SPECIES COMPOSITION, FOOD HABITS, AND THE ECONOMIC AND ECOLOGIC IMPACT OF WINTER BLACKBIRD FLOCKS

Crop depredation by blackbirds (Icteridae) and Starlings (sturnus vulgaris) in North America has long prompted experimentation with control techniques. These efforts have been centered in the northeast and northcentral United States where concentrated cultivation of vulnerable crops coincides with the location where flocks of blackbirds congregate in the fall prior to their migration south (Stone, et al., 1972; Wiens and Dyer, 1975). In these areas the high cost and logistic impracticality of implementing widespread controls has suggested the need for modifying agricultural practices instead (Wiens and Dyer, 1975). More recently, attention has been focused farther south, particularly in Kentucky and Tennessee where winter roosts of mixed flocks of blackbirds and Starlings commonly number over several million birds. These highly localized concentrations have prompted concern for both agricultural damage and danger to human health (Department of Army, 1975). A major difference between the problem in the South and that farther north is that in the South the birds present themselves as much more accessible targets for control measures. By virtue of their tremendous concentrations they make the potential for large scale extermination very real. It is quite conceivable that a significant proportion of the entire North American populations of these birds could be eliminated if extermination efforts were maintained for several years at the major winter roosts. Before such extermination is allowed to proceed, a number of questions must be answered. These can be divided into two areas. The first area deals with whether or not the control measures are actually justified--how much agricultural damage is done by the birds and how real is their threat to human health? The second area of questioning concerns the environmental impact of both the control measures themselves as well as the effect of suddenly removing such large numbers of birds from the ecosystem. This paper presents the results of a preliminary study aimed not at answering these questions so much as providing some insight into the factors which must be considered if accurate answers are to be obtained

SPECIES COMPOSITION, FOOD HABITS, AND THE ECONOMIC AND ECOLOGIC IMPACT OF WINTER BLACKBIRD FLOCKS

Crop depredation by blackbirds (Icteridae) and Starlings (sturnus vulgaris) in North America has long prompted experimentation with control techniques. These efforts have been centered in the northeast and northcentral United States where concentrated cultivation of vulnerable crops coincides with the location where flocks of blackbirds congregate in the fall prior to their migration south (Stone, et al., 1972; Wiens and Dyer, 1975). In these areas the high cost and logistic impracticality of implementing widespread controls has suggested the need for modifying agricultural practices instead (Wiens and Dyer, 1975). More recently, attention has been focused farther south, particularly in Kentucky and Tennessee where winter roosts of mixed flocks of blackbirds and Starlings commonly number over several million birds. These highly localized concentrations have prompted concern for both agricultural damage and danger to human health (Department of Army, 1975). A major difference between the problem in the South and that farther north is that in the South the birds present themselves as much more accessible targets for control measures. By virtue of their tremendous concentrations they make the potential for large scale extermination very real. It is quite conceivable that a significant proportion of the entire North American populations of these birds could be eliminated if extermination efforts were maintained for several years at the major winter roosts. Before such extermination is allowed to proceed, a number of questions must be answered. These can be divided into two areas. The first area deals with whether or not the control measures are actually justified--how much agricultural damage is done by the birds and how real is their threat to human health? The second area of questioning concerns the environmental impact of both the control measures themselves as well as the effect of suddenly removing such large numbers of birds from the ecosystem. This paper presents the results of a preliminary study aimed not at answering these questions so much as providing some insight into the factors which must be considered if accurate answers are to be obtained

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10−13), 1q42.13 (rs41271473, P=1.06 × 10−10), 4q24 (rs71597109, P=1.37 × 10−10), 4q35.1 (rs57214277, P=3.69 × 10−8), 6p21.31 (rs3800461, P=1.97 × 10−8), 11q23.2 (rs61904987, P=2.64 × 10−11), 18q21.1 (rs1036935, P=3.27 × 10−8), 19p13.3 (rs7254272, P=4.67 × 10−8) and 22q13.33 (rs140522, P=2.70 × 10−9). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10−13), 1q42.13 (rs41271473, P=1.06 × 10−10), 4q24 (rs71597109, P=1.37 × 10−10), 4q35.1 (rs57214277, P=3.69 × 10−8), 6p21.31 (rs3800461, P=1.97 × 10−8), 11q23.2 (rs61904987, P=2.64 × 10−11), 18q21.1 (rs1036935, P=3.27 × 10−8), 19p13.3 (rs7254272, P=4.67 × 10−8) and 22q13.33 (rs140522, P=2.70 × 10−9). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response

The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy

Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations. Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves. Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p  90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score. Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

An Extra-Limital Population of Black-tailed Prairie Dogs, Cynomys ludovicianus, in Central Alberta

An introduced population of Black-tailed Prairie Dogs, Cynomys ludovicianus, has persisted for the past 50 years east of Edmonton, Alberta, over 600 km northwest of the natural prairie range of the species. This colony has slowly expanded at this northern latitude within a transition ecotone between the Boreal Plains ecozone and the Prairies ecozone. Although this colony is derived from escaped animals, it is worth documenting, as it represents a significant disjunct range extension for the species and it is separated from the sylvatic plague (Yersina pestis) that threatens southern populations. The unique northern location of these Black-tailed Prairie Dogs makes them valuable for the study of adaptability and geographic variation, with implications for climate change impacts on the species, which is threatened in Canada

FOOD ITEMS AND FEEDING RATES FOR WILD WHOOPING CRANE COLTS IN WOOD BUFFALO NATIONAL PARK

Food habits of 5 whooping crane (Orus americana) colts in 4 nest ponds were recorded in the days following hatching in Wood Buffalo National Park (WBNP). In total, 93 hours of observations were made from blinds that were 60-80 m away from the nest. Spotting scopes and binoculars were used to identify food items. The adults were observed bringing the following items to the colts: adult dragonflies (Libellula sp., and Aeshna sp.), fish (Culaea inconstans), diving beetles (Rhantus binotatus, Acilius semisulcatus, Oraphoderus occidentalis, and Dytiscus alaskanus), damselflies (Enallagma sp., and Lestes sp.), snails (Lymnaea stagnalis, and Helisoma sp.), a vole (Clethrionomys gapped), a leech (unidentified), and a chorus frog (Pseudacris maculata). However, the food type most commonly consumed by the colts (88% of known items, n = 156) was dragonfly nymphs. Overall, females made most of the food deliveries (63% of deliveries for all nests, n = 194). Of the 4 nests, 2 hatched both eggs. Of these, 1 second hatched colt was preyed upon prior to being fed, and the other second hatched colt received fewer feedings than its older sibling when compared at equal ages. In addition, between 1998-99, 18 whooping crane colts had transmitters attached for a whooping crane colt mortality study. Five colt carcasses were located during the mortality study and necropsies revealed that 4 (1 was too decomposed) had only dragonfly nymphs in their digestive systems

MORTALITY OF WHOOPING CRANE COLTS IN WOOD BUFFALO NATIONAL PARK, CANADA, 1997-99

Twenty-two whooping crane (Grus americana) pairs with 2 young were monitored in Wood Buffalo National Park (WBNP) over 3 years to determine causes of colt mortality. The family groups were monitored from the ground, air, and with the aid ofradioteiemetry. We attached transmitters to 18 colts: 5 (28%) fledged, 5 (28%) succumbed to cumulative effects (head trauma, stress, exposure and/or infection), 4 (22%) were lost to unknown causes (3 of these went missing after they had lost their transmitters), 2 (11%) were taken by foxes (Vulpes vulpes), 1 (5.5%) was lost to raven (Corvus corax) predation, and 1 (5.5%) died of pneumonia. Of the 22 pairs we monitored, 16 young fledged. Of these, 2 (13%) were the younger sibling