Reactor Technology Options Study for Near-Term Deployment of GNEP Grid-Appropriate Reactors

World energy demand is projected to significantly increase over the coming decades. The International Energy Agency projects that electricity demand will increase 50% by 2015 and double by 2030, with most of the increase coming in developing countries as they experience double-digit rates of economic growth and seek to improve their standards of living. Energy is the necessary driver for human development, and the demand for energy in these countries will be met using whatever production technologies are available. Recognizing this inevitable energy demand and its implications for the United States, the U.S. National Security Strategy has proposed the Global Nuclear Energy Partnership (GNEP) to work with other nations to develop and deploy advanced nuclear recycling and reactor technologies. This initiative will help provide reliable, emission-free energy with less of the waste burden of older technologies and without making available separated plutonium that could be used by rogue states or terrorists for nuclear weapons. These new technologies will make possible a dramatic expansion of safe, clean nuclear energy to help meet the growing global energy demand. In other words, GNEP seeks to create an international regime to support large-scale growth in the worldwide use of nuclear energy without increasing the risk of nuclear weapon proliferation. This global expansion of nuclear power is strategically important to the United States for several reasons, including the following: (1) National security, by reducing the competition and potential for conflict over increasingly scarce fossil energy resources; (2) Economic security, by helping maintain stable prices for nonrenewable resources such as oil, gas, and coal; (3) Environmental security, by replacing or off-setting large-scale burning of greenhouse gas-emitting fuels for electricity production; and (4) Regaining technical leadership, through deployment of innovative U.S. technology-based reactors. Fully meeting the GNEP vision may require the deployment of thousands of reactors during the next century in dozens of countries, many of which are in the developing world where nuclear energy is not used currently. Such a large-scale deployment will have significant implications related to both fuel supply and spent fuel/waste management, both domestically and worldwide. Consequently, GNEP must address the development and demonstration of proliferation-resistant technologies to ensure both a safe and sustainable nuclear fuel cycle, and reactor designs that are appropriate for the range of needs across the global community. The focus of this report is the latter need, that is, the development and demonstration of proliferation-resistant reactors that are well matched to the needs and capabilities of developing countries

Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics

Alcohol dehydrogenases (ADH) participate in the biosynthetic pathway of aroma volatiles in fruit by interconverting aldehydes to alcohols and providing substrates for the formation of esters. Two highly divergent ADH genes (15% identity at the amino acid level) of Cantaloupe Charentais melon (Cucumis melo var. Cantalupensis) have been isolated. Cm-ADH1 belongs to the medium-chain zinc-binding type of ADHs and is highly similar to all ADH genes expressed in fruit isolated so far. Cm-ADH2 belongs to the short-chain type of ADHs. The two encoded proteins are enzymatically active upon expression in yeast. Cm-ADH1 has strong preference for NAPDH as a co-factor, whereas Cm-ADH2 preferentially uses NADH. Both Cm-ADH proteins are much more active as reductases with Kms 10–20 times lower for the conversion of aldehydes to alcohols than for the dehydrogenation of alcohols to aldehydes. They both show strong preference for aliphatic aldehydes but Cm-ADH1 is capable of reducing branched aldehydes such as 3-methylbutyraldehyde, whereas Cm-ADH2 cannot. Both Cm-ADH genes are expressed specifically in fruit and up-regulated during ripening. Gene expression as well as total ADH activity are strongly inhibited in antisense ACC oxidase melons and in melon fruit treated with the ethylene antagonist 1-methylcyclopropene (1-MCP), indicating a positive regulation by ethylene. These data suggest that each of the Cm-ADH protein plays a specific role in the regulation of aroma biosynthesis in melon fruit

Discovery of common and rare genetic risk variants for colorectal cancer.

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P < 5 × 10-8, bringing the number of known independent signals for CRC to ~100. New signals implicate lower-frequency variants, Krüppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding RNAs and somatic drivers, and support a role for immune function. Heritability analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies enabling rare variant analysis will improve understanding of biology underlying this risk and influence personalized screening strategies and drug development.Goncalo R Abecasis has received compensation from 23andMe and Helix. He is currently an employee of Regeneron Pharmaceuticals. Heather Hampel performs collaborative research with Ambry Genetics, InVitae Genetics, and Myriad Genetic Laboratories, Inc., is on the scientific advisory board for InVitae Genetics and Genome Medical, and has stock in Genome Medical. Rachel Pearlman has participated in collaborative funded research with Myriad Genetics Laboratories and Invitae Genetics but has no financial competitive interest

The DREAM Dataset: Supporting a data-driven study of autism spectrum disorder and robot enhanced therapy

We present a dataset of behavioral data recorded from 61 children diagnosed with Autism Spectrum Disorder (ASD). The data was collected during a large-scale evaluation of Robot Enhanced Therapy (RET). The dataset covers over 3000 therapy sessions and more than 300 hours of therapy. Half of the children interacted with the social robot NAO supervised by a therapist. The other half, constituting a control group, interacted directly with a therapist. Both groups followed the Applied Behavior Analysis (ABA) protocol. Each session was recorded with three RGB cameras and two RGBD (Kinect) cameras, providing detailed information of children’s behavior during therapy. This public release of the dataset comprises body motion, head position and orientation, and eye gaze variables, all specified as 3D data in a joint frame of reference. In addition, metadata including participant age, gender, and autism diagnosis (ADOS) variables are included. We release this data with the hope of supporting further data-driven studies towards improved therapy methods as well as a better understanding of ASD in general.CC BY 4.0DREAM - Development of robot-enhanced therapy for children with autism spectrum disorders