392 research outputs found
An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets.
Interleukin-27 (IL-27) is an immunoregulatory cytokine that suppresses inflammation through multiple mechanisms, including induction of IL-10, but the transcriptional network mediating its diverse functions remains unclear. Combining temporal RNA profiling with computational algorithms, we predict 79 transcription factors induced by IL-27 in T cells. We validate 11 known and discover 5 positive (Cebpb, Fosl2, Tbx21, Hlx, and Atf3) and 2 negative (Irf9 and Irf8) Il10 regulators, generating an experimentally refined regulatory network for Il10. We report two central regulators, Prdm1 and Maf, that cooperatively drive the expression of signature genes induced by IL-27 in type 1 regulatory T cells, mediate IL-10 expression in all T helper cells, and determine the regulatory phenotype of colonic Foxp3 <sup>+</sup> regulatory T cells. Prdm1/Maf double-knockout mice develop spontaneous colitis, phenocopying ll10-deficient mice. Our work provides insights into IL-27-driven transcriptional networks and identifies two shared Il10 regulators that orchestrate immunoregulatory programs across T helper cell subsets
Measurement of and charged current inclusive cross sections and their ratio with the T2K off-axis near detector
We report a measurement of cross section and the first measurements of the cross section
and their ratio
at (anti-)neutrino energies below 1.5
GeV. We determine the single momentum bin cross section measurements, averaged
over the T2K -flux, for the detector target material (mainly
Carbon, Oxygen, Hydrogen and Copper) with phase space restricted laboratory
frame kinematics of 500 MeV/c. The
results are and $\sigma(\nu)=\left( 2.41\
\pm0.022{\rm{(stat.)}}\pm0.231{\rm (syst.)}\ \right)\times10^{-39}^{2}R\left(\frac{\sigma(\bar{\nu})}{\sigma(\nu)}\right)=
0.373\pm0.012{\rm (stat.)}\pm0.015{\rm (syst.)}$.Comment: 18 pages, 8 figure
Physics Potential of the ICAL detector at the India-based Neutrino Observatory (INO)
The upcoming 50 kt magnetized iron calorimeter (ICAL) detector at the
India-based Neutrino Observatory (INO) is designed to study the atmospheric
neutrinos and antineutrinos separately over a wide range of energies and path
lengths. The primary focus of this experiment is to explore the Earth matter
effects by observing the energy and zenith angle dependence of the atmospheric
neutrinos in the multi-GeV range. This study will be crucial to address some of
the outstanding issues in neutrino oscillation physics, including the
fundamental issue of neutrino mass hierarchy. In this document, we present the
physics potential of the detector as obtained from realistic detector
simulations. We describe the simulation framework, the neutrino interactions in
the detector, and the expected response of the detector to particles traversing
it. The ICAL detector can determine the energy and direction of the muons to a
high precision, and in addition, its sensitivity to multi-GeV hadrons increases
its physics reach substantially. Its charge identification capability, and
hence its ability to distinguish neutrinos from antineutrinos, makes it an
efficient detector for determining the neutrino mass hierarchy. In this report,
we outline the analyses carried out for the determination of neutrino mass
hierarchy and precision measurements of atmospheric neutrino mixing parameters
at ICAL, and give the expected physics reach of the detector with 10 years of
runtime. We also explore the potential of ICAL for probing new physics
scenarios like CPT violation and the presence of magnetic monopoles.Comment: 139 pages, Physics White Paper of the ICAL (INO) Collaboration,
Contents identical with the version published in Pramana - J. Physic
Monitoring and prevalence rates of metabolic syndrome in military veterans with serious mental illness
Background: Cardiovascular disease is the leading cause of mortality among patients with serious mental illness (SMI) and the prevalence of metabolic syndrome-a constellation of cardiovascular risk factors-is significantly higher in these patients than in the general population. Metabolic monitoring among patients using second generation antipsychotics (SGAs)-a risk factor for metabolic syndrome-has been shown to be inadequate despite the release of several guidelines. However, patients with SMI have several factors independent of medication use that predispose them to a higher prevalence of metabolic syndrome. Our study therefore examines monitoring and prevalence of metabolic syndrome in patients with SMI, including those not using SGAs. Methods and Findings: We retrospectively identified all patients treated at a Veterans Affairs Medical Center with diagnoses of schizophrenia, schizoaffective disorder or bipolar disorder during 2005-2006 and obtained demographic and clinical data. Incomplete monitoring of metabolic syndrome was defined as being unable to determine the status of at least one of the syndrome components. Of the 1,401 patients included (bipolar disorder: 822; schizophrenia: 222; and schizoaffective disorder: 357), 21.4% were incompletely monitored. Only 54.8% of patients who were not prescribed SGAs and did not have previous diagnoses of hypertension or hypercholesterolemia were monitored for all metabolic syndrome components compared to 92.4% of patients who had all three of these characteristics. Among patients monitored for metabolic syndrome completely, age-adjusted prevalence of the syndrome was 48.4%, with no significant difference between the three psychiatric groups. Conclusions: Only one half of patients with SMI not using SGAs or previously diagnosed with hypertension and hypercholesterolemia were completely monitored for metabolic syndrome components compared to greater than 90% of those with these characteristics. With the high prevalence of metabolic syndrome seen in this population, there appears to be a need to intensify efforts to reduce this monitoring gap
Measuring the atmospheric neutrino oscillation parameters and constraining the 3+1 neutrino model with ten years of ANTARES data
The ANTARES neutrino telescope has an energy threshold of a few tens of
GeV. This allows to study the phenomenon of atmospheric muon neutrino disappearance
due to neutrino oscillations. In a similar way, constraints on the 3+1 neutrino model, which
foresees the existence of one sterile neutrino, can be inferred. Using data collected by the
ANTARES neutrino telescope from 2007 to 2016, a new measurement of m2
32 and 23 has
been performed | which is consistent with world best- t values | and constraints on the
3+1 neutrino model have been derived.Centre National
de la Recherche Scienti que (CNRS)Commissariat a l' energie atomique et aux energies
alternatives (CEA)Commission Européenne (FEDER fund and Marie Curie Program)Institut Universitaire de France (IUF)IdEx program and UnivEarthS Labex program at
Sorbonne Paris Cité (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02)Labex OCEVU
(ANR-11-LABX-0060) and the A*MIDEX project (ANR-11-IDEX-0001-02)Région ÎIle-de-
France (DIM-ACAV)Région Alsace (contrat CPER)Région Provence-Alpes-Côte d'Azur,
Département du Var and Ville de La Seyne-sur-MerBundesministerium für Bildung
und Forschung (BMBF)Istituto Nazionale di Fisica Nucleare (INFN)Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO)Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grantsExecutive Unit for Financing Higher Education,
Research, Development and Innovation (UEFISCDIÇ)Ministerio de Economía y
Competitividad (MINECO): Plan Estatal de Investigación (refs. FPA2015-65150-C3-1-P,
-2-P and -3-P, (MINECO/FEDER))Severo Ochoa Centre of Excellence and Red Consolider
MultiDark (MINECO), and Prometeo and Grisolía programs (Generalitat Valenciana)Ministry of Higher Education, Scienti c Research and Professional Trainin
ANTARES search for point-sources of neutrinos using astrophysical catalogs: a likelihood stacking analysis
A search for astrophysical point-like neutrino sources using the data
collected by the ANTARES detector between January 29, 2007 and December 31,
2017 is presented. A likelihood stacking method is used to assess the
significance of an excess of muon neutrinos inducing track-like events in
correlation with the location of a list of possible sources. Different sets of
objects are tested in the analysis: a) a sub-sample of the \textit{Fermi} 3LAC
catalog of blazars, b) a jet-obscured AGN population, c) a sample of soft
gamma-ray selected radio galaxies, d) a star-forming galaxy catalog , and e) a
public sample of 56 very-high-energy track events from the IceCube experiment.
None of the tested sources shows a significant association with the sample of
neutrinos detected by ANTARES. The smallest p-value is obtained for the radio
galaxies catalog with an equal weights hypothesis, with a pre-trial p-value
equivalent to a excess, equivalent to
post-trial.
In addition, the results of a dedicated analysis for the blazar MG3
J225517+2409 are also reported: this source is found to be the most significant
within the \textit{Fermi} 3LAC sample, with 5 ANTARES events located at less
than one degree from the source. This blazar showed evidence of flaring
activity in \textit{Fermi} data, in space-time coincidence with a high-energy
track detected by IceCube. An \emph{a posteriori} significance of for the combination of ANTARES and IceCube data is reported
Observation of the cosmic ray shadow of the Sun with the ANTARES neutrino telescope
[EN] The ANTARES detector is an undersea neutrino telescope in the Mediterranean Sea. The search for pointlike neutrino sources is one of the main goals of the ANTARES telescope, requiring a reliable method to evaluate the detector angular resolution and pointing accuracy. This work describes the study of the Sun ¿shadow¿ effect with the ANTARES detector. The shadow is the deficit in the atmospheric muon flux in the direction of the Sun caused by the absorption of the primary cosmic rays. This analysis is based on the data collected between 2008 and 2017 by the ANTARES telescope. The observed statistical significance of the Sun shadow detection is 3.7¿, with an estimated angular resolution of 0.59° +- 0.10°for downward-going muons. The pointing accuracy is found to be consistent with the expectations and no evidence of systematic pointing shifts is observed.The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique, Commissariat `a l'' energie atomique et aux energies alternatives, Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France, LabEx UnivEarthS (ANR-10-LABX-0023 and ANR-18-IDEX-0001), R ' egion Ile-de-France (DIM-ACAV), Region Alsace (contract CPER), Region Provence-Alpes-Cote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fur Bildung und Forschung, Germany; Istituto Nazionale di Fisica Nucleare, Italy; Nederlandse organisatie voor Wetenschappelijk Onderzoek, the Netherlands; Council of the President of the Russian Federation for Young Scientists and Leading Scientific Schools supporting grants, Russia; Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI), Romania; Ministerio de Ciencia, Innovacion, Investigacion y Universidades (MCIU): Programa Estatal de Generacion de Conocimiento (refs. PGC2018-096663-B-C41, -A-C42, -B-C43, -B-C44) (MCIU/FEDER), Severo Ochoa Centre of Excellence and MultiDark Consolider (MCIU), Junta de Andalucia (refs. SOMM17/6104/UGR and A-FQM-053-UGR18), Generalitat Valenciana: Grisolia (ref. GRISOLIA/2018/119), Spain; Ministry of Higher Education, Scientific Research and Professional Training, Morocco. We also acknowledge the technical support of Ifremer, AIM and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities.Albert, A.; Andre, M.; Anghinolfi, M.; Anton, G.; Ardid Ramírez, M.; Aubert, J.; Aublin, J.... (2020). Observation of the cosmic ray shadow of the Sun with the ANTARES neutrino telescope. Physical Review D: covering particles, fields, gravitation, and cosmology. 102(12):1-7. https://doi.org/10.1103/PhysRevD.102.122007S1710212Ageron, M., Aguilar, J. A., Al Samarai, I., Albert, A., Ameli, F., André, M., … Ardid, M. (2011). ANTARES: The first undersea neutrino telescope. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 656(1), 11-38. doi:10.1016/j.nima.2011.06.103Alexandreas, D. E., Allen, R. C., Berley, D., Biller, S. D., Burman, R. L., Cady, D. R., … Zhang, W. (1991). Observation of shadowing of ultrahigh-energy cosmic rays by the Moon and the Sun. Physical Review D, 43(5), 1735-1738. doi:10.1103/physrevd.43.1735Andreyev, Y. M., Zakidyshev, V. N., Karpov, S. N., & Khodov, V. N. (2002). Cosmic Research, 40(6), 559-564. doi:10.1023/a:1021553713199Borione, A., Catanese, M., Covault, C. E., Cronin, J. W., Fick, B. E., Gibbs, K. G., … van der Velde, J. C. (1994). Observation of the shadows of the Moon and Sun using 100 TeV cosmic rays. Physical Review D, 49(3), 1171-1177. doi:10.1103/physrevd.49.1171Cobb, J. H., Marshak, M. L., Allison, W. W. M., Alner, G. J., Ayres, D. S., Barrett, W. L., … Wall, D. (2000). Observation of a shadow of the Moon in the underground muon flux in the Soudan 2 detector. Physical Review D, 61(9). doi:10.1103/physrevd.61.092002Bartoli, B., Bernardini, P., Bi, X. J., Bleve, C., Bolognino, I., Branchini, P., … Cao, Z. (2012). Measurement of the cosmic ray antiproton/proton flux ratio at TeV energies with the ARGO-YBJ detector. Physical Review D, 85(2). doi:10.1103/physrevd.85.022002Abeysekara, A. U., Albert, A., Alfaro, R., Alvarez, C., Álvarez, J. D., Arceo, R., … Belmont-Moreno, E. (2018). Constraining the
p¯/p
ratio in TeV cosmic rays with observations of the Moon shadow by HAWC. Physical Review D, 97(10). doi:10.1103/physrevd.97.102005Adamson, P., Andreopoulos, C., Ayres, D. S., Backhouse, C., Barr, G., Barrett, W. L., … Bock, G. J. (2011). Observation in the MINOS far detector of the shadowing of cosmic rays by the sun and moon. Astroparticle Physics, 34(6), 457-466. doi:10.1016/j.astropartphys.2010.10.010Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., … Ansseau, I. (2019). Detection of the Temporal Variation of the Sun’s Cosmic Ray Shadow with the IceCube Detector. The Astrophysical Journal, 872(2), 133. doi:10.3847/1538-4357/aaffd1Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., … Barrios-Martít, J. (2018). The cosmic ray shadow of the Moon observed with the ANTARES neutrino telescope. The European Physical Journal C, 78(12). doi:10.1140/epjc/s10052-018-6451-3First search for neutrinos in correlation with gamma-ray bursts with the ANTARES neutrino telescope. (2013). Journal of Cosmology and Astroparticle Physics, 2013(03), 006-006. doi:10.1088/1475-7516/2013/03/006Aguilar, J. A., Al Samarai, I., Albert, A., André, M., Anghinolfi, M., Anton, G., … Astraatmadja, T. (2011). A fast algorithm for muon track reconstruction and its application to the ANTARES neutrino telescope. Astroparticle Physics, 34(9), 652-662. doi:10.1016/j.astropartphys.2011.01.003BECHERINI, Y., MARGIOTTA, A., SIOLI, M., & SPURIO, M. (2006). A parameterisation of single and multiple muons in the deep water or ice. Astroparticle Physics, 25(1), 1-13. doi:10.1016/j.astropartphys.2005.10.005Carminati, G., Bazzotti, M., Margiotta, A., & Spurio, M. (2008). Atmospheric MUons from PArametric formulas: a fast GEnerator for neutrino telescopes (MUPAGE). Computer Physics Communications, 179(12), 915-923. doi:10.1016/j.cpc.2008.07.014Yepes-Ramírez, H. (2013). Characterization of optical properties of the site of the ANTARES neutrino telescope. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 725, 203-206. doi:10.1016/j.nima.2012.11.143Fusco, L. A., & Margiotta, A. (2016). The Run-by-Run Monte Carlo simulation for the ANTARES experiment. EPJ Web of Conferences, 116, 02002. doi:10.1051/epjconf/201611602002Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., … Basa, S. (2017). First all-flavor neutrino pointlike source search with the ANTARES neutrino telescope. Physical Review D, 96(8). doi:10.1103/physrevd.96.082001Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., … Belhorma, B. (2020). ANTARES and IceCube Combined Search for Neutrino Point-like and Extended Sources in the Southern Sky. The Astrophysical Journal, 892(2), 92. doi:10.3847/1538-4357/ab7afbAdrián-Martínez, S., Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., … Basa, S. (2014). SEARCHES FOR POINT-LIKE AND EXTENDED NEUTRINO SOURCES CLOSE TO THE GALACTIC CENTER USING THE ANTARES NEUTRINO TELESCOPE. The Astrophysical Journal, 786(1), L5. doi:10.1088/2041-8205/786/1/l
Measurement of the atmospheric νe and νμ energy spectra with the ANTARES neutrino telescope
The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat a l'Energie Atomique et aux Energies Alternatives(CEA), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), Labex UnivEarthS(ANR-10-LABX-0023 and ANR-18-IDEX-0001), Region Ile-de-France (DIM-ACAV), Region Alsace (contrat CPER), Region Provence-AlpesCote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fur Bildung und Forschung (BMBF), Germany; Instituto Nazionale di Fisica Nucleare(INFN), Italy; Nederlandse Organisatie voor Wetenschappelijk Onderzoek(NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI), Romania; Ministerio de Ciencia e Innovacion (MCI) and Agencia Estatal de Investigacion: Programa Estatal de Generacion de Conocimiento (refs. PGC2018096663-B-C41, -A-C42, -B-C43, -B-C44) (MCI/FEDER), Severo Ochoa Centre of Excellence and MultiDark Consolider, Junta de Andalucia (ref. SOMM17/6104/UGR and A-FQM-053-UGR18), Generalitat Valenciana: Grisolia (ref. GRISOLIA/2018/119) and GenT (ref. CIDEGENT/2018/034) programs, Spain; Ministry of Higher Education, Scientific Research and Professional Training, Morocco. We also acknowledge the technical support of Ifremer, AIM and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities. The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat a l'Energie Atomique et aux Energies Alternatives(CEA), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), Labex UnivEarthS(ANR-10-LABX-0023 and ANR-18-IDEX-0001), Region Ile-de-France (DIM-ACAV), Region Alsace (contrat CPER), Region Provence-AlpesCote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fur Bildung und Forschung (BMBF), Germany; Instituto Nazionale di Fisica Nucleare(INFN), Italy; Nederlandse Organisatie voor Wetenschappelijk Onderzoek(NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI), Romania; Ministerio de Ciencia e Innovacion (MCI) and Agencia Estatal de Investigacion: Programa Estatal de Generacion de Conocimiento (refs. PGC2018096663-B-C41, -A-C42, -B-C43, -B-C44) (MCI/FEDER), Severo Ochoa Centre of Excellence and MultiDark Consolider, Junta de Andalucia (ref. SOMM17/6104/UGR and A-FQM-053-UGR18), Generalitat Valenciana: Grisolia (ref. GRISOLIA/2018/119) and GenT (ref. CIDEGENT/2018/034) programs, Spain; Ministry of Higher Education, Scientific Research and Professional Training, Morocco. We also acknowledge the technical support of Ifremer, AIM and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities.This letter presents a combined measurement of the energy spectra of atmospheric nu(e) and nu(mu) in the energy range between similar to 100 GeV and similar to 50 TeV with the ANTARES neutrino telescope. The analysis uses 3012 days of detector livetime in the period 2007-2017, and selects 1016 neutrinos interacting in (or close to) the instrumented volume of the detector, yielding shower-like events (mainly from nu(e) + (nu) over bar (e) charged current plus all neutrino neutral current interactions) and starting track events (mainly from nu(mu) + (nu) over bar (mu) charged current interactions). The contamination by atmospheric muons in the final sample is suppressed at the level of a few per mill by different steps in the selection analysis, including a Boosted Decision Tree classifier. The distribution of reconstructed events is unfolded in terms of electron and muon neutrino fluxes. The derived energy spectra are compared with previous measurements that, above 100 GeV, are limited to experiments in polar ice and, for nu(mu), to Super-Kamiokande.Centre National de la Recherche Scientifique (CNRS)French Atomic Energy CommissionCommission Europeenne (FEDER fund)Institut Universitaire de France (IUF)Labex UnivEarthS
ANR-10-LABX-0023
ANR-18-IDEX-0001Region Ile-de-FranceRegion Grand-EstRegion Provence-Alpes-Cote d'AzurRegion Provence-Alpes-Cote d'AzurFederal Ministry of Education & Research (BMBF)Instituto Nazionale di Fisica Nucleare(INFN), ItalyNetherlands Organization for Scientific Research (NWO)Netherlands GovernmentCouncil of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, RussiaConsiliul National al Cercetarii Stiintifice (CNCS)Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii (UEFISCDI)Spanish Government
PGC2018096663-B-C41
PGC2018096663-A-C42
PGC2018096663-B-C43
PGC2018096663-B-C44Severo Ochoa Centre of Excellence and MultiDark ConsoliderJunta de Andalucia
SOMM17/6104/UGR
A-FQM-053-UGR18Generalitat Valenciana: Grisolia program, Spain
GRISOLIA/2018/119Generalitat Valenciana: GenT program, Spain
CIDEGENT/2018/034Ministry of Higher Education, Scientific Research and Professional Training, MoroccoAgencia Estatal de Investigacion
PGC2018096663-B-C41
PGC2018096663-A-C42
PGC2018096663-B-C43
PGC2018096663-B-C44Commission Europeenne (Marie Curie Program
Seasonal Variation of Multiple-Muon Cosmic Ray Air Showers Observed in the NOvA Detector on the Surface
We report the rate of cosmic ray air showers with multiplicities exceeding 15
muon tracks recorded in the NOvA Far Detector between May 2016 and May 2018.
The detector is located on the surface under an overburden of 3.6 meters water
equivalent. We observe a seasonal dependence in the rate of multiple-muon
showers, which varies in magnitude with multiplicity and zenith angle. During
this period, the effective atmospheric temperature and surface pressure ranged
between 210 K to 230 K and 940mbar to 990mbar, respectively; the shower rates
are anti-correlated with the variation in the effective temperature. The
variations are about 30% larger for the highest multiplicities than the lowest
multiplicities and 20% larger for showers near the horizon than vertical
showers
- …