Raffinement et validation d'un alésoir acétabulaire à diamètre variable

Au Canada, le nombre d’arthroplasties totales de la hanche s’élevait à 24 253 en 2006 (à l’exception du Québec). Ce nombre d’arthroplasties représente des coûts annuels estimés à 463 millions de dollars canadiens. Pour diminuer ces coûts, le temps d’opération et le risque d’infection, un tout nouveau concept d’alésoir acétabulaire à diamètre variable (ADV) a été proposé par Jean-Sébastien Mérette. Malgré l’ingéniosité de ce concept, cette proposition requiert des modifications et des raffinements. Ce projet vise à proposer un système de coupe adapté pour l’ADV qui minimise les efforts de coupe et maximise la qualité de coupe, de concevoir un prototype fonctionnel de l’ADV pour vérifier les performances du système de coupe, de comparer les performances de l’ADV à celles des alésoirs conventionnels et de raffiner la conception de l’ADV pour qu’il soit un outil complètement fonctionnel. Pour ce faire, certains critères et contraintes de conception sont déterminés. Pour le prototype fonctionnel, certains critères et contraintes sont adaptés. La validation et le raffinement sont effectués à l’aide d’analyses numériques par éléments finis. À l’aide du prototype fonctionnel, le comportement et la qualité de coupe des alésoirs conventionnels sont comparés à l’ADV. Les essais sont effectués sur une machine à contrôles numériques et les efforts de coupe sont collectés à l’aide d’une plaque dynamométrique. Les cavités sont numérisées à l’aide d’un numériseur tridimensionnel à haute définition et analysées à l’aide d’un logiciel de CAO. Les résultats démontrent que l’ADV a un comportement similaire aux alésoirs conventionnels et la qualité de la cavité alésée est fortement améliorée. L’ADV serait peut-être la solution pour prolonger la stabilité à long terme de la prothèse, diminuer les coûts, minimiser les risques d’infection et faciliter l’utilisation

Transferability of Published Population Pharmacokinetic Models for Apixaban and Rivaroxaban to Subjects with Obesity Treated for Venous Thromboembolism: A Systematic Review and External Evaluations

International audienceApixaban and rivaroxaban have first-line use for many patients needing anticoagulation for venous thromboembolism (VTE). The pharmacokinetics of these drugs in non-obese subjects have been extensively studied, and, while changes in pharmacokinetics have been documented in obese patients, data remain scarce for these anticoagulants. The aim of this study was to perform an external validation of published population pharmacokinetic (PPK) models of apixaban and rivaroxaban in a cohort of obese patients with VTE. A literature search was conducted in the PubMed/MEDLINE, Scopus, and Embase databases following the PRISMA statement. External validation was performed using MonolixSuite software, using prediction-based and simulation-based diagnostics. An external validation dataset from the university hospitals of Brest and Rennes, France, included 116 apixaban pharmacokinetic samples from 69 patients and 121 rivaroxaban samples from 81 patients. Five PPK models of apixaban and 16 models of rivaroxaban were included, according to the inclusion criteria of the study. Two of the apixaban PPK models presented acceptable performances, whereas no rivaroxaban PPK model did. This study identified two published models of apixaban applicable to apixaban in obese patients with VTE. However, none of the rivaroxaban models evaluated were applicable. Dedicated studies appear necessary to elucidate rivaroxaban pharmacokinetics in this population

The scattering properties of debris discs and the case of HD181327

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Insight from laboratory measurements on dust in debris discs

International audienceExtreme adaptive optics instruments have revealed exquisite details on debris discs, allowing to extract the optical properties of the dust particles such as the phase function, the degree of polarisation and the spectral reflectance. These are three powerful diagnostic tools to understand the physical properties of the dust : the size, shape and composition of the dust particles. This can inform us on the population of parent bodies, also called planetesimals, which generate those particles through collisions. It is however very rare to be able to combine all those three observables for the same system, as this requires different high-contrast imaging techniques to suppress the starlight and reveal the faint scattered light emission from the dust. Due to its brightness, the ring detected around the A-type star HR 4796 is a notable exception, with both unpolarised and polarised images covering near-infrared wavelengths. Here, we show how measurements of dust particles in the laboratory can reproduce the observed near-infrared photo-polarimetric properties of the HR 4796 disc. Experimental characterisation of dust allows to bypass the current limitations of dust models to reproduce simultaneously the phase function, the degree of polarisation and the spectral reflectance

Integrated monitoring of chemicals and their effects on four sentinel species, Limanda limanda, Platichthys flesus, Nucella lapillus and Mytilus sp., in Seine Bay: A key step towards applying biological effects to monitoring

The International workshop on Integrated Assessment of CONtaminants impacts on the North sea (ICON) provided a framework to validate the application of chemical and biological assessment thresholds (BACs and EACs) in the Seine Bay in France. Bioassays (oyster larval anomalies, Corophium arenarium toxicity assay and DR Calux) for sediment and biomarkers: ethoxyresorufin-O-deethylase (EROD) activity, acetylcholinesterase (AChE) activity, lysosomal membrane stability (LMS), DNA strand breaks using the Comet assay, DNA adducts, micronucleus (MN), PAH metabolites, imposex, intersex and fish external pathologies were analysed in four marine sentinel species (Platichthys flesus, Limanda limanda, Mytilus sp. and Nucella lapilus). Polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and heavy metals were analysed in biota and sediment. Results for sediment and four species in 2008–2009 made it possible to quantify the impact of contaminants using thresholds (Environmental Assessment Criteria/EAC2008: 70% and EAC2009: 60%) and effects (EAC2008: 50% and EAC2009: 40%) in the Seine estuary. The Seine estuary is ranked among Europe's most highly polluted sites.Postprint1,95

Stable Tuna Mercury Concentrations since 1971 Illustrate Marine Inertia and the Need for Strong Emission Reductions under the Minamata Convention

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Transdisciplinary Bioblitz: Rapid biotic and abiotic inventory allows studying environmental changes over 60 years at the Biological Field Station of Paimpont (Brittany, France) and opens new interdisciplinary research opportunities

International audienceBackground - The Biological Field Station of Paimpont (Station Biologique de Paimpont, SBP), owned by the University of Rennes and located in the Brocéliande Forest of Brittany (France), has been hosting student scientific research and field trips during the last 60 years. The study area of the SBP is a landscape mosaic of 17 ha composed of gorse moors, forests, prairies, ponds and creeks. Land use has evolved over time. Historical surveys by students and researchers focused on insects and birds. With this study, we aimed to increase the range of taxa observations, document changes in species composition and landscape and provide a basis for interdisciplinary research perspectives. We gathered historical data, implemented an all-taxon biodiversity inventory (ATBI) in different habitats of the SBP study area, measured abiotic factors in the air, water and soil and performed a photographical landscape observation during the BioBlitz held in July 2017. New information - During the 24 h BioBlitz, organised by the SBP and the EcoBio lab from the University of Rennes and the French National Center of Scientific Research (CNRS), different habitats were individually sampled. Seventy-seven experts, accompanied by 120 citizens and 12 young people participating in the European Volunteer Service, observed, identified and databased 660 species covering 5 kingdoms, 8 phyla, 21 classes, 90 orders and 247 families. In total, there were 1819 occurrences including records identified to higher taxon ranks, thereby adding one more kingdom and four more phyla. Historical data collection resulted in 1176 species and 4270 occurrences databased. We also recorded 13 climatic parameters, 10 soil parameters and 18 water parameters during the BioBlitz. Current habitats were mapped and socio-ecological landscape changes were assessed with a diachronic approach using 32 historical photographs and historical maps. The coupling of historical biodiversity data with new biotic and abiotic data and a photographic comparison of landscape changes allows an integrative understanding of how the SBP changed from agriculturally-used land to a managed natural area within the last 60 years. Hence, this BioBlitz represents an important holistic sampling of biodiversity for studies on trophic webs or on trophic interactions or on very diverse, but connected, habitats. The integration of social, biotic and abiotic data opens innovative research opportunities on the evolution of socio-ecosystems and landscapes