Formação, ensino e pesquisa: percepções sobre a docência e a pesquisa no âmbito do ProfHistória

This paper discusses the relation between teaching and research with basic education History teachers in continual teaching education. It aims to point out how the relation between education, teaching and research is transversal to the teaching processes on higher education as well on basic education. The paper presents the research scenery – the Mestrado Profissional em Ensino de História – ProfHistória course (Universidade do Estado da Bahia – UNEB center) and details the research’s context in which this text is based. The scope of this paper is defined based on bibliographical dialogues with authors who discuss the teaching-researching relation, qualitative methodologies, and case studies. The research started in the 2020.1 semester with the newly joined class of ProfHistória – UNEB. It aims to know: how does the class reflect upon the formation, teaching, and research relation? Upon interpreting the research findings, data points to the hurdles teachers face through their professional careers, which raises questions about their own formation. Out concluding remarks take up the question asked at the beginning of the introduction of the text, about how does the class reflect upon the formation, teaching, and research relation, aiming to a teaching practice more involved with the current challenges of basic education. Keywords: teaching practices; teacher training; ProfHistória.O presente artigo discute a relação ensino e pesquisa com professores de História da educação básica em processo de formação continuada pela qualificação da sua docência. Busca-se apontar como a relação formação-ensino-pesquisa pode atravessar os processos e as relações no ensino superior. O texto apresenta o cenário da pesquisa, a saber, o Mestrado Profissional em Ensino de História – ProfHistória (polo Universidade do Estado da Bahia – UNEB), bem como detalha o contexto da investigação que dá lastro a este texto. A partir de diálogo bibliográfico com autores e autoras que discutem a relação entre ensino e pesquisa, metodologias qualitativas e estudos de caso, delimitamos o escopo deste trabalho. A pesquisa iniciou-se no semestre de 2020.1, com a turma que acabara de ingressar no ProfHistória-UNEB. Interessa saber: como o grupo vive a relação formação, ensino e pesquisa? Na interpretação dos achados da pesquisa, os dados apontam para os desafios enfrentados pelos docentes na constituição da sua trajetória profissional, o que levanta a discussão acerca da sua própria formação. As considerações finais retomam a questão posta na introdução deste texto: como o grupo pensa a relação formação, ensino e pesquisa em direção a uma prática docente mais implicada com os atuais desafios da realidade da educação básica. Palavras-chave: prática de ensino; formação docente; ProfHistória

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) has heterogeneous clinical and biological behavior. Whole-genome and -exome sequencing has contributed to the characterization of the mutational spectrum of the disease, but the underlying transcriptional profile is still poorly understood. We have performed deep RNA sequencing in different subpopulations of normal B-lymphocytes and CLL cells from a cohort of 98 patients, and characterized the CLL transcriptional landscape with unprecedented resolution. We detected thousands of transcriptional elements differentially expressed between the CLL and normal B cells, including protein-coding genes, noncoding RNAs, and pseudogenes. Transposable elements are globally derepressed in CLL cells. In addition, two thousand genes-most of which are not differentially expressed-exhibit CLL-specific splicing patterns. Genes involved in metabolic pathways showed higher expression in CLL, while genes related to spliceosome, proteasome, and ribosome were among the most down-regulated in CLL. Clustering of the CLL samples according to RNA-seq derived gene expression levels unveiled two robust molecular subgroups, C1 and C2. C1/C2 subgroups and the mutational status of the immunoglobulin heavy variable (IGHV) region were the only independent variables in predicting time to treatment in a multivariate analysis with main clinico-biological features. This subdivision was validated in an independent cohort of patients monitored through DNA microarrays. Further analysis shows that B-cell receptor (BCR) activation in the microenvironment of the lymph node may be at the origin of the C1/C2 differences

Problem-based learning and the Inverted Classroom as a learning strategy for the development of maths

Todo cambio en el ámbito educativo debe originarse con la identificación y planteamiento de problemas pedagógicos para lograr mejorar la calidad académica de los docentes y de los demás actores involucrados. El objetivo del proyecto fue realizar un diagnóstico de las competencias matemáticas por medio de las Pruebas Saber de 3° para diseñar estrategias basadas en el ABP y el aula invertida como herramientas que faciliten el aprendizaje y favorezcan la motivación y concentración en esta asignatura específica. El estudio fue de tipo descriptivo. La población estuvo conformada por los estudiantes de grado tercero de la Institución Educativa Departamental (IED) Rural San Pedro Apóstol, donde se realizó un análisis de los resultados de sus pruebas, evidenciando debilidad en los planteamientos e interpretaciones de problemas matemáticos. Por tal motivo, se hizo necesaria la implementación de estas dos herramientas metodológicas para mejorar la capacidad de razonamiento y acentuar un sólido pensamiento crítico en los estudiantes.Any change in the educational field must originate with the identification and approach of pedagogical problems to achieve the academic quality of the teachers and the other actors involved. The objective of the project was to make a diagnosis of the mathematical competences through the Knowledge Saber of 3 ° to design strategies based on the PBL and the Inverted Classroom as tools that facilitate learning and encourage motivation and concentration in this specific subject. The study was descriptive. The population was conformed by the students of third degree of the IED Rural San Pedro Apóstol, where an analysis of the results of their tests was made, evidencing weakness in the approaches and interpretations of mathematical problems. For this reason, it became necessary to implement these two methodological tools to improve the reasoning capacity and accentuate a solid critical thinking in student

Terrestrial behavior in titi monkeys (Callicebus, Cheracebus, and Plecturocebus) : potential correlates, patterns, and differences between genera

For arboreal primates, ground use may increase dispersal opportunities, tolerance to habitat change, access to ground-based resources, and resilience to human disturbances, and so has conservation implications. We collated published and unpublished data from 86 studies across 65 localities to assess titi monkey (Callicebinae) terrestriality. We examined whether the frequency of terrestrial activity correlated with study duration (a proxy for sampling effort), rainfall level (a proxy for food availability seasonality), and forest height (a proxy for vertical niche dimension). Terrestrial activity was recorded frequently for Callicebus and Plecturocebus spp., but rarely for Cheracebus spp. Terrestrial resting, anti-predator behavior, geophagy, and playing frequencies in Callicebus and Plecturocebus spp., but feeding and moving differed. Callicebus spp. often ate or searched for new leaves terrestrially. Plecturocebus spp. descended primarily to ingest terrestrial invertebrates and soil. Study duration correlated positively and rainfall level negatively with terrestrial activity. Though differences in sampling effort and methods limited comparisons and interpretation, overall, titi monkeys commonly engaged in a variety of terrestrial activities. Terrestrial behavior in Callicebus and Plecturocebus capacities may bolster resistance to habitat fragmentation. However, it is uncertain if the low frequency of terrestriality recorded for Cheracebus spp. is a genus-specific trait associated with a more basal phylogenetic position, or because studies of this genus occurred in pristine habitats. Observations of terrestrial behavior increased with increasing sampling effort and decreasing food availability. Overall, we found a high frequency of terrestrial behavior in titi monkeys, unlike that observed in other pitheciids

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Problem-based learning and the Inverted Classroom as a learning strategy for the development of maths.

Todo cambio en el ámbito educativo debe originarse con la identificación y planteamiento de problemas pedagógicos para lograr mejorar la calidad académica de los docentes y de los demás actores involucrados. El objetivo del proyecto fue realizar un diagnóstico de las competencias matemáticas por medio de las Pruebas Saber de 3° para diseñar estrategias basadas en el ABP y el aula invertida como herramientas que faciliten el aprendizaje y favorezcan la motivación y concentración en esta asignatura específica. El estudio fue de tipo descriptivo. La población estuvo conformada por los estudiantes de grado tercero de la Institución Educativa Departamental (IED) Rural San Pedro Apóstol, donde se realizó un análisis de los resultados de sus pruebas, evidenciando debilidad en los planteamientos e interpretaciones de problemas matemáticos. Por tal motivo, se hizo necesaria la implementación de estas dos herramientas metodológicas para mejorar la capacidad de razonamiento y acentuar un sólido pensamiento crítico en los estudiantes.Any change in the educational field must originate with the identification and approach of pedagogical problems to achieve the academic quality of the teachers and the other actors involved. The objective of the project was to make a diagnosis of the mathematical competences through the Knowledge Saber of 3 ° to design strategies based on the PBL and the Inverted Classroom as tools that facilitate learning and encourage motivation and concentration in this specific subject. The study was descriptive. The population was conformed by the students of third degree of the IED Rural San Pedro Apóstol, where an analysis of the results of their tests was made, evidencing weakness in the approaches and interpretations of mathematical problems. For this reason, it became necessary to implement these two methodological tools to improve the reasoning capacity and accentuate a solid critical thinking in students

Phospholipid makeup of the breast adipose tissue is impacted by obesity and mammary cancer in the mouse: Results of a pilot study

Obesity, an established risk factor for breast cancer (BC), is associated with systemic inflammation. The breast contains adipose tissue (bAT), yet whether it plays a role in BC progression in obese females is being intensively studied. There is scarce knowledge on the lipid composition of bAT in health and disease. The purpose of this pilot study was: 1) to determine whether obesity and BC are associated with inflammatory changes in bAT 2) to analyze for the first time the lipid profile of bAT in obese and lean mammary tumor-bearing and normal mice. Syngeneic E0771 mammary tumor cells were implanted into the mammary fat pad of lean and diet-induced obese C57BL/6 mice. BATs were analyzed four weeks after tumor cell inoculation by immunohistochemistry and mass spectrometry. Phospholipids were identified and subjected to ratiometric quantification using a TSQ Quantum Access Max triple quadrupole mass spectrometer utilizing precursor ion scan or neutral ion loss scan employing appropriate class specific lipid standards in a two step quantification process. Four main classes of phospholipids were analyzed: phosphatidylcholines phosphatidylserines, phosphatidylethanolamines and phosphatidylinositols. Our results showed that bAT in obese (normal and tumor-bearing) mice contained hypertrophic adipocytes compared with their corresponding samples in lean mice; higher numbers of macrophages and crown-like structures were observed in obese tumor bearers compared to obese normal mice. BAT from normal obese mice revealed higher concentrations of phosphatidylethanolamines. Furthermore, bAT from tumor-bearing mice expressed higher phosphatidylcholines than that from non-tumor bearing mice, suggesting the presence of the tumor is associated with phosphatidylcholines. Conversion of phosphatidylethanolamines to phosphatidylcholines will be investigated in E0771 cells. Additional studies are projected to investigate macrophage activation by these specific classes of phospholipids. Occurrence of triglycerides and free fatty acids will be examined in bAT and similar lipidomic analyses will be carried out visceral adipose tissue, highly inflamed in obesity