237 research outputs found
Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.
- Author
- Publication venue
- PLoS Genet
- Publication date
- 01/01/2013
- Field of study
The strongest BMI-associated GWAS locus in humans is the FTO gene. Rodent studies demonstrate a role for FTO in energy homeostasis and body composition. The phenotypes observed in loss of expression studies are complex with perinatal lethality, stunted growth from weaning, and significant alterations in body composition. Thus understanding how and where Fto regulates food intake, energy expenditure, and body composition is a challenge. To address this we generated a series of mice with distinct temporal and spatial loss of Fto expression. Global germline loss of Fto resulted in high perinatal lethality and a reduction in body length, fat mass, and lean mass. When ratio corrected for lean mass, mice had a significant increase in energy expenditure, but more appropriate multiple linear regression normalisation showed no difference in energy expenditure. Global deletion of Fto after the in utero and perinatal period, at 6 weeks of age, removed the high lethality of germline loss. However, there was a reduction in weight by 9 weeks, primarily as loss of lean mass. Over the subsequent 10 weeks, weight converged, driven by an increase in fat mass. There was a switch to a lower RER with no overall change in food intake or energy expenditure. To test if the phenotype can be explained by loss of Fto in the mediobasal hypothalamus, we sterotactically injected adeno-associated viral vectors encoding Cre recombinase to cause regional deletion. We observed a small reduction in food intake and weight gain with no effect on energy expenditure or body composition. Thus, although hypothalamic Fto can impact feeding, the effect of loss of Fto on body composition is brought about by its actions at sites elsewhere. Our data suggest that Fto may have a critical role in the control of lean mass, independent of its effect on food intake
A cohort evaluation on arterial stiffness and hypertensive disorders in pregnancy
- Author
- A Elvan-Taspinar
- A Gagnon
- A Hausvater
- A Khalil
- A Wang
- AA Khalil
- AJE Khalil
- AmericanCollegeofObstetricianandGynaecologist
- AO Robb
- AR Khoshdel
- B Avni
- B Williams
- B Williams
- B Williams
- B Williams
- C Kaihura
- C Nelson-Piercy
- CD Spielbergeer
- DJ Buysse
- E Agabiti-Rosei
- G Mancia
- George SH Yeo
- H Stepan
- JJ Walker
- JL Cox
- JR Barton
- JS Cnossen
- K Loi
- Kenneth YC Kwek
- Kok Hian Tan
- L Gordis
- LCY Poon
- LJ Vatten
- M Ronnback
- M Spasojevic
- National High Blood Pressure Education Program Working Group on High Blood Pressure in P
- O Lapaire
- ORR Erez
- R Akolekar
- RJ Levine
- RNJ Romero
- S Cohen
- S Rana
- S Venkatesha
- S Verlohren
- SA Hope
- SC Roesch
- Seang Mei Saw
- Singapore Department of Statistics
- T Kasdaglis
- Wai Yee Lim
- Y Giguere
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
10.1186/1471-2393-12-160BMC Pregnancy and Childbirth12-BPCM
Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.
- Author
- Arch Jonathan RS
- Ashrafian Houman
- Beall Craig
- Bellahcene Mohamed
- Brown Laurence A
- Cansell Céline
- Carling David
- Cawthorne Michael A
- Chuster André
- Czibik Gabor
- de Oliveira Figueiredo Márcio J
- Fekete Csaba
- Gandra Silvia
- Gereben Balázs
- Ghaffari Sahar
- Harikumar Parvathy
- Harper Andrew R
- Heisler Lora K
- Katritsis George
- Kyriakou Theodosios
- Lam Brian YH
- Lazdam Merzaka
- Martinez-Sanchez Aida
- Martínez de Morentin Pablo B
- McCrimmon Rory J
- Nguyen Chinh
- Nguyen-Tu Marie-Sophie
- O'Dowd Jacqueline F
- Oliver Peter L
- Parnis Julia
- Peirson Stuart N
- Petkevicius Kasparas
- Pinter Katalin
- Poncio Victor
- Pullen Timothy J
- Qi Nathan R
- Redwood Charles
- Rutter Guy A
- Sarma Dhruv
- Smith Mark A
- Steeples Violetta
- Sternick Eduardo B
- Stockenhuber Alexander
- Stocker Claire J
- Tretter László
- Tóth Mónika
- Wargent Edward T
- Watkins Hugh
- Willows Robin
- Withers Dominic J
- Woods Angela
- Wortmann Diana DJ
- Yavari Arash
- Yeo Giles SH
- Publication venue
- Cell Metab
- Publication date
- 01/04/2016
- Field of study
Despite significant advances in our understanding of the biology determining systemic energy homeostasis, the treatment of obesity remains a medical challenge. Activation of AMP-activated protein kinase (AMPK) has been proposed as an attractive strategy for the treatment of obesity and its complications. AMPK is a conserved, ubiquitously expressed, heterotrimeric serine/threonine kinase whose short-term activation has multiple beneficial metabolic effects. Whether these translate into long-term benefits for obesity and its complications is unknown. Here, we observe that mice with chronic AMPK activation, resulting from mutation of the AMPK γ2 subunit, exhibit ghrelin signaling-dependent hyperphagia, obesity, and impaired pancreatic islet insulin secretion. Humans bearing the homologous mutation manifest a congruent phenotype. Our studies highlight that long-term AMPK activation throughout all tissues can have adverse metabolic consequences, with implications for pharmacological strategies seeking to chronically activate AMPK systemically to treat metabolic disease
Prediction of neonatal respiratory morbidity by quantitative ultrasound lung texture analysis: a multicenter study.
- Author
- Bartha José Luis
- Bonet Carné Elisenda
- Botet Mussons Francisco
- Bugatto Fernando
- Burke Minke
- Carretero Lucena Pilar
- Cobo Cobo María Teresa
- Cruz Martínez Rogelio
- Delgado Juan Luis
- Deprest Jan
- Fetal Lung Texture Team.
- García Posada Raúl A.
- Gratacós Solsona Eduard
- Hernández Andrade Edgar
- Hyett Jon
- Iruretagoyena Igor
- Jacobsson Bo
- Kacerovsky Marian
- Palacio i Riera Montserrat
- Parra Cordero Mauro C.
- Pérez Moreno Álvaro
- Richter Jute
- Romero Roberto
- Sabrià Rius Joan
- Santisteve Ramon
- Schenone Mauro
- Tan Kai L.
- Vavilala Suseela
- Vilanova Josep
- Vives Àngels
- Yeo George SH.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND: Prediction of neonatal respiratory morbidity may be useful to plan delivery in complicated pregnancies. The limited predictive performance of the current diagnostic tests together with the risks of an invasive procedure restricts the use of fetal lung maturity assessment. OBJECTIVE: The objective of the study was to evaluate the performance of quantitative ultrasound texture analysis of the fetal lung (quantusFLM) to predict neonatal respiratory morbidity in preterm and early-term (<39.0 weeks) deliveries. STUDY DESIGN: This was a prospective multicenter study conducted in 20 centers worldwide. Fetal lung ultrasound images were obtained at 25.0-38.6 weeks of gestation within 48 hours of delivery, stored in Digital Imaging and Communication in Medicine format, and analyzed with quantusFLM. Physicians were blinded to the analysis. At delivery, perinatal outcomes and the occurrence of neonatal respiratory morbidity, defined as either respiratory distress syndrome or transient tachypnea of the newborn, were registered. The performance of the ultrasound texture analysis test to predict neonatal respiratory morbidity was evaluated. RESULTS: A total of 883 images were collected, but 17.3% were discarded because of poor image quality or exclusion criteria, leaving 730 observations for the final analysis. The prevalence of neonatal respiratory morbidity was 13.8% (101 of 730). The quantusFLM predicted neonatal respiratory morbidity with a sensitivity, specificity, positive and negative predictive values of 74.3% (75 of 101), 88.6% (557 of 629), 51.0% (75 of 147), and 95.5% (557 of 583), respectively. Accuracy was 86.5% (632 of 730) and positive and negative likelihood ratios were 6.5 and 0.3, respectively. CONCLUSION: The quantusFLM predicted neonatal respiratory morbidity with an accuracy similar to that previously reported for other tests with the advantage of being a noninvasive technique
Consensus guidelines for the use and interpretation of angiogenesis assays
- Author
- A Adini
- A Anisimov
- A Aspelund
- A Bikfalvi
- A Bouchet
- A Caporali
- A Fantin
- A Folch
- A Fraccaroli
- A Grutzkau
- A Haeger
- A Hayer
- A Helisch
- A Hruscha
- A Johns
- A Khademhosseini
- A Laude
- A Moldobaeva
- A Ny
- A Otani
- A Passaniti
- A Poltorak
- A Reade
- A Rossi
- A Sadanandam
- A Sakaue-Sawano
- A Scarpa
- A Scott
- A Stahl
- A Stahl
- A Stahl
- A Vargas
- A Vargas
- A Warth
- A Weiss
- A Weiss
- A Weiss
- A Zumsteg
- AA Hellingman
- AA Keskinov
- AA Nazarov
- AC Aplin
- AC Aplin
- AC Newman
- AC Tufan
- Adrian L. Harris
- AE Birsner
- AF Alghanem
- AF Orozco
- Agnes Noel
- AH Rizvi
- AJ Bastiaansen
- AJ Bastiaansen
- AJ Donato
- Alfred C. Aplin
- AM Cimpean
- AM Cimpean
- AM Ochsenbein
- Amber N. Stratman
- AN Stratman
- AN Stratman
- AN Stratman
- AN Stratman
- AN Stratman
- AN Stratman
- Anca M. Cimpean
- Andreas Bikfalvi
- Andrew C. Dudley
- Andrey Anisimov
- Anna Dimberg
- Anna M. Randi
- Anna-Karin Olsson
- AO Dokun
- AO Dokun
- AO Smith
- AQ Reuwer
- Arjan W. Griffioen
- AS Harney
- AV Gore
- AW Griffioen
- AW Griffioen
- AW Griffioen
- AW Griffioen
- AW Griffioen
- AY Nossent
- B Blouw
- B Garmy-Susini
- B Huang
- B St Croix
- B Uzzan
- Bahar Yetkin-Arik
- Barbara C. Böck
- Bart Ghesquière
- Bertan Cakir
- BH Annex
- BJ Vakoc
- BL Roman
- BM Hogan
- BM Kenyon
- BM Weinstein
- BM Weinstein
- BP Dranka
- Brant M. Weinstein
- Brenda R. Kwak
- C Abe
- C Bais
- C Betz
- C D’Souza-Schorey
- C Gentile
- C Korn
- C Monaco
- C Navarro-Requena
- C Poelma
- C Sarkar
- C Secondini
- C Stockmann
- C Viallard
- CA Bichsel
- CA Fernandez
- CA Staton
- CB Kimmel
- CB Moens
- CD Sarsons
- CF Buchanan
- Christopher C. W. Hughes
- CM Clavel
- CM Clavel
- CM Svensson
- CP Dagg
- CT Farrar
- CT Guy
- Curzio Ruegg
- CV Crosby
- CW Chiu
- D Boulate
- D Butler
- D Chalothorn
- D Fukumura
- D Fukumura
- D Fukumura
- D Gau
- D Hanahan
- D Hanahan
- D Hanahan
- D Huh
- D Kardamakis
- D Ribatti
- D Ribatti
- D Ribatti
- D Ribatti
- D Ribatti
- D Stibal
- D Thomas
- D Verdegem
- DA Berk
- DA Ingram
- DA MacDonald
- Dai Fukumura
- Daniel Castranova
- David O. Bates
- DC Duffy
- DC West
- DG DeNardo
- DH Ausprunk
- DH Ausprunk
- DH Nguyen
- DM Roth
- DO Croci
- DO Traktuev
- Domenico Ribatti
- DP Kodack
- DR Enis
- DR Senger
- DS Dohle
- DS Friedman
- DT Nguyen
- DTT Phan
- DY Stainier
- E Akbari
- E Allen
- E Berthier
- E Boscolo
- E Brown
- E Debefve
- E Morgan
- E Passalidou
- E Paunescu
- E Raymond
- E Rooijen van
- E Stabile
- E Wienholds
- E Zudaire
- EA Kleibeuker
- EA Kuczynski
- EA Pierce
- EB Brown
- ED Perryn
- EI Deryugina
- EI Deryugina
- EJ Huijbers
- EJ Yeo
- EK Sackmann
- Elisabeth Kuczynski
- Elizabeth Allen
- EY Lin
- EY Lin
- EY Lin
- EY Lin
- F Bussolino
- F Denizot
- F Hillen
- F Kuonen
- F Pezzella
- F Pezzella
- F Piffaretti
- F Pisati
- F Soulet
- F Soulet
- F Winkler
- F Yuan
- F Yuan
- Federico Bussolino
- FO Kok
- G Alexandrakis
- G Benton
- G Bergers
- G Bergers
- G Bergers
- G Bergers
- G Cheng
- G Christofori
- G Costa
- G Degenfeld von
- G Gruionu
- G Helmlinger
- G Hendrikx
- G Lorusso
- G Martano
- G Seano
- G Serini
- G Solinas
- G Tang
- GA Truskey
- Gabriel A. Rabinovich
- Gabriele Bergers
- GE Davis
- George Coukos
- George E. Davis
- GH Algire
- GJ Patti
- GK Varshney
- GK Varshney
- GM Birdsey
- GM Whitesides
- GR Martin
- GT Motz
- H Gerhardt
- H Huang
- H Lee
- H Naito
- H Ozaki
- H Xin
- Hellmut G. Augustin
- HF Clark
- HG Augustin-Voss
- HK Kleinman
- HM Jung
- HM Jung
- HM Shapiro
- Hong Xin
- HS Jeong
- HS Jeong
- Hynda K. Kleinmann
- I Ahmet
- I Keklikoglou
