The gray matter structural connectome and its relationship to alcohol relapse: Reconnecting for recovery.

Gray matter (GM) atrophy associated with alcohol use disorders (AUD) affects predominantly the frontal lobes. Less is known how frontal lobe GM loss affects GM loss in other regions and how it influences drinking behavior or relapse after treatment. The profile similarity index (PSI) combined with graph analysis allows to assess how GM loss in one region affects GM loss in regions connected to it, ie, GM connectivity. The PSI was used to describe the pattern of GM connectivity in 21 light drinkers (LDs) and in 54 individuals with AUD (ALC) early in abstinence. Effects of abstinence and relapse were determined in a subgroup of 36 participants after 3 months. Compared with LD, GM losses within the extended brain reward system (eBRS) at 1-month abstinence were similar between abstainers (ABST) and relapsers (REL), but REL had also GM losses outside the eBRS. Lower GM connectivities in ventro-striatal/hypothalamic and dorsolateral prefrontal regions and thalami were present in both ABST and REL. Between-networks connectivity loss of the eBRS in ABST was confined to prefrontal regions. About 3 months later, the GM volume and connectivity losses had resolved in ABST, and insula connectivity was increased compared with LD. GM losses and GM connectivity losses in REL were unchanged. Overall, prolonged abstinence was associated with a normalization of within-eBRS connectivity and a reconnection of eBRS structures with other networks. The re-formation of structural connectivities within and across networks appears critical for cognitive-behavioral functioning related to the capacity to maintain abstinence after outpatient treatment

General Analysis of Single Top Production and W Helicity in Top Decay

We provide a framework for the analysis of the W boson helicity in the decay of the top quark that is based on a general effective tbW coupling. Four independent coupling coefficients can be uniquely determined by the fractions of longitudinal and transverse W boson polarizations as well as the single top production rates for the t-channel and the s-channel processes. The knowledge of these coefficients can be used to discriminate models of electroweak symmetry breaking.Comment: Typo on Eqs. 5 and 6 correcte

An ensemble of specifically targeted proteins stabilizes cortical microtubules in the human parasite Toxoplasma gondii

Although all microtubules within a single cell are polymerized from virtually identical subunits, different microtubule populations carry out specialized and diverse functions, including directional transport, force generation, and cellular morphogenesis. Functional differentiation requires specific targeting of associated proteins to subsets or even subregions of these polymers. The cytoskeleton of Toxoplasma gondii, an important human parasite, contains at least five distinct tubulin-based structures. In this work, we define the differential localization of proteins along the cortical microtubules of T. gondii, established during daughter biogenesis and regulated by protein expression and exchange. These proteins distinguish cortical from mitotic spindle microtubules, even though the assembly of these subsets is contemporaneous during cell division. Finally, proteins associated with cortical microtubules collectively protect the stability of the polymers with a remarkable degree of functional redundancy

Dijet resonance from leptophobic Z' and light baryonic cold dark matter

In light of the recent CDF report on the excess in the Wjj channel, we analyze (non)supersymmetric U(1)_B x U(1)_L model, interpreting the dijet peak as a leptophobic U(1)_B gauge boson. If this excess is confirmed, it has an interesting implication for the baryonic cold dark matter (CDM) in the model: there should be light CDM with a few GeV mass, and direct detection cross section at the level of a few x 10^{-2} pb.Comment: 5 pages, 3 figures, version published in Phys. Lett.

A Chronic Care Model Program Incorporating Group Office Visits for Obesity Treatment in Primary Care

