Hasta que naturalmente muera: ejecución pública en Chile colonial (1700-1810)

Son escasas las referencias sobre la práctica de la ejecución en el pasado colonial chileno,[1] sobre todo en lo que concierne a la participación y al comportamiento de la gente enfrentada al ceremonial del patíbulo

¿Veis aquí el Potro del tormento? ¡Decid la verdad! Tortura judicial en la Real Audiencia de Santiago de Chile

La tortura ha estado presente a largo de los siglos, tanto dentro como fuera de la ley. Durante el siglo XX esta realidad se nos ha presentado particularmente evidente y cruda en el acontecer mundial y nacional. La amplitud de este hecho nos ha llevado a preguntarnos por su ejercicio durante el período colonial en Chile, tema del cual daremos ciertas impresiones respecto de su práctica judicial. Ese tipo de tortura, llamada también cuestión de tormento, se define como «una prueba en el proceso penal, la cual era subsidiaria y reiterable, y estaba destinada a provocar por medios violentos la confesión de culpabilidad de aquel contra quien hubiera ciertos indicios; o dirigida a veces, a obtener la acusación del reo contra sus cómplices, o también a forzar las declaraciones de los testigos».[1] Para tratar lo anterior nos hemos basado en el material encontrado tras la revisión de juicios por homicidio contenidos en el archivo de la Real Audiencia de Santiago. El período estudiado va desde el siglo XVII hasta la primera década del XIX

Blockade of TGF-β 1 Signalling Inhibits Cardiac NADPH Oxidase Overactivity in Hypertensive Rats

NADPH oxidases constitute a major source of superoxide anion (·O2 −) in hypertension. Several studies suggest an important role of NADPH oxidases in different effects mediated by TGF-β 1. In this study we show that chronic administration of P144, a peptide synthesized from type III TGF-β 1 receptor, significantly reduced the cardiac NADPH oxidase expression and activity as well as in the nitrotyrosine levels observed in control spontaneously hypertensive rats (V-SHR) to levels similar to control normotensive Wistar Kyoto rats. In addition, P144 was also able to reduce the significant increases in the expression of collagen type I protein and mRNA observed in hearts from V-SHR. In addition, positive correlations between collagen expression, NADPH oxidase activity, and nitrotyrosine levels were found in all animals. Finally, TGF-β 1-stimulated Rat-2 exhibited significant increases in NADPH oxidase activity that was inhibited in the presence of P144. It could be concluded that the blockade of TGF-β 1 with P144 inhibited cardiac NADPH oxidase in SHR, thus adding new data to elucidate the involvement of this enzyme in the profibrotic actions of TGF-β 1

Plan de trabajo y cronograma para la ejecución de actividades

Propuesta técnica que incluye el desarrollo de seis actividades que comprometen la entrega de resultados a través de siete productos principales. Las actividades entorno al cumplimiento del convenio son i) Construir la línea base de información secundaria disponible sobre biodiversidad para la cuenca del río Claro, Antioquia, que incluya, entre otros, datos sobre ecología, genética, uso, conservación, distribución, uso de hábitat, impactos e información espacial, procesos ecológicos; ii) Desarrollar un taller con actores clave en la gestión de la biodiversidad en la cuenca del río Claro, para la validación y robustecimiento de la línea base de información, así como para la identificación de vacíos de información y priorización de especies de interés, ecosistemas y temáticas, con miras a la construcción de agendas de investigación a largo plazo; iii) Construir propuestas de diseño de muestreo de la biodiversidad a diferentes niveles: especies, poblaciones, comunidades, ecosistemas, paisaje, ajustadas a las características socioecológicas de la cuenca del río Claro, para el establecimiento de plataformas de monitoreo, que incluyan además el recurso hídrico de la cuenca del río Claro, la diversidad subterránea, epígea y asociada al ecosistema cárstico; iv) Realizar al menos dos pre-salidas a la cuenca del río Claro, para el reconocimiento de las ventanas o localidades de trabajo y ajuste de las propuestas de diseño de muestreo, así como para la definición de aspectos logísticos; v) Evaluar el estado del conocimiento sobre la ecología del Jaguar ( Panthera onca ) en la cuenca del río Claro y generar una propuesta de muestreo no invasivo para conocer el estado de la diversidad genética de la especie en la región; vi) Articular la red de actores y expertos en grandes felinos para la construcción colectiva de herramientas de gestión y conservación para el Jaguar (Panthera onca).Bogotá, ColombiaCiencias Básicas de la Biodiversida

Contamination level and spatial distribution of heavy metals in water and sediments of El Guájaro Reservoir, Colombia

Heavy metals have become a subject of special concern worldwide, mainly due to high persistence in the environment, toxicity, biogeochemical recycling and ecological risk. Therefore, the objective of this investigation was to analyze the spatial–temporal distribution of heavy metals in water and sediments to determine the environmental status of El Guájaro Reservoir, where such studies have not been developed. Two measurement campaigns (dry and wet period) were carried out and eight sampling stations were selected. A comparison of water and sediment quality parameters with existing national and international regulations was done. Also, heavy metal distribution maps were generated, and the geoaccumulation index was calculated to identify sources and sediments contamination level. Based on the obtained results, agriculture and mining activities are the main causes of the reservoir contamination. This metals levels could be a potential risk for the aquatic life and the populations that are supplied from this water body

Propuesta metodológica para la elaboración de la linea base de la biodiversidad de la cuenca del río claro, Antioquia, a partir de información secundaria

La cuenca del río Claro es considerada como uno de los ecosistemas más importantes de la región hidrográfica del río Grande del Magdalena. Es una región única a nivel biológico por su riqueza en especies endémicas, como resultado del aislamiento que por millones de años tuvieron las especies que allí han habitado, de cambios en las coberturas de los bosques y en la distribución de las especies, así como por las alteraciones geológicas en el área durante el Pleistoceno, lo que ha conferido a la zona la denominación de refugio del Pleistoceno. Esta condición ha desencadenado la formación de suelos cársticos, fruto de la erosión de los suelos generada por millones de años, influyendo de forma representativa en el tipo de biota que allí se encuentra. Con el objetivo de construir una visión amplia de las múltiples dimensiones del conocimiento de la biodiversidad en la cuenca del río Claro, el Instituto Humboldt, propone la construcción de una línea base que articule las diferentes fuentes de información disponibles, en un proceso sistemático y riguroso, fundamentado en una revisión extensa y detallada, y siguiendo estándares de calidad y excelencia en términos de los resultados esperados. Con este fin, se han identificado siete componentes temáticos (Análisis espacial y administración de datos, Dinámica y funcionamiento de ecosistemas, Genética de la conservación, Calidad del recurso hídrico, Vertebrados e invertebrados terrestres y acuáticos, Insectos y Flora), agrupando aquellos enfocados a nivel de especies y aquellos relacionados con otros niveles y aspectos de la biodiversidad.Bogotá, ColombiaCiencias Básicas de la Biodiversida

Global assessment of marine plastic exposure risk for oceanic birds

Plastic pollution is distributed patchily around the world’s oceans. Likewise, marine organisms that are vulnerable to plastic ingestion or entanglement have uneven distributions. Understanding where wildlife encounters plastic is crucial for targeting research and mitigation. Oceanic seabirds, particularly petrels, frequently ingest plastic, are highly threatened, and cover vast distances during foraging and migration. However, the spatial overlap between petrels and plastics is poorly understood. Here we combine marine plastic density estimates with individual movement data for 7137 birds of 77 petrel species to estimate relative exposure risk. We identify high exposure risk areas in the Mediterranean and Black seas, and the northeast Pacific, northwest Pacific, South Atlantic and southwest Indian oceans. Plastic exposure risk varies greatly among species and populations, and between breeding and non-breeding seasons. Exposure risk is disproportionately high for Threatened species. Outside the Mediterranean and Black seas, exposure risk is highest in the high seas and Exclusive Economic Zones (EEZs) of the USA, Japan, and the UK. Birds generally had higher plastic exposure risk outside the EEZ of the country where they breed. We identify conservation and research priorities, and highlight that international collaboration is key to addressing the impacts of marine plastic on wide-ranging species

Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.

Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associated disorders and metabolic traits. By conditioning on SNPs associated with the CVD-related phenotypes, type 1 diabetes, type 2 diabetes, systolic blood pressure, diastolic blood pressure, high density lipoprotein, low density lipoprotein, triglycerides and waist hip ratio, we identified 65 novel independent BMD loci (26 with femoral neck BMD and 47 with lumbar spine BMD) at conditional FDR < 0.01. Many of the loci were confirmed in genetic expression studies. Genes validated at the mRNA levels were characteristic for the osteoblast/osteocyte lineage, Wnt signaling pathway and bone metabolism. The results provide new insight into genetic mechanisms of variability in BMD, and a better understanding of the genetic underpinnings of clinical comorbidity

Detection of the blazar S4 0954+65 at very-high-energy with the MAGIC telescopes during an exceptionally high optical state

The very high energy (VHE ¿ 100 GeV) -ray MAGIC observations of the blazar S4 0954+65, were triggered by an exceptionally high flux state of emission in the optical. This blazar has a disputed redshift of z = 0.368 or z ¿ 0.45 and an uncertain classification among blazar subclasses. The exceptional source state described here makes for an excellent opportunity to understand physical processes in the jet of S4 0954+65 and thus contribute to its classification. Methods. We investigated the multiwavelength (MWL) light curve and spectral energy distribution (SED) of the S4 0954+65 blazar during an enhanced state in February 2015 and have put it in context with possible emission scenarios. We collected photometric data in radio, optical, X-ray, and ¿-ray. We studied both the optical polarization and the inner parsec-scale jet behavior with 43 GHz data. Results. Observations with the MAGIC telescopes led to the first detection of S4 0954+65 at VHE. Simultaneous data with Fermi-LAT at high energy ¿-ray(HE, 100 MeV < E < 100 GeV) also show a period of increased activity. Imaging at 43 GHz reveals the emergence of a new feature in the radio jet in coincidence with the VHE flare. Simultaneous monitoring of the optical polarization angle reveals a rotation of approximately 100. Conclusions. The high emission state during the flare allows us to compile the simultaneous broadband SED and to characterize it in the scope of blazar jet emission models. The broadband spectrum can be modeled with an emission mechanism commonly invoked for flat spectrum radio quasars (FSRQs), that is, inverse Compton scattering on an external soft photon field from the dust torus, also known as external Compton. The light curve and SED phenomenology is consistent with an interpretation of a blob propagating through a helical structured magnetic field and eventually crossing a standing shock in the jet, a scenario typically applied to FSRQs and low-frequency peaked BL Lac objects (LBL). © ESO 2018.The financial support of the German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2015-69818-P, FPA2012-36668, FPA2015-68378-P, FPA2015-69210-C6-2-R, FPA2015-69210-C6-4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015-71662-C2-2-P, CSD2009-00064), and the Japanese JSPS and MEXT is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2012-0234 and SEV-2015-0548, and Unidad de Excelencia “María de Maeztu” MDM-2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre grant UMO-2016/22/M/ST9/00382 and by the Brazilian MCTIC, CNPq, and FAPERJ. IA acknowledges support by a Ramón y Cajal grant of the Ministerio de Economía, Industria y Competitividad (MINECO) of Spain. The research at the IAA–CSIC was supported in part by the MINECO through grants AYA2016–80889–P, AYA2013–40825–P, and AYA2010–14844, and by the regional government of Andalucía through grant P09–FQM–4784.Peer Reviewe

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe