41 research outputs found
CANNABIS USE AMONG A SAMPLE OF 16 TO 18 YEAR-OLD STUDENTS IN SWITZERLAND
Background: The aim of this study was to estimate the prevalence of cannabis use among Swiss students and to assess their
attitudes regarding health and safety issues associated with drug use.
Subjects and methods: After a workshop, 173 students (23.1% male, 75.7% female; 44.4% age 16, 43.8% age 17 and 11.8% age
18) from a Swiss school were surveyed by questionnaire.
Results: 59.3% (n=103) of all participants had tried cannabis, and 30.1% of those who reported cannabis use had consumed
more than 100 joints. Of those 103 students with cannabis experience, 6.8% rated the risk of cannabis-related psychic effects as low,
and 9.8% were not concerned about driving under the influence of cannabis. In cases of heavy cannabis use, the chance of increased
tobacco, alcohol or other drug use is higher than for those with less or no cannabis use at all (odds ratios of 4.33-10.86).
Conclusions: This paper deals primarily with cannabis prevalence data in adolescents from previous studies and sources, and
shows that our findings deviate significantly - and surprisingly - from past research. Our data from a school survey indicates higher
cannabis use than data from official drug policy studies. Additionally, our data shows that the studentsâ self-reported attitudes
towards health and safety issues were mostly realistic. The examination of methodological issues that might impact prevalence
estimates should be added to the cannabis literature
Scalable power system communications emulation with OPC UA
The dependability on real-time control is significantly increasing due to the transition from synchronous grids to converter-dominated grids. Distributed control schemes can significantly decrease the degree of single-points-of failure of Smart Grid control schemes, thereby introducing new complexity of power system communications. We propose a scalable approach for validation of distributed control schemes by emulating the communication in a decentralised manner, utilising the Open Platform Communications Unified Architecture service-oriented architecture in a controller-hardware-in-the-loop environment. As a proof-of-concept, we apply communication delay Denial-of-Service attacks to a converter-dominated communication-heavy and consensus-based microgrid control algorithm and thereby elaborate how scalable power systems communications emulation can help selecting appropriate mitigation strategies for telecommunication-based stress conditions
Safety and feasibility of intranasal heroin-assisted treatment: 4-week preliminary findings from a Swiss multicentre observational study
Background: Heroin-assisted treatment (HAT) is effective for individuals with severe opioid use disorder (OUD) who do not respond sufficiently to other opioid agonist treatments. It is mostly offered with injectable diacetylmorphine (DAM) or DAM tablets creating a barrier for individuals who need the rapid onset of action but are either unable or unwilling to inject, or primarily snort opioids. To explore another route of administration, we evaluated the safety and feasibility of intranasal (IN) DAM.
Methods: This is a multicentre observational cohort study among patients in Swiss HAT. All patients planning to receive IN DAM within the treatment centres were eligible to participate. Participants were either completely switched to IN DAM or received IN DAM in addition to other DAM formulations or opioid agonists. Patients were followed up for four weeks. Sociodemographic characteristics, current HAT regimen, reasons for starting IN DAM, IN DAM doses, number of injection events in the sample, IN DAM continuation rate, and appearance of adverse events and nose-related problems were evaluated.
Results: Participants (nâ=â52) reported vein damage, preference for nasal route of administration, and desire of a stronger effect or for a less harmful route of administration as primary reasons for switching to IN DAM. After four weeks, 90.4% of participants (nâ=â47) still received IN DAM. Weekly average realised injection events decreased by 44.4% from the month before IN DAM initiation to the month following. No severe adverse events were reported.
Conclusions: After four weeks, IN DAM was a feasible and safe alternative to other routes of administration for patients with severe OUD in HAT. It addressed the needs of individuals with OUD and reduced injection behaviour. More long-term research efforts are needed to systematically assess efficacy of and patient satisfaction with IN DAM
Report and preliminary results of R/V SONNE Cruise SO251 - Extreme events Archived in the GEologial Record of JAPAN's subduction margins (EAGER-JAPAN)
Leg A SO251-1, Yokohama - Yokohama, 04.10.2016 - 15.10.2016, Leg B SO251-2, Yokohama - Yokohama, 18.10.2016 - 02.11.201
Artificial Intelligence for Science in Quantum, Atomistic, and Continuum Systems
Advances in artificial intelligence (AI) are fueling a new paradigm of
discoveries in natural sciences. Today, AI has started to advance natural
sciences by improving, accelerating, and enabling our understanding of natural
phenomena at a wide range of spatial and temporal scales, giving rise to a new
area of research known as AI for science (AI4Science). Being an emerging
research paradigm, AI4Science is unique in that it is an enormous and highly
interdisciplinary area. Thus, a unified and technical treatment of this field
is needed yet challenging. This work aims to provide a technically thorough
account of a subarea of AI4Science; namely, AI for quantum, atomistic, and
continuum systems. These areas aim at understanding the physical world from the
subatomic (wavefunctions and electron density), atomic (molecules, proteins,
materials, and interactions), to macro (fluids, climate, and subsurface) scales
and form an important subarea of AI4Science. A unique advantage of focusing on
these areas is that they largely share a common set of challenges, thereby
allowing a unified and foundational treatment. A key common challenge is how to
capture physics first principles, especially symmetries, in natural systems by
deep learning methods. We provide an in-depth yet intuitive account of
techniques to achieve equivariance to symmetry transformations. We also discuss
other common technical challenges, including explainability,
out-of-distribution generalization, knowledge transfer with foundation and
large language models, and uncertainty quantification. To facilitate learning
and education, we provide categorized lists of resources that we found to be
useful. We strive to be thorough and unified and hope this initial effort may
trigger more community interests and efforts to further advance AI4Science
Twenty-three unsolved problems in hydrology (UPH) â a community perspective
This paper is the outcome of a community initiative to identify major unsolved scientific problems in hydrology motivated by a need for stronger harmonisation of research efforts. The procedure involved a public consultation through on-line media, followed by two workshops through which a large number of potential science questions were collated, prioritised, and synthesised. In spite of the diversity of the participants (230 scientists in total), the process revealed much about community priorities and the state of our science: a preference for continuity in research questions rather than radical departures or redirections from past and current work. Questions remain focussed on process-based understanding of hydrological variability and causality at all space and time scales.
Increased attention to environmental change drives a new emphasis on understanding how change propagates across interfaces within the hydrological system and across disciplinary boundaries. In particular, the expansion of the human footprint raises a new set of questions related to human interactions with nature and water cycle feedbacks in the context of complex water management problems. We hope that this reflection and synthesis of the 23 unsolved problems in hydrology will help guide research efforts for some years to come
Corals on the slope (Aptian, Maestrat Basin, Spain)
The term âreefâ has been frequently misused when applied to fossil coral communities. Our popular but biased view of coral community structure based on the idyllic picture of recent tropical reefs has failed to recognize that, in many fossil examples, alternative states of community structure with no or limited framework may occur. The Aptian colonial scleractinians analysed in the western Maestrat Basin (eastern Spain) constitute an example of non-reef-building coral populations, which thrived in marly slope settings. These corals developed within the photic zone but below the storm wave-base. All colonies are found well-preserved in life position. They are mostly decimetres in size and mainly occur isolated giving rise to a continuous and uniform (dominated by domal and massive forms) unbound growth fabric with a low to medium degree of development (coral skeletal volume = 5â20%). Occasionally, however, colonies growing on top of each other forming small metre-sized bioherms are also present. A total of 21 species were identified. Coral diversity in each sample location varies between three and nine species. These numbers of species are comparable with those exhibited by coeval coral assemblages from other basins of the Tethys, but are comparatively low when compared with diversities exhibited by many Recent and fossil coral communities. The corals studied apparently found optimal ecological conditions for their development on the marly slopes of the western Maestrat Basin. This is primarily expressed in the unusually large dimensions (up to 2.3 m in width) of some of the coral colonies when compared to other Cretaceous occurrences, and in the persistence and resilience of the coral populations. The observed coral genera and species (suborders Archeocaeniina, Faviina, Fungiina and Microsolenina) are very common in the time interval between the Barremian and the Early Albian and most of them have been reported from several other localities in the western and central Tethyan realm. In addition, the coral-bearing levels also contain the poorly known and exotic genera Agrostyliastraea and Procladocora. There are no significant differences at species level or in community structure between the Early and Late Aptian faunas investigated. Therefore, the coral communities as well as the environmental conditions controlling them would have been relatively stable during the time intervals when these corals flourished. An important palaeoecological implication is that comparatively low species diversities and the absence of reef frameworks do not necessarily imply unfavourable environmental conditions for coral growth. Furthermore, this study may serve as an example for the analysis of other level-bottom coral communities displaying a loose growth fabric