up by the presynaptic dopamine reuptake transporter (DAT-1) and causes selective death of the eight dopaminergic neurons of the adult hermaphrodite. Using a forward genetic approach to find genes that protect against 6-OHDA-mediated neurodegeneration, we identified tsp-17, which encodes a member of the tetraspanin family of membrane proteins. We show that TSP-17 is expressed in dopaminergic neurons and provide genetic, pharmacological and biochemical evidence that it inhibits DAT-1, thus leading to increased 6-OHDA uptake in tsp-17 loss-of-function mutants. TSP-17 also protects against toxicity conferred by excessive intracellular dopamine. We provide genetic and biochemical evidence that TSP-17 acts partly via the DOP-2 dopamine receptor to negatively regulate DAT-1. tsp-17 mutants also have subtle behavioral phenotypes, some of which are conferred by aberrant dopamine signaling. Incubating mutant worms in liquid medium leads to swimming-induced paralysis. In the L1 larval stage, this phenotype is linked to lethality and cannot be rescued by a dop-3 null mutant. In contrast, mild paralysis occurring in the L4 larval stage is suppressed by dop-3, suggesting defects in dopaminergic signaling. In summary, we show that TSP-17 protects against neurodegeneration and has a role in modulating behaviors linked to dopamine signaling