Effect of Vinyl Flooring on the Modal Properties of a Steel Footbridge

Damping ratios associated with non structural elements play an important role in mitigating the pedestrian-induced vibrations of slender footbridges. In particular, this paper analyses the effect of vinyl flooring on the modal parameters of steel footbridges. Motivated by the unexpected high experimental damping ratios of the first vibration modes of a real footbridge, whose deck was covered by a vinyl flooring, this paper aims at assessing more accurately the experimental damping ratios generated by this non-structural element on steel footbridges. For this purpose, a laboratory footbridge was built and vinyl flooring was installed on it. Its numerical and experimental modal parameters without and with the vinyl flooring were determined. The operational modal analysis method was used to estimate experimentally the modal parameters of the structure. The damping ratios associated with the vinyl flooring were obtained via the substraction between the experimental damping ratios of the laboratory footbridge with and without the vinyl flooring. An average increase of the damping ratios of 2.069% was observed due to the vinyl flooring installed. According to this result, this type of pavement may be a useful tool to significantly increase the damping ratios of steel footbridges in order to reduce pedestrian-induced vibrationsMinisterio de Economía y Competitividad DPI2014-53947-RFondo Europeo de Desarrollo Regional DPI2014-53947-

The Caldera. No. 25 Special Edition 2022. 70 years

Especial: Instituto Caldas, 70 años de historia En las siguientes páginas, los estudiantes rinden homenaje a nuestra querida Institución, a través, especialmente, de la Palabra. Mi eterna gratitud a cada uno de ellos, jóvenes lectores, escritores, dibujantes pero, sobre todo, Caldistas de CORAZÓN: Laura Camila Herrera, Victoria Chacón Gil, María Paula Méndez, Steven Gómez Guerrero, Constanza Narváez Solano, Yatana Zea Arenas, Carolina Valencia Neira, Valery Samara Meza, Steffy Picón Carrillo y Gabriela Portilla Castellanos.Especial 70 años. Instituto Caldas 6 Reloj Solar 2021 43 IX Concurso de Lectura en Voz Alta 46 La Cuna de Excélsior 48 Equipo de Maestros 51 Perfiles Caldistas 54 Expresiones Caldistas 58 Día Caldista 98 Galería de Imágenes 103Special: Instituto Caldas, 70 years of history In the following pages, the students pay homage to our beloved Institution, especially through the Word. My eternal gratitude to each of them, young readers, writers, cartoonists but, above all, Caldistas of HEART: Laura Camila Herrera, Victoria Chacón Gil, María Paula Méndez, Steven Gómez Guerrero, Constanza Narváez Solano, Yatana Zea Arenas, Carolina Valencia Neira, Valery Samara Meza, Steffy Picón Carrillo and Gabriela Portilla Castellanos

Cross-disease Meta-analysis of Genome-wide Association Studies for Systemic Sclerosis and Rheumatoid Arthritis Reveals IRF4 as a New Common Susceptibility Locus

Objectives: Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that share clinical and immunological characteristics. To date, several shared SSc- RA loci have been identified independently. In this study, we aimed to systematically search for new common SSc-RA loci through an inter-disease meta-GWAS strategy. Methods: We performed a meta-analysis combining GWAS datasets of SSc and RA using a strategy that allowed identification of loci with both same-direction and opposingdirection allelic effects. The top single-nucleotide polymorphisms (SNPs) were followed-up in independent SSc and RA case-control cohorts. This allowed us to increase the sample size to a total of 8,830 SSc patients, 16,870 RA patients and 43,393 controls. Results: The cross-disease meta-analysis of the GWAS datasets identified several loci with nominal association signals (P-value < 5 x 10-6), which also showed evidence of association in the disease-specific GWAS scan. These loci included several genomic regions not previously reported as shared loci, besides risk factors associated with both diseases in previous studies. The follow-up of the putatively new SSc-RA loci identified IRF4 as a shared risk factor for these two diseases (Pcombined = 3.29 x 10-12). In addition, the analysis of the biological relevance of the known SSc-RA shared loci pointed to the type I interferon and the interleukin 12 signaling pathways as the main common etiopathogenic factors. Conclusions: Our study has identified a novel shared locus, IRF4, for SSc and RA and highlighted the usefulness of cross-disease GWAS meta-analysis in the identification of common risk loci

