Infrared Spectral Energy Distributions of Seyfert Galaxies: Spitzer Space Telescope Observations of the 12 micron Sample of Active Galaxies

The mid-far-infrared spectral energy distributions (SEDs) of 83 active galaxies, mostly Seyfert galaxies, selected from the extended 12 micron sample are presented. The data were collected using all three instruments, IRAC, IRS, and MIPS, aboard the Spitzer Space Telescope. The IRS data were obtained in spectral mapping mode, and the photometric data from IRAC and IRS were extracted from matched, 20 arcsec diameter circular apertures. The MIPS data were obtained in SED mode, providing very low resolution spectroscopy (R ~ 20) between ~ 55 and 90 microns in a larger, 20 by 30 arcsec synthetic aperture. We further present the data from a spectral decomposition of the SEDs, including equivalent widths and fluxes of key emission lines; silicate 10 and 18 micron emission and absorption strengths; IRAC magnitudes; and mid-far infrared spectral indices. Finally, we examine the SEDs averaged within optical classifications of activity. We find that the infrared SEDs of Seyfert 1s and Seyfert 2s with hidden broad line regions (HBLR, as revealed by spectropolarimetry or other technique) are qualitatively similar, except that Seyfert 1s show silicate emission and HBLR Seyfert 2s show silicate absorption. The infrared SEDs of other classes with the 12 micron sample, including Seyfert 1.8-1.9, non-HBLR Seyfert 2 (not yet shown to hide a type 1 nucleus), LINER and HII galaxies, appear to be dominated by star-formation, as evidenced by blue IRAC colors, strong PAH emission, and strong far-infrared continuum emission, measured relative to mid-infrared continuum emission.Comment: 78 pages, 13 figure

Deficiency of Broad Line AGNs in Compact Groups of Galaxies

Based on a new survey of AGN activity in Compact Groups of Galaxies, we report a remarkable deficiency of Broad Line AGNs as compared to Narrow Line AGNs. The cause of such deficiency could be related to the average low luminosity of AGNs in CGs: $10^{39}$ erg s$^{-1}$. This result may imply lower accretion rates in CG AGNs, making Broad Line Regions (BLR) undetectable, or may indicate a genuine absence of BLRs. Both phenomena are consistent with gas stripping through tidal interaction and dry mergers.Comment: Accepted for publication in ApJ Lette

The dusty heart of nearby active galaxies. I. High-spatial resolution mid-IR spectro-photometry of Seyfert galaxies

We present 8-13 micron imaging and spectroscopy of 9 type 1 and 10 type 2 AGN obtained with the VLT/VISIR instrument at spatial resolution <100 pc. The emission from the host galaxy sources is resolved out in most cases. The silicate absorption features are moderately deep and emission features are shallow. We compare the mid-IR luminosities to AGN luminosity tracers and found that the mid-IR radiation is emitted quite isotropically. In two cases, IC5063 and MCG-3-34-64, we find evidence for extended dust emission in the narrow-line region. We confirm the correlation between observed silicate feature strength and Hydrogen column density recently found in Spitzer data. In a further step, our 3D clumpy torus model has been used to interpret the data. We show that the strength of the silicate feature and the mid-IR spectral index can be used to get reasonable constraints on the dust distribution in the torus. The mid-IR spectral index, alpha, is almost exclusively determined by the radial dust distribution power-law index, a, and the silicate feature depth is mostly depending on the average number of clouds, N0, along an equatorial line-of-sight and the torus inclination. A comparison of model predictions to our type 1 and type 2 AGN reveals typical average parameters a=-1.0+/-0.5 and N0=5-8, which means that the radial dust distribution is rather shallow. As a proof-of-concept of this method, we compared the model parameters derived from alpha and the silicate feature to more detailed studies of IR SEDs and interferometry and found that the constraints on a and N0 are consistent. Finally, we might have found evidence that the radial structure of the torus changes from low to high AGN luminosities towards steeper dust distributions, and we discuss implications for the IR size-luminosity relation. (abridged)Comment: 22 pages, 13 figues, 6 tables; Accepted for publication in A&A; Note that this is the second submitted paper from the series, but we changed paper order. This one will be referred to as paper I, the previously submitted arXiv:0909.4539 will become paper I

Spitzer Quasar and ULIRG Evolution Study (QUEST). IV. Comparison of 1-Jy Ultraluminous Infrared Galaxies with Palomar-Green Quasars

We report the results from a comprehensive study of 74 ultraluminous infrared galaxies (ULIRGs) and 34 Palomar-Green (PG) quasars within z ~ 0.3$ observed with the Spitzer Infrared Spectrograph (IRS). The contribution of nuclear activity to the bolometric luminosity in these systems is quantified using six independent methods that span a range in wavelength and give consistent results within ~ +/-10-15% on average. The average derived AGN contribution in ULIRGs is ~35-40%, ranging from ~15-35% among "cool" (f_25/f_60 =< 0.2) optically classified HII-like and LINER ULIRGs to ~50 and ~75% among warm Seyfert 2 and Seyfert 1 ULIRGs, respectively. This number exceeds ~80% in PG QSOs. ULIRGs fall in one of three distinct AGN classes: (1) objects with small extinctions and large PAH equivalent widths are highly starburst-dominated; (2) systems with large extinctions and modest PAH equivalent widths have larger AGN contributions, but still tend to be starburst-dominated; and (3) ULIRGs with both small extinctions and small PAH equivalent widths host AGN that are at least as powerful as the starbursts. The AGN contributions in class 2 ULIRGs are more uncertain than in the other objects, and we cannot formally rule out the possibility that these objects represent a physically distinct type of ULIRGs. A morphological trend is seen along the sequence (1)-(2)-(3), in general agreement with the standard ULIRG - QSO evolution scenario and suggestive of a broad peak in extinction during the intermediate stages of merger evolution. However, the scatter in this sequence, implies that black hole accretion, in addition to depending on the merger phase, also has a strong chaotic/random component, as in local AGN. (abridged)Comment: 61 pages, 39 figures, 16 tables, accepted for publication in ApJS, June 2009 issue. Unabbreviated version can be found at http://www.astro.umd.edu/~veilleux/pubs/quest4.pd

Definitions of disease burden across the spectrum of metastatic castration-sensitive prostate cancer: comparison by disease outcomes and genomics

BACKGROUND: Several definitions have attempted to stratify metastatic castrate-sensitive prostate cancer (mCSPC) into low and high-volume states. However, at this time, comparison of these definitions is limited. Here we aim to compare definitions of metastatic volume in mCSPC with respect to clinical outcomes and mutational profiles. METHODS: We performed a retrospective review of patients with biochemically recurrent or mCSPC whose tumors underwent somatic targeted sequencing. 294 patients were included with median follow-up of 58.3 months. Patients were classified into low and high-volume disease per CHAARTED, STAMPEDE, and two numeric (≤3 and ≤5) definitions. Endpoints including radiographic progression-free survival (rPFS), time to development of castration resistance (tdCRPC), and overall survival (OS) were evaluated with Kaplan-Meier survival curves and log-rank test. The incidence of driver mutations between definitions were compared. RESULTS: Median OS and tdCRPC were shorter for high-volume than low-volume disease for all four definitions. In the majority of patients (84.7%) metastatic volume classification did not change across all four definitions. High volume disease was significantly associated with worse OS for all four definitions (CHAARTED: HR 2.89; p < 0.01, STAMPEDE: HR 3.82; p < 0.01, numeric ≤3: HR 4.67; p < 0.01, numeric ≤5: HR 3.76; p < 0.01) however, were similar for high (p = 0.95) and low volume (p = 0.79) disease across all four definitions. Those with discordant classification tended to have more aggressive clinical behavior and mutational profiles. Patients with low-volume disease and TP53 mutation experienced a more aggressive course with rPFS more closely mirroring high-volume disease. CONCLUSIONS: The spectrum of mCSPC was confirmed across four different metastatic definitions for clinical endpoints and genetics. All definitions were generally similar in classification of patients, outcomes, and genetic makeup. Given these findings, the simplicity of numerical definitions might be preferred, especially when integrating metastasis directed therapy. Incorporation of tumor genetics may allow further refinement of current metastatic definitions

