End-uses of electricity in households of Karnataka state, India

This paper describes the results of a survey of electricity consumption in a sample consisting of 1,165 households in four districts of Karnataka state in India. The survey revealed the patterns of consumption of electricity in AEH[1] and non-AEH[2] households, the stock of electrical appliances used by the households, the differences in the consumption of electricity in urban and rural areas, the use of other sources of energy for domestic purposes, and the degree of penetration of energy-efficient appliances/devices. The analysis of electricity consumption of appliances in AEH households showed that the consumption of electricity is mainly due to lighting, air circulation, water-heating and cooking. In non-AEH households, the end-uses accounting for most of the consumption of electricity are lighting, entertainment and air circulation. The survey also yielded the appliance elasticities and the degree of penetration of energy-efficient devices. As a result policy-makers can take corrective actions by promoting efficiency improvements in certain end-use devices so that increases in the penetration of these devices would not significantly affect the overall electricity requirement for the domestic sector

Anharmonic vs. relaxational sound damping in glasses: I. Brillouin scattering from densified silica

This series discusses the origin of sound damping and dispersion in glasses. In particular, we address the relative importance of anharmonicity versus thermally activated relaxation. In this first article, Brillouin-scattering measurements of permanently densified silica glass are presented. It is found that in this case the results are compatible with a model in which damping and dispersion are only produced by the anharmonic coupling of the sound waves with thermally excited modes. The thermal relaxation time and the unrelaxed velocity are estimated.Comment: 9 pages with 7 figures, added reference

Toward Understanding the B[e] Phenomenon. II. New Galactic FS CMa Stars

FS CMa stars form a group of objects with the B[e] phenomenon that were previously known as unclassified B[e] stars or B[e] stars with warm dust (B[e]WD) until recently. They exhibit strong emission-line spectra and strong IR excesses, most likely due to recently formed circumstellar dust. These properties have been suggested to be due to ongoing or recent rapid mass exchange in binary systems with hot primaries and various types of secondaries. The first paper of this series reported an analysis of the available information about previously known Galactic objects with the B[e] phenomenon, the initial selection of the FS CMa group objects, and a qualitative explanation of their properties. This paper reports the results of our new search for more FS CMa objects in the IRAS Point Source Catalog. We present new photometric criteria for identifying FS CMa stars as well as the first results of our observations of nine new FS CMa group members. With this addition, the FS CMa group has now 40 members, becoming the largest among the dust-forming hot star groups. We also present nine objects with no evidence for the B[e] phenomenon, but with newly discovered spectral line emission and /or strong IR excesses.Fil: Miroshnichenko, A. S.. The University Of North Carolina At Greensboro; Estados UnidosFil: Manset, N.. Canada France Hawaii Telescope; Estados UnidosFil: Kusakin, A.V.. Lomonosov Moscow State University; Rusia. Fesenkov Astrophysical Institute; RusiaFil: Chentsov, E.L.. Russian Academy Of Sciences; RusiaFil: Klochkova, V. G.. Russian Academy Of Sciences; RusiaFil: Zharikov, S. V.. Universidad Nacional Autónoma de México; MéxicoFil: Gray, R. O.. Appalachian State University (appstate);Fil: Grankin, K. N.. Ulugh Beg Astronomical Institute Uzbekistan Academy Of Sciences; UzbekistánFil: Gandet, T. L.. Lizard Hollow Observatory; Estados UnidosFil: Bjorkman, K. S.. University Of Toledo (utoledo); Estados UnidosFil: Rudy, R. J.. The Aerospace Corporation; Estados UnidosFil: Lynch, D. K.. The Aerospace Corporation; Estados UnidosFil: Venturini, C. C.. The Aerospace Corporation; Estados UnidosFil: Mazuk, S.. The Aerospace Corporation; Estados UnidosFil: Puetter, R. C.. University of California at San Diego; Estados UnidosFil: Perry, R. B.. National Aeronautics and Space Administration; Estados UnidosFil: Levato, Orlando Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Complejo Astronómico "El Leoncito". Universidad Nacional de Córdoba. Complejo Astronómico "El Leoncito". Universidad Nacional de la Plata. Complejo Astronómico "El Leoncito". Universidad Nacional de San Juan. Complejo Astronómico "El Leoncito"; ArgentinaFil: Grosso, Monica Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Complejo Astronómico "El Leoncito". Universidad Nacional de Córdoba. Complejo Astronómico "El Leoncito". Universidad Nacional de la Plata. Complejo Astronómico "El Leoncito". Universidad Nacional de San Juan. Complejo Astronómico "El Leoncito"; ArgentinaFil: Bernabei, S.. Istituto Nazionale di Astrofisica; ItaliaFil: Polcaro, V. F.. Istituto Nazionale di Astrofisica; ItaliaFil: Viotti, R. F.. Istituto Nazionale di Astrofisica; ItaliaFil: Norci, L.. Dublin City University; IrlandaFil: Kuratov, K. S.. Fesenkov Astrophysical Institute; Kazajistá

B[e] Stars with Warm Dust: Revealing the Nature of Unclassified B[e] Stars and Expanding the Family

Until recently, unclassified B[e] stars represented half of the entire B[e] group. Our study of these objects with strong emission-line spectra and IRAS fluxes, decreasing toward longer wavelengths, resulted in a suggestion that they currently form dust in their envelopes. The objects have been tentatively called B[e] stars with warm dust (B[e]WD). Their luminosity range (?3 orders of magnitude) is much larger compared to previous suggestions that dust formation occurs only near very luminous hot stars. A significant fraction of B[e]WD are recognized or suspected binaries. The group has been expanded with both previously detected hot emission-line stars with IR fluxes, typical for confirmed B[e]WD, and new candidates, found in recent all-sky surveys. Currently the number of B[e]WD members and candidates is ?60 with an opportunity to find more in existing stellar catalogs. Main observational and physical properties of B[e]WD and their envelopes are summarized. Our results on newly found group members are presented. Partially based on observations obtained at the Canada-France-Hawaii Telescope (CFHT).Fil: Miroshnichenko, A. S.. University of North Carolina at Greensboro; Estados UnidosFil: Bernabei, S.. Istituto Nazionale di Astrofisica; ItaliaFil: Bjorkman, K. S.. University Of Toledo (utoledo); Estados UnidosFil: Chentsov, E. L.. Russian Academy of Sciences; RusiaFil: Klochkova, V. G.. Russian Academy of Sciences; RusiaFil: Gray, R. O.. Appalachian State University; Estados UnidosFil: Levato, H.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Complejo Astronómico "El Leoncito". Universidad Nacional de Córdoba. Complejo Astronómico "El Leoncito". Universidad Nacional de la Plata. Complejo Astronómico "El Leoncito". Universidad Nacional de San Juan. Complejo Astronómico "El Leoncito"; ArgentinaFil: Grosso, Monica Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio. Universidad Nacional de San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio; ArgentinaFil: Hinkle, K. H.. National Optical Astronomy Observatory; Estados UnidosFil: Kuratov, K. S.. Fesenkov Astrophysical Institute; KazajistánFil: Kusakin, A. V.. Universitetskij pr; RusiaFil: García Lario, P.. European Space Astronomy Centre; EspañaFil: Perea Calderón, J. V.. European Space Astronomy Centre; EspañaFil: Polcaro, V. F.. Istituto di Astrofisica Spaziale e Fisica Cosmica; ItaliaFil: Viotti, R. F.. Istituto di Astrofisica Spaziale e Fisica Cosmica; ItaliaFil: Norci, L.. Dublin City University; IrlandaFil: Manset, N.. Canada France Hawaii Telescope; Estados UnidosFil: Men’shchikov, A. B.. Saint Mary’s University; CanadáFil: Rudy, R. J.. The Aerospace Corporation; Estados UnidosFil: Lynch, D. K.. The Aerospace Corporation; Estados UnidosFil: Venturini, C. C.. The Aerospace Corporation; Estados UnidosFil: Mazuk, S.. The Aerospace Corporation; Estados UnidosFil: Puetter, R. C.. University of California; Estados UnidosFil: Perry, R. B.. National Aeronautics and Space Administration; Estados UnidosFil: Gandet, T. L.. Lizard Hollow Observatory; Estados Unido

A single nanobody neutralizes multiple epochally evolving human noroviruses by modulating capsid plasticity

Acute gastroenteritis caused by human noroviruses (HuNoVs) is a significant global health and economic burden and is without licensed vaccines or antiviral drugs. The GII.4 HuNoV causes most epidemics worldwide. This virus undergoes epochal evolution with periodic emergence of variants with new antigenic profiles and altered specificity for histo-blood group antigens (HBGA), the determinants of cell attachment and susceptibility, hampering the development of immunotherapeutics. Here, we show that a llama-derived nanobody M4 neutralizes multiple GII.4 variants with high potency in human intestinal enteroids. The crystal structure of M4 complexed with the protruding domain of the GII.4 capsid protein VP1 revealed a conserved epitope, away from the HBGA binding site, fully accessible only when VP1 transitions to a “raised” conformation in the capsid. Together with dynamic light scattering and electron microscopy of the GII.4 VLPs, our studies suggest a mechanism in which M4 accesses the epitope by altering the conformational dynamics of the capsid and triggering its disassembly to neutralize GII.4 infection.Instituto de VirologíaFil: Salmen, Wilhelm. Baylor College of Medicine. Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology; Estados UnidosFil: Hu, Liya. Baylor College of Medicine. Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology; Estados UnidosFil: Bok, Marina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnologicas; ArgentinaFil: Bok, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chaimongkol, Natthawan. National Institutes of Health. National Institute of Allergy and Infectious Diseases. Caliciviruses Section; Estados UnidosFil: Ettayebi, Khalil. Baylor College of Medicine. Department of Molecular Virology and Microbiology; Estados UnidosFil: Sosnovtsev, Stanislav V. National Institutes of Health. National Institute of Allergy and Infectious Diseases. Caliciviruses Section; Estados UnidosFil: Soni, Kaundal. Baylor College of Medicine. Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology; Estados UnidosFil: Ayyar, B. Vijayalakshmi. Baylor College of Medicine. Department of Molecular Virology and Microbiology; Estados UnidosFil: Shanker, Sreejesh. Baylor College of Medicine. Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology; Estados UnidosFil: Neill, Frederick H. Baylor College of Medicine. Department of Molecular Virology and Microbiology; Estados UnidosFil: Sankaran, Banumathi. Berkeley Center for Structural Biology. Molecular Biophysics and Integrated Bioimaging. Lawrence Berkeley Laboratory; Estados UnidosFil: Atmar, Robert L. Baylor College of Medicine. Department of Molecular Virology and Microbiology; Estados UnidosFil: Atmar, Robert L. Baylor College of Medicine. Department of Medicine; Estados UnidosFil: Estes, Mary K. Baylor College of Medicine. Department of Molecular Virology and Microbiology; Estados UnidosFil: Estes, Mary K. Baylor College of Medicine. Department of Medicine; Estados UnidosFil: Green, Kim Y. National Institutes of Health. National Institute of Allergy and Infectious Diseases. Caliciviruses Section; Estados UnidosFil: Parreño, Gladys Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virologia e Innovaciones Tecnologicas (IVIT); ArgentinaFil: Parreño, Gladys Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Prasad, B. V. Venkataram. Baylor College of Medicine. Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology; Estados UnidosFil: Prasad, B. V. Venkataram. Baylor College of Medicine. Department of Molecular Virology and Microbiology; Estados Unido

Advanced Technologies for Oral Controlled Release: Cyclodextrins for oral controlled release

Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability and bioavailability enhancement; (2) to modify the drug release site and/or time profile; and (3) to reduce or prevent gastrointestinal side effects and unpleasant smell or taste, to prevent drug-drug or drug-additive interactions, or even to convert oil and liquid drugs into microcrystalline or amorphous powders. A more recent trend focuses on the use of CDs as nanocarriers, a strategy that aims to design versatile delivery systems that can encapsulate drugs with better physicochemical properties for oral delivery. Thus, the aim of this work was to review the applications of the CDs and their hydrophilic derivatives on the solubility enhancement of poorly water soluble drugs in order to increase their dissolution rate and get immediate release, as well as their ability to control (to prolong or to delay) the release of drugs from solid dosage forms, either as complexes with the hydrophilic (e.g. as osmotic pumps) and/ or hydrophobic CDs. New controlled delivery systems based on nanotechonology carriers (nanoparticles and conjugates) have also been reviewed

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology

Predictors of tuberculosis (TB) and antiretroviral (ARV) medication non-adherence in public primary care patients in South Africa: A cross sectional study

Background: Despite the downward trend in the absolute number of tuberculosis (TB) cases since 2006 and the fall in the incidence rates since 2001, the burden of disease caused by TB remains a global health challenge. The co-infection between TB and HIV adds to this disease burden. TB is completely curable through the intake of a strict anti-TB drug treatment regimen which requires an extremely high and consistent level of adherence.The aim of this study was to investigate factors associated with adherence to anti-TB and HIV treatment drugs. Methods: A cross-sectional survey method was used. Three study districts (14 primary health care facilities in each) were selected on the basis of the highest TB caseload per clinic. All new TB and new TB retreatment patients were consecutively screened within one month of anti-tuberculosis treatment. The sample comprised of 3107 TB patients who had been on treatment for at least three weeks and a sub-sample of the total sample were on both anti-TB treatment and anti-retro-viral therapy(ART) (N = 757). Data collection tools included: a Socio-Demographic Questionnaire; a Post-Traumatic-Stress-Disorder (PTSD) Screen; a Psychological Distress Scale; the Alcohol Use Disorder Identification Test (AUDIT); and self-report measures of tobacco use, perceived health status and adherence to anti-TB drugs and ART. Results: The majority of the participants (N = 3107) were new TB cases with a 55.9% HIV co-infection rate in this adult male and female sample 18 years and older. Significant predictors of non-adherence common to both anti-TB drugs and to dual therapy (ART and anti-TB drugs) included poverty, having one or more co-morbid health condition, being a high risk for alcohol mis-use and a partner who is HIV positive. An additional predictor for non-adherence to anti-TB drugs was tobacco use. Conclusions: A comprehensive treatment programme addressing poverty, alcohol mis-use, tobacco use and psycho-social counseling is indicated for TB patients (with and without HIV). The treatment care package needs to involve not only the health sector but other relevant government sectors, such as social development.IS

Innate Immune Responses of Pulmonary Epithelial Cells to Burkholderia pseudomallei Infection

10.1371/journal.pone.0007308PLoS ONE410