A Hierarchy of Sovereigns through the Limitation of Tribal Criminal Jurisdiction

Tribal criminal jurisdiction has been limited by the enactment of the Indian Bill of Rights and acts that give states criminal jurisdiction over tribal lands instead of allowing tribal nations to self-govern criminal acts that occur on their lands. Additionally, Congress has used its plenary power to erode the tribal criminal jurisdiction. The United States Constitution recognizes three sovereigns: States, Foreign Nations, and Tribal Nations. This erosion, along with United States Supreme Court decisions, created a hierarchical class of sovereignty in the sovereigns recognized by the United States Constitution, with tribal nations occupying the lowest position on this hierarchy. In this lower position, tribal members, as American citizens, also occupy a lower position than any other American citizen group. In an effort to rebuild the tribal criminal jurisdiction and provide tribal members, who are victims of crimes by non-members, an appropriate remedy, a federal district court should be created on tribal reservations to provide transparency and inclusion for tribal nations

Irish women in the diaspora: exclusions and inclusions

Irish women have a long history of emigration which provides parallels with the experiences of women now moving to settle in Ireland. In both cases, women migrants have been needed to fill the massive deficit of paid domestic labor in rapidly industrialising economies. Over the last two centuries, these destinations for Irish women have included the USA, Britain and Australia, as well as Canada, New Zealand, South Africa and Argentina. Some of the complexities in the positioning of migrant Irish women within the “diaspora spaces” they occupy are explored in this article. I identify ongoing disadvantage for certain groups of Irish-born women, drawing on evidence primarily from Britain, which has the largest contemporary diasporic Irish population. Comparisons are made with Irish women's experiences in the USA and Australia, using Census and survey data generated by and for the 2002 Task Force on Policy regarding Emigrants. The concept of diaspora explicitly includes those identifying themselves as Irish over several generations. I use qualitative findings from the Irish 2 Project, a recent study of the large second-generation Irish population in Britain, to examine narratives of women living in Manchester who grew up in “Irish” households and are subsequently negotiating hybrid identities in adulthood. These offer insights into longitudinal dimensions of migrant experience and the continuing significance of ethnic difference

Constraining the Geometry of the Neutron Star RX J1856.5-3754

RX J1856.5-3754 is one of the brightest, nearby isolated neutron stars, and considerable observational resources have been devoted to its study. In previous work, we found that our latest models of a magnetic, hydrogen atmosphere matches well the entire spectrum, from X-rays to optical (with best-fitting neutron star radius R=14 km, gravitational redshift z_g~0.2, and magnetic field B~4x10^12 G). A remaining puzzle is the non-detection of rotational modulation of the X-ray emission, despite extensive searches. The situation changed recently with XMM-Newton observations that uncovered 7 s pulsations at the 1% level. By comparing the predictions of our model (which includes simple dipolar-like surface distributions of magnetic field and temperature) with the observed brightness variations, we are able to constrain the geometry of RX J1856.5-3754, with one angle < 6 deg and the other angle = 20-45 deg, though the solutions are not definitive given the observational and model uncertainties. These angles indicate a close alignment between the rotation and magnetic axes or between the rotation axis and the observer. We discuss our results in the context of RX J1856.5-3754 being a normal radio pulsar and a candidate for observation by future X-ray polarization missions such as Constellation-X or XEUS.Comment: 7 pages, 6 figures; MNRAS, accepte

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

Maintenance of endoplasmic reticulum (ER) function is achieved in part through Ire1 (inositol-requiring enzyme 1), a transmembrane protein activated by protein misfolding in the ER. The cytoplasmic nuclease domain of Ire1 cleaves the messenger RNA (mRNA) encoding XBP-1 (X-box–binding protein 1), enabling splicing and production of this active transcription factor. We recently showed that Ire1 activation independently induces the rapid turnover of mRNAs encoding membrane and secreted proteins in Drosophila melanogaster cells through a pathway we call regulated Ire1-dependent decay (RIDD). In this study, we show that mouse fibroblasts expressing wild-type Ire1 but not an Ire1 variant lacking nuclease activity also degrade mRNAs in response to ER stress. Using a second variant of Ire1 that is activated by a small adenosine triphosphate analogue, we show that although XBP-1 splicing can be artificially induced in the absence of ER stress, RIDD appears to require both Ire1 activity and ER stress. Our data suggest that cells use a multitiered mechanism by which different conditions in the ER lead to distinct outputs from Ire1

The needle in the haystack - Where to look for more isolated cooling neutron stars

Context: Isolated cooling neutron stars with thermal X-ray emission remain rarely detected objects despite many searches investigating the ROSAT data. Aims: We simulate the population of close-by young cooling neutron stars to explain the current observational results. Given the inhomogeneity of the neutron star distribution on the sky it is particularly interesting to identify promising sky regions with respect to on-going and future searches. Methods: Applying a population synthesis model the inhomogeneity of the progenitor distribution and the inhomogeneity of the X-ray absorbing interstellar medium are considered for the first time. The total number of observable neutron stars is derived with respect to ROSAT count rates. In addition, we present sky maps of neutron star locations and discuss age and distance distributions of the simulated neutron stars. Implications for future searches are discussed. Results: With our advanced model we can successfully explain the observed logN - logS distribution of close-by neutron stars. Cooling neutron stars will be most abundant in the directions of rich OB associations. New candidates are expected to be identified behind the Gould Belt, in particular in the Cygnus-Cepheus region. They are expected to be on average younger and then hotter than the known population of isolated cooling neutron stars. In addition, we propose to use data on runaway stars to search for more radio-quiet cooling neutron stars.Comment: 18 pages, 14 figures; added Erratum after bug in code was discovered, updated results in Appendix, main conclusions do not chang

Transit timing variation and activity in the WASP-10 planetary system

Transit timing analysis may be an effective method of discovering additional bodies in extrasolar systems which harbour transiting exoplanets. The deviations from the Keplerian motion, caused by mutual gravitational interactions between planets, are expected to generate transit timing variations of transiting exoplanets. In 2009 we collected 9 light curves of 8 transits of the exoplanet WASP-10b. Combining these data with published ones, we found that transit timing cannot be explained by a constant period but by a periodic variation. Simplified three-body models which reproduce the observed variations of timing residuals were identified by numerical simulations. We found that the configuration with an additional planet of mass of $\sim$0.1 $M_{\rm{J}}$ and orbital period of $\sim$5.23 d, located close to the outer 5:3 mean motion resonance, is the most likely scenario. If the second planet is a transiter, the estimated flux drop will be $\sim$0.3 per cent and can be observable with a ground-based telescope. Moreover, we present evidence that the spots on the stellar surface and rotation of the star affect the radial velocity curve giving rise to spurious eccentricity of the orbit of the first planet. We argue that the orbit of WASP-10b is essentially circular. Using the gyrochronology method, the host star was found to be $270 \pm 80$ Myr old. This young age can explain the large radius reported for WASP-10b.Comment: MNRAS accepte

PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response

Poly(ADP-ribose) polymerases (PARPs; also known as ADP-ribosyl transferase D proteins) modify acceptor proteins with ADP-ribose modifications of varying length (reviewed in refs 1, 2, 3). PARPs regulate key stress response pathways, including DNA damage repair and the cytoplasmic stress response. Here, we show that PARPs also regulate the unfolded protein response (UPR) of the endoplasmic reticulum (ER). Human PARP16 (also known as ARTD15) is a tail-anchored ER transmembrane protein required for activation of the functionally related ER stress sensors PERK and IRE1α during the UPR. The third identified ER stress sensor, ATF6, is not regulated by PARP16. As is the case for other PARPs that function during stress, the enzymatic activity of PARP16 is upregulated during ER stress when it ADP-ribosylates itself, PERK and IRE1α. ADP-ribosylation by PARP16 is sufficient for activating PERK and IRE1α in the absence of ER stress, and is required for PERK and IRE1α activation during the UPR. Modification of PERK and IRE1α by PARP16 increases their kinase activities and the endonuclease activity of IRE1α. Interestingly, the carboxy-terminal luminal tail of PARP16 is required for PARP16 function during ER stress, suggesting that it transduces stress signals to the cytoplasmic PARP catalytic domain.National Cancer Institute (U.S.) (Cancer Center Support Core Grant P30-CA14051)National Institutes of Health (U.S.) (Grant 5R01 GM087465-02)Kathy and Curt Marble Cancer Research FundJeptha H. and Emily V. Wade FundVirginia and D.K. Ludwig Fund for Cancer Researc