Cooling of the Earth: A parameterized convection study of whole versus layered models

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95162/1/ggge36.pd

Matter Effects in Atmospheric Neutrino Oscillations

The Kamiokande II and IMB data on contained events induced by atmospheric neutrinos exhibit too low a ratio of muons to electrons, which has been interpreted as a possible indication of neutrino oscillations. At the same time, the recent data on upward--going muons in underground detectors have shown no evidence for neutrino oscillations, strongly limiting the allowed region of oscillation parameter space. In this paper we confront different types of neutrino oscillation hypotheses with the experimental results. The matter effects in $\nu_\mu \leftrightarrow \nu_e$ and in $\nu_\mu \leftrightarrow \nu_{sterile}$ oscillations are discussed and shown to affect significantly the upward--going muons.Comment: LaTeX, 13 pages, 4 figures (appended as postscript file in the end of the paper, one should cut them and process separately), Roma n. 91

Evaluation of Population-Level Changes Associated With the 2021 US Preventive Services Task Force Lung Cancer Screening Recommendations in Community-Based Health Care Systems

Importance: The US Preventive Services Task Force (USPSTF) released updated lung cancer screening recommendations in 2021, lowering the screening age from 55 to 50 years and smoking history from 30 to 20 pack-years. These changes are expected to expand screening access to women and racial and ethnic minority groups. Objective: To estimate the population-level changes associated with the 2021 USPSTF expansion of lung cancer screening eligibility by sex, race and ethnicity, sociodemographic factors, and comorbidities in 5 community-based health care systems. Design, Setting, and Participants: This cohort study analyzed data of patients who received care from any of 5 community-based health care systems (which are members of the Population-based Research to Optimize the Screening Process Lung Consortium, a collaboration that conducts research to better understand how to improve the cancer screening processes in community health care settings) from January 1, 2010, through September 30, 2019. Individuals who had complete smoking history and were engaged with the health care system for 12 or more continuous months were included. Those who had never smoked or who had unknown smoking history were excluded. Exposures: Electronic health record-derived age, sex, race and ethnicity, socioeconomic status (SES), comorbidities, and smoking history. Main Outcomes and Measures: Differences in the proportion of the newly eligible population by age, sex, race and ethnicity, Charlson Comorbidity Index, chronic obstructive pulmonary disease diagnosis, and SES as well as lung cancer diagnoses under the 2013 recommendations vs the expected cases under the 2021 recommendations were evaluated using χ2 tests. Results: As of September 2019, there were 341 163 individuals aged 50 to 80 years who currently or previously smoked. Among these, 34 528 had electronic health record data that captured pack-year and quit-date information and were eligible for lung cancer screening according to the 2013 USPSTF recommendations. The 2021 USPSTF recommendations expanded screening eligibility to 18 533 individuals, representing a 53.7% increase. Compared with the 2013 cohort, the newly eligible 2021 population included 5833 individuals (31.5%) aged 50 to 54 years, a larger proportion of women (52.0% [n = 9631]), and more racial or ethnic minority groups. The relative increases in the proportion of newly eligible individuals were 60.6% for Asian, Native Hawaiian, or Pacific Islander; 67.4% for Hispanic; 69.7% for non-Hispanic Black; and 49.0% for non-Hispanic White groups. The relative increase for women was 13.8% higher than for men (61.2% vs 47.4%), and those with a lower comorbidity burden and lower SES had higher relative increases (eg, 68.7% for a Charlson Comorbidity Index score of 0; 61.1% for lowest SES). The 2021 recommendations were associated with an estimated 30% increase in incident lung cancer diagnoses compared with the 2013 recommendations. Conclusions and Relevance: This cohort study suggests that, in diverse health care systems, adopting the 2021 USPSTF recommendations will increase the number of women, racial and ethnic minority groups, and individuals with lower SES who are eligible for lung cancer screening, thus helping to minimize the barriers to screening access for individuals with high risk for lung cancer

Mass hierarchy discrimination with atmospheric neutrinos in large volume ice/water Cherenkov detectors

Large mass ice/water Cherenkov experiments, optimized to detect low energy (1-20 GeV) atmospheric neutrinos, have the potential to discriminate between normal and inverted neutrino mass hierarchies. The sensitivity depends on several model and detector parameters, such as the neutrino flux profile and normalization, the Earth density profile, the oscillation parameter uncertainties, and the detector effective mass and resolution. A proper evaluation of the mass hierarchy discrimination power requires a robust statistical approach. In this work, the Toy Monte Carlo, based on an extended unbinned likelihood ratio test statistic, was used. The effect of each model and detector parameter, as well as the required detector exposure, was then studied. While uncertainties on the Earth density and atmospheric neutrino flux profiles were found to have a minor impact on the mass hierarchy discrimination, the flux normalization, as well as some of the oscillation parameter (\Delta m^2_{31}, \theta_{13}, \theta_{23}, and \delta_{CP}) uncertainties and correlations resulted critical. Finally, the minimum required detector exposure, the optimization of the low energy threshold, and the detector resolutions were also investigated.Comment: 23 pages, 16 figure

