Moyo Vol. IX N 1

Durica, Paul. Editor\u27s Letter . 4. Fisher, D. The More you Resist, Babe, The More it Excites Me (Support for Beatty\u27s Bid) . 5. Ward, Luc. The haunting of Barney Hall. Mysteries of the Fourth Floor Revealed . 6. Million, Chris. Not Your Crocodile Dundee (Interview with Chet Snouffer) . 8. Curry, Kim. Phobia or Philia? Student Questions Prejudices Against Specters . 13. Hankinson, Tom. Supernatural is Super-Boring. Denison Sutdent Non-Plussed by Multiple Ghostly Experiences . 20. Anderson, Chris. Run, Rita, Run. Denison\u27s Marathon professor . 22. Durica, Paul. Night in Nine (Séance in Buxton Stirs More Than Spirits) . 10

Moyo Vol. IX N 2

Million, Chris. Dirge For a Restroom, the Search For a Progressive Potty Rages on . 4. Fisher, Dan. The White Crow: Compassionate Activism in a Tibetan Community-in-Exile . 5. Barrett, Laura. Indie Films for Indie Spirit (Cinema is the Most Important Art) . 6. Levine, Robert. American interview. Making a Film About Making a Film: A Cozy Chat With Two Independent Filmmakers . 8. Hiller, Andy. Cameras and Cappuccinos . 9. Shuba, Jason J. Technology on Trial: Appreciating Modernity (Technology as Human Progress) . 12. Dunson, Jim. Technology on Trial: The Role of Choice (Can Progress be The Only Option?) . 13. Levine, Robert. Cash, Blood, and Coffee (Life as an NYC Film Intern) . 14. Durica, Paul. The Lost Crusade: Former Editor Muses on the Myth of True Love . 22. Hankinson, Tom. The Real Appeal of Cinema . 23

Exile Vol. XLV No. 2

43rd Year Title Page 3 Epigraph by Ezra Pound 5 Table of Contents 7 Contributors Notes 74-75 Editorial Board 76 INTERVIEWS The Art of Hearing: Interview with Stanley Plumly by Alison Stine \u2700 23-27 ART Self-Portrait by Angela Bliss \u2799 8 For a Living by Angela Bliss \u2799 12 Untitled by Frazier Taylor \u2702 22 Untitled by Amy Deaner \u2799 29 Perfect Knee by David Tulkin \u2701 34 Untitled by Amy Deaner \u2799 43 Still Light by Angela Bliss \u2799 62 Hiding Nature by Amy Deaner \u2799 64 Self-Portrait A by Sarah Leyrer \u2701 73 POETRY Bolted Back by Michelle Grindstaff \u2702 9 Squall by Georgia Riepe \u2702 10 Loaves and Fishes by Maeghan Demmons \u2701 11 World Cafe by Katie Kroner \u2701 28 Gurney Surfer by Tom Hankinson \u2702 31 Japanese Beetles by Alison Stine \u2700 32-33 Shoveling by Bekah Taylor \u2700 40 Tobacco Country by K. Moore \u2701 41 Winton Place by Rachel Colina \u2702 42 Bottom of the Ninth by Michelle Grindstaff \u2702 61 Fall Burning by Alison Stine \u2700 63 rocking by Bekah Taylor \u2700 71 The Armor of the Beach by Georgia Riepe \u2702 72 PROSE In the Aisles of the Night by Tom Dussel \u2701 13-21 From Those Uninvolved by Justin Walker \u2799 30 Frame by Paul Durica \u2700 35-39 The Rose by Rachel Bolton \u2799 44-60 Stop at the Soldier by Hillary Campbell \u2700 65-70 All submissions are reviewed on an anonymous basis, and all editorial decisions are shared equally among the members of the Editorial Board. -76 Cover Art Untitled by Kris Lewis \u2799 / Back Cover Art Figure 25 by Todd Gys \u2799 -76 Printed by Printing Arts Press -7

