Estado

This article contains the Spanish translation of the entry “Staat”, of Hermann Heller, with an introduction to his political and juridical thought.Este artículo contiene la traducción al castellano de la entrada “Estado” de Hermann Heller, con una introducción a su pensamiento político y jurídico

Density of States Extracted from Modified Recursion Relations

We evaluate the density of states (DOS) associated with tridiagonal symmetric Hamiltonian matrices and study the effect of perturbation on one of its entries. Analysis is carried out by studying the resulting three-term recursion relation and the corresponding orthogonal polynomials of the first and second kind. We found closed form expressions for the new DOS in terms of the original one when perturbation affects a single diagonal or off-diagonal site or a combination of both. The projected DOS is also calculated numerically and its relation to the average DOS is explored both analytically and numerically.Comment: 15 pages including 8 figures (one in color

Andean roots and tubers: Ahipa, arracacha, maca and yacon

At least 25 species of root and tuber crops from 16 genera and 15 families are native to South America. Apart from the 7 species of potato (Solanum spp.), there are nine lesser known species native to the Andes that are grown for their edible underground organs and are traditionally, but not exclusively, cultivated by indigenous people who use them for subsistence or as cash crops. This book is the first of two volumes to deal in depth with the biology and genetic resources of these Andean root and tuber crops, and, following an introduction, is divided into 4 multiauthor sections: (1) ahipa (Pachyrhizus ahipa) by M. Sorensen, W. J. Gruneberg and B. Orting; (2) arracacha (Arracacia xanthorrhiza) by M. Hermann; (3) maca (Lepidium meyenii) by C. F. Quiros and R. Aliaga Cardenas; and yacon (Smallanthus sonchifolius) by A. Grau and J. Rea. Each section follows the standard format for the series and reviews aspects of their taxonomy, botany, origin, ecology, properties, uses, conservation, evaluation of diversity and breeding. In addition, full accounts are given of crop production areas, agronomy, limitations, prospects and research needs. A single appendix lists research workers by country. (Abstract © CAB ABSTRACTS, CAB International

Thymidine Metabolism as Confounding Factor of 3'-Deoxy-3'-[18F]Fluorothymidine Uptake after Therapy in a Colorectal Cancer Model.

Non-invasive monitoring of tumor therapy response helps in developing personalized treatment strategies. Here, we performed sequential positron emission tomography (PET) and diffusion-weighted magnetic resonance imaging (DW-MRI) to evaluate changes induced by a FOLFOX-like combination chemotherapy in colorectal cancer (CRC) xenografts, to identify the cellular and molecular determinants of these imaging biomarkers. Methods: Tumor bearing CD1 nude mice, engrafted with FOLFOX-sensitive Colo205 CRC xenografts, were treated with FOLFOX (5 fluorouracil, leucovorin and oxaliplatin) in weekly intervals. On d1, d2, d6, d9 and d13 of therapy, tumors were assessed by in vivo imaging and ex vivo analyses. In addition, HCT116 xenografts, which did not respond to the FOLFOX treatment, were imaged on d1 of therapy. Results: In Colo205 xenografts, FOLFOX induced a profound increase in uptake of the proliferation PET tracer 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT), which was accompanied by increases in markers for proliferation (Ki67, TK1) and for activated DNA damage response (DDR; γH2AX), whereas the effect on cell death was minimal. As tracer uptake was unaltered in the HCT116 model, these changes appear to be specific for tumor response. Conclusion: We demonstrate that [18F]FLT PET can non-invasively monitor molecular alterations induced by a cancer treatment, including thymidine metabolism and DDR. The cellular or imaging changes may not, however, be directly related to therapy response as assessed by volumetric measurements

Thermal variational principle and gauge fields

A Feynman-Jensen version of the thermal variational principle is applied to hot gauge fields, Abelian as well as non-Abelian: scalar electrodynamics (without scalar self-coupling) and the gluon plasma. The perturbatively known self-energies are shown to derive by variation from a free quadratic (''Gaussian'') trial Lagrangian. Independence of the covariant gauge fixing parameter is reached (within the order $g^3$ studied) after a reformulation of the partition function such that it depends on only even powers of the gauge field. Also static properties (Debye screening) are reproduced this way. But because of the present need to expand the variational functional, the method falls short of its potential nonperturbative power.Comment: 36 pages, LaTeX, no figures. Updated version: new title, section on static properties and some references adde

Design concepts for the Cherenkov Telescope Array CTA: an advanced facility for ground-based high-energy gamma-ray astronomy

Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA