11 research outputs found
Efeito da ventilação com diferentes frações inspiradas de oxigênio e do alopurinol na isquemia-reperfusão pulmonar em ratos
Priming nanoparticle-guided diagnostics and therapeutics towards human organs-on-chips microphysiological system
Recipient-Related Clinical Risk Factors for Primary Graft Dysfunction after Lung Transplantation: A Systematic Review and Meta-Analysis
Estimating the global incidence of traumatic brain injury
OBJECTIVE Traumatic brain injury (TBI)—the “silent epidemic”—contributes to worldwide death and disability more
than any other traumatic insult. Yet, TBI incidence and distribution across regions and socioeconomic divides remain
unknown. In an effort to promote advocacy, understanding, and targeted intervention, the authors sought to quantify the case burden of TBI across World Health Organization (WHO) regions and World Bank (WB) income groups.
METHODS Open-source epidemiological data on road traffic injuries (RTIs) were used to model the incidence of TBI
using literature-derived ratios. First, a systematic review on the proportion of RTIs resulting in TBI was conducted, and a
meta-analysis of study-derived proportions was performed. Next, a separate systematic review identified primary source
studies describing mechanisms of injury contributing to TBI, and an additional meta-analysis yielded a proportion of TBI
that is secondary to the mechanism of RTI. Then, the incidence of RTI as published by the Global Burden of Disease
Study 2015 was applied to these two ratios to generate the incidence and estimated case volume of TBI for each WHO
region and WB income group.
RESULTS Relevant articles and registries were identified via systematic review; study quality was higher in the highincome countries (HICs) than in the low- and middle-income countries (LMICs). Sixty-nine million (95% CI 64–74 million) individuals worldwide are estimated to sustain a TBI each year. The proportion of TBIs resulting from road traffic collisions was greatest in Africa and Southeast Asia (both 56%) and lowest in North America (25%). The incidence of RTI was similar in Southeast Asia (1.5% of the population per year) and Europe (1.2%). The overall incidence of TBI per
100,000 people was greatest in North America (1299 cases, 95% CI 650–1947) and Europe (1012 cases, 95% CI 911– 1113) and least in Africa (801 cases, 95% CI 732–871) and the Eastern Mediterranean (897 cases, 95% CI 771–1023). The LMICs experience nearly 3 times more cases of TBI proportionally than HICs.
CONCLUSIONS Sixty-nine million (95% CI 64–74 million) individuals are estimated to suffer TBI from all causes each year, with the Southeast Asian and Western Pacific regions experiencing the greatest overall burden of disease. Head injury following road traffic collision is more common in LMICs, and the proportion of TBIs secondary to road traffic col-lision is likewise greatest in these countries. Meanwhile, the estimated incidence of TBI is highest in regions with higherquality data, specifically in North America and Europe
Phenotypic spectrum and prevalence of INPP5E mutations in Joubert Syndrome and related disorders
<p>Joubert syndrome and related disorders (JSRD) are clinically and genetically heterogeneous ciliopathies sharing a peculiar midbrain-hindbrain malformation known as the 'molar tooth sign'. To date, 19 causative genes have been identified, all coding for proteins of the primary cilium. There is clinical and genetic overlap with other ciliopathies, in particular with Meckel syndrome (MKS), that is allelic to JSRD at nine distinct loci. We previously identified the INPP5E gene as causative of JSRD in seven families linked to the JBTS1 locus, yet the phenotypic spectrum and prevalence of INPP5E mutations in JSRD and MKS remain largely unknown. To address this issue, we performed INPP5E mutation analysis in 483 probands, including 408 JSRD patients representative of all clinical subgroups and 75 MKS fetuses. We identified 12 different mutations in 17 probands from 11 JSRD families, with an overall 2.7% mutation frequency among JSRD. The most common clinical presentation among mutated families (7/11, 64%) was Joubert syndrome with ocular involvement (either progressive retinopathy and/or colobomas), while the remaining cases had pure JS. Kidney, liver and skeletal involvement were not observed. None of the MKS fetuses carried INPP5E mutations, indicating that the two ciliopathies are not allelic at this locus.</p>