Moyo Vol. X N 1

Million, Chris. Coming Around to Reality: Former Cult Member Turned Editor Uses You for His Own Therapeutic Purposes . 4. Louden, Annie. A Disciple of Mr. Dewey, and All His Dirty Little Decimals: Confession of a Book-Hoarding Monomaniac . 5. Soucy, Kate. 14 Days in Dumay: Reflections After a Trip to Haiti . 6. Frieberg, Alicia. Foreign Hostel Encounters:Ireland, Land of Ire . 8. Fisher, Dan. Open the Road Wider. Open The Road Wider. The Girft of the Reverend Jusan Fudo William Frank Parker . 10. Barrett, Laura. Requiem for An Okay Cat . Cinema Annex Formerly Home to One Heck of an Adequate Feline . 11. The Editors. Late-Night Delivery Frightens Editors into Submission . 12. 2nd Chief Angel of the Quill. A Statement from the Mystic and Calorific Band of the Wingless Angels . 13. Miller, Jeremy. Rapunzel, Rapunzel, Let Down Your Keycard! Denison man Struggles to Reach Girlfriend at Medium Security Prison... er... University . 15. Mallinger, Adam. Cult-Invated Taste: Pop Cult Vs. Pop Culture . 16.; Million, Chris. A Day in the Lights. A Ballet Boy\u27s Continued Search for masculinity . 18. Newitt, Heidi. Show Us Your Tits! A Feminist Glimpse Into the Overt Misogyny in Popular Culture Today . 20. Woods, Lindsay. Stuck in the Doledrums. Attempted Seduction of U.S. Senator Strikes Out . 22. Hankinson, Tom. Wingless Angels Just a Bunch of Dorks: Denison\u27s Secret Society-Watch Out, They Might Hit You With a Pocket Protector . 20. Silverstein, Illana. First Contact: Improvisational Dance on Campus . 32. Dunson, Jim. Philosophy of Pecan Pie: The Culmination of a Grand Tradition of Cu-lino-Epistemological Thought . Kovach, Steve. Empirical Test Goes Horribly Awry: Frozen Yogurt Proves Less Philosophically Fruitful than Pie . 34

Moyo Vol. X N 2

Million, Chris. Editor\u27s Letter . 4. Kaczur, Erin. Why It Sucks to be Human: I Would Like to Change My Casing, Not My Underwear . 5. Dunson, Jim and Tom Hankinson. MoYummy: Our Staff Connoisseurs Hit the Spots That Hit the Spot . 6. Fisher, Dan. Happy, O Monk, Is Thy Shadow! A No Pluses, No Minuses Memory of a Spiritual Friend . 10. Reuss, Liz. Who is S/He? Leslie Feinberg Interview Inspires Introspection . 11. Marston, Jennifer. MoYo Millenium Picks: Ghandi Can Forget it . 12. Bungard, Chris. Pop The Cork on Ireland. Strictly No Drinking Stritly Ignored . 13. Wilson, Kalyn. Pagans in print: The Craft--So Much more Than Sabrina . 14. Mallinger, Adam. DU Press Release Revisited . 16. Zellner, Kelli. Denison University\u27s Campus Compact--Myth or Reality? DU\u27s Bubble, Burst . 17. Hankinson, Tom. Bureaucracy--Friend of the Common man. An Explication Rather Than an Expletive . 18. The TasyPaycheck. A Very Tasty Quiz: The Denison Social Hierarchy - Do You Cut it? 20. Mong, Derek. The Armpit Epiphany . 21. Curry, Kim. Hot Child in The City: An Unaccustomed look Back from a Big Apple Intern . 22. Million, Chris. Their Last Chance! 32. Kovach, Steve. Risk-y Business: Strategies for Getting More enjoyment Out of World Conquest . 34

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset and to empirically validate the PRSs in prospective studies. The development dataset comprised 94,075 case subjects and 75,017 control subjects of European ancestry from 69 studies, divided into training and validation sets. Samples were genotyped using genome-wide arrays, and single-nucleotide polymorphisms (SNPs) were selected by stepwise regression or lasso penalized regression. The best performing PRSs were validated in an independent test set comprising 11,428 case subjects and 18,323 control subjects from 10 prospective studies and 190,040 women from UK Biobank (3,215 incident breast cancers). For the best PRSs (313 SNPs), the odds ratio for overall disease per 1 standard deviation in ten prospective studies was 1.61 (95%CI: 1.57-1.65) with area under receiver-operator curve (AUC) = 0.630 (95%CI: 0.628-0.651). The lifetime risk of overall breast cancer in the top centile of the PRSs was 32.6%. Compared with women in the middle quintile, those in the highest 1% of risk had 4.37- and 2.78-fold risks, and those in the lowest 1% of risk had 0.16- and 0.27-fold risks, of developing ER-positive and ER-negative disease, respectively. Goodness-of-fit tests indicated that this PRS was well calibrated and predicts disease risk accurately in the tails of the distribution. This PRS is a powerful and reliable predictor of breast cancer risk that may improve breast cancer prevention programs.NovartisEli Lilly and CompanyAstraZenecaAbbViePfizer UKCelgeneEisaiGenentechMerck Sharp and DohmeRocheCancer Research UKGovernment of CanadaArray BioPharmaGenome CanadaNational Institutes of HealthEuropean CommissionMinistère de l'Économie, de l’Innovation et des Exportations du QuébecSeventh Framework ProgrammeCanadian Institutes of Health Researc

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms