Gradillas Regodón, V. & Gradillas González, C. (2018). Suicidiología clínica. Evaluación y tratamiento de las tendencias autodestructivas en la práctica profesional. Málaga: Editorial Universidad de Málaga. 253 PP. ISBN: 978-84-9747-843-4

En esta reseña se describen y analizan los principales factores que pueden contribuir a entender y luchar contra la epidemia del siglo XXI: el suicidio.This review describes and analyzes the main factors that can contribute to understanding and fighting the epidemic of the 21st century: suicide.Esta revisão descreve e analisa os principais fatores que podem contribuir para compreender e combater a epidemia do século XXI: o suicídio

Insights Into Succesful ESG Implementation in Organizations

In a world where organizations are increasingly held accountable for the impact of their operations on the environment and society, environmental, social, and governance (ESG) reporting and metrics have emerged as the primary paradigm for assessing an organization’s sustainability efforts. Yet, it is an area with competing concepts, an ever-expanding set of measures and requirements, and a growing ratings and standards industry. In this article, we discuss how ESG initiatives and measurements can help organizations create value rather than merely being a compliance exercise. We do so by firstly, emphasizing the importance of ESG reporting and ratings for organizations, notwithstanding their limitations. Secondly, we highlight the need for transparency of the ESG metrics and activities being implemented by organizations and the priority of avoiding greenwashing risks. Finally, we stress the requirement of senior management involvement and accountability in ESG initiatives that create long-term value

Understanding the adoption of voluntary environmental, social and governance (ESG) standards in the real estate sector

The environmental performance of the real estate sector has been subject to growing scrutiny in recent years, with the United Nations estimating that the sector accounts for a substantial share of global energy consumption and energy-related greenhouse gas emissions. In turn, environmental, social and governance (ESG) factors are becoming increasingly significant investment considerations for real estate investors. In this context, voluntary ESG standards are becoming central in promoting sustainable and responsible practices among real estate players, and in helping them to address global challenges. Thus, this report is of importance in three respects: first, we review the academic literature in relation to the drivers of organizational adoption of voluntary ESG standards; second, we analyse GRESB’s Real Estate Benchmark, the de facto industry standard for ESG activities in the real estate industry; and finally, we provide recommendations for industry professionals and future researchers interested in the adoption of voluntary ESG standards in the real estate industry

Relación entre el déficit de vitamina D y el síndrome metabólico en población adulta de la Comunidad de Madrid

Introducción: El síndrome metabólico (SM) y sus consecuencias se han constituido como un problema sanitario creciente en el siglo XXI. Se trata de una entidad clínica definida por un conjunto de alteraciones metabólicas y vasculares. La resistencia insulínica (RI) es la hipótesis más aceptada para explicar la etiopatogenia del síndrome. Sin embargo, el diagnóstico de esta entidad, incluso su propia existencia, es controvertido, sobre todo porque, a lo largo de la última década, los criterios diagnósticos del SM han ido cambiando. El objetivo del presente estudio es conocer si la presencia de SM, según criterios armonizados de IDF/ AHA / NHLBI, se asocia con la presencia de déficit de vitamina D, así como conocer si existe asociación entre el déficit de vitamina D y cada uno de los componentes del SM. Material y métodos: Se trata de un estudio observacional de corte transversal, que analiza una muestra de 326 individuos mayores de 18 años, seleccionados de un centro de salud de Alcalá de Henares. Resultados: En la población de estudio la prevalencia de SM fue del 36,1% y del déficit de vitamina D, 25 OH-VitD < 20 ng/ml, del 56,3%. El SM fue más frecuente en el grupo de pacientes con déficit de vitamina D, 43,4%, respecto al grupo sin déficit, 26,8% (p=0,006), siendo la razón de prevalencia de SM de 1,62 (IC95%: 1,13-2,31). Esta asociación se mantuvo tras el ajuste por edad, sexo e índice de masa corporal. Conclusiones: Existe una asociación significativa entre el déficit de vitamina D y el SM, situaciones clínicas de elevada prevalencia en nuestra población. Se demuestra una asociación inversa entre el déficit de vitamina D y: cifras de presión arterial, niveles de triglicéridos en plasma y de HDL colesterol. No se demuestra asociación entre déficit de vitamina D y: DM tipo 2, HOMA ni tampoco con glucemia plasmática ni la HbA1c

Dynamics of mammary infections in organic dairy farms in Northern Spain

The objective of this paper is to evaluate the microbiological state and the dynamics of the mammary infections of organic farms in North Spain to discover if the high somatic cell count (SCC) observed in these farms is associated to a high incidence of mastitis. Microbiological cultures and SCC were performed in 8,496 foremilk samples collected from 160 cows in five representative organic farms from February 2006 to January 2008. Even though 79.3% of cultures were positive, only 21.2% of the total fit our diagnosis of mastitis (clinical, subclinical and chronic). The great prevalence of Corynebacterium bovis (teat canal-region pathogen) in the positive cultures that did not fit the mastitis diagnosis criteria (nearly 70%) compared with those that did (27%) was found to be related to lack of post-milking teat disinfection. The study prevalence of mastitis was 69.2% (66.7% subclinical mastitis, 27.8% clinical mastitis); the mean monthly prevalence was 47.4%; the mean monthly incidence was 12.9% and the mean duration of infection was 3.84 ± 3.98 months The high SCC in foremilk samples from old cows (three or more lactations) not diagnosed as mastitis compared to the heifers, reflects a worsening health status of the animals over time. When compared with the conventional sector in Northern Spain, these parameters indicate a poorer udder health in the studied organic herds with a high presence of chronic subclinical processesINIA (Ref. RTA2006-00132-C02-01)S

Ayahuasca Beverages: Phytochemical Analysis and Biological Properties

Ayahuasca is a psychoactive beverage, originally consumed by indigenous Amazon tribes, of which consumption has been increasing worldwide. The aim of this study was to evaluate the phytochemical profile, as well as the antioxidant, anti-inflammatory and antimicrobial properties of decoctions of four individual plants, a commercial mixture and four mixtures of two individual plants used in the Ayahuasca preparation. For this purpose, a phytochemical characterization was performed, determining the content of flavonoids, total phenolic compounds, and analyzing the phenolic profile. Besides, 48 secondary metabolites were investigated by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-Q/TOF-MS) and their concentration estimated with real standards when present. The antioxidant activity was evaluated by both the β-carotene bleaching test and DPPH free radical scavenging assay, and the anti-inflammatory activity was determined by a protein denaturation method. Finally, the antimicrobial properties were evaluated using the disc diffusion assay, resazurin microtiter method, anti-quorum sensing and anti-biofilm activity assays. The obtained results showed that, in general, the samples have a high content of phenolic compounds and flavonoids with noticeable differences, reflecting on remarkable antioxidant and anti-inflammatory activities. Significant antimicrobial properties were also observed, with emphasis on the effect of B. caapi and P. harmala on planktonic and biofilm cells of A. baumannii, inhibiting both the biofilm formation and the production of violacein pigment.info:eu-repo/semantics/publishedVersio

Characterisation of the phenolic profile of Acacia retinodes and Acacia mearnsii flowers’ extracts

Acacia spp. is an invasive species that is widespread throughout the Portuguese territory. Thus, it is pertinent to better understand this species in order to find different applications that will value its use. To evaluate the phenolic profile in Acacia flowers, ethanolic extracts obtained through an energized guided dispersive extraction were analysed, focusing on two species, Acacia retinodes and Acacia mearnsii, at two flowering stages. The phytochemical profile of each extract was determined by ultra-high performance liquid chromatography coupled with quadrupole time-offlight mass spectrometry and high-performance liquid chromatography coupled with diode array detector. The FTIR-ATR technique was used to distinguish the different samples’ compositions. The results showed the presence of high concentrations of phenolic compounds (>300 mg GAE/g extract), among which are flavonoids (>136 mg QE/g extract), for all combinations of species/flowering stages. The phytochemical profile showed a complex composition with 21 compounds identified and quantified (the predominant ones being epicatechin, rutin, vanillin, and catechol). Both species and flowering stages presented significant variations regarding the presence and quantity of phenols and flavonoids, so much so that a principal component analysis performed with FTIR-ATR spectra data of the extracts was able to discriminate between species and flowering stages.info:eu-repo/semantics/publishedVersio

An Overview of CSR Practices RESPONSE Benchmarking Report

This report summarizes selected findings of a three‐year research effort undertaken by INSEAD, Copenhagen Business School (CBS), Bocconi University, and the Leon Kosminski Academy. It is part of a larger European Commission‐funded study, entitled "RESPONSE”. This project has aimed at understanding how multinational firms see their responsibility towards society and how this is aligned (or not) with the expectations of their stakeholders. Preliminary findings were developed in a final report which was presented at a conference in autumn 2007 at INSEAD, Fontainebleau (please find link in the appendix)

Evaluation of the Cytotoxicity of Ayahuasca Beverages

Ayahuasca is a beverage consumed at shamanic ceremonies and currently has gained popularity on recreational scenarios. It contains beta-carboline alkaloids and N,N-dimethyltryptamine, which possesses hallucinogenic effects. Only a few studies have elicited the psychoactive effects and the dose of such compounds on neurological dopaminergic cells or animals. In this work, we aimed to study the cytotoxic effects of these compounds present in ayahuasca beverages and on five different teas (Banisteriopsis caapi, Psychotria viridis, Peganum harmala, Mimosa tenuiflora and Dc Ab (commercial name)) preparations on dopaminergic immortalized cell lines. Moreover, a characterization of the derivative alkaloids was also performed. All the extracts were characterized by chromatographic systems and the effect of those compounds in cell viability and total protein levels were analyzed in N27 dopaminergic neurons cell line. This is the first article where cytotoxicity of ayahuasca tea is studied on neurological dopaminergic cells. Overall, results showed that both cell viability and protein contents decreased when cells were exposed to the individual compounds, as well as to the teas and to the two mixtures based on the traditional ayahuasca beverages. View Full-Texinfo:eu-repo/semantics/publishedVersio

Metabolic clustering analysis as a strategy for compound selection in the drug discovery pipeline for leishmaniasis

A lack of viable hits, increasing resistance, and limited knowledge on mode of action is hindering drug discovery for many diseases. To optimize prioritization and accelerate the discovery process, a strategy to cluster compounds based on more than chemical structure is required. We show the power of metabolomics in comparing effects on metabolism of 28 different candidate treatments for Leishmaniasis (25 from the GSK Leishmania box, two analogues of Leishmania box series, and amphotericin B as a gold standard treatment), tested in the axenic amastigote form of Leishmania donovani. Capillary electrophoresis–mass spectrometry was applied to identify the metabolic profile of Leishmania donovani, and principal components analysis was used to cluster compounds on potential mode of action, offering a medium throughput screening approach in drug selection/prioritization. The comprehensive and sensitive nature of the data has also made detailed effects of each compound obtainable, providing a resource to assist in further mechanistic studies and prioritization of these compounds for the development of new antileishmanial drugs