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER), "A way of making Europe".Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk. Imputed total C4, C4A, C4B, and HERV-K CN were analyzed in 26,633 individuals and validated in an independent cohort. Our results showed that higher C4 CN confers protection to SSc, and deviations from CN parity of C4A and C4B augmented risk. The protection contributed per copy of C4A and C4B differed by sex. Stronger protection was afforded by C4A in men and by C4B in women. C4 CN correlated well with its gene expression and serum protein levels, and less C4 was detected for both in SSc patients. Conditioned analysis suggests that C4 genetics strongly contributes to the SSc association within the major histocompatibility complex locus and highlights classical alleles and amino acid variants of HLA-DRB1 and HLA-DPB1 as C4-independent signals

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Revisión de las teorías de campo de compresiones en hormigón estructural

Tesis Univ. Granada. Departamento de Mecánica de Estructuras e Ingeniería Hidráulic

The Economic Impact Associated with the Direct Connection Strength of Micropiles in Foundation Retrofit Projects

Building foundations are usually retrofitted with directly connected micropiles; however, at the present time, there are different approaches for predicting shear capacity in the micropile–foundation connection. At first, the concrete shear strength was considered. Nowadays, in the EU countries, it is prescribed to use the shear strength of the interface between successive concrete casts at different times. This implies a reduction of the connection capacity by half, and these values are not in consonance with the lab results. This work analyses the economic impact of the previous considerations on retrofit projects with micropiles. To this aim, firstly, seven different formulations were applied to 29 building projects, and the results were compared. Secondly, a Monte Carlo sensitivity analysis was performed using bond stress distribution data obtained from lab tests. Thus, numerical results acquired by comparing European and American regulations show an average difference in cost of around 40%, which may reach up to 50%. Moreover, the Monte Carlo simulation confirms that the connection strength may become a limitation in retrofit projects, also indicating that the application of European codes usually leads to the most expensive designs. Finally, the results show that it is not worth improving the connection to exceed a bond stress of 0.60 MPa, since no relevant savings are produced by achieving higher values

La salud y el uso de los servicios de salud por las mujeres de las áreas urbana y rural en las zonas de alta y muy alta marginación socioeconómica de la región fronteriza de Chiapas

En este ensayo se analizan diversos indicadores de salud, de autopercepción de salud, y de uso de servicios de salud relativos a 2 558 mujeres de 15 a 49 años que habitan en localidades urbanas y rurales de municipios de alta y muy alta marginación socioeconómica de la región fronteriza de Chiapas. Las únicas que no presentaron condiciones tan desfavorables (socioeconómicas, de salud y uso de servicios) fueron las mujeres urbanas de alta marginación. Los bajos valores observados en diversos indicadores no correspondieron a un mayor uso de los servicios de salud, lo cual sugiere una baja percepción de riesgos a la salud. Se concluye que es necesario evaluar los programas de atención materno infantil en la región y realizar investigaciones sobre las percepciones de riesgo a la salud y su relación con el uso de los servicios respectivos

Morphological and molecular identification of Phytophthora capsici L. in pipiana pumpkin and its greenhouse management

L a calabaza pipiana es importante en la alimentación de la población en el centro-sur de México . Sus semillas se consumen directamente tostadas y aderezadas con sal; además, son el ingrediente principal para elaborar platillos típicos como el mole verde o pipian, así como diferentes dulces tradicionales. Algunos microorganismos del suelo causan severos problemas en frutos, lo que afecta el rendimiento. El objetivo del estudio fue identificar morfológica y molecularmente al oomicete causante de la pudrición de frutos de calabaza pipiana, y evaluar opciones de control químico y biológico en invernadero. Durante agosto y septiembre de 2011, en la zona norte del estado de Guerrero, se colectaron frutos de calabaza pipiana con síntomas de pudrición. La identificación morfológica se realizó con las claves propuestas por Gallegly y Hong (2008), y la molecular fue mediante la reacción en cadena de la polimerasa, ITS-PCR. En ambas pruebas se identificó a Phytophthora capsici como el causante de la pudrición de frutos de calabaza pipiana. Las secuencias obtenidas tuvieron 99 % de similitud con P. capsici en sandía de Estados Unidos y en calabaza de Italia, depositadas en el banco de genes (GenBank). Los ingredientes activos, propamocarb+fosetil y metalaxil+clorotalonil, mostraron control al retrasar seis días la presencia del patógeno en frutos, mientras que los agentes de biocontrol la retardaron cuatro días