Electroweak quark-lepton symmetry and weak topological-charge confinement in the Standard Model with Dirac neutrinos

The standard electroweak model with Dirac neutrinos is extended by way of the principles of electroweak quark-lepton symmetry and weak topological-charge confinement to account for quark-lepton charge relations which, if not accidental, are indicative of charge structures. A mixing in quarks and leptons of underlying integer local charges with integer weak topological charges associated with an additive group Z_3, fixed by the anomaly cancellation requirement, is discussed. It is found that the electroweak difference between topological quarks and leptons is the nonequivalence between the topological vacua of their weak field configurations, produced by a four-instanton which carries the topological charge, induces the universal fractional piece of charge distinguishing quarks from leptons, and breaks the underlying symmetry. The constituent quarks of the standard model appear as coming from topological quarks, via the weak four-instanton event. Dual transitions occur for leptons. It is shown that several other fundamental problems left open in the standard electroweak model with Dirac neutrinos are solved: the one-to-one correspondence between quark and lepton flavors, the existence of three generations, the conservation and ungauging of B-L, the electric charge quantization, and the confinement of fractional electric charges.Comment: 23 pages, 1 figure, uses IJMPA.cl

Presymmetry beyond the Standard Model

We go beyond the Standard Model guided by presymmetry, the discrete electroweak quark-lepton symmetry hidden by topological effects which explain quark fractional charges as in condense matter physics. Partners of the particles of the Standard Model and the discrete symmetry associated with this partnership appear as manifestations of a residual presymmetry and its extension from matter to forces. This duplication of the spectrum of the Standard Model keeps spin and comes nondegenerated about the TeV scale.Comment: 6 pages, 11 figures. To be published in the proceedings of DPF-2009, Detroit, MI, July 2009, eConf C09072

The XMM-Newton wide-field survey in the COSMOS field II: X-ray data and the logN-logS

We present the data analysis and the X-ray source counts for the first season of XMM-Newton observations in the COSMOS field. The survey covers ~2 deg^2 within the region of sky bounded by 9^h57.5^m<R.A.<10^h03.5^m; 1^d27.5^m<DEC<2^d57.5^m with a total net integration time of 504 ks. A maximum likelihood source detection was performed in the 0.5-2 keV, 2-4.5 keV and 4.5-10 keV energy bands and 1390 point-like sources were detected in at least one band. Detailed Monte Carlo simulations were performed to fully test the source detection method and to derive the sky coverage to be used in the computation of the logN-logS relations. The 0.5--2 keV and 2--10 keV differential logN-logS were fitted with a broken power-law model which revealed a Euclidean slope (alpha~2.5) at the bright end and a flatter slope (alpha~1.5) at faint fluxes. In the 5--10 keV energy band a single power-law provides an acceptable fit to the observed source counts with a slope alpha~2.4. A comparison with the results of previous surveys shows good agreement in all the energy bands under investigation in the overlapping flux range. We also notice a remarkable agreement between our logN-logS relations and the most recent model of the XRB. The slightly different normalizations observed in the source counts of COSMOS and previous surveys can be largely explained as a combination of low counting statistics and cosmic variance introduced by the large scale structure

Absence of system xc⁻ on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis

Background: Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability. Accumulating evidence points to a key role for neuroinflammation, oxidative stress, and excitotoxicity in this degenerative process. System x(c)- or the cystine/glutamate antiporter could tie these pathological mechanisms together: its activity is enhanced by reactive oxygen species and inflammatory stimuli, and its enhancement might lead to the release of toxic amounts of glutamate, thereby triggering excitotoxicity and neurodegeneration. Methods: Semi-quantitative Western blotting served to study protein expression of xCT, the specific subunit of system x(c)-, as well as of regulators of xCT transcription, in the normal appearing white matter (NAWM) of MS patients and in the CNS and spleen of mice exposed to experimental autoimmune encephalomyelitis (EAE), an accepted mouse model of MS. We next compared the clinical course of the EAE disease, the extent of demyelination, the infiltration of immune cells and microglial activation in xCT-knockout (xCT(-/-)) mice and irradiated mice reconstituted in xCT(-/-) bone marrow (BM), to their proper wild type (xCT(+/+)) controls. Results: xCT protein expression levels were upregulated in the NAWM of MS patients and in the brain, spinal cord, and spleen of EAE mice. The pathways involved in this upregulation in NAWM of MS patients remain unresolved. Compared to xCT(+/+) mice, xCT(-/-) mice were equally susceptible to EAE, whereas mice transplanted with xCT(-/-) BM, and as such only exhibiting loss of xCT in their immune cells, were less susceptible to EAE. In none of the above-described conditions, demyelination, microglial activation, or infiltration of immune cells were affected. Conclusions: Our findings demonstrate enhancement of xCT protein expression in MS pathology and suggest that system x(c)- on immune cells invading the CNS participates to EAE. Since a total loss of system x(c)- had no net beneficial effects, these results have important implications for targeting system x(c)- for treatment of MS

Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection.

Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal. The mechanisms of cell death regulating T-cell numbers at sites of infection are incompletely characterized. T-cell death in cultures of peripheral blood mononuclear cells (PBMC) showed 'classic' features of apoptosis following exposure to pneumococci. Conversely, purified CD3(+) T-cells cultured with pneumococci demonstrated necrosis with membrane permeabilization. The death of purified CD3(+) T-cells was not inhibited by necrostatin, but required the bacterial toxin pneumolysin. Apoptosis of CD3(+) T-cells in PBMC cultures required 'classical' CD14(+) monocytes, which enhanced T-cell activation. CD3(+) T-cell death was enhanced in HIV-seropositive individuals. Monocyte-mediated CD3(+) T-cell apoptotic death was Fas-dependent both in vitro and in vivo. In the early stages of the T-cell dependent host response to pneumococci reduced Fas ligand mediated T-cell apoptosis was associated with decreased bacterial clearance in the lung and increased bacteremia. In summary monocytes converted pathogen-associated necrosis into Fas-dependent apoptosis and regulated levels of activated T-cells at sites of acute bacterial infection. These changes were associated with enhanced bacterial clearance in the lung and reduced levels of invasive pneumococcal disease

The VVDS type-1 AGN sample: The faint end of the luminosity function

In a previous paper (Gavignaud et al. 2006), we presented the type-1 Active Galactic Nuclei (AGN) sample obtained from the first epoch data of the VIMOS-VLT Deep Survey (VVDS). The sample consists of 130 faint, broad-line AGN with redshift up to z=5 and 17.5< I <24.0, selected on the basis of their spectra. In this paper we present the measurement of the Optical Luminosity Function up to z=3.6 derived from this sample, we compare our results with previous results from brighter samples both at low and at high redshift. Our data, more than one magnitude fainter than previous optical surveys, allow us to constrain the faint part of the luminosity function up to high redshift. By combining our faint VVDS sample with the large sample of bright AGN extracted from the SDSS DR3 (Richards et al., 2006b) and testing a number of different evolutionary models, we find that the model which better represents the combined luminosity functions, over a wide range of redshift and luminosity, is a luminosity dependent density evolution (LDDE) model, similar to those derived from the major X-surveys. Such a parameterization allows the redshift of the AGN space density peak to change as a function of luminosity and explains the excess of faint AGN that we find at 1.0< z <1.5. On the basis of this model we find, for the first time from the analysis of optically selected samples, that the peak of the AGN space density shifts significantly towards lower redshift going to lower luminosity objects. This result, already found in a number of X-ray selected samples of AGN, is consistent with a scenario of "AGN cosmic downsizing", in which the density of more luminous AGN, possibly associated to more massive black holes, peaks earlier in the history of the Universe, than that of low luminosity ones.Comment: 13 pages, 10 figures, submitted to A&

<i>Phytophthora betacei</i>, a new species within <i>Phytophthora</i> clade 1c causing late blight on <i>Solanum betaceum </i>in Colombia

Over the past few years, symptoms akin to late blight disease have been reported on a variety of crop plants in South America. Despite the economic importance of these crops, the causal agents of the diseases belonging to the genus Phytophthora have not been completely characterized. In this study, a new Phytophthora species was described in Colombia from tree tomato (Solanum betaceum), a semi-domesticated fruit grown in northern South America. Comprehensive phylogenetic, morphological, population genetic analyses, and infection assays to characterize this new species, were conducted. All data support the description of the new species, Phytophthora betacei sp. nov. Phylogenetic analyses suggest that this new species belongs to clade 1c of the genus Phytophthora and is a close relative of the potato late blight pathogen, P. infestans. Furthermore, it appeared as the sister group of the P. andina strains collected from wild Solanaceae (clonal lineage EC-2). Analyses of morphological and physiological characters as well as host specificity showed high support for the differentiation of these species. Based on these results, a complete description of the new species is provided and the species boundaries withinPhytophthora clade 1c in northern South America are discussed

Regime transitions in stratified shear flows: the link between horizontal and inclined ducts

We present an analytical model that provides the transition curves between different regimes of stratified shear flows in inclined ducts for high Schmidt number values. These curves are described by constant values of a generalized Reynolds number multiplied by the aspect ratio of the duct, showing good agreement with previous experimental results. The generalized Reynolds number is obtained by extending to inclined ducts the solution of a one-dimensional model of a stratified shear flow in a horizontal duct within a regime where advection is neglected in the momentum equation but included in the density transport equation