25 research outputs found
Conservation Laws in Doubly Special Relativity
Motivated by various theoretical arguments that the Planck energy (Ep - 10^19
GeV) - should herald departures from Lorentz invariance, and the possibility of
testing these expectations in the not too distant future, two so-called "Doubly
Special Relativity" theories have been suggested -- the first by
Amelino-Camelia (DSR1) and the second by Smolin and Magueijo (DSR2). These
theories contain two fundamental scales -- the speed of light and an energy
usually taken to be Ep. The symmetry group is still the Lorentz group, but in
both cases acting nonlinearly on the energy-momentum sector. Accordingly, since
energy and momentum are no longer additive quantities, finding their values for
composite systems (and hence finding the correct conservation laws) is a
nontrivial matter. Ultimately it is these possible deviations from simple
linearly realized relativistic kinematics that provide the most promising
observational signal for empirically testing these models. Various
investigations have narrowed the conservation laws down to two possibilities
per DSR theory. We derive unique exact results for the energy-momentum of
composite systems in both DSR1 and DSR2, and indicate the general strategy for
arbitrary nonlinear realizations of the Lorentz group.Comment: V2: Extensive revisions: merged with gr-qc/0205093, new author added,
references added, discussion amplified. 4 pages, revtex4; V3: Revised in
response to referee comments; no physics changes; version to appear in
Physical Review
Quantum Theory of Noncommutative Fields
Generalizing the noncommutative harmonic oscillator construction, we propose
a new extension of quantum field theory based on the concept of "noncommutative
fields". Our description permits to break the usual particle-antiparticle
degeneracy at the dispersion relation level and introduces naturally an
ultraviolet and an infrared cutoff. Phenomenological bounds for these new
energy scales are given.Comment: LaTeX file, JHEP3.cls, subequations.sty; 12 pages, no figures. Final
version published in JHEP with some references adde
Observation of the Ankle and Evidence for a High-Energy Break in the Cosmic Ray Spectrum
We have measured the cosmic ray spectrum at energies above eV using
the two air fluorescence detectors of the High Resolution Fly's Eye experiment
operating in monocular mode. We describe the detector, PMT and atmospheric
calibrations, and the analysis techniques for the two detectors. We fit the
spectrum to models describing galactic and extragalactic sources. Our measured
spectrum gives an observation of a feature known as the ``ankle'' near eV, and strong evidence for a suppression near eV.Comment: 14 pages, 9 figures. To appear in Physics Letters B. Accepted versio
Gamma-Ray Bursts: The Underlying Model
A pedagogical derivation is presented of the ``fireball'' model of gamma-ray
bursts, according to which the observable effects are due to the dissipation of
the kinetic energy of a relativistically expanding wind, a ``fireball.'' The
main open questions are emphasized, and key afterglow observations, that
provide support for this model, are briefly discussed. The relativistic outflow
is, most likely, driven by the accretion of a fraction of a solar mass onto a
newly born (few) solar mass black hole. The observed radiation is produced once
the plasma has expanded to a scale much larger than that of the underlying
``engine,'' and is therefore largely independent of the details of the
progenitor, whose gravitational collapse leads to fireball formation. Several
progenitor scenarios, and the prospects for discrimination among them using
future observations, are discussed. The production in gamma- ray burst
fireballs of high energy protons and neutrinos, and the implications of burst
neutrino detection by kilometer-scale telescopes under construction, are
briefly discussed.Comment: In "Supernovae and Gamma Ray Bursters", ed. K. W. Weiler, Lecture
Notes in Physics, Springer-Verlag (in press); 26 pages, 2 figure
Lorentz breaking Effective Field Theory and observational tests
Analogue models of gravity have provided an experimentally realizable test
field for our ideas on quantum field theory in curved spacetimes but they have
also inspired the investigation of possible departures from exact Lorentz
invariance at microscopic scales. In this role they have joined, and sometime
anticipated, several quantum gravity models characterized by Lorentz breaking
phenomenology. A crucial difference between these speculations and other ones
associated to quantum gravity scenarios, is the possibility to carry out
observational and experimental tests which have nowadays led to a broad range
of constraints on departures from Lorentz invariance. We shall review here the
effective field theory approach to Lorentz breaking in the matter sector,
present the constraints provided by the available observations and finally
discuss the implications of the persisting uncertainty on the composition of
the ultra high energy cosmic rays for the constraints on the higher order,
analogue gravity inspired, Lorentz violations.Comment: 47 pages, 4 figures. Lecture Notes for the IX SIGRAV School on
"Analogue Gravity", Como (Italy), May 2011. V.3. Typo corrected, references
adde
The exposure of the hybrid detector of the Pierre Auger Observatory
The Pierre Auger Observatory is a detector for ultra-high energy cosmic rays.
It consists of a surface array to measure secondary particles at ground level
and a fluorescence detector to measure the development of air showers in the
atmosphere above the array. The "hybrid" detection mode combines the
information from the two subsystems. We describe the determination of the
hybrid exposure for events observed by the fluorescence telescopes in
coincidence with at least one water-Cherenkov detector of the surface array. A
detailed knowledge of the time dependence of the detection operations is
crucial for an accurate evaluation of the exposure. We discuss the relevance of
monitoring data collected during operations, such as the status of the
fluorescence detector, background light and atmospheric conditions, that are
used in both simulation and reconstruction.Comment: Paper accepted by Astroparticle Physic
The surface detector array of the Telescope Array experiment
The Telescope Array (TA) experiment, located in the western desert of
Utah,USA, is designed for observation of extensive air showers from extremely
high energy cosmic rays. The experiment has a surface detector array surrounded
by three fluorescence detectors to enable simultaneous detection of shower
particles at ground level and fluorescence photons along the shower track. The
TA surface detectors and fluorescence detectors started full hybrid observation
in March, 2008. In this article we describe the design and technical features
of the TA surface detector.Comment: 32 pages, 17 figure
Galectin-3 interacts with PD-1 and counteracts the PD-1 pathway-driven regulation of T cell and osteoclast activity in Rheumatoid Arthritis
OBJECTIVE: Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation and bone erosions. The glycosylated programmed death-1 (PD-1) receptor plays an important role in regulating immune responses and maintaining tolerance. In this study, we focus on two features observed in RA: impaired PD-1 signaling, and Galectin-3 (Gal-3) upregulation. We hypothesize that Gal-3 binds PD-1 and PD-1 ligands, potentially contributing to impaired PD-1 signaling. METHODS: PD-1 and Gal-3 levels in RA synovial fluid (SF) and plasma were evaluated by ELISA. PD-1 and Gal-3 interaction was examined by Surface Plasmon Resonance and ELISA. PD-1, PD-L1 and Gal-3 expression on mononuclear cells from SF and peripheral blood as well as fibroblast-like synoviocytes were examined by flow cytometry. Effects of Gal-3 and PD-L1 on osteoclast formation was evaluated by tartrate-resistant acid phosphatase assay. RESULTS: We show that Gal-3 binds PD-1 and PD-L1. Results demonstrated high expression of PD-1 and Gal-3 on mononuclear cells, especially from SF. Gal-3 inhibited PD-1 signaling when PD-L1 was present. Furthermore, a role of Gal-3 in osteoclast formation was observed in vitro, both directly but also through PD-1:PD-L1 inhibition. CONCLUSIONS: Effects of Gal-3 on the PD-1 signaling axis are proposed to be inhibitory, meaning high Gal-3 levels in the complex synovial microenvironment are not desirable in RA. Preventing Gal-3's inhibitory role on PD-1 signaling could therefore be a therapeutic target in RA by affecting inflammatory T cell responses and osteoclasts
Time-domain response of the ARIANNA detector
The Antarctic Ross Ice Shelf Antenna Neutrino Array (ARIANNA) is a high-energy neutrino detector designed to record the Askaryan electric field signature of cosmogenic neutrino interactions in ice. To understand the inherent radio-frequency (RF) neutrino signature, the time-domain response of the ARIANNA RF receiver must be measured. ARIANNA uses Create CLP5130-2N log-periodic dipole arrays (LPDAs). The associated effective height operator converts incident electric fields to voltage waveforms at the LDPA terminals. The effective height versus time and incident angle was measured, along with the associated response of the ARIANNA RF amplifier. The results are verified by correlating to field measurements in air and ice, using oscilloscopes. Finally, theoretical models for the Askaryan electric field are combined with the detector response to predict the neutrino signature