12 research outputs found
Teacher Educators Wrestling with Issues of Diversity in Online Courses
- Publication venue
- NSUWorks
- Publication date
- 10/02/2014
- Field of study
This manuscript provides an overview of the findings of an ongoing qualitative exploratory study that examined how preservice and inservice teachers in two different online education courses (ED 600 and ED 500) developed an understanding of the multifaceted issues that affect diverse learners. The study also investigated the instructors’ reflections about their courses through their individual journals. An analysis of the study participants\u27 Discussion Board posts and interactions online revealed how the Discussion Board forum was used as a critical, reflective space for participants\u27 to engage in self-reflection and to exchange and challenge one another\u27s ideas. The journals also revealed the instructors\u27 overall aspirations for the course, and their role in cultivating an online community in their courses
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
- Clark Graeme R
- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
- Cochran Barbara
- Cole Shelley
- Colhoun Helen
- Colhoun Helen M
- Collins Francis S
- Collins Rory
- Connell John M
- Cooper Cyrus
- Cooper Jackie A
- Cooper Matthew N
- Cooper Richard S
- Coresh Josef
- Cornelis Marilyn C
- Corre Tanguy
- Corsi Anna Maria
- Couper David
- Cousminer Diana L
- Coviello Andrea D
- Cox David
- Crawford Dana
- Crisponi Laura
- Croteau-Chonka Damien C
- Cucca Francesco
- Cummings Steven R
- Cupples Adrienne L
- Cupples L Adrienne
- Curhan Gary
- d'Adamo Pio
- Dahgam Santosh
- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
- Davies Gail
- Daw E Warwick
- Day Felix R
- Day Ian N M
- de Andrade Mariza
- de Boer Ian H
- de Boer Rudolf A
- de Faire Ulf
- de Geus Eco J C
- Deary Ian J
- Dedoussis George
- Dedoussis George V
- Dedoussis George V Z
- Deelen Joris
- Deelman Ewa
- Dehghan Abbas
- Delgado Graciela
- Deloukas Panagiotis
- Deloukas Panos
- Demerath Ellen W
- Demirkan Ayse
- Demirkan Ayşe
- Den Hertog Heleen M
- Denniff Matthew
- Dennison Elaine M
- Dermitzakis Emmanouil T
- Deshmukh Harshal
- Deshmukh Harshal A
- Devuyst Olivier
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S
- Dimitriou Maria
- Ding Jingzhong
- Do Ron
- Dominiczak Anna F
- Doney Alex
- Dong Yanbin
- Donnelly Louise A
- Doumatey Ayo
- Dreisbach Albert W
- Drong Alexander W
- Duggan David
- Dumitrescu Logan
- Duncan Bruce B
- Duncan Emma L
- Dupuis Josee
- Dupuis Josée
- Durbin Richard
- Durda Peter
- Döring Angela
- Dörr Marcus
- Eastell Richard
- Easton Douglas F
- Ebrahim Shah
- Econs Michael J
- Edkins Sarah
- Egan Josephine
- Ehret Georg
- Eiriksdottir Gudny
- Eisman John A
- Eklund Niina
- El Mokhtari NourEddine
- Elks Cathy E
- Ellinghaus David
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Endlich Karlhans
- Epstein Stephen E
- Erbel Raimund
- Erdmann Jeanette
- Erdos Michael R
- Eriksson Joel
- Eriksson Johan
- Eriksson Niclas
- Eriksson Per
- Ernst Florian
- Esko Tonu
- Esko Tõnu
- Esko Tönu
- Estrada Karol
- Eury Elodie
- Evangelou Evangelos
- Evans Alun
- Evans David M
- Eyheramendy Susana
- Eyjolfsson Gudmundur Ingi
- Fagerholm Emma
- Falhammar Henrik
- Fall Tove
- Farrall Martin
- Fauser Bart C J M
- Fava Cristiano
- Feenstra Bjarke
- Fehrmann Rudolf
- Feitosa Mary
- Feranil Alan B
- Ferrannini Ele
- Ferrario Marco M
- Ferreira Teresa
- Ferreli Liana
- Ferrières Jean
- Ferrucci Luigi
- Fischer Krista
- Florez Jose C
- Folkersen Lasse
- Folsom Aaron R
- Fontanillas Pierre
- Ford Ian
- Fornage Myriam
- Foroud Tatiana
- Forouhi Nita G
- Forrester Terrence
- Forsblom Carol
- Foster Meredith C
- Fowke Jay
- Fowkes F Gerald R
- Fowkes Gerard R
- Fox Caroline S
- Fox Ervin R
- Franceschini Nora
- Franco Oscar H
- Franco-Cereceda Anders
- Franke Andre
- Franke Lude
- Franks Paul W
- Frants Rune
- Fraser Ross M
- Frayling Timothy M
- Freedman Barry I
- Freimer Nelson B
- Freitag Daniel F
- Friedrich Nele
- Froguel Philippe
- Frost Morten
- Fuchsberger Christian
- Galan Pilar
- Ganesh Santhi K
- Ganna Andrea
- Gansevoort Ron T
- Gao Xiaoyi
- Garcia Melissa
- Garcia-Giralt Natàlia
- Garnaas Maija
- Gasparini Paolo
- Gauguier Dominique
- Gaunt Tom R
- Gautvik Kaare M
- Geller Frank
- Gharavi Ali G
- Giedraitis Vilmantas
- Gieger Christian
- Gierman Hinco J
- Gigante Bruna
- Gill Geoffrey V
- Giroux Sylvie
- Giulianini Franco
- Glass Daniel
- Glazer Nicole
- Glazer Nicole L
- Glenn Kim
- Glorioso Nicola
- Go Alan S
- Go Min Jin
- Godson Catherine
- Goel Anuj
- Goessling Wolfram
- Golay Alain
- Goldstein Benjamin A
- Goltzman David
- Gong Jian
- González-Macías Jesús
- Goodall Alison H
- Goodarzi Mark O
- Goodloe Robert
- Gordin Daniel
- Gordon Scott D
- Gorski Mathias
- Grabe Hans-Jörgen
- Graff Misa
- Grallert Harald
- Grammer Tanja B
- Gravito Martha L
- Greenwood Celia M T
- Grewal Jagvir
- Grimsby Jonna
- Grobbee Diederick E
- Groop Leif
- Groop Per-Henrik
- Gross Myron
- Groves Christopher J
- Grundberg Elin
- Grässler Jürgen
- Gräßler Jürgen
- Gu Harvest F
- Gu Tianwei
- Guarrera Simonetta
- Gudbjartsson Daniel F
- Gudnason Villi
- Gudnason Vilmundur
- Guiducci Candace
- Guo Qun
- Guo Xiuqing
- Gurdasani Deepti
- Gustafsson Stefan
- Gyllensten Ulf
- Gyllensten Ulf B
- Hadjadj Samy
- Hadley David
- Haessler Jeff
- Hager Jörg
- Haiman Christopher
- Haines Jonathan
- Hall Alistair S
- Hall Per
- Hallan Stein
- Haller Toomas
- Hallmans Goran
- Hallmans Göran
- Hamsten Anders
- Han Bok-Ghee
- Hankinson Susan E
- Hanson Robert L
- Hardy Rebecca
- Haritunians Talin
- Harjutsalo Valma
- Harris Tamara
- Hartikainen Anna-Liisa
- Hartman Catharina A
- Hass Merli
- Hassanali Neelam
- Hassinen Maija
- Hastie Nicholas D
- Hastie Nick
- Hattersley Andrew T
- Haun Margot
- Havulinna Aki S
- Hayward Caroline
- Hazen Stanley L
- He Bing
- He Chunyan
- Heard-Costa Nancy L
- Heath Andrew C
- Heath Simon
- Heckbert Susan R
- Hedblad Bo
- Hedman Åsa K
- Heid Iris M
- Heikkilä Kauko
- Heikkilä Outi
- Heiss Gerardo
- Heliövaara Markku
- Helmer Catherine
- Helmer Quinta
- Henders Anjali K
- Henderson Brian
- Hengstenberg Christian
- Henneman Peter
- Hercberg Serge
- Herder Christian
- Hernandez Dena
- Hernandez Dena G
- Herrera Lizbeth
- Herzig Karl-Heinz
- Hicks Andrew A
- Hietala Kustaa
- Higashio Julia
- Hillege Hans L
- Hilton Gina
- Hindorff Lucia
- Hingorani Aroon
- Hirschhorn Joel N
- Hivert Marie-France
- Ho Weang K
- Hocking Lynne J
- Hoffmann Wolfgang
- Hofman Albert
- Holliday Elizabeth G
- Holm Hilma
- Holmen Oddgeir
- Homuth Georg
- Hopewell Jemma C
- Horikoshi Momoko
- Hosseini Mohsen
- Hottenga Jouke-Jan
- Hovingh G Kees
- Howard Philip
- Hsiung Chao Agnes
- Hsu Yi-Hsiang
- Hu Frank B
- Huang Huateng
- Huang Jinyan
- Hui Jennie
- Humphries Steve E
- Hundertmark Claudia
- Hung Yi-Jen
- Hunt Sarah E
- Hunt Steven C
- Hunter David J
- Husted Lise Bjerre
- Hveem Kristian
- Hwang Shih-Jen
- Hyppönen Elina
- Igl Wilmar
- Ikram M Arfan
- Illig Thomas
- Imboden Medea
- Ingelsson Erik
- Ingle Catherine
- Ingvarsson Thorvaldur
- Ioannidis John P A
- Iribarren Carlos
- Isaacs Aaron
- Isakova Tamara
- Islam Muhammad
- Ittermann Till
- Iwai Naoharu
- Jackson Anne U
- Jackson Rebecca
- Jacobs Gunnar
- Jafar Tazeen H
- James Alan L
- Jameson Karen A
- Jang Yangsoo
- Janipalli Charles S
- Jansen Hanneke
- Janssens A Cecile J W
- Jarvelin Marjo-Riitta
- Jeff Janina
- Jenny Nancy
- Johannsdottir Hrefna
- Johansen Berit
- Johansson Ingegerd
- Johansson Åsa
- Johnson Andrew
- Johnson Louise
- Johnson Paul C D
- Johnson Toby
- Jones Graeme
- Jones Michelle R
- Jousilahti Pekka
- Ju Sung Yun
- Jukema J Wouter
- Jula Antti
- Juliusdottir Thorhildur
- Justice Anne E
- Järvelin Marjo-Riitta
- Jöckel Karl-Heinz
- Kaakinen Marika
- Kahali Bratati
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- Kaleebu Pontiano
- Kammerer Candace M
- Kanaya Alka
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- Kollerits Barbara
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- Kooner Ishminder K
- Kooner Jaspal
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- Kronenberg Florian
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- Kuulasmaa Kari
- Kuusisto Johanna
- Kuznetsova Tatiana
- Kwan Tony
- Kytö Janne
- Kyvik Kirsten O
- Kähönen Mika
- König Inke R
- Körner Antje
- Köttgen Anna
- Laakso Markku
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- LaCroix Andrea
- Lacroix Andrea Z
- Ladenvall Claes
- Ladouceur Martin
- Lagou Vasiliki
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- Lawlor Debbie A
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- Lindgren Cecilia M
- Lindström Jaana
- Lips Paul
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- Liu Jianjun
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- Lopez Lorna M
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- Lorentzon Mattias
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- Lyytikäinen Leo-Pekka
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- MacCluer Jean
- Macgregor Stuart
- Mach François
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- Maestroni Anna
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- Mahajan Anubha
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- Manolio Teri
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- Meulenbelt Ingrid
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- Ogihara Toshio
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- Oldehinkel Albertine J
- Olden Matthias
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- Olsson Christian
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- Ongen Halit
- Onland-Moret N Charlotte
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- Ordovas Jose M
- Org Elin
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- Palotie Aarno
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- Panduru Nicolae Mircea
- Pankow James
- Papamarkou Theodore
- Parish Sarah
- Park Jeong E
- Park Lani
- Parker Alex N
- Parkkonen Maija
- Parsa Afshin
- Parts Leopold
- Parving Hans-Henrik
- Paré Guillaume
- Pasko Dorota
- Pastinen Tomi
- Patel Millan S
- Paterson Andrew D
- Patsy Bruce
- Pattaro Cristian
- Paulweber Bernhard
- Peacock Munro
- Pechlivanis Sonali
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- Pennell Craig E
- Penninx Brenda W
- Peralta Carmen A
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- Peters Marjolein J
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- Pharoah Paul
- Pihur Vasyl
- Pirastu Mario
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- Pols Huibert A P
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- Prokopenko Inga
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- Quertermous Thomas
- Quibrera Miguel
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- Rafelt Suzanne
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- Rankinen Tuomo
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- Rathmann Wolfgang
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- Rayner N William
- Rayner Nigel W
- Redline Susan
- Reeve Jonathan
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- Reid David M
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- Reinmaa Eva
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- Rosse Stephanie
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- Samani Nilesh
- Sambrook Philip N
- Sandholm Niina
- Sandhu Manjinder S
- Sanghera Dharambir K
- Sanna Serena
- Saraheimo Markku
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- Sattar Naveed
- Savage David A
- Saxena Richa
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- Scherag André
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- Seielstad Mark
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- Semple Robert
- Sengupta Sebanti
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- Serafinceanu Cristian
- Service Susan K
- Seshadri Sudha
- Seufferlein Thomas
- Shah Sonia
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- Sham Pak Chung
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- Stavarachi Monica
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- Steinle Nanette I
- Steinthorsdottir Valgerdur
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- Stirrups Kathleen
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- Stolk Ronald P
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- Tammesoo Mar-Liis
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- Wilson Scott G
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- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
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- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
TRY plant trait database – enhanced coverage and open access
- Author
- Aakala Tuomas
- Abedi Mehdi
- Acosta Alicia T. R.
- Adamidis George C.
- Adamson Kairi
- Aiba Masahiro
- Albert Cécile H.
- Alcántara Julio M.
- Alcázar C Carolina
- Aleixo Izabela
- Ali Hamada
- Amiaud Bernard
- Ammer Christian
- Amoroso Mariano M.
- Anand Madhur
- Anderson Carolyn
- Anten Niels
- Antos Joseph
- Apgaua Deborah Mattos Guimarães
- Ashman Tia‐Lynn
- Asmara Degi Harja
- Asner Gregory P.
- Aspinwall Michael
- Atkin Owen
- Aubin Isabelle
- Baastrup‐Spohr Lars
- Bahalkeh Khadijeh
- Bahn Michael
- Baker Timothy
- Baker William J.
- Bakker Jan P.
- Baldocchi Dennis
- Baltzer Jennifer
- Banerjee Arindam
- Baranger Anne
- Barlow Jos
- Barneche Diego R.
- Baruch Zdravko
- Bastianelli Denis
- Battles John
- Bauerle William
- Bauters Marijn
- Bazzato Erika
- Beckmann Michael
- Beeckman Hans
- Beer Arend Jacobus
- Beest Mariska
- Beierkuhnlein Carl
- Bekker Renee
- Belfry Gavin
- Belluau Michael
- Beloiu Mirela
- Benavides Raquel
- Benomar Lahcen
- Berdugo‐Lattke Mary Lee
- Berenguer Erika
- Bergamin Rodrigo
- Bergmann Carlucci Marcos
- Bergmann Joana
- Berner Logan
- Bernhardt‐Römermann Markus
- Bigler Christof
- Bjorkman Anne D.
- Blackman Chris
- Blanco Carolina
- Blonder Benjamin
- Blumenthal Dana
- Bocanegra‐González Kelly T.
- Bodegom Peter M.
- Boeckx Pascal
- Bohlman Stephanie
- Boisvert‐Marsh Laura
- Bond William
- Bond‐Lamberty Ben
- Boom Arnoud
- Boonman Coline C. F.
- Bordin Kauane
- Boughton Elizabeth H.
- Boukili Vanessa
- Bowman David M. J. S.
- Bravo Sandra
- Brendel Marco Richard
- Breugel Michiel
- Broadley Martin R.
- Brown Kerry A.
- Bruelheide Helge
- Brumnich Federico
- Bruun Hans Henrik
- Bruy David
- Buchanan Serra W.
- Bucher Solveig Franziska
- Buchmann Nina
- Buitenwerf Robert
- Bunker Daniel E.
- Burrascano Sabina
- Burslem David F. R. P.
- Butterfield Bradley J.
- Byun Chaeho
- Böhning‐Gaese Katrin
- Bönisch Gerhard
- Bürger Jana
- Caccianiga Marco
- Cadotte Marc
- Cailleret Maxime
- Camac James
- Camarero Jesús Julio
- Campany Courtney
- Campetella Giandiego
- Campos Juan Antonio
- Cano‐Arboleda Laura
- Canullo Roberto
- Carbognani Michele
- Carvalho Fabio
- Casanoves Fernando
- Castagneyrol Bastien
- Catford Jane A.
- Cavender‐Bares Jeannine
- Cerabolini Bruno E. L.
- Cervellini Marco
- Chacón‐Madrigal Eduardo
- Chapin F. Stuart
- Chapin Kenneth
- Chelli Stefano
- Chen Anping
- Chen Si‐Chong
- Cherubini Paolo
- Chianucci Francesco
- Choat Brendan
- Chung Kyong‐Sook
- Chytrý Milan
- Ciccarelli Daniela
- Coll Lluís
- Collins Courtney G.
- Conti Luisa
- Coomes David
- Cornelissen Johannes H. C.
- Cornwell William K.
- Corona Piermaria
- Coyea Marie
- Craine Joseph
- Craven Dylan
- Cromsigt Joris P. G. M.
- Csecserits Anikó
- Cufar Katarina
- Cuntz Matthias
- Dahlin Kyla M.
- Dainese Matteo
- Dalke Igor
- Dalle Fratte Michele
- Dang‐Le Anh Tuan
- Danihelka Jirí
- Dannoura Masako
- Dawson Samantha
- De Frutos Angel
- De Long Jonathan R.
- Dechant Benjamin
- Delagrange Sylvain
- Delpierre Nicolas
- Derroire Géraldine
- Dias Arildo S.
- Diaz‐Toribio Milton Hugo
- Dimitrakopoulos Panayiotis G.
- Dios Victor Resco
- Dobrowolski Mark
- Doktor Daniel
- Domingues Tomas F.
- Dong Ning
- Dransfield John
- Dressler Stefan
- Duarte Leandro
- Ducouret Emilie
- Dullinger Stefan
- Durka Walter
- Duursma Remko
- Dymova Olga
- Díaz Sandra
- Dřevojan Pavel
- Eckstein Rolf Lutz
- Ejtehadi Hamid
- Elser James
- Emilio Thaise
- Engemann Kristine
- Erfanian Mohammad Bagher
- Erfmeier Alexandra
- Esquivel‐Muelbert Adriane
- Esser Gerd
- Estiarte Marc
- E‐Vojtkó Anna
- Fagan William F.
- Fagúndez Jaime
- Falster Daniel S.
- Fan Ying
- Fang Jingyun
- Farris Emmanuele
- Fazlioglu Fatih
- Feng Yanhao
- Fernandez‐Mendez Fernando
- Ferrara Carlotta
- Ferreira Joice
- Fidelis Alessandra
- Finegan Bryan
- Firn Jennifer
- Flowers Timothy J.