Mid-infrared spectroscopy of infrared-luminous galaxies at z~0.5-3

We present results on low-resolution mid-infrared (MIR) spectra of 70 infrared-luminous galaxies obtained with the Infrared Spectrograph (IRS) onboard Spitzer. We selected sources from the European Large Area Infrared Survey (ELAIS) with S15 > 0.8 mJy and photometric or spectroscopic z > 1. About half of the sample are QSOs in the optical, while the remaining sources are galaxies, comprising both obscured AGN and starbursts. We classify the spectra using well-known infrared diagnostics, as well as a new one that we propose, into three types of source: those dominated by an unobscured AGN (QSOs), obscured AGN, and starburst-dominated sources. Starbursts concentrate at z ~ 0.6-1.0 favored by the shift of the 7.7-micron PAH band into the selection 15 micron band, while AGN spread over the 0.5 < z < 3.1 range. Star formation rates (SFR) are estimated for individual sources from the luminosity of the PAH features. An estimate of the average PAH luminosity in QSOs and obscured AGN is obtained from the composite spectrum of all sources with reliable redshifts. The estimated mean SFR in the QSOs is 50-100 Mo yr^-1, but the implied FIR luminosity is 3-10 times lower than that obtained from stacking analysis of the FIR photometry, suggesting destruction of the PAH carriers by energetic photons from the AGN. The SFR estimated in obscured AGN is 2-3 times higher than in QSOs of similar MIR luminosity. This discrepancy might not be due to luminosity effects or selection bias alone, but could instead indicate a connection between obscuration and star formation. However, the observed correlation between silicate absorption and the slope of the near- to mid-infrared spectrum is compatible with the obscuration of the AGN emission in these sources being produced in a dust torus.Comment: 32 pages, 24 figures, 15 tables, accepted for publication in MNRA

Cocaine Self-Administration and Extinction Leads to Reduced Glial Fibrillary Acidic Protein Expression and Morphometric Features of Astrocytes in the Nucleus Accumbens Core

As a more detailed picture of nervous system function emerges, diversity of astrocyte function becomes more widely appreciated. While it has been shown that cocaine experience impairs astroglial glutamate uptake and release in the nucleus accumbens (NAc), few studies have explored effects of self-administration on the structure and physiology of astrocytes. We investigated the effects of extinction from daily cocaine self-administration on astrocyte characteristics including GFAP expression, surface area, volume, and colocalization with a synaptic marker

Lectin-like bacteriocins from pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor

Lectin-like bacteriocins consist of tandem monocot mannose-binding domains and display a genus-specific killing activity. Here we show that pyocin L1, a novel member of this family from Pseudomonas aeruginosa, targets susceptible strains of this species through recognition of the common polysaccharide antigen (CPA) of P. aeruginosa lipopolysaccharide that is predominantly a homopolymer of d-rhamnose. Structural and biophysical analyses show that recognition of CPA occurs through the C-terminal carbohydrate-binding domain of pyocin L1 and that this interaction is a prerequisite for bactericidal activity. Further to this, we show that the previously described lectin-like bacteriocin putidacin L1 shows a similar carbohydrate-binding specificity, indicating that oligosaccharides containing d-rhamnose and not d-mannose, as was previously thought, are the physiologically relevant ligands for this group of bacteriocins. The widespread inclusion of d-rhamnose in the lipopolysaccharide of members of the genus Pseudomonas explains the unusual genus-specific activity of the lectin-like bacteriocins