13 research outputs found

    El soborno transnacional y el tráfico de influencias internacional en el Código Penal Argentino

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    Los delitos de soborno transnacional y de tráfico de influencia internacional se encuentran previstos en el art. 258 bis del Código Penal argentino, formando parte del Título XI, de los Delitos contra la Administración Pública y del Capítulo VI, denominado Cohecho y Tráfico de Influencias. Su incorporación a la legislación penal de nuestro país, se inscribe en el marco de un mundo globalizado y en la necesidad de los Estados y Organismos Internacionales de encontrar mecanismos destinados a detectar, investigar y castigar actos de corrupción que se caracterizan por su transnacionalidad, a partir de que estas conductas han ido ganando terreno también en la escena internacional, constituyendo una manifestación de lo que la teoría denomina criminalidad no convencional

    Mitochondria and Energetic Depression in Cell Pathophysiology

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    Mitochondrial dysfunction is a hallmark of almost all diseases. Acquired or inherited mutations of the mitochondrial genome DNA may give rise to mitochondrial diseases. Another class of disorders, in which mitochondrial impairments are initiated by extramitochondrial factors, includes neurodegenerative diseases and syndromes resulting from typical pathological processes, such as hypoxia/ischemia, inflammation, intoxications, and carcinogenesis. Both classes of diseases lead to cellular energetic depression (CED), which is characterized by decreased cytosolic phosphorylation potential that suppresses the cell’s ability to do work and control the intracellular Ca2+ homeostasis and its redox state. If progressing, CED leads to cell death, whose type is linked to the functional status of the mitochondria. In the case of limited deterioration, when some amounts of ATP can still be generated due to oxidative phosphorylation (OXPHOS), mitochondria launch the apoptotic cell death program by release of cytochrome c. Following pronounced CED, cytoplasmic ATP levels fall below the thresholds required for processing the ATP-dependent apoptotic cascade and the cell dies from necrosis. Both types of death can be grouped together as a mitochondrial cell death (MCD). However, there exist multiple adaptive reactions aimed at protecting cells against CED. In this context, a metabolic shift characterized by suppression of OXPHOS combined with activation of aerobic glycolysis as the main pathway for ATP synthesis (Warburg effect) is of central importance. Whereas this type of adaptation is sufficiently effective to avoid CED and to control the cellular redox state, thereby ensuring the cell survival, it also favors the avoidance of apoptotic cell death. This scenario may underlie uncontrolled cellular proliferation and growth, eventually resulting in carcinogenesis

    Le problème des homoeoméries dans le système d'Anaxagore

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    Muñoz Valle Isodoro. Le problème des homoeoméries dans le système d'Anaxagore. In: L'antiquité classique, Tome 45, fasc. 2, 1976. pp. 587-592

    Data on distribution of screwworm fly Wohlfahrtia magnifica (Schiner) in Southwestern Europe (diptera sarcophagidae)

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    The facade of the church of Saint Spirit in Urbino: from scientific investigations to restoration

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    The state of advanced deterioration of the church of Saint Spirito of Urbino has induced the Superintendence for the Historical Artistic and Demoetnoanthropological Heritage of the Marches-Urbino and the Archiepiscopal Curia to program an intervention of restoration. Before that, the facade was covered from black crusts, grey deposits and yellowish films. The bricks of the wall, until to a height of approximately three meters from the bottom, moreover they were interested from processes of detachment, disintegration and exfoliation. In such area the presence of humidity was rather obvious and was attributable to phenomena of rising dump. In order to identify the constituent materials and to estimate of the state of conservation they have been carry out scientific investigations, whose it turns out have supplied profits indications for the restoration
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