- Flynn Dan F. B.
- Fontana Veronika
- Forey Estelle
- Forgiarini Cristiane
- Frangipani Marcelo
- Frank Dorothea
- François Louis
- Frenette‐Dussault Cedric
- Freschet Grégoire T.
- Fry Ellen L.
- Fyllas Nikolaos M.
- Gachet Sophie
- Gallagher Rachael
- Ganade Gislene
- Ganga Francesca
- García‐Palacios Pablo
- Gargaglione Verónica
- Garnier Eric
- Garrido Jose Luis
- Gasper André Luís
- Gea‐Izquierdo Guillermo
- Gibson David
- Gillison Andrew N.
- Giroldo Aelton
- Glasenhardt Mary‐Claire
- Gleason Sean
- Gliesch Mariana
- Goldberg Emma
- Gonzalez‐Akre Erika
- Gonzalez‐Andujar Jose L.
- González‐Melo Andrés
- González‐Robles Ana
- Graae Bente Jessen
- Granda Elena
- Graves Sarah
- Green Walton A.
- Gregor Thomas
- Gross Nicolas
- Guerin Greg R.
- Gutiérrez Alvaro G.
- Göldel Bastian
- Günther Angela
- Haddock Lillie
- Haines Anna
- Hall Jefferson
- Hambuckers Alain
- Han Wenxuan
- Harrison Sandy P.
- Hattingh Wesley
- Hawes Joseph E.
- He Pengcheng
- He Tianhua
- Heberling Jacob Mason
- Helm Aveliina
- Hempel Stefan
- Hentschel Jörn
- Hereş Ana‐Maria
- Herz Katharina
- Heuertz Myriam
- Hickler Thomas
- Hietz Peter
- Higuchi Pedro
- Hipp Andrew L.
- Hirons Andrew
- Hock Maria
- Hogan James Aaron
- Holl Karen
- Honnay Olivier
- Hornstein Daniel
- Hou Enqing
- Hough‐Snee Nate
- Hovstad Knut Anders
- Hérault Bruno
- Ichie Tomoaki
- Igić Boris
- Illa Estela
- Isaac Marney
- Ishihara Masae
- Ivanov Leonid
- Ivanova Larissa
- Iversen Colleen M.
- Izquierdo Jordi
- Jackson Benjamin
- Jackson Robert B.
- Jactel Hervé
- Jagodzinski Andrzej M.
- Jandt Ute
- Jansen Steven
- Jenkins Thomas
- Jentsch Anke
- Jespersen Jens Rasmus Plantener
- Jiang Guo‐Feng
- Johansen Jesper Liengaard
- Johnson David
- Jokela Eric J.
- Joly Carlos Alfredo
- Jordan Gregory J.
- Joseph Grant Stuart
- Junaedi Decky
- Junker Robert R.
- Justes Eric
- Kabzems Richard
- Kane Jeffrey
- Kaplan Zdenek
- Kattenborn Teja
- Kattge Jens
- Kavelenova Lyudmila
- Kearsley Elizabeth
- Kempel Anne
- Kenzo Tanaka
- Kerkhoff Andrew
- Khalil Mohammed I.
- Kinlock Nicole L.
- Kissling Wilm Daniel
- Kitajima Kaoru
- Kitzberger Thomas
- Kjøller Rasmus
- Klein Tamir
- Kleunen Mark
- Kleyer Michael
- Klimešová Jitka
- Klipel Joice
- Kloeppel Brian
- Klotz Stefan
- Knops Johannes M. H.
- Kohyama Takashi
- Koike Fumito
- Kollmann Johannes
- Komac Benjamin
- Komatsu Kimberly
- Kraft Nathan J. B.
- Kramer Koen
- Kreft Holger
- Kumarathunge Dushan
- Kuppler Jonas
- Kurokawa Hiroko
- Kurosawa Yoko
- Kuyah Shem
- König Christian
- Kühn Ingolf
- Laclau Jean‐Paul
- Lafleur Benoit
- Lallai Erik
- Lamb Eric
- Lamprecht Andrea
- Larkin Daniel J.
- Laughlin Daniel
- Lavorel Sandra
- Le Bagousse‐Pinguet Yoann
- Leadley Paul
- Lee Tali
- Lens Frederic
- Lewis Simon L.
- Lhotsky Barbara
- Li Xine
- Li Yuanzhi
- Lichstein Jeremy W.
- Liebergesell Mario
- Lim Jun Ying
- Lin Yan‐Shih
- Linares Juan Carlos
- Liu Chunjiang
- Liu Daijun
- Liu Udayangani
- Livingstone Stuart
- Llusià Joan
- Lohbeck Madelon
- Lopez‐Gonzalez Gabriela
- Lososová Zdeňka
- Louault Frédérique
- Lukeš Petr
- Lukács Balázs A.
- Luo Yunjian
- Lussu Michele
- López‐García Álvaro
- Ma Siyan
- Maciel Rabelo Pereira Camilla
- Mack Michelle
- Maire Guerric
- Maire Vincent
- Malhado Ana Claudia Mendes
- Mallik Azim
- Manning Peter
- Manzoni Stefano
- Marchetti Zuleica
- Marchino Luca
- Marcilio‐Silva Vinicius
- Marcon Eric
- Marignani Michela
- Markesteijn Lars
- Marques Marcia
- Martin Adam
- Martínez‐Garza Cristina
- Martínez‐Vilalta Jordi
- Mason Kelly
- Mason Norman
- Massad Tara Joy
- Masse Jacynthe
- Mayrose Itay
- Mazzochini Guilherme G.
- Mašková Tereza
- McCarthy James
- McCormack M. Luke
- McCulloh Katherine
- McFadden Ian R.
- McGill Brian J.
- McPartland Mara Y.
- Medeiros Juliana S.
- Medlyn Belinda
- Meerts Pierre
- Mehrabi Zia
- Meir Patrick
- Melo Felipe P. L.
- Mencuccini Maurizio
- Meredieu Céline
- Merwe Stephni
- Messier Julie
- Metsaranta Juha
- Michaletz Sean T.
- Michelaki Chrysanthi
- Migalina Svetlana
- Milla Ruben
- Miller Jesse E. D.
- Minden Vanessa
- Ming Ray
- Mokany Karel
- Moles Angela T.
- Molnár Attila, V
- Molofsky Jane
- Molz Martin
- Montgomery Rebecca A.
- Monty Arnaud
- Moravcová Lenka
- Moreno‐Martínez Alvaro
- Moretti Marco
- Mori Akira S.
- Mori Shigeta
- Morris Dave
- Morrison Jane
- Mucina Ladislav
- Mueller Sandra
- Muir Christopher D.
- Munoz François
- Myers‐Smith Isla H.
- Myster Randall W.
- Mäkelä Annikki
- Mäkinen Harri
- Mészáros Ilona
- Müller Sandra Cristina
- Nagano Masahiro
- Naidu Shawna
- Narayanan Ayyappan
- Natesan Balachandran
- Negoita Luka
- Nelson Andrew S.
- Neuschulz Eike Lena
- Ni Jian
- Niedrist Georg
- Nieto Jhon
- Niinemets Ülo
- Nolan Rachael
- Nottebrock Henning
- Nouvellon Yann
- Novakovskiy Alexander
- Nystuen Kristin Odden
- O\u27Grady Anthony
- O\u27Hara Kevin
- O\u27Reilly‐Nugent Andrew
- Oakley Simon
- Oberhuber Walter
- Ohtsuka Toshiyuki
- Oliveira Ricardo
- Olson Mark E.
- Onipchenko Vladimir
- Onoda Yusuke
- Onstein Renske E.
- Ordonez Jenny C.
- Osada Noriyuki
- Ostonen Ivika
- Ottaviani Gianluigi
- Otto Sarah
- Overbeck Gerhard E.
- Ozinga Wim A.
- Pahl Anna T.
- Paine C. E. Timothy
- Pakeman Robin J.
- Papageorgiou Aristotelis C.
- Parfionova Evgeniya
- Patacca Marco
- Paula Susana
- Paule Juraj
- Pauli Harald
- Pausas Juli G.
- Peco Begoña
- Penuelas Josep
- Perea Antonio
- Peri Pablo Luis
- Petisco‐Souza Ana Carolina
- Petraglia Alessandro
- Petritan Any Mary
- Phillips Oliver L.
- Pierce Simon
- Pillar Valério D.
- Pinho Bruno X.
- Pisek Jan
- Plas Fons
- Pomogaybin Alexandr
- Poorter Hendrik
- Portsmuth Angelika
- Poschlod Peter
- Potvin Catherine
- Pounds Devon
- Powell A. Shafer
- Power Sally A.
- Prentice Iain Colin
- Prinzing Andreas
- Puglielli Giacomo
- Pyšek Petr
- Pärtel Meelis
- Raevel Valerie
- Rammig Anja
- Ransijn Johannes
- Ray Courtenay A.
- Reich Peter B.
- Reichstein Markus
- Reid Douglas E. B.
- Ribeiro Sabina
- Richardson Sarah
- Riibak Kersti
- Rillig Matthias C.
- Riviera Fiamma
- Robert Elisabeth M. R.
- Roberts Scott
- Robroek Bjorn
- Roddy Adam
- Rodrigues Arthur Vinicius
- Rogers Alistair
- Rollinson Emily
- Rolo Victor
- Ronzhina Dina
- Roscher Christiane
- Rosell Julieta A.
- Rosenfield Milena Fermina
- Rossi Christian
- Roux Elizabeth
- Roux Peter C.
- Roy David B.
- Royer‐Tardif Samuel
- Ruiz‐Peinado Ricardo
- Rumpf Sabine B.
- Rusch Graciela M.
- Ryo Masahiro
- Réjou‐Méchain Maxime
- Römermann Christine
- Rüger Nadja
- Sack Lawren
- Saldaña Angela
- Salgado‐Negret Beatriz
- Salguero‐Gomez Roberto
- Sande Masha T.
- Santacruz‐García Ana Carolina
- Santa‐Regina Ignacio
- Santos Joaquim
- Sardans Jordi
- Scalon Marina C.
- Schamp Brandon
- Scherer‐Lorenzen Michael
- Schleuning Matthias
- Schmid Bernhard
- Schmidt Marco
- Schmitt Sylvain
- Schneider Julio V.
- Schowanek Simon D.
- Schrader Julian
- Schrodt Franziska
- Schuldt Bernhard
- Schurr Frank
- Selaya Garvizu Galia
- Semchenko Marina
- Seymour Colleen
- Sfair Julia C.
- Sharpe Joanne M.
- Sheppard Christine S.
- Sheremetiev Serge
- Shiodera Satomi
- Shipley Bill
- Shovon Tanvir Ahmed
- Siebenkäs Alrun
- Sierra Carlos
- Silva Ana Carolina
- Silva Mateus
- Silva Vasco
- Sitzia Tommaso
- Sjöman Henrik
- Slot Martijn
- Smith Nicholas G.
- Sodhi Darwin
- Soltis Douglas
- Soltis Pamela
- Somers Ben
- Sonnier Grégory
- Sosinski Enio Egon, Jr
- Soudzilovskaia Nadejda A.
- Souza Alexandre F.
- Spasojevic Marko
- Sperandii Marta Gaia
- Stan Amanda B.
- Stegen James
- Steinbauer Klaus
- Stephan Jörg G.
- Sterck Frank
- Stojanovic Dejan B.
- Strydom Tanya
- Suarez Maria Laura
- Svenning Jens‐Christian
- Svitková Ivana
- Svitok Marek
- Svoboda Miroslav
- Swaine Emily
- Swenson Nathan
- Sørensen Mia Vedel
- Tabarelli Marcelo
- Takagi Kentaro
- Tappeiner Ulrike
- Tarifa Rubén
- Tarin Tonantzin
- Tautenhahn Susanne
- Tauugourdeau Simon
- Tavsanoglu Cagatay
- Tedersoo Leho
- Thiffault Nelson
- Thom Dominik
- Thomas Evert
- Thompson Ken
- Thornton Peter E.
- Thuiller Wilfried
- Tichý Lubomír
- Tissue David
- Tjoelker Mark G.
- Tng David Yue Phin
- Tobias Joseph
- Torres‐Ruiz José M.
- Treurnicht Martina
- Trivellone Valeria
- Trolliet Franck
- Trotsiuk Volodymyr
- Tsakalos James L.
- Tsiripidis Ioannis
- Tysklind Niklas
- Tóthmérész Béla
- Török Péter
- Umehara Toru
- Usoltsev Vladimir
- Vadeboncoeur Matthew
- Vaezi Jamil
- Valladares Fernando
- Vamosi Jana
- Van Cleemput Elisa
- Van Meerbeek Koenraad
- Vanderwel Mark
- Vanselow Kim André
- Varone Laura
- Vasquez Valderrama Maribel Yesenia
- Vassilev Kiril
- Vellend Mark
- Veneklaas Erik J.
- Verbeeck Hans
- Verheyen Kris
- Vibrans Alexander
- Vieira Ima
- Villacís Jaime
- Violle Cyrille
- Vivek Pandi
- Vårhammar Angelica
- Wagner Katrin
- Waldram Matthew
- Waldron Anthony
- Walker Anthony P.
- Waller Martyn
- Walther Gabriel
- Wang Feng
- Wang Han
- Wang Weiqi
- Watkins Harry
- Watkins James
- Weber Ulrich
- Weedon James T.
- Weg Martine
- Wei Liping
- Weigelt Patrick
- Weiher Evan
- Wells Aidan W.
- Wellstein Camilla
- Wenk Elizabeth
- Werner Gijsbert D. A.
- Westoby Mark
- Westwood Alana
- White Philip John
- Whitten Mark
- Williams Mathew
- Winkler Daniel E.
- Winter Klaus
- Wirth Christian
- Womack Chevonne
- Wright Ian J.
- Wright Justin
- Wright S. Joseph
- Ximenes Fabiano
- Yamada Toshihiro
- Yamaji Keiko
- Yanai Ruth
- Yankov Nikolay
- Yguel Benjamin
- Zanini Kátia Janaina
- Zanne Amy E.
- Zelený David
- Zhao Yun‐Peng
- Zheng Ji
- Zheng Jingming
- Ziemińska Kasia
- Zirbel Chad R.
- Zizka Georg
- Zotz Gerhard
- Zo‐Bi Irié Casimir
- Öllerer Kinga
- Publication venue
- John Wiley and Sons
- Publication date
- 10/01/2020
- Field of study
Plant traits - the morphological, anatomical, physiological, biochemical and phenological characteristics of plants - determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait‐based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits - almost complete coverage for ‘plant growth form’. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait–environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives
Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study
- Author
- A Chiolero
- A Sobczyk-Kopciol
- BJ Nicklas
- Brian E Henderson
- Ching-Ping Hong
- Christopher A Haiman
- Christopher S Carlson
- D Kleinbaum
- Dana C Crawford
- DE Levy
- James Pankow
- Jay H Fowke
- Jeffrey Haessler
- JoAnn E Manson
- JP Higgins
- JR Pauly
- KA Fawcett
- Kari E North
- Kristine R Monroe
- Lawrence N Kolonel
- Lewis H Kuller
- Loic Le Marchand
- Lucia A Hindorff
- Lynne R Wilkens
- M Bes-Rastrollo
- Marylyn D Ritchie
- MD Fesinmeyer
- Megan D Fesinmeyer
- Melissa Allen
- Misa Graff
- MS Almén
- MT Hassanein
- Myron D Gross
- Nathalie Schnetz-Boutaud
- Nora Franceschini
- Petra Bůžková
- Ping Mayo
- R Development Core Team
- Rebecca R Rohde
- RF Gillum
- RJ Loos
- Robert Goodloe
- Ross L Prentice
- SC Gorber
- SF Grant
- Shelley-Ann Love
- Tara C Matise
- TC Matise
- Ulrike Peters
- Unhee Lim
- YS Mineur
- Publication venue
- BMC
- Publication date
- 01/01/2013
- Field of study
<p>Abstract</p> <p>Background</p> <p>Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored.</p> <p>Methods</p> <p>As part of the ‘Population Architecture using Genomics and Epidemiology (PAGE)’ Consortium, we investigated interaction between genetic risk factors associated with BMI and smoking for 10 single nucleotide polymorphisms (SNPs) previously identified in genome-wide association studies. We included 6 studies with a total of 56,466 subjects (16,750 African Americans (AA) and 39,716 European Americans (EA)). We assessed effect modification by testing an interaction term for each SNP and smoking (current vs. former/never) in the linear regression and by stratified analyses.</p> <p>Results</p> <p>We did not observe strong evidence for interactions and only observed two interactions with p-values <0.1: for rs6548238/<it>TMEM18</it>, the risk allele (C) was associated with BMI only among AA females who were former/never smokers (β = 0.018, p = 0.002), vs. current smokers (β = 0.001, p = 0.95, p<sub>interaction</sub> = 0.10). For rs9939609/<it>FTO</it>, the A allele was more strongly associated with BMI among current smoker EA females (β = 0.017, p = 3.5x10<sup>-5</sup>), vs. former/never smokers (β = 0.006, p = 0.05, p<sub>interaction</sub> = 0.08).</p> <p>Conclusions</p> <p>These analyses provide limited evidence that smoking status may modify genetic effects of previously identified genetic risk factors for BMI. Larger studies are needed to follow up our results.</p> <p>Clinical Trial Registration</p> <p>NCT00000611</p
Putting Britain on the Roe Map: The Emergence of the Berle-Means Corporation in the United Kingdom
- Author
- A T K Grant
- A W Welford
- Adolf Berle
- Alfred D Chandler
- Alfred D Chandler
- Alfred D Chandler
- Alfred D Chandler
- Allan Flanders
- Andrei Shleifer
- Andrew Cox
- Andrew Cox
- Arthur Francis
- Barry Supple
- Barry Supple
- Bernard Elbaum
- Bernard S Black
- Brian R Cheffins
- Brian R Cheffins
- Brian R Cheffins
- Brian R. Cheffins
- Colin Mayer
- D Smith
- D Smith
- David Kynaston
- David S Ruder
- Donald H Chew
- Eddy Wymeersch
- Erik Bergl�f
- Erik Bergl�f
- Forrest Capie
- Frank H Easterbrook
- Frank H Easterbrook
- Frits Bolkestein
- G P Stapledon
- George C Lodge
- Gregory A Mark
- Harold Perkin
- Henry N Butler
- Herbert Jacobs
- Ian M Ramsay
- Jean-Jacques Van Helten
- Joe Sanderson
- Joel Krieger
- John Armstrong
- John C Coffee
- John C Coffee
- John E Parkinson
- John Scott
- John Scott
- John Scott
- John Scott
- Jonathan Charkham
- Jonathan R Macey
- Joseph A Grundfest
- Julian Franks
- Klaus J Hopt
- Klaus J Hopt
- Klaus J Hopt
- Kristine Bruland
- Kristine Bruland
- La Porta
- La Porta
- La Porta
- Lawrence A Cunningham
- Le D�fi Am�rican
- Leonard S Sealy
- Leslie Hannah
- Leslie Hannah
- Leslie Hannah
- Leslie Hannah
- Leslie Hannah
- Leslie Hannah
- Lewis D Gilbert
- Louis Lowenstein
- Marc Goergen
- Mark A Fox
- Mark J Roe
- Mark J Roe
- Mark J Roe
- Mark J Roe
- Mark J Roe
- Merton H Miller
- Michael Adams
- Michael Collins
- Michael H Best
- Mindset
- O Kahn-Freund
- P Florence
- P Florence
- P Rao
- Paul L Davies
- Paul L Davies
- Paul L Davies
- Peter A Hall
- Pieter W Moerland
- Ranald C Michie
- Ranald C Michie
- Randall K Morck
- Richard Waters
- Robert A Bateman
- Robert A G Monks
- Robert Fitzgerald
- Roderick Floud
- Ronald J Daniels
- Ronald J Daniels
- Ronald J Gilson
- Ross Grantham
- Ross Mckibbin
- S J Prais
- Shareholders
- Steen Thomsen
- Stefan Prigge
- Stephen Prowse
- Steve Nyman
- Steven N Kaplan
- Steven N Kaplan
- Takeo Hoshi
- W A Thomas
- Will Hutton
- William L Cary
- William P Kennedy
- Youssef Cassis
- Youssef Cassis
- Youssef Cassis
- Youssef Cassis
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2000
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
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- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha Afshar Etemadi
- Alexander Peter.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali Altaf
- Ali I.A.M.
- Ali Syamlan
- Aliannejad Rasoul
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Zoe
- Allen L.
- Allen Meryem
- Allen Schvearn
- Allibone S.
- Allison K.S.
- Allos R.
- Ally S.M.
- AlMalik A.
- Almalki F.
- Almohammed I.
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- Alvaro A.
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- Amin V.
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- Andolfo I.
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- Andreucci E.
- Andrew Angela
- Andrew B.
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- Zongo Olivier
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- Zyndorf Marissa
- Zöllner S.
- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Price-Fixing Overcharges: Legal and Economic Evidence
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- A Cawson
- A Sheer
- Adair B Morse
- Adelaide Walters
- Akira Kudo
- Albert F Calvert
- Alec Burnside
- Alexander Schaub
- Alexis Jacquemin
- Alexis Jacquemin
- Alfred A Parker
- Allen T Demaree
- Almarin Phillips
- Ananth N Madhavan
- Andre E Sayous
- Andrew Gavin
- Andrew Henley
- Andrew R Dick
- Archibald H Stockder
- Arnold H Lozowick
- Arthur G Fraas
- B B Wallace
- B C French
- Barbara Alexander
- Barbara Epstein
- Barbara Epstein
- Bjarke Fog
- Bolotova
- Brian Woodall
- Bruce H Kobayashi
- Carmen
- Caroline M Hoxby
- Catherine J Market Morrison
- Charles A Bane
- Charles E Edgerton
- Charles J Bullock
- Christer Fallenius
- Christopher Harding
- Cindy R Alexander
- Clemens A Wurm
- Corwin Edwards
- Craig A Gallet
- Craig M Newmark
- D C Coleman
- D E Buschena
- D F Leach
- D Filson
- D G Goyder
- D J Lecraw
- D Johnsen
- D Low
- Dale R Funderburk
- Daniel Barbezat
- Daniel L Rubinfeld
- Darren Bush
- David Besanko
- David Boies
- David C Smith
- David F Lean
- David Genesove
- David Genesove
- David Gerber
- David H Macgregor
- David J Teece
- David R Kamerschen
- De Rousiers
- Deborah Spar
- Dennis Swann
- Dennis W Carlton
- Dennis W Carlton
- Dermot Gately
- Donald L Alexander
- Douglas F Greer
- Douglas H Ginsberg
- Durand E Dana
- E Andrews
- E B Whitney
- E O Merchant
- E Timberlake
- Earle Gray
- Ec
- Edmund Newell
- Elie Appelbaum
- Elizabeth Granitz
- Elliot Jones
- Ervin Hexner
- Eugene Staley
- F C Fourie
- F M Scherer
- F M Scherer
- Fiona Wood
- Francis W Hirst
- Francis Walker
- Frank A Fetter
- Frank A Scott
- Franklin Fisher
- Franklin M Fisher
- Frederic Jenny
- Fritz Kleinw�chter
- Frode Steen
- Ftc
- G B Richardson
- G C Allen
- G D Thompson
- G K Sarkar
- Gary Becker
- Gary R Spratling
- George A Hay
- George J Mailmath
- George J Stigler
- George Symeonidis
- George W Stocking
- Glenn Ellison
- Grant Fleming
- Gregory J Werden
- Gregory J Werden
- Greta Devos
- H R Tosdal
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- Harold C Passer
- Harry Maurer
- Heinrich Kronstein
- Henrik Gommesen
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- Henry R Seager
- Herbert Beckerath
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- Hermann Levy
- Hideaki Miyajima
- Howard Adler
- Hugh Grant
- In Lee
- In Lee
- J Bosch
- J Leitzinger
- J Mcclave
- J W F Rowe
- James B Lieber
- James B Stewart
- James E Duggan
- James M Clabault
- James M Griffin
- James M Griffin
- Janice Kinghorn
- Jeffery H Howard
- Jeffrey E Zimmerman
- Jeffrey K Mackie-Mason
- Jeffrey M Marvel
- Jens Fej�
- Jeremiah W Jenks
- Jeremiah W Jenks
- Jesse W Markham
- Joel Davidow
- John C Beyer
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- John D Guilfoil
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- John Heath
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- John M. Connor
- John S Mcgee
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- Jon P Nelson
- Jonathan B Baker
- Jonathan B Baker
- Jonathan Groner
- Jonathan S Feinstein
- Joseph E Harrington
- Joseph Stiglitz
- Julian L Clarke
- June H Taylor
- Karen Clay
- Karen Donovan
- Karl Aiginger
- Karl Aiginger
- Karl Pribram
- Kenneth G Elzinga
- Kenneth G Elzinga
- Kenneth Hendricks
- Kftc
- Kishi
- Kosmas Tsokhas
- Kristine Bruland
- Kurt Eichenwald
- Kurt Wiedenfeld
- Kwangshik Shin
- L A Fisher
- L F Haber
- Lars-Hendrik R�ller
- Laura H Baldwin
- Lawrence J White
- Lawrence Shepard
- Lewis H Haney
- Louis Domeratzky
- Louis Lister
- Louis Marlio
- Luke M Froeb
- M C L Benni
- M Finkelstein
- M J Peck
- M Rieber
- Margaret C Levenstein
- Margaret C Levenstein
- Margaret Levenstein
- Margaret Levenstein
- Mark A Cohen
- Mark A Cohen
- Mark A Cohen
- Mark Tilton
- Martin Pesendorfer
- Matthew Josephson
- Mcmillan John
- Merih Uctum
- Michael Beckmann
- Michael Block
- Michael D Hausfeld
- Michael F Sproul
- Michael L Denger
- Milton Friedman
- Morris A Adelman
- Mukesh Eswaran
- Nancy S Borgeson
- Nicholas J Powers
- Nicolas De Roos
- Nicolas Schmitt
- Oecd
- Oris C Herfindahl
- Orley C Ashenfelter
- Patrick Bajari
- Paul A Grout
- Paul G Barnett
- Paul Joskow
- Paul L Eckbo
- Paul M Sweezy
- Paul W Macavoy
- Peter Asch
- Peter Crampton
- Peter Reuter
- Peter Z Grossman
- Philip C Newman
- R A Ippolito
- R Prain
- R S Daggett
- Ralph G M Sultan
- Ray Rees
- Richard A Lord
- Richard A Posner
- Richard E Just
- Richard F Adams
- Richard J Pierce
- Richard S Newfarmer
- Richard Smith
- Robert F Lanzillotti
- Robert G Hansen
- Robert H Lande
- Robert H Porter
- Robert H Porter
- Robert Liefmann
- Robert M Price
- Robert Read
- Robert S Pyndyck
- Robert W Crandall
- Rolf Weder
- Roman Piotrowski
- Roy Curtis
- Rudolf K Michels
- Runar Br�nnlund
- Salil K Mehra
- Samuel M Loescher
- Sanjib Bhuhan
- Schr�ter
- Scott Morton
- Seonghoon Jeon
- Shin Hasagawa
- Sigmund J Prais
- Simon J Evenett
- Srabana Gupta
- Stat-Usa
- Stephen C Pirrong
- Steven A Morrison
- Steven B Webb
- Steven Berry
- Steven C Salop
- Steven K Holloway
- Steven Martin
- Steven N Wiggins
- Svend Albaek
- Takkeo Kikkawa
- Tay-Cheng Ma
- Taylor C Robert
- Tftc
- Tftc-Oecd
- Thurman W Arnold
- U S Congress
- Ukcc
- Ussg Advisory Group
- Valerie Y Suslow
- Van Eden
- Vernon Mund
- Victor P Goldberg
- Von Beckerath
- Von Hirsch
- W C Labys
- W Erickson
- W G Taylor
- W J Reader
- W Oualid
- W S Comanor
- Wayne E Baker
- Wendell Berge
- Wilbur L Fugate
- Willard F Mueller
- William E Kovacic
- William Elliott
- William F Notz
- William G Christie
- William G Shepard
- William Graebner
- William H Landes
- William J Hausman
- William Page
- William S Stevens
- William Sjostrom
- Wils
- Wyatt Wells
- Xuezheng Wang
- Yinne Yu
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2005
- Field of study
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
- Author
- A N'Diaye
- A Scherag
- A Scuteri
- Abdullah Kutlar
- Adam B Murphy
- Adebowale A Adeyemo
- Adesola Ogunniyi
- Adeyinka Ademola
- AJ Myers
- AL Price
- Alan B Zonderman
- Albert M Levin
- Alex P Reiner
- Amidou N'Diaye
- Andrew B Singleton
- Angela Britton
- Ann G Schwartz
- Ann Hsing
- Anselm J M Hennis
- Babatunde Salako
- Badri Padhukasahasram
- Bamidele O Tayo
- Barbara McKnight
- Barbara Nemesure
- Barbara V Howard
- Barry I Freedman
- BE Bernstein
- Benjamin A Rybicki
- BF Voight
- BF Voight
- BN Howie
- Brendan J Keating
- Brian E Henderson
- Bruce M Psaty
- Cameron Palmer
- Carl D Langefeld
- Caroline Fox
- Cathryn H Bock
- Charles Kooperberg
- Charles N Rotimi
- Charleston W K Chiang
- Chris S Carlson
- Christine B Ambrosone
- Christine Neslund-Dudas
- Christopher A Haiman
- Christopher I Amos
- CJ Willer
- CJ Willer
- Curtis A Pettaway
- Curtis C Harris
- D Falush
- D Meyre
- Daniel A Shriner
- David Duggan
- David J Van Den Berg
- David Siscovick
- Dena G Hernandez
- Dezheng Huo
- DG Hernandez
- Diane L Kamen
- Diane M Becker
- Digna R Velez Edwards
- Donald W Bowden
- Donna K Arnett
- Edmond K Kabagambe
- Edward A Ruiz-Narvaez
- EK Speliotes
- Elisa V Bandera
- Elizabeth K Speliotes
- Elizabeth M Gillanders
- Ellen Demerath
- Eric A Klein
- Eric E Schadt
- Erwin P Bottinger
- Esther M John
- Evandine Rampersaud
- Fang Chen
- FJ Ortega
- G Bhatia
- G Chevillard
- G Thorleifsson
- Gary K Chen
- Gary S Gilkeson
- GB Ehret
- George J Papanicolaou
- Gerhard A Coetzee
- Graham Casey
- Gregory Burke
- Guanjie Chen
- Guillaume Lettre
- Guo Li
- H Xie
- H Zhong
- Hakon Hakonarson
- Heather Ochs-Balcom
- Helen Lyon
- Herman Taylor
- Ida J Spruill
- IM Heid
- Imran Morhason-Bello
- Ingrid B Borecki
- J Dupuis
- J Ernst
- James J Yang
- Janet L Stanford
- Jason H Moore
- JC Chambers
- Jennifer J Hu
- Jie Zhou
- Jing Hua Zhao
- Jingzhong Ding
- JK Pickrell
- JK Pritchard
- JoAnn E Manson
- Joanne M Jordan
- Joel N Hirschhorn
- John Carpten
- John K Wiencke
- John S Witte
- Jonathan P Bradfield
- Jorge L Rodriguez-Gil
- Joseph M Zmuda
- Josyf C Mychaleckyj
- JP Bradfield
- Julie R Palmer
- Jyotika K Fernandes
- Karen C Johnson
- Kari E North
- Katherine L Nathanson
- Kelly J Hunt
- Keri L Monda
- Kira C Taylor
- KM Flegal
- Krista A Zanetti
- Kristine R Monroe
- Kurt Lohman
- L Cheng
- L Keoki Williams
- Lara Sucheston
- Larry Atwood
- Laura J Rasmussen-Torvik
- Laurence N Kolonel
- Lawrence F Bielak
- Leslie A Lange
- Leslie Bernstein
- Lewis H Kuller
- Lisa B Signorello
- Lisa Chu
- Lisa R Yanek
- Loic Le Marchand
- Lorna H McNeill
- M Cristina Leske
- MA Nalls
- Maggie C Y Ng
- Mara Vitolins
- Margaret A Tucker
- Margaret R Spitz
- Margaret Wrensch
- Marguerite R Irvin
- Mariaelisa Graff
- Marian Neuhouser
- Mary Cushman
- Mary F Feitosa
- Mary K Wojczynski
- Matthew A Allison
- MC Campbell
- MC Ng
- Melinda C Aldrich
- Michael A Nalls
- Michael F Press
- Michael J Thun
- Michele K Evans
- Michèle M Sale
- Neil A Zakai
- Neil E Caporaso
- Nicholette D Palmer
- Oladosu Ojengbede
- Olufunmilayo I Olopade
- Omri Gottesman
- P Clerc
- Pamela J Schreiner
- Patricia A Peyser
- Patricia Dubbert
- PC Sabeti
- Phyllis J Goodman
- Quiyin Cai
- R Saxena
- Rajiv Nadukuru
- Regina G Ziegler
- Richard S Cooper
- Rick A Kittles
- RJF Loos
- Robert C Millikan
- Ruth J F Loos
- Ryan W Driver
- S Shifman
- Sandra L Deming-Halverson
- Sanjay R Patel
- Sara S Strom
- Sarah Nyante
- Scott M Williams
- SG Coetzee
- Shad B Smith
- Shamika Ketkar
- Sharon L R Kardia
- Simin Liu
- SJ Kang
- Sonja I Berndt
- SR Browning
- Stefan Ambs
- Stephen J Chanock
- Struan F A Grant
- Sue A Ingles
- Suh-Yuh Wu
- Suhn K Rhie
- Sun J Kang
- Susan Redline
- Suzanne Kolb
- Sylvia Wassertheil-Smoller
- T Murray
- Talin Haritunians
- Tamara Harris
- Taylor R Young
- Temidayo O Ogundiran
- Thomas H Mosley
- Thomas W Winkler
- Timothy D Howard
- TM Frayling
- TM Teslovich
- Todd L Edwards
- Ulrich Broeckel
- Ulrike Peters
- Uma Nayak
- Vaneet Lotay
- Virginia J Howard
- W Timothy Garvey
- W Wen
- Wei Zhao
- Wei Zheng
- Wei-Min Chen
- William J Blot
- William Maixner
- Xiaofeng Zhu
- Xifeng Wu
- Xiuqing Guo
- Y Li
- Y Okada
- Yan A Meng
- Yan V Sun
- Ye Feng
- Yii-Der I Chen
- Yingchang Lu
- Yonglan Zheng
- Yongmei Liu
- Youfang Liu
- Zhaoming Wang
- Publication venue
- Publication date
- 01/06/2013
- Field of study
<p>Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 x 10(-11)) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 x 10(-10)). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 x 10(-8)). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 x 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.</p>
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Biallelic variants in ribonuclease inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute, necrotizing encephalopathy
- Author
- Acosta Maria T.
- Adam Margaret
- Adams David R.
- Alvarez Raquel L.
- Alvey Justin
- Amendola Laura
- Andrews Ashley
- Arbogast Thomas
- Ashley Euan A.
- Bacino Carlos A.
- Bademci Guney
- Balasubramanyam Ashok
- Baldridge Dustin
- Bale Jim
- Bamshad Michael
- Barbouth Deborah
- Bayrak-Toydemir Pinar
- Beck Anita
- Beggs Alan H.
- Behrens Edward
- Bejerano Gill
- Bellen Hugo J.
- Bennett Jimmy
- Benseler Susa M.
- Berg-Rood Beverly
- Bernier Francois P.
- Bernstein Jonathan A.
- Berry Gerard T.
- Bican Anna
- Bivona Stephanie
- Blue Elizabeth
- Bohnsack John
- Bonner Devon
- Botto Lorenzo
- Boyd Brenna
- Briere Lauren C.
- Brown Gabrielle
- Burke Elizabeth A.
- Burrage Lindsay C.
- Butte Manish J.
- Byers Peter
- Byrd William E.
- Carey John
- Carrasquillo Olveen
- Cassini Thomas
- Chanprasert Sirisak
- Chao Hsiao-Tuan
- Chinn Ivan
- Clark Gary D.
- Coakley Terra R.
- Cobban Laurel A.
- Cogan Joy D.
- Coggins Matthew
- Cole F. Sessions
- Colley Heather A.
- Cope Heidi
- Cope Heidi
- Corona Rosario
- Craigen William J.
- Crouse Andrew B.
- Cunningham Michael
- Dai Hongzheng
- Dasari Surendra
- Davis Erica E.
- Davis Joie
- Dayal Jyoti G.
- Dell'Angelica Esteban C.
- Dickson Patricia
- Dipple Katrina
- Doherty Daniel
- Dorrani Naghmeh
- Doss Argenia L.
- Douine Emilie D.
- D’Souza Precilla
- Earl Dawn
- Eckstein David J.
- El-Dairi Mays
- Emrick Lisa T.
- Eng Christine M.
- Esser Michael J.
- Falk Marni
- Fieg Elizabeth L.
- Fisher Paul G.
- Fogel Brent L.
- Forghani Irman
- Gahl William A.
- Ganetzky Rebecca
- Glass Ian
- Gochuico Bernadette
- Goddard Page C.
- Godfrey Rena A.
- Golden-Grant Katie
- Grajewski Alana
- Hadley Don
- Hahn Sihoun
- Halley Meghan C.
- Hamid Rizwan
- Hassey Kelly
- Hayes Nichole
- High Frances
- Hing Anne
- Hisama Fuki M.
- Holm Ingrid A.
- Hom Jason
- Horike-Pyne Martha
- Huang Alden
- Hubshman Monika Weisz
- Hutchison Sarah
- Innes A. Micheil
- Introne Wendy
- Isasi Rosario
- Izumi Kosuke
- Jamal Fariha
- Jarvik Gail P.
- Jarvik Jeffrey
- Jayadev Suman
- Jean-Marie Orpa
- Jobanputra Vaidehi
- Karaviti Lefkothea
- Ketkar Shamika
- Kiley Dana
- Kilich Gonench
- Kobren Shilpa N.
- Kohane Isaac S.
- Kohler Jennefer N.
- Korrick Susan
- Kozuira Mary
- Krakow Deborah
- Kranz Peter G.
- Krasnewich Donna M.
- Kravets Elijah
- Lalani Seema R.
- Lam Byron
- Lam Christina
- Lamont Ryan E.
- Lanpher Brendan C.
- Lanza Ian R.
- LeBlanc Kimberly
- Lee Brendan H.
- Levitt Roy
- Lewis Richard A.
- Liu Pengfei
- Liu Xue Zhong
- Longo Nicola
- Loo Sandra K.
- Loscalzo Joseph
- Maas Richard L.
- Macnamara Ellen F.
- MacRae Calum A.
- Maduro Valerie V.
- Maghiro Audrey Stephannie
- Mahoney Rachel
- Malicdan May Christine V.
- Mamounas Laura A.
- Manolio Teri A.
- Mao Rong
- Maravilla Kenneth
- Markert M. Louise
- Marom Ronit
- Marth Gabor
- Martin Beth A.
- Martin Martin G.
- Martínez-Agosto Julian A.
- Marwaha Shruti
- McCauley Jacob
- McConkie-Rosell Allyn
- McCray Alexa T.
- McGee Elisabeth
- Mefford Heather
- Merritt J. Lawrence
- Might Matthew
- Mirzaa Ghayda
- Morava Eva
- Moretti Paolo
- Mulvihill John
- Muraresku Colleen
- Nakano-Okuno Mariko
- Nelson Stanley F.
- Newman John H.
- Nicholas Sarah K.
- Nickerson Deborah
- Nieves-Rodriguez Shirley
- Novacic Donna
- Oglesbee Devin
- Orengo James P.
- Pace Laura
- Pak Stephen
- Pallais J. Carl
- Palmer Christina G.S.
- Papp Jeanette C.
- Parboosingh Jillian S.
- Parker Neil H.
- Parsons Simon J.
- Peter Chang Ta Chen
- Phillips John A.
- Ping-Yee Au Billie
- Posey Jennifer E.
- Potocki Lorraine
- Pusey Swerdzewski Barbara N.
- Quinlan Aaron
- Rao Deepak A.
- Raper Anna
- Raskind Wendy
- Renteria Genecee
- Reuter Chloe M.
- Rives Lynette
- Robertson Amy K.
- Rodan Lance H.
- Roehrs Philip
- Rosenfeld Jill A.
- Rosenwasser Natalie
- Rossignol Francis
- Ruzhnikov Maura
- Sacco Ralph
- Sadeghpour Azeda
- Sampson Jacinda B.
- Saporta Mario
- Schaechter Judy
- Schedl Timothy
- Schoch Kelly
- Schoch Kelly
- Scott C. Ron
- Scott Daryl A.
- Seto Elaine
- Shashi Vandana
- Shashi Vandana
- Shin Jimann
- Silverman Edwin K.
- Sinsheimer Janet S.
- Sisco Kathy
- Smith Edward C.
- Smith Edward C.
- Smith Kevin S.
- Solnica-Krezel Lilianna
- Solomon Ben
- Sondheimer Neal
- Spillmann Rebecca C.
- Stoler Joan M.
- Sullivan Jennifer A.
- Sullivan Kathleen
- Sun Angela
- Sutton Shirley
- Sweetser David A.
- Sybert Virginia
- Tabor Holly K.
- Tan Amelia L.M.
- Tan Queenie K.-G.
- Tarakad Arjun
- Tekin Mustafa
- Telischi Fred
- Tennison Michael
- Thorson Willa
- Tifft Cynthia J.
- Toro Camilo
- Tran Alyssa A.
- Tyndall Amanda V.
- Undiagnosed Diseases Network
- Ungar Rachel A.
- Urv Tiina K.
- Valdez Purnima
- Vanderver Adeline
- Velinder Matt
- Viskochil Dave
- Vogel Tiphanie P.
- Wahl Colleen E.
- Walker Melissa
- Wallace Stephanie
- Walley Nicole M.
- Wambach Jennifer
- Wan Jijun
- Wang Lee-kai
- Wangler Michael F.
- Ward Patricia A.
- Wegner Daniel
- Wener Mark
- Wenger Tara
- Westerfield Monte
- Wheeler Matthew T.
- Whitlock Jordan
- Wolfe Lynne A.
- Woodward Kristine E.
- Worley Kim
- Wright Nicola A.M.
- Xiao Changrui
- Yamamoto Shinya
- Yang John
- Zhang Zhe
- Zuchner Stephan
- Publication venue
- Elsevier Inc
- Publication date
- 13/05/2023
- Field of study
Mendelian etiologies for acute encephalopathies in previously healthy children are poorly understood, with the exception of RAN binding protein 2 (RANBP2)–associated acute necrotizing encephalopathy subtype 1 (ANE1). We provide clinical, genetic, and neuroradiological evidence that biallelic variants in ribonuclease inhibitor (RNH1) confer susceptibility to a distinctive ANE subtype.
This study aimed to evaluate clinical data, neuroradiological studies, genomic sequencing, and protein immunoblotting results in 8 children from 4 families who experienced acute febrile encephalopathy.
All 8 healthy children became acutely encephalopathic during a viral/febrile illness and received a variety of immune modulation treatments. Long-term outcomes varied from death to severe neurologic deficits to normal outcomes. The neuroradiological findings overlapped with ANE but had distinguishing features. All affected children had biallelic predicted damaging variants in RNH1: a subset that was studied had undetectable RNH1 protein. Incomplete penetrance of the RNH1 variants was evident in 1 family.
Biallelic variants in RNH1 confer susceptibility to a subtype of ANE (ANE2) in previously healthy children. Intensive immunological treatments may alter outcomes. Genomic sequencing in children with unexplained acute febrile encephalopathy can detect underlying genetic etiologies, such as RNH1, and improve outcomes in the probands and at-risk siblings
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Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- Abad Vanessa
- Abate Getahun
- Abbas Anum
- Ackerman Jamie
- Ackerman Ronald
- Ackermann Jeremy
- Adams Atoya
- Adams Mark S.
- Adams Michael R.
- Adelglass Jeffrey
- Afework Sarah
- Ahmad Nina
- Akamine Christine
- Ake Julie A.
- Al-Ibrahim Mohamed S.
- Albert Gary
- Alcaide Maria L.
- Alderson Nathan
- Aleman Lily
- Alemán José O.
- Allaw Mohammed
- Alva E. Javier Pretell
- Alvarado Hilario
- Amador Carmen
- Andersen James
- Anderson Corey G.
- Anderson Evan J.
- Anderson Victoria R.
- Andes David R.
- Andrasik Michele P.
- Andree Stephanie
- Andrews Jeb
- Andriesen Jessica G.
- Andriulis Victoria
- Ansel Jessica L.
- Anthony Codi M.
- Antwi Mohammed
- Arduino Roberto C.
- Aristy Florida
- Arnold Valerie K.
- Arrazcaeta Alicia
- Atmar Robert L.
- Avworo Ayoade
- Bacher Christina
- Baden Lindsey R.
- Badillo Diana
- Bainbridge Emma
- Baka Michele
- Baker Sherrie
- Balani Bindu
- Ball Brandy
- Bances Karla Beatriz Tafur
- Baron Mira
- Barranco-Santana Elizabeth
- Bartilucci Darlene
- Bashour Jennifer
- Batteiger Teresa A.
- Baudelaire Clarisse
- Bazan Jose A.
- Becerra Maria G.
- Becker Teresa
- Beckmann David
- Bedimo Roger J.
- Belhorn Linda R.
- Benavides Alfredo Gilberto Guerreros
- Beninati Genevieve
- Benitez Jorge A.
- Bennett Annette R.
- Bennett Elizabeth
- Beresnev Tatiana
- Berman Megan
- Bermudez Maria I.
- Bernard Marcia
- Bernstein David I.
- Berry Andrea
- Berry Jennifer
- Berthaud Vladimir
- Bialobok Kristin
- Billings Joanne L.
- Bittner Zachary
- Blevins Jeanne
- Blumenthal Jill
- Boas Rebecca
- Bocchini Joseph
- Bold Tyler D.
- Bondell Alison
- Bondy Paul
- Borger Judith
- Borgetti Scott
- Boscia Joseph
- Boswell Dean M.
- Bourgeois Tana
- Bowers Maggie
- Bradley Paul S.
- Brady Judith
- Brakema Riemke
- Bran Andres
- Branche Angela R.
- Brandenburg Boerries
- Brandon Donald M.
- Bravo Eric
- Briskin Toby
- Broder Gail
- Brosz Adam B.
- Browder David
- Browder Lesley
- Brown Cynthia
- Brown Jeremy
- Brownlee Robert
- Bruce Elizabeth
- Bueno Cynthia
- Bullock Delia
- Bunce Catherine A.
- Burch Cortney
- Burgett Michelle L.
- Burgher Abram
- Butcher Michael B.
- Buynak Robert J.
- Bäcker Martín
- Cade LaShondra
- Calderon Rafael
- Calderone Richard
- Caldwell Amy
- Calinescu Cornell
- Call Robert S.
- Callis Jim
- Camacho-Gonzalez Andres
- Campbell Thomas B.
- Campbell Wesley
- Cancilla Michael
- Cannon Kevin D.
- Cantos Valeria D.
- Carmody Ellie
- Carpenter Christopher
- Carr Melissa
- Carrascal Monica B.
- Carsons Steven E.
- Carvajal Marianela
- Casey Denise
- Caso Jorge
- Castellino Flora
- Castellon Marvin
- Castro Mario
- Catan Hannah
- Cavert Winston
- Chacón Jorge A.
- Chadwick Mesha M.
- Chamberlain Amy
- Chan Austin
- Chang Jennifer
- Chebib Mouna G.
- Chen Corey M.
