Life and death in Iron Age Orkney: an osteoarchaeological examination of the human skeletal remains from the burial ground at Knowe of Skea, Westray

Archaeological excavations were conducted by EASE Archaeology at the Knowe of Skea on the island of Westray between 2000 and 2009 and discovered a multi-phase site with evidence for activity dating from the Neolithic through to the Viking era. Excavations revealed that the site had been used as a burial ground for a prolonged period during the Iron Age. Human remains recovered during the first seasons of excavations were radiocarbon dated to the turn of the first millennium BC/AD. These dates highlighted the significance of this burial ground; burial evidence of Iron Age date is sparse in Atlantic Scotland and often overlooked due to the lack of a recognisable, dominant burial rite. Burials of individuals of all ages, including a very high number of infants, were recovered and represent the largest known collection of burials of this date from Scotland. Iron Age research in Atlantic Scotland has traditionally been dominated by study and discussion of the impressive stone-built architecture of domestic buildings and working places of a population about which very little is actually known. Examination of the burials from this site and comparisons with similar sites in the Orkney Islands is building a greater understanding of the treatment of the dead in this region during a period for which so little evidence exists. The burials had been placed in the rubble of earlier collapsed buildings which appears to be a common feature of many Iron Age burials in the Orkney Islands and north-eastern Scotland. Site records, photographs and views of excavators were consulted and combined with the results of the osteological analysis to determine burial patterns at the site according to age, sex or burial location. The large volume of infant remains recovered from the site created the possibility to investigate such high infant mortality and the general health of infants and children. High numbers of infant burials can often lead to suggestions of infanticide; the likelihood of this is also discussed. The results of basic stable isotope analysis (13C and 15N) were examined to interpret breastfeeding and weaning practice. The evidence provided in the results of isotopic analysis was also used to interpret the diet of this population and compared with archaeological evidence of diet from excavation of domestic sites across Atlantic Scotland. Of particular interest was the extent to which the population of the islands may have exploited marine and other wild resources when compared with similar dietary studies in the rest of Scotland and Britain. Results of osteoarchaeological analysis of the human skeletal remains from the Knowe of Skea allowed a deeper understanding of the lifestyle and health of a population for which there has been little evidence to date

Safe storage of methadone in the home. An Irish audit of the effectiveness of information provision in pharmacies.

Background: Safe storage of oral methadone at home is an important issue given the risk of accidental paediatric consumption. Pharmacy protocols centre on provision of information to patients relating to general and paediatric dangers of methadone and safe storage of methadone in the home. Aim: The study aimed to audit the effectiveness of pharmacy provision of information on safety of methadone consumption and storage in the home. Methods: The study involved an audit of five criteria relating to patient awareness of general dangers of methadone use and paediatric risks, patient information recall on safe storage of methadone in the home; take home methadone dispensing in child resistant containers and safe and secured storage of methadone. Audit information was collected using a survey with consecutive adult patients attending a specialist methadone clinic over the course of four weeks (n=94), and telephone interviews with dispensing pharmacists recorded in the specialist clinic register (n=43). Results: None of the criteria reached a 100% standard. 51% reported never being provided with safety information. 97% of patients were aware of the dangers of methadone use, with females significantly more aware of dangers of methadone to users. 86% did not place their take-home methadone in a locked place. 90% reported they would seek medical help if a child had accidentally consumed methadone. 58% of pharmacists never questioned patients around storage, but 58% reported counselling patients on safe storage. Conclusions: Safe storage of methadone warrants regular and proactive pharmacy provision of information around harms associated with methadone

Purchasing Over The Counter (OTC) Medicinal Products Containing Codeine - Easy Access, Advertising, Misuse and Perceptions of Medicinal Risk.

PURPOSE: Codeine containing medicines can carry a number of health risks associated with the increase in reported misuse and dependence, however they are still readily available over the counter (OTC) in many countries. The aim of this novel study was to report on the results of a survey of customers purchasing OTC codeine containing medicinal products at pharmacies in Ireland, South Africa and England; exploring use, sources of knowledge and perception of risks. METHODS: The study design was an exploratory cross sectional survey. It involved a customer self-administered questionnaire at the point of purchase (n=1230).  Relationships between categorical variables were analysed using Pearson chi-square for bivariate analysis. Continuous scale variables were analysed using one way analysis of variance. RESULTS: In Ireland 6% stated they purchased codeine containing products weekly, in South Africa 13% and in England 16%. In Ireland and England women are more likely to view codeine containing products as harmful. In England older adults are more likely to perceive codeine containing products as harmful. A higher proportion of customers in South Africa opposed restricting codeine containing products to prescription only when compared with people in Ireland and England. CONCLUSIONS: Codeine containing products are widely purchased and used in all three jurisdictions. Whilst the majority of customers appear to have some awareness and knowledge of risks, it does not materially impact on their purchasing behaviour with a substantial minority purchasing/using such products on a weekly basis. This regularity of purchase whilst indicative of the popularity of such products, may also be a potential indicator of misuse. Future research is needed in relation to cultural and gendered differences and targeted information giving and harm reduction initiatives for safe usage of these medicinal products

ERK in Learning and Memory: A Review of Recent Research

The extracellular signal-regulated kinase (ERK) pathway is a member of the mitogen-activated protein kinase (MAPK) superfamily, which is an important, highly conserved family of enzymes associated with cell membrane receptors and regulative targets. In the central nervous system, there is almost no mature neuronal proliferation and differentiation, but the regulation of MAPK and its upstream and downstream molecular pathways is still widespread, with the ERK signaling pathway being one of the most actively studied signal transduction pathways. It is activated by a variety of cell growth factors and substances which promote mitotic activity, and transmits extracellular signals from the cell surface to the nucleus, which transmission plays an important role in the process of cell proliferation and differentiation. In recent years, accumulating evidence has shown that the ERK signaling pathway has an important link with the higher functions of learning and memory

Microglia in the normally aged hippocampus

The hippocampus plays important roles in the regulation and combination of short and long term memory and spatial navigation with other brain centers. Aging is accompanied by a functional decline of the hippocampus and degenerative disease. Microglia are major immune cells in the central nervous system and response to degenerative changes in the aged brain. In this respect, functional and morphological changes of the hippocampus have been closely related to microglial changes during normal aging with or without disease. Therefore, in this review, we discuss morphological and functional changes of the hippocampus and microglia in the aging brain

Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor.

Evidence suggests that flavonoid-rich foods are capable of inducing improvements in memory and cognition in animals and humans. However, there is a lack of clarity concerning whether flavonoids are the causal agents in inducing such behavioral responses. Here we show that supplementation with pure anthocyanins or pure flavanols for 6 weeks, at levels similar to that found in blueberry (2% w/w), results in an enhancement of spatial memory in 18 month old rats. Pure flavanols and pure anthocyanins were observed to induce significant improvements in spatial working memory (p = 0.002 and p = 0.006 respectively), to a similar extent to that following blueberry supplementation (p = 0.002). These behavioral changes were paralleled by increases in hippocampal brain-derived neurotrophic factor (R = 0.46, p<0.01), suggesting a common mechanism for the enhancement of memory. However, unlike protein levels of BDNF, the regional enhancement of BDNF mRNA expression in the hippocampus appeared to be predominantly enhanced by anthocyanins. Our data support the claim that flavonoids are likely causal agents in mediating the cognitive effects of flavonoid-rich foods

Clinical Skills in Undergraduate Nurse Education: Transforming and Harnessing Student Engagement through Problem Based Learning utilising a Blended Teaching Approach

The Covid-19 pandemic has had a transformative effect on teaching and facilitating clinical skills within undergraduate nursing programmes. Traditionally, clinical nursing skills have been taught face to face in the Department of Nursing and Health Care in South East Technological University (SETU), however, due to the pandemic, skills content has had to be taught through a blended format, predominantly on-line. The curriculum remained unchanged, with clinical skill content to be delivered, and learning outcomes which were required to be met. There was significant pressure to deliver skills teaching in an effective way despite the enforced change due to the pandemic restrictions on face-to-face teaching. Online student engagement was a priority for the working group as active engagement has been shown to enhance students' motivation to learn and increase students' satisfaction in achieving their educational goals. Furthermore, positive student engagement can reduce the sense of isolation and lend itself to improved students’ performance. This paper provides an overview of how some of the academic team of a higher institute of technology, in the Republic of Ireland, creatively met these challenges, through on-line delivery and a blended learning approach. The module teams utilised the application of Problem Based Learning (PBL), underpinned with a philosophical framework based on Critical Social Theory (CST) principles. In order to achieve this, an acronym was devised, namely RAPID (Recognise, Assessment, Plan, Interventions and Discuss). The students were supported to develop a Portfolio of Clinical Scenarios, to enhance their learning which empowered the students to further develop their critical thinking skills. Recommendations include a problem based learning and interdisciplinary structured nursing approach to patient assessment using the acronym RAPID. This enabled students to develop their problem-solving skills. Therefore, applying it to real world problem-based patient case scenarios, which can enhance student motivation and engagement