Implementación red de datos, red Wifi, planta telefónica IP en las instalaciones de la empresa Tecnoplac

Implementación red de datos, Red WIFI y Planta Telefónica IP en las instalaciones de la Empresa TECNOPLAC S.A. es un documento en el cual de forma organizada se muestra la implementación de la red de datos utilizada en esta empresa del sector industrial, además de las tecnológicas como Redes WIFI, Voz sobre IP, que aprovechan la red para extender sus usos y mejorar en servicios dentro de la organización. La red de datos de la empresa TECNOPLAC S.A. provee servicios de red como son: Servidor de datos, Servidor de Dominio, Servicio de Voz sobre IP, conexión inalámbrica, servicios de impresión, software centralizado, herramientas de mantenimiento en red, internet, servicios de correo electrónico, servicios de integración de planeación, servicios de Telepresencia, a 4 edificios los cuales hacen parte de la empresa y son el pilar fundamental de esta, estos se encuentran distribuidos en ubicaciones estratégicas a través de 193 puntos de red. La solución de ultima milla es en fibra óptica y este servicio es suministrado por la empresa de Telecomunicaciones UNE S.A., la empresa TECNOPLAC S.A. hace un año contaba con una canal dedicado de 2 megas a través del cual se manejaba el trafico de 35 equipos entre portátiles y PC de escritorio, pero en este momento se cuenta con una canal dedicado de 3 megas 1:1 debido a que se incremento el numero de computadores de escritorio y portátiles a 45 y además se le agrego a la red un equipo de videoconferencia para el cual se debe tener un canal con un ancho de banda disponible entre 512 y 1 mega.Incluye anexos, bibliografí

Proteomic Identification of Dengue Virus Binding Proteins in Aedes aegypti Mosquitoes and Aedes albopictus Cells

The main vector of dengue in America is the mosquito Aedes aegypti, which is infected by dengue virus (DENV) through receptors of midgut epithelial cells. The envelope protein (E) of dengue virus binds to receptors present on the host cells through its domain III that has been primarily recognized to bind cell receptors. In order to identify potential receptors, proteins from mosquito midgut tissue and C6/36 cells were purified by affinity using columns with the recombinant E protein domain III (rE-DIII) or DENV particles bound covalently to Sepharose 4B to compare and evaluate their performance to bind proteins including putative receptors from female mosquitoes of Ae. aegypti. To determine their identity mass spectrometric analysis of purified proteins separated by polyacrylamide gel electrophoresis was performed. Our results indicate that both viral particles and rE-DIII bound proteins with the same apparent molecular weights of 57 and 67 kDa. In addition, viral particles bound high molecular weight proteins. Purified proteins identified were enolase, beta-adrenergic receptor kinase (beta-ARK), translation elongation factor EF-1 alpha/Tu, and cadherin

Impacto de la variabilidad climática en la economía de los productores de plátano de comunidades nativas de la Amazonia Peruana

The objective of this study was to analyze the climatic variability that generates impact on the production and yield of banana, this was obtained with the analysis of meteorological data of temperature, precipitation and winds from the meteorological station of the National University of Ucayali and with quantitative data from a survey of 66 banana producers. 100% of the surveyed producers perceived climatic variations, these being the main causes of production losses, as is the case of the Santa Elisa native community and the Santa Elena village, which suffered economic losses between S /. 310.33 and 1029.37 caused by the low yield of this vegetable. This low and high yield are related to variations and climatic events; the increase in temperature causes the soil to lose the humidity that the plantations need for their proper development, and it also generates the proliferation of pests and diseases that modify the production process. However, the high yield is related to the floods, since the rising waters of the river favors the yield due to the amount of decomposed organic matter that is carried by the flow, fertilizing the banks where this vegetable is grown.El objetivo del presente estudio fue analizar la variabilidad climática que genera impacto en la producción y rendimiento del plátano, esto se obtuvo con el análisis de datos meteorológicos de temperatura, precipitación y vientos de la estación meteorológica de la Universidad Nacional de Ucayali y con datos cuantitativos de una encuesta realizada a 66 productores de plátano. El 100% de los productores encuestados percibió variaciones climáticas, siendo estas, las principales causas de pérdidas en la producción, como es el caso de la comunidad nativa Santa Elisa y el caserío Santa Elena que sufrieron pérdidas económicas entre S/. 310.33 y 1029.37 ocasionadas por el bajo rendimiento de este vegetal. Este bajo y alto rendimiento están relacionados con las variaciones y los eventos climáticos; el incremento de la temperatura hace que el suelo pierda la humedad que las plantaciones necesitan para su adecuado desarrollo, además genera la proliferación de plagas y enfermedades que modifican el proceso de producción. Sin embargo, el alto rendimiento está relacionado con las inundaciones, ya que la creciente de las aguas del río favorece el rendimiento por la cantidad de materia orgánica descompuesta que es acarreada por el caudal fertilizando las orillas donde se cultiva este vegetal.&nbsp

Una dieta enriquecida con CLA mejora el daño a órganos asociados al síndrome metabólico en ratas hipertensas espontáneas

