Evaluation of post therapy functional status and residual weakness of patients with Guillain-Barre Syndrome

ABSTRACT: Introduction: The annual global incidence of Guillain-Barre Syndrome is approximately 1–2 per 100,000 person-years. Data on Guillain-Barre Syndrome is very rare from Pakistan, we conducted a retrospective study to assess the clinical presentation, and treatment response of these patients

Role of Hypogonadotropic Hypogonadism in Psychosocial Deprivation among Females Patients

Background: Patients with rare diseases such as congenital hypogonadotropic hypogonadism (CHH) are often challenged to be isolated, lack proper medical care and face negative social consequences. Furthermore, pubertal development is the period of rapid and nearly simultaneous transformation of biological, physical, social, and psychological domains of an individual. Hence, the process of personal transformation is also affected in children with pubertal delay. Due to delay in the growth process, the individual looks different from her or his peers and may have negative consequences on the psychological and social interactions. Objective: The disparities in the growth and development may cause an increase in psychosocial problems and negative peer relationship. Hence, this study was designed to observe psychosocial consequences of delayed puberty in female with CHH. Design: Cross sectional study. Place & duration of study: The data were collected from CHH patients visiting public sector hospitals over a period of 18 months. Patients & Methods: The demographic information, complete medical history, psychological and psychosocial symptoms of the 52 female CHH patients were recorded on the questionnaire. Results: The present study demonstrated that most of the patients were frustrated due to poor body image, low self-esteem, feeling themselves behind the peers, and were with complaints of depression and anxiety. The other psychological symptoms include anger, irritability, loneliness, eating and sleeping disturbances. Conclusion: It was concluded that the delayed sexual maturation has resulted in frustration, low self-esteem and increased anxiety and depression in cohort of local females with CHH

Data Augmentation-based Novel Deep Learning Method for Deepfaked Images Detection

Recent advances in artificial intelligence have led to deepfake images, enabling users to replace a real face with a genuine one. deepfake images have recently been used to malign public figures, politicians, and even average citizens. deepfake but realistic images have been used to stir political dissatisfaction, blackmail, propagate false news, and even carry out bogus terrorist attacks. Thus, identifying real images from fakes has got more challenging. To avoid these issues, this study employs transfer learning and data augmentation technique to classify deepfake images. For experimentation, 190,335 RGB-resolution deepfake and real images and image augmentation methods are used to prepare the dataset. The experiments use the deep learning models: convolutional neural network (CNN), Inception V3, visual geometry group (VGG19) and VGG16 with a transfer learning approach. Essential evaluation metrics (accuracy, precision, recall, F1-score, confusion matrix and AUC-ROC curve score) are used to test the efficacy of the proposed approach. Results revealed that the proposed approach achieves an accuracy, recall, F1-score and AUC-ROC score of 90% and 91% precision, with our fine-tuned VGG16 model outperforming other DL models in recognizing real and deepfakes

EFFECT OF CROSS FIT EXERCISES ON WEIGHT LOSS OF MALES IN LAHORE

The purpose of this research was to explore the effect of Cross Fit, a latest fitness techniques being used all over the world to get a good physique and health, in reducing weight of male persons ranging from 18 to 25 years. A sample of 8 male students ranging age from 18 to 25 years to measure the change in variables like Body weight, %age Fat ratio, %age of Total Body Water contents, %age of Lean Muscle Mass after applying Cross Fit training program in pre and post analysis. After designing and applying a 28 days Cross Fit plan and diet plans for each individual according to their Basal Metabolic Rate (BMR) and Total Daily Energy Expenditure (TDEE), it was found that there is a positive significant change in these variables mentioned above which showed that Cross Fit training program d