Molecular markers of risk of subsequent invasive breast cancer in women with ductal carcinoma in situ: protocol for a population-based cohort study

INTRODUCTION: Ductal carcinoma in situ (DCIS) of the breast is a non-obligate precursor of invasive breast cancer (IBC). Many DCIS patients are either undertreated or overtreated. The overarching goal of the study described here is to facilitate detection of patients with DCIS at risk of IBC development. Here, we propose to use risk factor data and formalin-fixed paraffin-embedded (FFPE) DCIS tissue from a large, ethnically diverse, population-based cohort of 8175 women with a first diagnosis of DCIS and followed for subsequent IBC to: identify/validate miRNA expression changes in DCIS tissue associated with risk of subsequent IBC; evaluate ipsilateral IBC risk in association with two previously identified marker sets (triple immunopositivity for p16, COX-2, Ki67; Oncotype DX Breast DCIS score); examine the association of risk factor data with IBC risk. METHODS AND ANALYSIS: We are conducting a series of case-control studies nested within the cohort. Cases are women with DCIS who developed subsequent IBC; controls (2/case) are matched to cases on calendar year of and age at DCIS diagnosis. We project 485 cases/970 controls in the aim focused on risk factors. We estimate obtaining FFPE tissue for 320 cases/640 controls for the aim focused on miRNAs; of these, 173 cases/346 controls will be included in the aim focused on p16, COX-2 and Ki67 immunopositivity, and of the latter, 156 case-control pairs will be included in the aim focused on the Oncotype DX Breast DCIS score®. Multivariate conditional logistic regression will be used for statistical analyses. ETHICS AND DISSEMINATION: Ethics approval was obtained from the Institutional Review Boards of Albert Einstein College of Medicine (IRB 2014-3611), Kaiser Permanente Colorado, Kaiser Permanente Hawaii, Henry Ford Health System, Mayo Clinic, Marshfield Clinic Research Institute and Hackensack Meridian Health, and from Lifespan Research Protection Office. The study results will be presented at meetings and published in peer-reviewed journals

Three-Neutrino Oscillations of Atmospheric Neutrinos, theta13, Neutrino Mass Hierarchy and Iron Magnetized Detectors

We derive predictions for the Nadir angle (theta_n) dependence of the ratio Nmu-/Nmu+ of the rates of the mu- and mu+ multi-GeV events, and for the mu- - mu+ event rate asymmetry, A_{mu-mu+}=[Nmu- - Nmu+]/[Nmu- + Nmu+], in iron-magnetized calorimeter detectors (MINOS, INO) in the case of 3-neutrino oscillations of the atmospheric nu_mu and antinu_mu, driven by one neutrino mass squared difference, |Delta m^2_{31}| >> Delta m^2_{21}. The asymmetry A_{mu- mu+} (the ratio Nmu-/Nmu+) is shown to be particularly sensitive to the Earth matter effects in the atmospheric neutrino oscillations, and thus to the values of sin^2(theta13) and sin^2(theta23), theta13 and theta23 being the neutrino mixing angles limited by the CHOOZ and Palo Verde experiments and that responsible for the dominant atmospheric nu_mu -> nu_tau (antinu_mu -> antinu_tau) oscillations. It is also very sensitive to the type of neutrino mass spectrum which can be with normal (Delta m^2_{31}>0) or with inverted (Delta m^2_{31} 0.50, sin^2(2 theta13)>0.06 and Delta m^2_{31}=(2-3) 10^{-3} eV^2, the Earth matter effects produce a relative difference between the integrated asymmetries barA_{mu- mu+} and barA^{2nu}_{mu- mu+}$ in the mantle (cos(theta_n)=0.30-0.84) and core (cos(theta_n)=0.84-1.0) bins, which is bigger in absolute value than ~15%, can reach the values of (30-35)%, and thus can be sufficiently large to be observable. The sign of the indicated asymmetry difference is anticorrelated with the sign of Delta m^2_{31}. An observation of the Earth matter effects in the Nadir angle distribution of the asymmetry A_{mu- mu+} (ratio Nmu-/Nmu+) would clearly indicate that sin^2(2 theta13)>0.06 and sin^2(theta23)>0.50, and would lead to the determination of the sign of Delta m^2_{31}.Comment: 27 pages, 9 figure