Background. Obesity is a chronic disease of epidemic proportions. Primary care providers are on the front line of diagnosing and treating obesity and need better tools to deliver top-notch obesity care. Methods. A pilot randomized trial was conducted to test a chronic care model (CCM) program for obesity compared to usual care. Primary care patients, 18 years and older, with a body mass index (BMI) between 27 and 45 were enrolled. Sixteen weekly 90-minute group office visits were structured with the first 30 minutes encompassing individualized clinical assessments and the final 60 minutes containing the group-based standardized intensive lifestyle training. The primary outcome was weight change at 16 weeks. Secondary outcomes were weight change at 24 weeks, change in diet and physical activity behaviors, self-efficacy for weight control behaviors, and physiologic markers of cardiovascular risk at 16 and 24 weeks. Results. The participants (19 in the active arm and 10 in the control arm) were 49.8 ± 11.5 years old (mean ± SD), 97% women, 55% white, and 41% black. Weight change in the control arm at week 16 was 0.25+ 2.21 kg (mean + SD) and that for the active arm was -5.74 + 4.50 kg (n=16). The difference between the two arms was significant (p = 0.0002). Both the intent-to-treat analysis using the last observation carried forward approach and the analysis including completers only provided similar siginificant results. Conclusions. This study demonstrated that a CCM program incorporating group office visits was feasible and effective for obesity treatment in primary care settings

Influence of momentum-dependent interactions on balance energy and mass dependence

We aim to study the role of momentum-dependent interactions in transverse flow as well as in its disappearance. For the present study, central collisions involving mass between 24 and 394 are considered. We find that momentum-dependent interactions have different impact in lighter colliding nuclei compared to heavier colliding nuclei. In lighter nuclei, the contribution of mean field towards the flow is smaller compared to heavier nuclei where binary nucleon-nucleon collisions dominate the scene. The inclusion of momentum-dependent interactions also explains the energy of vanishing flow in $^{12}C+^{12}C$ reaction which was not possible with the static equation of state. An excellent agreement of our theoretical attempt is found for balance energy with experimental data throughout the periodic table

Disappearance of Transverse Flow in Central Collisions for Heavier Nuclei

For the first time, mass dependence of balance energy only for heavier systems has been studied. Our results are in excellent agreement with the data which allow us to predict the balance energy of U+U, for the first time, around 37-39 MeV/nucleon. Also our results indicate a hard equation of state along with nucleon-nucleon cross-section around 40 mb.Comment: 4 pages, 3 figures, submitted to Phys. Rev. Let

An innovative framework for higher education to evaluate learning gain: a case study based upon the discipline of marketing

© 2019, © 2019 Society for Research into Higher Education. The value for money of UK undergraduate degree courses is under increasingly critical scrutiny. Understanding the level of learning achieved by students on any particular course has therefore become of paramount importance as an indicator of teaching quality. The change to the learning that a student undertaking a course has acquired can be expressed as being their ‘learning gain’ and this paper applies a course level lens to investigate this using an innovative bottom-up approach which considers both the distance travelled by each student (explicit knowledge), and also their journey travelled (tacit understanding). Benchmarking learning gain data was collected from undergraduate marketing students, and gaps in perceived learning were identified. Changes to the teaching were implemented to address issues identified, and data was collected from the next cohort of students for comparison. Students reported significant improvements in learning after the changes in teaching had been implemented

Structure, stability and stress properties of amorphous and nanostructured carbon films

Structural and mechanical properties of amorphous and nanocomposite carbon are investigated using tight-binding molecular dynamics and Monte Carlo simulations. In the case of amorphous carbon, we show that the variation of sp^3 fraction as a function of density is linear over the whole range of possible densities, and that the bulk moduli follow closely the power-law variation suggested by Thorpe. We also review earlier work pertained to the intrinsic stress state of tetrahedral amorphous carbon. In the case of nanocomposites, we show that the diamond inclusions are stable only in dense amorphous tetrahedral matrices. Their hardness is considerably higher than that of pure amorphous carbon films. Fully relaxed diamond nanocomposites possess zero average intrinsic stress.Comment: 10 pages, 6 figure

Passive SSH Key Compromise via Lattices

We demonstrate that a passive network attacker can opportunistically obtain private RSA host keys from an SSH server that experiences a naturally arising fault during signature computation. In prior work, this was not believed to be possible for the SSH protocol because the signature included information like the shared Diffie-Hellman secret that would not be available to a passive network observer. We show that for the signature parameters commonly in use for SSH, there is an efficient lattice attack to recover the private key in case of a signature fault. We provide a security analysis of the SSH, IKEv1, and IKEv2 protocols in this scenario, and use our attack to discover hundreds of compromised keys in the wild from several independently vulnerable implementations