The purpose of this study was to provide evidence that dietary CLA can prevent the pathogenesis of metabolic syndrome in tissue structure, suggesting potential benefits in the onset of this syndrome. Wistar male spontaneous hypertensive rats (SHR), were classified into two groups that were fed a standard diet for eight weeks: one with 7.5% sunflower oil (V-SHR group), and the other with 6% sunflower oil and 1.5% CLA (CLA-SHR group). A control healthy group consisted of Kyoto-Wistar male rats fed the standard diet with 7.5% sunflower oil. The animals were sacrificed, and sections of liver, kidneys and aorta were fixed in 10% formaldehyde, and then stained with Hematoxylin and Eosin. Only in the V-SHR group, the stain of the aorta indicated irregular endothelial morphology; liver parenchyma was characterized by an infiltration of inflammatory neutrophils, fibrosis, thickening of the portal vein epithelium, hepatocyte hyperplasia and steatosis. The renal tissue of this group evidenced hyperplasia in the cells of the endothelial of Bowman´s capsule. Abnormal histological changes were not observed in either the control group or the rats fed with CLA, suggesting a protective role of CLA in the onset of metabolic syndrome.El objetivo del presente estudio fue proporcionar evidencia que el CLA dietario puede evitar la patogénesis del síndrome metabólico en la estructura tisular, lo que sugiere beneficios potenciales en el desarrollo de este síndrome. Dos grupos de ratas Wistar macho espontáneamente hipertensas (SHR) fueron alimentadas con una dieta normal por 8 semanas: una dieta contenía 7.5% de aceite de girasol (grupo VSHR), y el otro contenía 6% de aceite de girasol y 1.5% de CLA (grupo CLA-SHR). A un grupo testigo sano de ratas macho Kyoto-Wistar les fue proporcionada una dieta normal con 7.5% de aceite de girasol. Los animales fueron sacrificados y se tomaron secciones de hígado, riñones y aorta, las cuales fueron fijadas en formaldehído al 10% y teñidas con Hematoxilina y Eosina. Las tinciones de aorta mostraron morfología irregular del endotelio en la aorta solo en el grupo V-SHR; el parénquima hepático se caracterizó por infiltración de neutrófilos inflamatorios, fibrosis y engrosamiento del epitelio de la vena porta, hiperplasia hepática y esteatosis. El tejido renal de este mismo grupo evidenció hiperplasia en las células del endotelio de la cápsula de Bowman. No se observaron cambios anormales histológicos tanto en el grupo testigo como en el alimentado con CLA, lo que sugiere un papel protector del CLA en el desarrollo del síndrome metabólico

Fecal occult blood and calprotectin testing to prioritize primary care patients for colonoscopy referral: The advantage study

AbstractColonoscopy is the gold standard for colorectal cancer (CRC) diagnosis and screening, but endoscopy services are usually overburdened. This study aims to investigate the usefulness of fecal hemoglobin (fHb) and calprotectin (FC) for the identification of patients with high probability of CRC who need urgent referral.MethodsIn a multicenter prospective study, we enrolled symptomatic patients referred from primary care for colonoscopy. Prior to bowel preparation, fHb and FC quantitative tests were performed. The diagnostic performance was estimated for each biomarker/combination. We built a multivariable predictive model based on logistic regression, translated to a nomogram and a risk calculator to assist clinicians in the decision‐making process.ResultsThe study included 1224 patients, of whom 69 (5.6%) had CRC. At the fHb cut‐offs of >0 and 10 μg/g, the negative predictive values for CRC were 98.8% (95% confidence interval 97.8%–99.3%) and 98.6% (95%CI 97.7%–99.1%), and the sensitivities were 85.5% (95%CI 75.0%–92.8%) and 79.7% (95%CI 68.3%–88.4%), respectively. When we added the cut‐off of 150 μg/g of FC to both fHb thresholds, the sensitivity of fecal tests improved. In the multivariate logistic regression model, the concentration of fHb was an independent predictor for CRC; age and gender were also independently associated with CRC.ConclusionsfHb and FC are useful as part of a triage tool to identify those symptomatic patients with high probability of CRC. This can be easily applied by physicians to prioritize high‐risk patients for urgent colonoscopy

The sole DNA ligase in entamoeba histolytica is a high-fidelity DNA ligase involved in DNA damage repair

"The protozoan parasite Entamoeba histolytica is exposed to reactive oxygen and nitric oxide species that have the potential to damage its genome. E. histolytica harbors enzymes involved in DNA repair pathways like Base and Nucleotide Excision Repair. The majority of DNA repairs pathways converge in their final step in which a DNA ligase seals the DNA nicks. In contrast to other eukaryotes, the genome of E. histolyticaencodes only one DNA ligase (EhDNAligI), suggesting that this ligase is involved in both DNA replication and DNA repair. Therefore, the aim of this work was to characterize EhDNAligI, its ligation fidelity and its ability to ligate opposite DNA mismatches and oxidative DNA lesions, and to study its expression changes and localization during and after recovery from UV and H2O2 treatment. We found that EhDNAligI is a high-fidelity DNA ligase on canonical substrates and is able to discriminate erroneous base-pairing opposite DNA lesions. EhDNAligI expression decreases after DNA damage induced by UV and H2O2 treatments, but it was upregulated during recovery time. Upon oxidative DNA damage, EhDNAligI relocates into the nucleus where it co-localizes with EhPCNA and the 8-oxoG adduct. The appearance and disappearance of 8-oxoG during and after both treatments suggest that DNA damaged was efficiently repaired because the mainly NER and BER components are expressed in this parasite and some of them were modulated after DNA insults. All these data disclose the relevance of EhDNAligI as a specialized and unique ligase in E. histolytica that may be involved in DNA repair of the 8-oxoG lesions.

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

Epidemiologic Features and Control Measures during Monkeypox Outbreak, Spain, June 2022

During June 2022, Spain was one of the countries most affected worldwide by a multicountry monkeypox outbreak with chains of transmission without identified links to disease-endemic countries. We provide epidemiologic features of cases reported in Spain and the coordinated measures taken to respond to this outbreak.S