Atmospheric Neutrino Oscillations, theta(13) and Neutrino Mass Hierarchy

We derive predictions for the Nadir angle (theta(n)) dependence of the ratio N(mu)/N(e) of the rates of the mu-like and e-like multi-GeV events measured in water-Cerenkov detectors in the case of 3-neutrino oscillations of the atmospheric nu(e) (antinu(e)) and nu(mu) (antinu(mu)), driven by one neutrino mass squared difference, |Delta m2(31)| ~ (2.5 - 3.0) x 10^(-3) eV^2 >> Delta m2(21). This ratio is particularly sensitive to the Earth matter effects in the atmospheric neutrino oscillations, and thus to the values of sin^2(theta(13)) and sin^2(theta(23)), theta(13) and theta(23) being the neutrino mixing angle limited by the CHOOZ and Palo Verde experiments and that responsible for the dominant atmospheric nu(mu) -> nu(tau) (antinu(mu) -> antinu(tau)) oscillations. It is also sensitive to the type of neutrino mass spectrum which can be with normal (Delta m2(31) > 0) or with inverted (Delta m2(31) < 0) hierarchy. We show that for sin^2(theta(13)) > 0.01, sin^2(theta(23)) > 0.5 and at cos(theta(n)) > 0.4, the Earth matter effects modify substantially the theta(n)-dependence of the ratio N(mu)/N(e) and in a way which cannot be reproduced with sin^2(theta(13)) = 0 and a different value of sin^2(theta(23)). For normal hierarchy the effects can be as large as ~ 25% for cos(theta(n)) ~ (0.5 - 0.8), can reach ~ 35% in the Earth core bin cos(theta(n)) ~ (0.84 - 1.0), and might be observable. They are typically by ~ 10% smaller in the inverted hierarchy case. An observation of the Earth matter effects in the Nadir angle distribution of the ratio N(mu)/N(e) would clearly indicate that sin^2(theta(13)) > 0.01 and sin^2(theta(23)) > 0.50.Comment: 22 p

Comparing and contrasting the νμ→ντ\nu_{\mu} \to \nu_{\tau} and νμ→νs\nu_{\mu} \to \nu_s solutions to the atmospheric neutrino problem with SuperKamiokande data

The $\nu_{\mu} \to \nu_{\tau}$ and $\nu_{\mu} \to \nu_s$ solutions to the atmospheric neutrino problem are compared with SuperKamiokande data. The differences between these solutions due to matter effects in the Earth are calculated for the ratio of $\mu$-like to $e$-like events and for up-down flux asymmetries. These quantities are chosen because they are relatively insensitive to theoretical uncertainties in the overall neutrino flux normalisation and detection cross-sections and efficiencies. A $\chi^2$ analysis using these quantities is performed yielding $3\sigma$ ranges which are approximately given by $(0.725 - 1.0, 4 \times 10^{-4} - 2 \times 10^{-2} eV^2)$ and $(0.74 - 1.0, 1 \times 10^{-3} - 2 \times 10^{-2} eV^2)$ for $(\sin^2 2\theta,\Delta m^2)$ for the $\nu_{\mu} \to \nu_{\tau}$ and $\nu_{\mu} \to \nu_s$ solutions, respectively. Values of $\Delta m^2$ smaller than about $2 \times 10^{-3}$ eV$^2$ are disfavoured for the $\nu_{\mu} \to \nu_s$ solution, suggesting that future long baseline experiments should see a positive signal if this scenario is the correct one.Comment: revtex, 22 pages, 12 figure

Atmospheric neutrino oscillations with three neutrinos and a mass hierarchy

A comprehensive formalism for the description of neutrino oscillations in the Earth in a general scheme with three massive neutrinos and the mass hierarchy m_1<<m_2<<m_3 is presented. Using this formalism, which is valid both in vacuum and in a medium, the matter effect on the oscillations of low-energy neutrinos is discussed, pointing out the existence of very long oscillations which are independent of the neutrino masses and the neutrino energy, and are very sensitive to the matter density along the neutrino trajectory. As an example of application of the formulation, a fit of the Kamiokande atmospheric neutrino data with the matter effect taken into account for neutrinos propagating in the Earth is presented. The results of the fit indicate that 4*10^{-3} eV^2 < m_3^2 nu_e, nu_munu_tau, nu_enu_tau) could be large. Hence, long-baseline experiments with reactor (CHOOZ and Palo Verde) and accelerator (K2K, MINOS and ICARUS) neutrinos could observe neutrino oscillations in all channels with a relatively large statistics.Comment: 42 pages, including 7 figure

The analysis of European lacquer : optimization of thermochemolysis temperature of natural resins

In order to optimize chromatographic analysis of European lacquer, thermochemolysis temperature was evaluated for the analysis of natural resins. Five main ingredients of lacquer were studied: sandarac, mastic, colophony, Manila copal and Congo copal. For each, five temperature programs were tested: four fixed temperatures (350, 480, 550, 650 degrees C) and one ultrafast thermal desorption (UFD), in which the temperature rises from 350 to 660 degrees C in 1 min. In total, the integrated signals of 27 molecules, partially characterizing the five resins, were monitored to compare the different methods. A compromise between detection of compounds released at low temperatures and compounds formed at high temperatures was searched. 650 degrees C is too high for both groups, 350 degrees C is best for the first, and 550 degrees C for the second. Fixed temperatures of 480 degrees C or UFD proved to be a consensus in order to detect most marker molecules. UFD was slightly better for the molecules released at low temperatures, while 480 degrees C showed best compounds formed at high temperatures