Use of recurrence quantification analysis to examine associations between changes in text structure across an expressive writing intervention and reductions in distress symptoms in women wth breast cancer

The current study presents an exploratory analysis of using Recurrence Quantification Analysis (RQA) to analyze text data from an Expressive Writing Intervention (EWI) for Danish women treated for Breast Cancer. The analyses are based on the analysis of essays from a subsample with the average age 54.6 years (SD = 9.0), who completed questionnaires for cancer-related distress (IES) and depression symptoms (BDI-SF). The results show a significant association between an increase in recurrent patterns of text structure from first to last writing session and a decrease in cancer-related distress at 3 months post-intervention. Furthermore, the change in structure from first to last essay displayed a moderate, but significant correlation with change in cancer-related distress from baseline to 9 months post-intervention. The results suggest that changes in recurrence patterns of text structure might be an indicator of cognitive restructuring that leads to amelioration of cancer-specific distress

Global temporal typing patterns in foreign language writing: Exploring language proficiency through recurrence quantification analysis (RQA)

Recurrence quantification analysis (RQA) is a time-series analysis method that uses autocorrelation properties of typing data to detect regularities within the writing process. The following paper first gives a detailed introduction to RQA and its application to time series data. We then apply RQA to keystroke logging data of first and foreign language writing to illustrate how outcome measures of RQA can be understood as skill-driven constraints on keyboard typing performance. Forty native German students performed two prompted writing assignments, one in German and one in English, a standardized copy task, and a standardized English placement test. We assumed more fluent and skilled writing to reveal more structured typing time series patterns. Accordingly, we expected writing in a well-mastered first language to coincide with higher values in relevant RQA measures as compared to writing in a foreign language. Results of mixed model ANOVAs confirmed our hypothesis. We further observed that RQA measures tend to be higher, thus indicating more structured data, whenever parameters of pause, burst, and revision analyses indicate more fluent writing. Multiple regression analyses revealed that, in addition to typing skills, language proficiency significantly predicts outcomes of RQA. Thus, the present data emphasize RQA being a valuable resource for studying time series data that yields meaningful information about the effort a writer must exert during text production

Zur physikalischen Musiklehre: Bemerkungen zu einigen Aufs�tzen des Herrn J. W�rschmidt

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On the Structure of Measurement Noise in Eye-Tracking

Past research has discovered fractal structure in eye movement variability and interpreted this result as having theoretical ramifications. No research has, however, investigated how properties of the eye-tracking instrument might affect the structure of measurement varia-bility. The current experiment employed fractal and multifractal methods to investigate whether an eye-tracker produced intrinsic random variation and how features of the data recording procedure affected the structure measurement variability. The results of this experiment revealed that the structure of variation from a fake eye was indeed random and uncorrelated in contrast to the fractal structure from a fixated, real human eye. Moreover, the results demonstrated that data-averaging generally changes the structure of variation, introducing spurious structure into eye movement variability

The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane.

Mitochondria are cellular organelles with crucial functions in the generation and distribution of ATP, the buffering of cytosolic Ca2+ and the initiation of apoptosis. Compounds that interfere with these functions are termed mitochondrial toxins, many of which are derived from microbes, such as antimycin A, oligomycin A, and ionomycin. Here, we identify the mycotoxin phomoxanthone A (PXA), derived from the endophytic fungus Phomopsis longicolla, as a mitochondrial toxin. We show that PXA elicits a strong release of Ca2+ from the mitochondria but not from the ER. In addition, PXA depolarises the mitochondria similarly to protonophoric uncouplers such as CCCP, yet unlike these, it does not increase but rather inhibits cellular respiration and electron transport chain activity. The respiration-dependent mitochondrial network structure rapidly collapses into fragments upon PXA treatment. Surprisingly, this fragmentation is independent from the canonical mitochondrial fission and fusion mediators DRP1 and OPA1, and exclusively affects the inner mitochondrial membrane, leading to cristae disruption, release of pro-apoptotic proteins, and apoptosis. Taken together, our results suggest that PXA is a mitochondrial toxin with a novel mode of action that might prove a useful tool for the study of mitochondrial ion homoeostasis and membrane dynamics

Prevention and treatment of renal osteodystrophy in children on chronic renal failure: European guidelines

Childhood renal osteodystrophy (ROD) is the consequence of disturbances of the calcium-regulating hormones vitamin D and parathyroid hormone (PTH) as well as of the somatotroph hormone axis associated with local modulation of bone and growth cartilage function. The resulting growth retardation and the potentially rapid onset of ROD in children are different from ROD in adults. The biochemical changes of ROD as well as its prevention and treatment affect calcium and phosphorus homeostasis and are directly associated with the development of cardiovascular disease in pediatric renal patients. The aims of the clinical and biochemical surveillance of pediatric patients with CRF or on dialysis are prevention of hyperphosphatemia, avoidance of hypercalcemia and keeping the calcium phosphorus product below 5 mmol(2)/l(2). The PTH levels should be within the normal range in chronic renal failure (CRF) and up to 2–3 times the upper limit of normal levels in dialysed children. Prevention of ROD is expected to result in improved growth and less vascular calcification

Os interiores domésticos após a expansão da economia exportadora paulista

The present article aims at describing São Paulo city dwellings and at studying its trade and crafts production in the first half of the 19th Century. Our work is chiefly based on information collected from post-mortem inventories registered in São Paulo capital city. Memorialists have described São Paulo city and its market as insignificant until coffee cultivation took over as the main economic activity. However, our research has found out that, on the contrary, the domestic trade had been very active since the beginning of the 19th century.Este artigo se propõe a descrever os interiores domésticos dos paulistanos e a refletir sobre o comércio e a produção artesanal da cidade de São Paulo na primeira metade do Oitocentos. Baseamo-nos principalmente nas informações dos inventários post-mortem da capital. Os memorialistas descreveram a cidade e seu mercado acanhados até o advento do café. Nossa pesquisa, ao contrário, identificou-os muito ativo desde o início do século XIX