Comparação de pH e matéria seca em três processos de silagem com forragem de gergelim (Sesamum indicum) nos trópicos secos.

El objetivo de este estudio fue comparar el pH y la materia seca (MS) en tres procesos de ensilaje con planta de ajonjolí en climas secos. Los experimentos se realizaron en la Facultad de Medicina Veterinaria y Zootecnia No. 1 de la Universidad Autónoma de Guerrero. En el experimento 1, se ensiló forraje de maíz combinado con forraje de ajonjolí (T1: 100:00, T2: 75:25, T3: 50:50, T4: 25:75 y T5: 00:100% respectivamente). En el experimento 2 se ensiló forraje de ajonjolí mezclado con melaza (T1:0, T2:4, T3:8 y T4:12% respectivamente) En el experimento 3 se ensiló planta de ajonjolí sola (T1), con melaza 8% (T2), planta presecada sola (T3) y planta presecada con melaza 8% (T4). Se realizaron síes microsilos por tratamiento (6 réplicas). Los diseños experimentales fueron completamente al azar. En el experimento 1, el pH más bajo fue para el T1 con un valor de 3.83, en el experimento 2 fue para el T4 con un valor de 3.94 y en el experimento 3 fue para el T2 con un valor de 4.00. Para la MS, el contenido fue mayor para el T1 con 28.55%, en el experimento 2 fue para el T4 con 27.63% y en el experimento 3 fue para el T3 con 36.00%. Todos los experimentos mostraron diferencia estadística (p< 0.0001) entre tratamientos. Sin embargo, los valores para pH y MS son aceptables para prácticamente todos los tratamientos, en acuerdo con otras investigaciones. Por lo tanto, se concluye que al ensilar forraje de ajonjolí mezclado con forraje de maíz, melaza o planta presercada se logra mejorar la fermentación ácida y se incrementa el contenido de materia seca. Sin embargo, es necesario realizar evaluaciones posteriores de las propiedades físico-químicas y determinar su valor nutritivo.The objective of this study was to compare the pH and dry matter (DM) in three silage processes with sesame plants in dry climates. The experiments were carried out at the Faculty of Veterinary Medicine and Zootechnics No. 1 of the Autonomous University of Guerrero. In experiment 1, corn forage combined with sesame forage was ensiled (T1: 100:00, T2: 75:25, T3: 50:50, T4: 25:75 and T5: 00:100% respectively). In experiment 2 sesame forage mixed with molasses (T1:0, T2:4, T3:8 and T4:12% respectively) was ensiled. In experiment 3 sesame plant alone (T1) was ensiled with 8% molasses ( T2), pre-dried plant alone (T3) and pre-dried plant with 8% molasses (T4). Six microsilos per treatment (6 replicates) were made. The experimental designs were completely randomized. In experiment 1, the lowest pH was for T1 with a value of 3.83, in experiment 2 it was for T4 with a value of 3.94 and in experiment 3 it was for T2 with a value of 4.00. For DM, the content was higher for T1 with 28.55%, in experiment 2 it was for T4 with 27.63% and in experiment 3 it was for T3 with 36.00%. All the experiments showed statistical difference (p< 0.0001) between treatments. However, the values for pH and DM are acceptable for practically all treatments, in agreement with other investigations. Therefore, it is concluded that ensiling sesame forage mixed with corn forage, molasses or presercated plant improves acid fermentation and increases the dry matter content. However, it is necessary to carry out further evaluations of the physical-chemical properties and determine its nutritive value.O objetivo deste estudo foi comparar o pH e a matéria seca (MS) em três processos de silagem com plantas de gergelim em climas secos. Os experimentos foram realizados na Faculdade de Medicina Veterinária e Zootecnia nº 1 da Universidade Autônoma de Guerrero. No experimento 1, a forragem de milho combinada com a forragem de gergelim foi ensilada (T1: 100:00, T2: 75:25, T3: 50:50, T4: 25:75 e T5: 00:100% respectivamente). No experimento 2 a forragem de gergelim foi ensilada misturada com melaço (T1:0, T2:4, T3:8 e T4:12% respectivamente) - planta seca sozinha (T3) e planta pré-seca com 8% de melaço (T4). Seis microsilos por tratamento (6 réplicas) foram feitos. Os delineamentos experimentais foram inteiramente casualizados. No experimento 1, o menor pH foi para T1 com valor de 3,83, no experimento 2 foi para T4 com valor de 3,94 e no experimento 3 foi para T2 com valor de 4,00. Para MS o teor foi maior para T1 com 28,55%, no experimento 2 foi para T4 com 27,63% e no experimento 3 foi para T3 com 36,00%. Todos os experimentos apresentaram diferença estatística (p< 0,0001) entre os tratamentos. No entanto, os valores de pH e MS são aceitáveis ​​para praticamente todos os tratamentos, concordando com outras investigações. Portanto, conclui-se que a ensilagem de forragem de gergelim misturada com forragem de milho, melaço ou planta preservada melhora a fermentação ácida e aumenta o teor de matéria seca. No entanto, é necessário realizar mais avaliações das propriedades físico-químicas e determinar seu valor nutritivo

Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry

Aim To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers (NHCW). Methods Observational cohort study based on the SEMI-COVID-19 Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 in Spain. Patients aged 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality. Results As of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age of HCW was 52 (15) years and 62.4% were women. Prevalence of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p = 0.024 and 0.7% vs. 4.8%; p<0.001 respectively). Age, male sex and comorbidity, were independently associated with higher in-hospital mortality and healthcare working with lower mortality (OR 0.211, 95%CI 0.067-0.667, p = 0.008). 30-days survival was higher in HCW (0.968 vs. 0.851 p<0.001). Conclusions Hospitalized COVID-19 HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 in HCW does not carry more clinical severity nor mortality

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Global data on earthworm abundance, biomass, diversity and corresponding environmental properties

Publisher Copyright: © 2021, The Author(s).Earthworms are an important soil taxon as ecosystem engineers, providing a variety of crucial ecosystem functions and services. Little is known about their diversity and distribution at large spatial scales, despite the availability of considerable amounts of local-scale data. Earthworm diversity data, obtained from the primary literature or provided directly by authors, were collated with information on site locations, including coordinates, habitat cover, and soil properties. Datasets were required, at a minimum, to include abundance or biomass of earthworms at a site. Where possible, site-level species lists were included, as well as the abundance and biomass of individual species and ecological groups. This global dataset contains 10,840 sites, with 184 species, from 60 countries and all continents except Antarctica. The data were obtained from 182 published articles, published between 1973 and 2017, and 17 unpublished datasets. Amalgamating data into a single global database will assist researchers in investigating and answering a wide variety of pressing questions, for example, jointly assessing aboveground and belowground biodiversity distributions and drivers of biodiversity change.Peer reviewe

Global data on earthworm abundance, biomass, diversity and corresponding environmental properties

Earthworms are an important soil taxon as ecosystem engineers, providing a variety of crucial ecosystem functions and services. Little is known about their diversity and distribution at large spatial scales, despite the availability of considerable amounts of local-scale data. Earthworm diversity data, obtained from the primary literature or provided directly by authors, were collated with information on site locations, including coordinates, habitat cover, and soil properties. Datasets were required, at a minimum, to include abundance or biomass of earthworms at a site. Where possible, site-level species lists were included, as well as the abundance and biomass of individual species and ecological groups. This global dataset contains 10,840 sites, with 184 species, from 60 countries and all continents except Antarctica. The data were obtained from 182 published articles, published between 1973 and 2017, and 17 unpublished datasets. Amalgamating data into a single global database will assist researchers in investigating and answering a wide variety of pressing questions, for example, jointly assessing aboveground and belowground biodiversity distributions and drivers of biodiversity change

Global data on earthworm abundance, biomass, diversity and corresponding environmental properties

Publisher Copyright: © 2021, The Author(s).Earthworms are an important soil taxon as ecosystem engineers, providing a variety of crucial ecosystem functions and services. Little is known about their diversity and distribution at large spatial scales, despite the availability of considerable amounts of local-scale data. Earthworm diversity data, obtained from the primary literature or provided directly by authors, were collated with information on site locations, including coordinates, habitat cover, and soil properties. Datasets were required, at a minimum, to include abundance or biomass of earthworms at a site. Where possible, site-level species lists were included, as well as the abundance and biomass of individual species and ecological groups. This global dataset contains 10,840 sites, with 184 species, from 60 countries and all continents except Antarctica. The data were obtained from 182 published articles, published between 1973 and 2017, and 17 unpublished datasets. Amalgamating data into a single global database will assist researchers in investigating and answering a wide variety of pressing questions, for example, jointly assessing aboveground and belowground biodiversity distributions and drivers of biodiversity change.Peer reviewe

Global data on earthworm abundance, biomass, diversity and corresponding environmental properties

Earthworms are an important soil taxon as ecosystem engineers, providing a variety of crucial ecosystem functions and services. Little is known about their diversity and distribution at large spatial scales, despite the availability of considerable amounts of local-scale data. Earthworm diversity data, obtained from the primary literature or provided directly by authors, were collated with information on site locations, including coordinates, habitat cover, and soil properties. Datasets were required, at a minimum, to include abundance or biomass of earthworms at a site. Where possible, site-level species lists were included, as well as the abundance and biomass of individual species and ecological groups. This global dataset contains 10,840 sites, with 184 species, from 60 countries and all continents except Antarctica. The data were obtained from 182 published articles, published between 1973 and 2017, and 17 unpublished datasets. Amalgamating data into a single global database will assist researchers in investigating and answering a wide variety of pressing questions, for example, jointly assessing aboveground and belowground biodiversity distributions and drivers of biodiversity change