- Cheng Margaret
- Cho Iksung
- Choquette Karin
- Chouteau R. Michelle
- Chow Brian D.W.
- Choza Laura Julia Camacho
- Chrisley Lisa
- Christensen Shane G.
- Chu Hanh
- Chu Laurence
- Chughtai Waseem
- Chung Michael
- Ciambruschini Annie
- Cicogna Cristina
- Clarence B. Creech I I
- Clark Alexander
- Clark Jesse L.
- Claybrook Phillip
- Clement Andrea
- Clement Lauren
- Clemons Steve
- Cohen Lisa
- Cohen Stuart H.
- Coleman Jacob
- Colindres Roberto A. Viau
- Connor Joseph P.
- Conway James H.
- Cooksey Erin
- Coombs Robert W.
- Cooney Maureen
- Cooper Deanna
- Coplan Paul
- Corey Lawrence
- Cornelison Raymond
- Corral Barbara
- Coslet Jordan
- Coston Erin
- Cotugno Michael J.
- Cramer Paul
- Cromer Charnell
- Cross Marshall A.
- Cruz-Valdez Aurelio
- Curlin Marcel
- Curry LaKondria
- Custers Jerome
- Cutz Erika A.
- DallaPiazza Michelle
- Dandachi Dima
- Danford Elizabeth
- Dang Lyly
- Daniels Stephen
- Davis Joseph D.
- Davis Matthew G.
- Davis William B.
- Davis Yvonne
- Davit Rajesh K.
- de Groot Anne Marit
- De La Cruz Luis I.
- De La Matta Rodriguez Claudia
- De Proost Ian
- Dedon Christopher
- Dedon Jon F.
- Deese Teresa
- Degan Emily
- DeHaan Elliot
- del Rio Carlos
- Delgado Ernesto
- Delgado Michael
- Delgado Mike
- Dellaero David
- Denham Douglas S.
- Desai Chinar
- Desai Parul
- Desjardins Michael
- Deutsch Karen
- Dever Michael E.
- Devine Naomi
- Dickey Michelle
- Diemert David J.
- Dietz Craig
- Doblecki-Lewis Susanne
- Domínguez Sandra Janeth Ortega
- Dong Jennifer L.
- Dora Tambra
- Dorcely Brenda
- Doust Matthew W.
- Downing Frances
- Dube Michael P.
- Dubovsky Filip
- Ducheneaux Pete
- Duhart Aeiress
- Duke Elizabeth
- Dunbar Debora
- Dunbar Haoua
- Duncanson Daniel
- Dunkle Lisa M.
- Dunlevy Hillary
- Duran Adriana Sordo
- Dye Amy
- Dyer Carmel B.
- Dzigiel Sarah
- Díaz-Miralrio Secia
- Easley Mary
- Eaton Niles
- Ebuh Georgette
- Ebuh Valentine M.
- Eckert Lynn
- Eckhardt Benjamin
- Eder Frank S.
- Edupuganti Srilatha
- Edward M. Tavel Jr
- Edwards Leslie A.
- Eickhoff Mark
- El Sahly Hana M.
- Ellerbeck Edward
- Ellsworth Grant
- Elnagar Elwaleed
- Engler Victoria
- Enright Kendra
- Ensz David J.
- Eppenbach Sally
- Erickson Sandra
- Eron Joseph J.
- Escallon Sebastian Garcia
- Esinhart Tiffany
- Espinosa Claudia
- Essink Brandon J.
- Estrada Denisse Alejandra González
- Everette Elizabeth
- Ewers Evan C.
- Ewing Beverly
- Falk Amy
- Falsey Ann R.
- Fas Norberto
- Fay Michael
- Fearon Szheckera
- Feijoo Brittany
- Feldman Gregory J.
- Felsen Uriel R.
- Fentanes María José Reyes
- Fichtenbaum Carl
- Fiel Tom
- Fierro Carlos A.
- Finkelstein Kenneth
- Finley Jon
- Fiorillo Suzanne
- Fitz-Patrick David
- Florescu Diana F.
- Flume Patrick
- Fogarty Charles M.
- Foley Jennifer
- Follmann Dean
- Folmar Pink
- Folsom Lyndsea
- Fong Youyi
- Ford Stacy
- Forero Lina M.
- Forgosh Les B.
- Formentini Elizabeth
- Fouts Rhodna
- Fragoso Veronica G.
- Franco-Vitteri Doris
- Frank Ian
- Frederick Raiser III
- Freeman George H.
- Freese Lena R.
- Freudemann Karen
- Frey Sharon E.
- Fried David L.
- Friesen Luke
- Fry James
- Furey Dawn
- Galloway Christopher
- Galloway Sarah
- Galván Jorge F. Méndez
- Garcia Edgar
- Garcia Jenina
- Garcia-Fragoso Veronica
- García Iris
- Garvey Janet
- Gay Cynthia L.
- Gebhardt Bruce C.
- Geiger Grant
- Gelderblom Huub G.
- George H. Bauer Jr
- Geuss Georgettea
- Ghadishah Elham
- Gharib Elie
- Gharib Suzanne
- Gibson Richard L.
- Gilbert Peter B.
- Giorza Juan Luis Yrivarren
- Gipson Teletha
- Glenn Gregory M.
- Goecker Erin A.
- Goepfert Paul A.
- Goldenberg James N.
- Gomez Blanca
- Gonzales-Zamora Jose
- Gonzalez Celia
- Gonzalez Lazaro
- Gonzalez Viviana
- González Luis H.
- Gordon Bryan
- Gordon Sarah
- Gorman Richard
- Gottschlich Gregory M.
- Gottschlich Melissa
- Gower Shanda
- Graciaa Daniel S.
- Graham Irene
- Grant Amber
- Gray Brett
- Gray Glenda E.
- Gray Roni
- Green Allison
- Green Sinikka L.
- Greene Caroline
- Greene Rusty
- Greninger Alex
- Griffin Carl P.
- Grillo Joseph
- Grinsztejn Beatriz
- Grossberg Robert M.
- Grunstra Bernard
- Guanira-Carranza Juan V.
- Guarin Laura Hernandez
- Guerrero Laura Ruy Sanchez
- Guerrero Sonia
- Guillory Clint C.
- Guiney Caitlin J.
- Guizar Sharzhaad Molina
- Gular Catherine Q.
- Gunaratne Shauna H.
- Haber Milton
- Hachigian Greg
- Haggag Amina Z.
- Hall Evelyn
- Halpert David
- Hamilton Holli
- Hammershaimb Elizabeth
- Han-Conrad Laurie J.
- Harden Kate
- Harmon Esther L.
- Harper Charles
- Harper Wayne L.
- Harrell Nicole
- Harrington Hannah
- Harrison Kristina
- Harrison Tavane
- Harshell Shana
- Hartman William R.
- Hartvickson Robyn
- Hatlen Timothy J.
- Hauge Kirsten
- Haughey Lynne A.
- Haynes Michelle
- Headden Gary
- Healy C. Mary
- Healy Catherine Mary
- Hedges Parke
- Heerwegh Dirk
- Hegmann Theresa
- Heimonen Jessica
- Heinzig-Cartwright Destiny S.
- Henderson Jeffrey A.
- Henderson Renea
- Henderson Sheryl L.
- Hendriks Jenny
- Hennekes Gayle D.
- Hepburn Matthew
- Herati Ramin
- Herc Erica
- Hernandez Will
- Hernández Alejandro Quintín Barrat
- Herrera Vida Veronica Ruiz
- Hilder Robin
- Hill Janet
- Hill John M.
- Hinojosa Zindy Yazmín Zárate
- Hirsch Ian
- Ho Ken
- Hoberman Alejandro
- Hoft Daniel
- Hojat Leila
- Holdeman Troy
- Hollister Ripley R.
- Holloway Lisa
- Holt Gregory
- Hong Matthew
- Hong Rosamond
- Hong Stephan
- Horn Amanda
- Horton Manisha
- Horwith Gary
- Hosek Sybil G.
- Hoseyni Cyrus
- Howenstine Patty
- Huang Ying
- Huang Yunda
- Huang Yunda
- Huffine Cory J.
- Huffine Esther S.
- Hull Christine
- Hurst James W.
- Huskey Shamika
- Hussain Mary
- Hussey Julie
- Hussey Morgan
- Hutchens Mark
- Hutchins Tanya
- Hutter Julia
- Huynh Vincent
- Ibarra Jessica
- Immergluck Lilly
- Ince Dilek
- Ingalsbe-Geno Sarah M.
- Inniss Asha
- Irani Farah
- Israelsen Ryan
- Iverson Leslie
- Iwuala Genevieve
- Jackson Lisa A.
- Jackson-Booth Peta-Gay
- Jacobs Michael
- Jacobsen Colleen
- Jacobson Jeffrey M.
- Jacqmein Jeffry
- Jaegle Kate
- Jaffer Shireen H.
- Jahromi Maryam
- James Frank
- Janes Holly E.
- Jay Melanie
- Jeanfreau Robert
- Jeanfreau Susan
- Jeffrey Dugas Sr
- Jennings William
- Jenson Natasa
- Jerome Keith R.
- John W. McGettigan Jr
- Johnson Danyel
- Johnson Diane H.
- Johnson Erica
- Johnson Jennie
- Johnson Jennifer A.
- Johnson John
- Johnson Kristen
- Johnson Lisa
- Johnson Maria
- Johnston Carrie
- Jones Kathleen S.
- Jones William H.
- Jones-López Edward C.
- Jordan Bailey
- Joseph Eron Jr
- Juraszek Jarek
- Justman Jessica E.
- Kahney Scott
- Kalams Spyros A.
- Kamidani Satoshi
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- Áñez Germán
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2023
- Field of study
Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health