36 research outputs found
Erratum: First observation and amplitude analysis of the B- -> D+K-pi(-) decay [Phys. Rev. D 91, 092002 (2015)]
Determination of gamma and-2 beta(s) from charmless two-body decays of beauty mesons
Using the latest LHCb measurements of time-dependent CP violation in the
B^0_s -> K^+K^- decay, a U-spin relation between the decay amplitudes of B^0_s
-> K^+K^- and B^0 -> \pi^+\pi^- decay processes allows constraints to be placed
on the angle gamma of the unitarity triangle and on the B^0_s mixing phase
-2\beta_s. Results from an extended approach, which uses additional inputs on
B^0 -> \pi^0\pi^0 and B^+ -> \pi^+\pi^0 decays from other experiments and
exploits isospin symmetry, are also presented. The dependence of the results on
the maximum allowed amount of U-spin breaking is studied. At 68% probability,
the value \gamma = ( 63.5 +7.2 -6.7 ) degrees modulo 180 degrees is determined.
In an alternative analysis, the value -2\beta_s = -0.12 +0.14 -0.16 rad is
found. In both measurements, the uncertainties due to U-spin breaking effects
up to 50% are included.Comment: updated to v2 with minor changes after journal revie
Measurement of the lifetime of the meson using the decay mode
The difference in total widths between the and mesons is
measured using 3.0fb of data collected by the LHCb experiment in 7 and 8
TeV centre-of-mass energy proton-proton collisions at the LHC. Through the
study of the time evolution of and
decays, the width difference is measured to be
where the first uncertainty is statistical and the second
systematic. The known lifetime of the meson is used to convert this to a
precise measurement of the lifetime,
where the first uncertainty is
statistical and the second systematic.Comment: 19 pagers, 3 figure
Measurement of the CP-violating phase in decays and limits on penguin effects
Time-dependent CP violation is measured in the channel for each resonant final state using data
collected with an integrated luminosity of 3.0 fb in collisions
using the LHCb detector. The final state with the largest rate,
, is used to measure the CP-violating angle to be . This result can be used to
limit the size of penguin amplitude contributions to CP violation measurements
in, for example, decays. Assuming approximate
SU(3) flavour symmetry and neglecting higher order diagrams, the shift in the
CP-violating phase is limited to be within the interval
[, +] at 95% confidence level. Changes to the limit
due to SU(3) symmetry breaking effects are also discussed.Comment: 18 pages, 6 figures; v2-updated from reviewers comments and added a
figur
Study of the rare B-s(0) and B-0 decays into the pi(+) pi(-) mu(+) mu(-) final state
A search for the rare decays and is performed in a data set corresponding to an integrated
luminosity of 3.0 fb collected by the LHCb detector in proton-proton
collisions at centre-of-mass energies of 7 and 8 TeV. Decay candidates with
pion pairs that have invariant mass in the range 0.5-1.3 GeV/ and with
muon pairs that do not originate from a resonance are considered. The first
observation of the decay and the first
evidence of the decay are obtained and the
branching fractions, restricted to the dipion-mass range considered, are
measured to be and
, where the third
uncertainty is due to the branching fraction of the decay , used as a normalisation.Comment: 21 pages, 3 figures, 2 Table
An increased Bax/Bcl-2 ratio in circulating inflammatory cells predicts primary response to infliximab in inflammatory bowel disease patients
Background: Predicting the response of inflammatory bowel disease (IBD) patients to infliximab (IFX) is an unmet clinical need. The expression and density of transmembrane tumor necrosis factor-α in circulating leukocytes maybe directly related to response by promoting apoptosis. Aim: We tested the hypothesis that direct apoptosis assessment by real-time polymerase chain reaction evaluation of pro-apoptotic (Bax) and anti-apoptotic (Bcl-2) proteins in peripheral blood mononuclear cells (PBMCs) might be associated with response to IFX. Methods: IFX naïve patients (Crohn�s disease, 32 and ulcerative colitis, 20; 35 responders and 17 non-responders) were evaluated for Bax and Bcl-2 mRNA expression levels before and 2 weeks after the first infusion. In a subset of patients, apoptosis was also evaluated using flow cytometry. Results: After the first infusion, Bax increased more in responders than in non-responders (0.7± 0.38 vs 0.81 ± 0.32 and 0.86 ± 0.37 vs 0.87 ± 0.45, respectively, p = 0.071). Bcl-2 decreased more in responders than in non-responders (0.71 ± 0.12 vs 0.63 ± 0.13 and 0.81 ± 0.28 vs 0.77 ± 0.27, respectively, p = 0.038). The Bax/Bcl-2 ratio increased more in responders than in non-responders (0.99 ± 0.5 vs 1.3 ± 0.51 and 1.03 ± 0.17 vs 1.1 ± 0.28, respectively, p = 0.005). The Bax/Bcl-2 ratio was able to predict response in 33/52 patients and was correlated to flow cytometry-assessed apoptosis (r = 0.911; p < 0.001). Conclusions: An increased Bax/Bcl-2 ratio in PBMCs was associated with therapeutic response to IFX in IBD patients. © Author(s) 2018
An increased Bax/Bcl-2 ratio in circulating inflammatory cells predicts primary response to infliximab in inflammatory bowel disease patients
Background: Predicting the response of inflammatory bowel disease (IBD) patients to infliximab (IFX) is an unmet clinical need. The expression and density of transmembrane tumor necrosis factor-α in circulating leukocytes maybe directly related to response by promoting apoptosis. Aim: We tested the hypothesis that direct apoptosis assessment by real-time polymerase chain reaction evaluation of pro-apoptotic (Bax) and anti-apoptotic (Bcl-2) proteins in peripheral blood mononuclear cells (PBMCs) might be associated with response to IFX. Methods: IFX naïve patients (Crohn�s disease, 32 and ulcerative colitis, 20; 35 responders and 17 non-responders) were evaluated for Bax and Bcl-2 mRNA expression levels before and 2 weeks after the first infusion. In a subset of patients, apoptosis was also evaluated using flow cytometry. Results: After the first infusion, Bax increased more in responders than in non-responders (0.7± 0.38 vs 0.81 ± 0.32 and 0.86 ± 0.37 vs 0.87 ± 0.45, respectively, p = 0.071). Bcl-2 decreased more in responders than in non-responders (0.71 ± 0.12 vs 0.63 ± 0.13 and 0.81 ± 0.28 vs 0.77 ± 0.27, respectively, p = 0.038). The Bax/Bcl-2 ratio increased more in responders than in non-responders (0.99 ± 0.5 vs 1.3 ± 0.51 and 1.03 ± 0.17 vs 1.1 ± 0.28, respectively, p = 0.005). The Bax/Bcl-2 ratio was able to predict response in 33/52 patients and was correlated to flow cytometry-assessed apoptosis (r = 0.911; p < 0.001). Conclusions: An increased Bax/Bcl-2 ratio in PBMCs was associated with therapeutic response to IFX in IBD patients. © Author(s) 2018