Biology and reproductive traits of Drymoea veliterna (Druce, 1885) (Lepidoptera: Geometridae)

Despite the urban and landscape impact caused by Drymoea veliterna (Druce, 1885) (Lepidoptera: Geometridae) larvae on trees of the genus Croton L. (Euphorbiaceae) in the Neotropics, there is no information about its biology and reproductive traits. In this study, we describe the life cycle and reproductive traits of this species. Its life cycle lasts approximately 56 days, the larvae develop during 24 days on average and the longevity of the females is 7 days on average. Females have an average fecundity of 207 eggs. Regarding their reproductive system, the presence of previtellogenic eggs in the reproductive tract of the females is emphasized. The bursa copulatrix and a highly sclerotized signum is depicted. The number of spermatophores found in the reproductive tract of the females was quantified. Male and female genitalia were schematized

Diplomado: Llevando tus clases a otro nivel, ¡vive la experiencia!

El presente trabajo buscar permear en la realidad académica de los docentes, en la medida que propone la elaboración de un proyecto de investigación orientado al fortalecimiento e implementación de herramientas didácticas para la transformación de las clases virtuales, brindando nuevas ópticas de las plataformas digitales en la educación, su evolución e integración como mediadores y facilitadores del proceso de enseñanza aprendizaje que se esta viviendo en la actualidad, como es bien sabido la llegada del covid-19 generó un cambio en la manera de enseñar y aprender para muchos, puesto que para no detener el proceso de formación se continuó a través de clases virtuales, que hoy día en muchas instituciones se mantiene a pesar de la alternancia; dentro de este proceso se evidenció que a muchos docentes la implementación de las tecnologías de la información y la comunicación no les fue tan sencillo y los recursos pedagógicos con los cuales mediaban los encuentros carecían en ocasiones de significado, atracción e interés y a su vez para los estudiantes fue un cambio radical en la apropiación del conocimiento, en la atención y concentración entre otros tantos factores que permitieron que el proceso de enseñanza se viera transformado y alterado. De allí surge nuestra propuesta de construir un diplomado para docentes, que facilite y promueva didácticas de intervención por medio del uso de las plataformas digitales, permitiendo que los encuentros sean cercanos, didácticos, prácticos y experienciales, fomentando aprendizajes desde plataformas cercanas a los estudiantes, apropiando el sentimiento de pertenencia y cercanía junto con la apropiación de nuevos saberes para el docente, que le permite seguir en la construcción del saber al adquirir nuevas prácticas.This work seeks to permeate the academic reality of teachers, insofar as it proposes the development of a research project aimed at strengthening and implementing didactic tools for the transformation of virtual classes, providing new perspectives of digital platforms in the education, its evolution and integration as mediators and facilitators of the teaching-learning process that is currently being lived, as is well known, the arrival of the covid-19 generated a change in the way of teaching and learning for many, since for not stopping the training process was continued through virtual classes, which today in many institutions is maintained despite the alternation; Within this process, it was evidenced that for many teachers the implementation of information and communication technologies was not so simple and the pedagogical resources with which they mediated the meetings sometimes lacked meaning, attraction and interest and in turn for the students. students were a radical change in the appropriation of knowledge, attention and concentration among many other factors that allowed the teaching process to be transformed and altered. Hence our proposal to build a diploma for teachers, which facilitates and promotes intervention didactics using digital platforms, allowing meetings to be close, didactic, practical, and experiential, promoting learning from platforms close to students, appropriating the feeling of belonging and closeness together with the appropriation of new knowledge for the teacher, which allows him to continue in the construction of knowledge by acquiring new practices.Introducción. -- Planteamiento del problema. -- Objetivos. -- Objetivo general. -- Objetivos específicos. --Justificación. -- Marco conceptual. -- Estado del arte. -- Marco metodológico. -- Propuesta de intervención. -- Ficha Técnica. -- Referencias

Noninvasive Biomarkers for the Diagnosis of Liver Fibrosis and Cirrhosis

The clinical importance of monitoring liver fibrosis lies in the morbidity and mortality of the chronic liver diseases in relation to the stage and progression of fibrosis. Whether the fibrosis stabilizes or regresses depends on the specific treatment. Liver biopsy, the current standard for the diagnosis, has implicit limitations due to sampling heterogeneity. There are noninvasive imaging methods, such as transient elastography that measures the stiffness of the liver, but it has some limitations (feasibility and unreliability), particularly in obese patients. FibroTest is the most widely used noninvasive serological method worldwide which is efficacious in the extreme stages of fibrosis, but these methods cannot discern intermediate stages. Liver fibrosis is a dynamic response that involves multiple cellular and molecular events with an excessive deposit of extracellular matrix. Even though there is much information on the pathophysiology of fibrosis, that knowledge is still incomplete, greatly hindering the development of both an accurate treatment and a noninvasive diagnostic method with adequate sensitivity for all the stages of fibrosis. It is known that IGFBP participates in liver homeostasis, and thus these proteins can be used as serum biomarkers during the progression of liver fibrosis in chronic hepatitis C

Desarrollo de la habilidad oral a través del juego en estudiantes de cuarto grado de educación básica primaria

El presente estudio denominado “Desarrollo de la habilidad oral a través del juegoenestudiantesdecuartogrado de educación básica primaria” implementado en la Institución Educativa Claretiano “Gustavo Torres Parra”, se desarrolló en tres etapas: la etapa de diagnóstico donde se observó el contexto y se detectó el problema, el cual se enfocó en la habilidad oral. Luego se procedió a la etapa de intervención, que consistió en la implementación del juego como estrategia para el mejoramiento del elemento comunicativo en el inglés, y por último, se procedió al análisis y discusión de resultados. El estudio se llevó a cabo a través delmétodo investigación-acción, que permitió la aplicación de seis ciclos. Al final del estudio se llegó a la conclusión que el juego es una herramienta que facilita ampliamente el desarrollo de la habilidad oral, mejora la actitud del aprendiz frente al inglés, y se propone el trabajo en grupo para fortalecer la confianza del estudiante y alcanzar los objetivos propuestos

COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study

Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41–0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02–1.04; HR = 1.79, 95% CI:1.04–3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated

The evolving landscape of COVID‐19 and post‐COVID condition in patients with chronic lymphocytic leukemia: A study by ERIC, the European research initiative on CLL

In this retrospective international multicenter study, we describe the clinical characteristics and outcomes of patients with chronic lymphocytic leukemia (CLL) and related disorders (small lymphocytic lymphoma and high-count monoclonal B lymphocytosis) infected by SARS-CoV-2, including the development of post-COVID condition. Data from 1540 patients with CLL infected by SARS-CoV-2 from January 2020 to May 2022 were included in the analysis and assigned to four phases based on cases disposition and SARS-CoV-2 variants emergence. Post-COVID condition was defined according to the WHO criteria. Patients infected during the most recent phases of the pandemic, though carrying a higher comorbidity burden, were less often hospitalized, rarely needed intensive care unit admission, or died compared to patients infected during the initial phases. The 4-month overall survival (OS) improved through the phases, from 68% to 83%, p = .0015. Age, comorbidity, CLL-directed treatment, but not vaccination status, emerged as risk factors for mortality. Among survivors, 6.65% patients had a reinfection, usually milder than the initial one, and 16.5% developed post-COVID condition. The latter was characterized by fatigue, dyspnea, lasting cough, and impaired concentration. Infection severity was the only risk factor for developing post-COVID. The median time to resolution of the post-COVID condition was 4.7 months. OS in patients with CLL improved during the different phases of the pandemic, likely due to the improvement of prophylactic and therapeutic measures against SARS-CoV-2 as well as the emergence of milder variants. However, mortality remained relevant and a significant number of patients developed post-COVID conditions, warranting further investigations

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes and functional assays of all major human and murine immune cell subsets. Notably, the Guidelines contain helpful tables highlighting phenotypes and key differences between human and murine cells. Another useful feature of this edition is the flow cytometry analysis of clinical samples with examples of flow cytometry applications in the context of autoimmune diseases, cancers as well as acute and chronic infectious diseases. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid. All sections are written and peer‐reviewed by leading flow cytometry experts and immunologists, making this edition an essential and state‐of‐the‐art handbook for basic and clinical researchers.DFG, 389687267, Kompartimentalisierung, Aufrechterhaltung und Reaktivierung humaner Gedächtnis-T-Lymphozyten aus Knochenmark und peripherem BlutDFG, 80750187, SFB 841: Leberentzündungen: Infektion, Immunregulation und KonsequenzenEC/H2020/800924/EU/International Cancer Research Fellowships - 2/iCARE-2DFG, 252623821, Die Rolle von follikulären T-Helferzellen in T-Helferzell-Differenzierung, Funktion und PlastizitätDFG, 390873048, EXC 2151: ImmunoSensation2 - the immune sensory syste

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries