Mount Rushmore National Memorial Official Playing Cards

Set of playing cards in box - Mt. Rushmore National Memorial Official Playing Cards. Distributed by Rushmore Photo & Gifts, Inc. Rapid City, SD 57701. Designed in the USA, printed in China. There is a total of 56 cards. Each card has a picture of Mount Rushmore on the front. On the back, there is a picture of a National Park. distributed by Rushmore Photo & Gifts, inc. (American, ?-present )https://scholarsjunction.msstate.edu/fvw-artifacts/4688/thumbnail.jp

Abraham Lincoln Portrait Magnet

At the magnet\u27s front, a portrait of Abraham Lincoln is featured against an American Flag backdrop. On the reverse, a short biographical blurb about Lincoln is given.https://scholarsjunction.msstate.edu/fvw-artifacts/4152/thumbnail.jp

LncRNAs GIHCG and SPINT1-AS1 Are Crucial Factors for Pan-Cancer Cells Sensitivity to Lapatinib

Lapatinib is a small molecule inhibitor of EGFR (HER1) and ERBB2 (HER2) receptors, which is used for treatment of advanced or metastatic breast cancer. To find the drug resistance mechanisms of treatment for EGFR/ERBB2 positive tumors, we analyzed the possible effects of lncRNAs. In this study, using CCLE (Cancer Cell Line Encyclopedia) database, we explored the relationship between the lncRNAs and Lapatinib sensitivity/resistance, and then validated those findings through in vitro experiments. We found that the expression of EGFR/ERBB2 and activation of ERBB pathway was significantly related to Lapatinib sensitivity. GO (Gene Oncology) analysis of top 10 pathways showed that the sensitivity of Lapatinib was positively correlated with cell keratin, epithelial differentiation, and cell-cell junction, while negatively correlated with signatures of extracellular matrix. Forty-four differentially expressed lncRNAs were found between the Lapatinib sensitive and resistant groups (fold-change > 1.5, P < 0.01). Gene set variation analysis (GSVA) was performed based on 44 lncRNAs and genes in the top 10 pathways. Five lncRNAs were identified as hub molecules. Co-expression network was constructed by more than five lncRNAs and 199 genes in the top 10 pathways, and three lncRNAs (GIHCG, SPINT1-AS1, and MAGI2-AS3) and 47 genes were identified as close-related molecules. The three lncRNAs in epithelium-derived cancers were differentially expressed between sensitive and resistant groups, but no significance was found in non-epithelium-derived cancer cells. Correlation analysis showed that SPINT1-AS1 (R = −0.715, P < 0.001) and GIHCG (R = 0.557, P = 0.013) were correlated with the IC50 of epithelium-derived cancer cells. In further experiments, GIHCG knockdown enhanced cancer cell susceptibility to Lapatinib, while high level of SPINT1-AS1 was a sensitive biomarker of NCI-N87 and MCF7 cancer cells to Lapatinib. In conclusions, lncRNAs GIHCG and SPINT1-AS1 were involved in regulating Lapatinib sensitivity. Up-regulation of GIHCG was a drug-resistant biomarker, while up-regulation of SPINT1-AS1 was a sensitive indicator

Towards a European ITS for freight transport and logistics: results of current EU funded research and prospects for the future

Objective The purpose of this paper is to review the developments of the last 15 years in the field of Freight Transport research and innovation, primarily (but not exclusively) in Europe focusing on the “Intelligent Transport Systems” aspects. Document type: Articl

Homogeneous and heterogeneous catalysts for multicomponent reactions

[EN] Organic synthesis performed through multicomponent reactions is an attractive area of research in organic chemistry. Multicomponent reactions involve more than two starting reagents that couple in an exclusive ordered mode under the same reaction conditions to form a single product which contains the essential parts of the starting materials. Multicomponent reactions are powerful tools in modern drug discovery processes, because they are an important source of molecular diversity, allowing rapid, automated and high throughput generation of organic compounds. This review aims to illustrate progress in a large variety of catalyzed multicomponent reactions performed with acid, base and metal heterogeneous and homogeneous catalysts. Within each type of multicomponent approach, relevant products that can be obtained and their interest for industrial applications are presented.The authors wish to gratefully acknowledge the Generalitat Valenciana for the financial support in the project CONSOLIDER-INGENIO 2010 (CSD2009-00050)Climent Olmedo, MJ.; Corma Canós, A.; Iborra Chornet, S. (2012). Homogeneous and heterogeneous catalysts for multicomponent reactions. RSC Advances. 2(1):16-58. https://doi.org/10.1039/c1ra00807bS16582

Deterministic and stochastic analysis of groundwater in unconfined aquifer model

In several developed countries, groundwater has been recognised as one of the most important natural source of fresh water. It can now be understood why many researchers from all corners from applied science have devoted their attention in developing new methods, models that could be used to monitor and understand the movement of this water within subsurface. The literature nowadays revealed different type of geological formations, including confined, leaky and unconfined aquifers. The movement of water within these three aquifers cannot be captured using the same mathematical models. The Theis model was introduced to capture flow within a confined aquifer, while the Hantush model was suggested to predict the flow within leaky aquifer, these two partial differential equations cannot account for the flow within an unconfined aquifer, and more precisely they are linear equations. To capture flow within an unconfined aquifer, a new mathematical equation was suggested and happens to be integro-differential type. The study of this model is not popular maybe due to the complexity of the mathematical setting. In this dissertation, we considered the model of groundwater flowing within an unconfined aquifer. We derived the conditions under which the exact solution can be obtained. We suggested numerical solutions using different schemes including forward Euler, Crank-Nicholson and Atangana-Batogna schemes. For each of them, we presented detailed study underpinning the stability of the used scheme. To conclude, we suggested a new numerical scheme that combines the fundamental theorem of calculus, Adams-Bashforth and the trapezoidal rule. The method is a new door for investigation in the field of modelling as it is highly accurate and efficient. In addition to this, we argued that differential equations with constant coefficient cannot capture complexities with statistical setting, to solve this problem in case; we converted all parameters included in our equation into distribution functions. The new model was also solved numerically. Lastly, we present numerical simulations from a software package called MATLAB, using normal and statistical data.National Research Foundation (NRF)University of the Free Stat