Acute mechanical bowel obstruction among adults see at the Lake Akintola

No Abstrac

Differing Endoplasmic Reticulum Stress Response to Excess Lipogenesis versus Lipid Oversupply in Relation to Hepatic Steatosis and Insulin Resistance

Mitochondrial dysfunction and endoplasmic reticulum (ER) stress have been implicated in hepatic steatosis and insulin resistance. The present study investigated their roles in the development of hepatic steatosis and insulin resistance during de novo lipogenesis (DNL) compared to extrahepatic lipid oversupply. Male C57BL/6J mice were fed either a high fructose (HFru) or high fat (HFat) diet to induce DNL or lipid oversupply in/to the liver. Both HFru and HFat feeding increased hepatic triglyceride within 3 days (by 3.5 and 2.4 fold) and the steatosis remained persistent from 1 week onwards (p<0.01 vs Con). Glucose intolerance (iAUC increased by ∼60%) and blunted insulin-stimulated hepatic Akt and GSK3β phosphorylation (∼40–60%) were found in both feeding conditions (p<0.01 vs Con, assessed after 1 week). No impairment of mitochondrial function was found (oxidation capacity, expression of PGC1α, CPT1, respiratory complexes, enzymatic activity of citrate synthase & β-HAD). As expected, DNL was increased (∼60%) in HFru-fed mice and decreased (32%) in HFat-fed mice (all p<0.05). Interestingly, associated with the upregulated lipogenic enzymes (ACC, FAS and SCD1), two (PERK/eIF2α and IRE1/XBP1) of three ER stress pathways were significantly activated in HFru-fed mice. However, no significant ER stress was observed in HFat-fed mice during the development of hepatic steatosis. Our findings indicate that HFru and HFat diets can result in hepatic steatosis and insulin resistance without obvious mitochondrial defects via different lipid metabolic pathways. The fact that ER stress is apparent only with HFru feeding suggests that ER stress is involved in DNL per se rather than resulting from hepatic steatosis or insulin resistance

Role of Routine Preoperative Laboratory Testing in Patients Undergoing Elective, Low-Risk Day Case Surgery

No Abstract

The Acceptance and the Perception of Mastectomy by Males whose Spouses are Diagnosed with Breast Cancer in South Western, Nigeria: Are male spouses an obstacle?

Of several modalities of treatments available for breast cancers, mastectomy is the most dramatic and traumatic. This is because it involves the removal of an organ of a woman's sexuality and with the attendant risk of marital disharmony. This study investigated the perception and the acceptance of mastectomy among male spouses of female patients with breast cancers. We prospectively recruited 108 participants from two teaching hospitals and a private hospital in South Western, Nigeria. The study recruited spouses of female patients newly diagnosed with breast cancers that were yet to have surgery. Relevant data were obtained through interview of the participants by the authors. The mean age of participants in the study was 44.34(±5.7) years. Less than half (48.1%) of the participants accepted the procedure for their female spouses prior to counseling which rose up to 84.3% after counseling. The main reason for declining mastectomy was disfigurement. Age greater than 65 years (p=0.0274), previous knowledge of mastectomy (p=0.0107) and counseling (p&lt;0.001) were associated with higher acceptance rate while educational status, religion and social class showed no statistical significant difference. Spouses of patients with locally advanced diseases accepted mastectomy more readily for their female partners as compared to those with early and metastatic diseases (p&lt;0.001). About 79% of those who accepted the procedure prior to counseling would exhibit negative behavior toward their partners. Majority of male spouses of females with breast cancers would not readily accept mastectomy for their female spouses and would have negative perception of their partners after mastectomy. We thus recommend that health care workers should involve men in breast cancer related education.Keywords: Acceptance, mastectomy, male spouse, female breast cancer and obstacl

Search for supersymmetry in events with at least one photon, missing transverse momentum, and large transverse event activity in proton-proton collisions at root s=13TeV

Peer reviewe