276 research outputs found
Ca II Triplet Spectroscopy of Small Magellanic Cloud Red Giants. I. Abundances and Velocities for a Sample of Clusters
We have obtained near-infrared spectra covering the Ca II triplet lines for a
number of stars associated with 16 SMC clusters using the VLT + FORS2. These
data compose the largest available sample of SMC clusters with
spectroscopically derived abundances and velocities. Our clusters span a wide
range of ages and provide good areal coverage of the galaxy. Cluster members
are selected using a combination of their positions relative to the cluster
center as well as their abundances and radial velocities. We determine mean
cluster velocities to typically 2.7 km/s and metallicities to 0.05 dex (random
errors), from an average of 6.4 members per cluster. (continued in paper)Comment: 68 pages, 15 figures, Accepted to AJ Reason for the replacement:
section 7 and fig. 9 have been modified according referee suggestion
Complete mitochondrial DNA sequences provide new insights into the Polynesian motif and the peopling of Madagascar
More than a decade of mitochondrial DNA (mtDNA) studies have given the 'Polynesian motif' renowned status as a marker for tracing the late-Holocene expansion of Austronesian speaking populations. Despite considerable research on the Polynesian motif in Oceania, there has been little equivalent work on the western edge of its expansion - leaving major issues unresolved regarding the motif's evolutionary history. This has also led to considerable uncertainty regarding the settlement of Madagascar. In this study, we assess mtDNA variation in 266 individuals from three Malagasy ethnic groups: the Mikea, Vezo, and Merina. Complete mtDNA genome sequencing reveals a new variant of the Polynesian motif in Madagascar; two coding region mutations define a Malagasy-specific sub-branch. This newly defined 'Malagasy motif' occurs at high frequency in all three ethnic groups (13-50%), and its phylogenetic position, geographic distribution, and estimated age all support a recent origin, but without conclusively identifying a specific source region. Nevertheless, the haplotype's limited diversity, similar to those of other mtDNA haplogroups found in our Malagasy groups, best supports a small number of initial settlers arriving to Madagascar through the same migratory process. Finally, the discovery of this lineage provides a set of new polymorphic positions to help localize the Austronesian ancestors of the Malagasy, as well as uncover the origin and evolution of the Polynesian motif itself
A Complete Set of Solutions For Caustic-Crossing Binary Microlensing Events
We present a method to analyze binary-lens microlensing light curves with one
well-sampled fold caustic crossing. In general, the surface of chi^2 shows
extremely complicated behavior over the 9-parameter space that characterizes
binary lenses. This makes it difficult to systematically search the space and
verify that a given local minimum is a global minimum. We show that for events
with well-monitored caustics, the caustic-crossing region can be isolated from
the rest of the light curve and easily fit to a 5-parameter function. Four of
these caustic-crossing parameters can then be used to constrain the search in
the larger 9-parameter space. This allows a systematic search for all solutions
and thus identification of all local minima. We illustrate this technique using
the PLANET data for MACHO 98-SMC-1, an excellent and publicly available
caustic-crossing data set. We show that a very broad range of parameter
combinations are compatible with the PLANET data set, demonstrating that
observations of binary-lens lightcurves with sampling of only one caustic
crossing do not yield unique solutions. The corollary to this is that the time
of the second caustic crossing cannot be reliably predicted on the basis of
early data including the first caustic crossing alone. We investigate the
requirements for determination of a unique solution and find that occasional
observations of the first caustic crossing may be sufficient to derive a
complete solution.Comment: 31 pages + 8 figures + 2 table
Resolving the ancestry of Austronesian-speaking populations
There are two very different interpretations of the prehistory of Island Southeast Asia (ISEA), with genetic evidence invoked in support of both. The “out-of-Taiwan” model proposes a major Late Holocene expansion of Neolithic Austronesian speakers from Taiwan. An alternative, proposing that Late Glacial/postglacial sea-level rises triggered largely autochthonous dispersals, accounts for some otherwise enigmatic genetic patterns, but fails to explain the Austronesian language dispersal. Combining mitochondrial DNA (mtDNA), Y-chromosome and genome-wide data, we performed the most comprehensive analysis of the region to date, obtaining highly consistent results across all three systems and allowing us to reconcile the models. We infer a primarily common ancestry for Taiwan/ISEA populations established before the Neolithic, but also detected clear signals of two minor Late Holocene migrations, probably representing Neolithic input from both Mainland Southeast Asia and South China, via Taiwan. This latter may therefore have mediated the Austronesian language dispersal, implying small-scale migration and language shift rather than large-scale expansion
Physics at a Neutrino Factory
In response to the growing interest in building a Neutrino Factory to produce
high intensity beams of electron- and muon-neutrinos and antineutrinos, in
October 1999 the Fermilab Directorate initiated two six-month studies. The
first study, organized by N. Holtkamp and D. Finley, was to investigate the
technical feasibility of an intense neutrino source based on a muon storage
ring. This design study has produced a report in which the basic conclusion is
that a Neutrino Factory is technically feasible, although it requires an
aggressive R&D program. The second study, which is the subject of this report,
was to explore the physics potential of a Neutrino Factory as a function of the
muon beam energy and intensity, and for oscillation physics, the potential as a
function of baseline.Comment: 133 pages, 64 figures. Report to the Fermilab Directorate. Available
from http://www.fnal.gov/projects/muon_collider/ This version fixes some
printing problem
The two metallicity groups of the globular cluster M22: a chemical perspective
We present a detailed chemical composition analysis of 35 red giant stars in
the globular cluster M22. High resolution spectra for this study were obtained
at five observatories, and analyzed in a uniform manner. We have determined
abundances of representative light proton-capture, alpha, Fe-peak and
neutron-capture element groups. Our aim is to better understand the peculiar
chemical enrichment history of this cluster, in which two stellar groups are
characterized by a different content in iron, neutron capture elements Y, Zr
and Ba, and alpha element Ca. The principal results of this study are: (i)
substantial star-to-star metallicity scatter (-2.0<[Fe/H]<-1.6); (ii)
enhancement of s-process/r-process neutron-capture abundance ratios in a
fraction of giants, positively correlated with metallicity; (iii) sharp
separation between the s-process rich and s-process poor groups by [La/Eu]
ratio; (iv) possible increase of [Cu/Fe] ratios with increasing [Fe/H],
suggesting that this element also has a significant s-process component; and
(v) presence of Na-O and C-N anticorrelations in both the stellar groups.Comment: 26 pages, 19 figures. Accepted for publication in A&
Three-dimensional stochastic model of actin–myosin binding in the sarcomere lattice
The effect of molecule tethering in three-dimensional (3-D) space on bimolecular binding kinetics is rarely addressed and only occasionally incorporated into models of cell motility. The simplest system that can quantitatively determine this effect is the 3-D sarcomere lattice of the striated muscle, where tethered myosin in thick filaments can only bind to a relatively small number of available sites on the actin filament, positioned within a limited range of thermal movement of the myosin head. Here we implement spatially explicit actomyosin interactions into the multiscale Monte Carlo platform MUSICO, specifically defining how geometrical constraints on tethered myosins can modulate state transition rates in the actomyosin cycle. The simulations provide the distribution of myosin bound to sites on actin, ensure conservation of the number of interacting myosins and actin monomers, and most importantly, the departure in behavior of tethered myosin molecules from unconstrained myosin interactions with actin. In addition, MUSICO determines the number of cross-bridges in each actomyosin cycle state, the force and number of attached cross-bridges per myosin filament, the range of cross-bridge forces and accounts for energy consumption. At the macroscopic scale, MUSICO simulations show large differences in predicted force-velocity curves and in the response during early force recovery phase after a step change in length comparing to the two simplest mass action kinetic models. The origin of these differences is rooted in the different fluxes of myosin binding and corresponding instantaneous cross-bridge distributions and quantitatively reflects a major flaw of the mathematical description in all mass action kinetic models. Consequently, this new approach shows that accurate recapitulation of experimental data requires significantly different binding rates, number of actomyosin states, and cross-bridge elasticity than typically used in mass action kinetic models to correctly describe the biochemical reactions of tethered molecules and their interaction energetics
Ancestry of the Iban Is Predominantly Southeast Asian: Genetic Evidence from Autosomal, Mitochondrial, and Y Chromosomes
Humans reached present-day Island Southeast Asia (ISEA) in one of the first major human migrations out of Africa. Population movements in the millennia following this initial settlement are thought to have greatly influenced the genetic makeup of current inhabitants, yet the extent attributed to different events is not clear. Recent studies suggest that south-to-north gene flow largely influenced present-day patterns of genetic variation in Southeast Asian populations and that late Pleistocene and early Holocene migrations from Southeast Asia are responsible for a substantial proportion of ISEA ancestry. Archaeological and linguistic evidence suggests that the ancestors of present-day inhabitants came mainly from north-to-south migrations from Taiwan and throughout ISEA approximately 4,000 years ago. We report a large-scale genetic analysis of human variation in the Iban population from the Malaysian state of Sarawak in northwestern Borneo, located in the center of ISEA. Genome-wide single-nucleotide polymorphism (SNP) markers analyzed here suggest that the Iban exhibit greatest genetic similarity to Indonesian and mainland Southeast Asian populations. The most common non-recombining Y (NRY) and mitochondrial (mt) DNA haplogroups present in the Iban are associated with populations of Southeast Asia. We conclude that migrations from Southeast Asia made a large contribution to Iban ancestry, although evidence of potential gene flow from Taiwan is also seen in uniparentally inherited marker data
Routes for breaching and protecting genetic privacy
We are entering the era of ubiquitous genetic information for research,
clinical care, and personal curiosity. Sharing these datasets is vital for
rapid progress in understanding the genetic basis of human diseases. However,
one growing concern is the ability to protect the genetic privacy of the data
originators. Here, we technically map threats to genetic privacy and discuss
potential mitigation strategies for privacy-preserving dissemination of genetic
data.Comment: Draft for comment
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