RELATIONSHIP BETWEEN SOCIAL CONTROL AND SPORTS

The main objective of the study is to evaluate the effects and relationship between social control and sports. Social control is extremely basic for each general public. Without social control, society and in addition individual can't exist. Hence, the need of social control is exceptionally basic. Social control is important for the presence and association of a general public. Players learn violent strategies from sports, this give them a better cure for deviant behaviors. players learns how to obey the laws in sports this enables to develop discipline in society and help to promote cultural values and also it help to develop better instruction among people. Sports are a useful to create accountability environment in society. Results of this research work showed that the sports have positive effect on social control

'Aariz: A Benchmark Dataset for Automatic Cephalometric Landmark Detection and CVM Stage Classification

The accurate identification and precise localization of cephalometric landmarks enable the classification and quantification of anatomical abnormalities. The traditional way of marking cephalometric landmarks on lateral cephalograms is a monotonous and time-consuming job. Endeavours to develop automated landmark detection systems have persistently been made, however, they are inadequate for orthodontic applications due to unavailability of a reliable dataset. We proposed a new state-of-the-art dataset to facilitate the development of robust AI solutions for quantitative morphometric analysis. The dataset includes 1000 lateral cephalometric radiographs (LCRs) obtained from 7 different radiographic imaging devices with varying resolutions, making it the most diverse and comprehensive cephalometric dataset to date. The clinical experts of our team meticulously annotated each radiograph with 29 cephalometric landmarks, including the most significant soft tissue landmarks ever marked in any publicly available dataset. Additionally, our experts also labelled the cervical vertebral maturation (CVM) stage of the patient in a radiograph, making this dataset the first standard resource for CVM classification. We believe that this dataset will be instrumental in the development of reliable automated landmark detection frameworks for use in orthodontics and beyond

EFFECT OF CROSS FIT EXERCISES ON WEIGHT LOSS OF MALES IN LAHORE

The purpose of this research was to explore the effect of Cross Fit, a latest fitness techniques being used all over the world to get a good physique and health, in reducing weight of male persons ranging from 18 to 25 years. A sample of 8 male students ranging age from 18 to 25 years to measure the change in variables like Body weight, %age Fat ratio, %age of Total Body Water contents, %age of Lean Muscle Mass after applying Cross Fit training program in pre and post analysis. After designing and applying a 28 days Cross Fit plan and diet plans for each individual according to their Basal Metabolic Rate (BMR) and Total Daily Energy Expenditure (TDEE), it was found that there is a positive significant change in these variables mentioned above which showed that Cross Fit training program d

CEPHA29: Automatic Cephalometric Landmark Detection Challenge 2023

Quantitative cephalometric analysis is the most widely used clinical and research tool in modern orthodontics. Accurate localization of cephalometric landmarks enables the quantification and classification of anatomical abnormalities, however, the traditional manual way of marking these landmarks is a very tedious job. Endeavours have constantly been made to develop automated cephalometric landmark detection systems but they are inadequate for orthodontic applications. The fundamental reason for this is that the amount of publicly available datasets as well as the images provided for training in these datasets are insufficient for an AI model to perform well. To facilitate the development of robust AI solutions for morphometric analysis, we organise the CEPHA29 Automatic Cephalometric Landmark Detection Challenge in conjunction with IEEE International Symposium on Biomedical Imaging (ISBI 2023). In this context, we provide the largest known publicly available dataset, consisting of 1000 cephalometric X-ray images. We hope that our challenge will not only derive forward research and innovation in automatic cephalometric landmark identification but will also signal the beginning of a new era in the discipline

(20S)-20-Acet­oxy-4-pregnene-3,16-dione from Commiphora wightii

The title triterpene compound, C23H32O4, isolated from Commiphora wightii features four trans-fused rings, among which the five-membered ring adopts an envelope conformation, the cyclo­hexene ring adopts a half-chair conformation and the two cyclo­hexane rings exist in chair conformations. The asymmetric unit contains two independent mol­ecules. Weak inter­molecular C—H⋯O hydrogen bonding is present in the crystal structure

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London