- I Kholova
- I Martinez-Corral
- I Masaki
- I Mattsby-Baltzer
- I Moreno-Jimenez
- IF Tannock
- IK Zervantonakis
- IK Zervantonakis
- IL Weissman
- IM Aspalter
- Ingeborg Klaassen
- International Chicken Genome Sequencing C
- IP Torres Filho
- IW Tattersal
- J Borges
- J Chen
- J Folkman
- J Folkman
- J Folkman
- J Folkman
- J Hoarau-Vechot
- J Kalucka
- J Laurent
- J Laurent
- J LeCouter
- J Loegl
- J Muppidi
- J Nissanov
- J Nurro
- J Patel
- J Sandison
- J Torres-Vazquez
- J Waltenberger
- J Wilting
- J Zhang
- J Zhou
- JA Nagy
- JA Villefranc
- JA Villefranc
- JA Yu
- Jan Kitajewski
- JB Wyckoff
- JC Wigle
- JC Yao
- JE Lahteenvuo
- Jeffrey W. Pollard
- JH Gao
- JH Harmey
- JI Lundin
- Jimmy Stalin
- JJ Belch
- JJ Sheu
- JK Patel
- JL Lucitti
- JM Buescher
- JM Herbert
- JM Melero-Martin
- JM Melero-Martin
- JM Melero-Martin
- Joanna Kalucka
- Johannes Waltenberger
- Jonathan W. Song
- Joyce Bischoff
- JP Cooke
- JP Nolan
- JP Sleeman
- JQ Yu
- JR Beijnum van
- JR Beijnum van
- JR Beijnum van
- JR Beijnum van
- JR Beijnum van
- JR Beijnum van
- JR Beijnum van
- JR Neely
- JS Miller
- JS Schechner
- JS Silvestre
- Juan M. Melero-Martin
- Judy R. van Beijnum
- Jussi Nurro
- JW Baish
- JW Baish
- JW Song
- JW Song
- JW Song
- JY Perentes
- K Bock De
- K Hida
- K Inagaki
- K Jung
- K Kawakami
- K Lu
- K Norrby
- K Yaniv
- K Zhi
- K-T Kang
- Kari Alitalo
- KE Bogt van der
- KH Wong
- KJ Gotink
- KM Argraves
- KM Chrobak
- KM Connor
- KM Downs
- KM Downs
- KM Downs
- KM Kwan
- KM Malinda
- KM Malinda
- KM Marien
- KM Shaw
- Koen Marien
- Kristian Pietras
- KS Samkoe
- KS Samkoe
- KT Kang
- KT Kang
- L Dumartin
- L Eklund
- L Gambardella
- L Guedez
- L Guen Le
- L Huang
- L Jakobsson
- L Morbidelli
- L Nebuloni
- L Norgren
- L Schaad
- LA Herzenberg
- Lance L. Munn
- LB Rivera
- LB Rivera
- LC Hamming
- LE Jao
- LE Smith
- LE Smith
- LI Shlush
- LK Chang
- LL Bischel
- LM Ebert
- LM Ellis
- Lois E. H. Smith
- M Ackermann
- M Arditi
- M Arras
- M Baker
- M Bani
- M Bulkowska
- M Chen
- M Chiba
- M Dellian
- M Fujita
- M Garcia-Caballero
- M Gotberg
- M Hagedorn
- M Hellstrom
- M Inoue
- M Jeltsch
- M Jost
- M Kamei
- M Kucinska
- M Leunig
- M Masiero
- M Merjaneh
- M Mura
- M Nguyen
- M Paez-Ribes
- M Palma De
- M Palma De
- M Palma De
- M Papoutsi
- M Potente
- M Potente
- M Prewett
- M Prokopi
- M Schmittnaegel
- M Schmittnaegel
- M Singh
- M Skobe
- M Snuderl
- M Stroh
- M Sugimoto
- M Upreti
- M Venero Galanternik
- M Westerfield
- M Winderlich
- M Won
- M Yuan
- M Ziche
- M. Luisa Iruela-Arispe
- MA Gimbrone Jr
- MA Lijkwan
- Marcus Fruttiger
- Marius Raica
- Mark J. Post
- Maureen Van de Velde
- MB Gorbet
- MB Powner
- MC Kibbey
- MC Mullins
- MC Oostrom van
- ME Hartnett
- ME Pennesi
- ME Pitulescu
- ME Staab
- Melita Irving
- Mervin C. Yoder
- MG Krzystolik
- MI Bogorad
- Michele De Palma
- MJ Hamm
- MJ Siemerink
- MN Nakatsu
- MN Nakatsu
- MP Craig
- MR Mancuso
- MR Ritter
- MS Rogers
- MW Laschke
- N Bhattacharjee
- N Chang
- N Gao
- N Guex
- N Koike
- N Lange
- N Linde
- N Prasain
- N Rigamonti
- N Weidner
- Nan W. Hultgren
- Napoleone Ferrara
- ND Kirkpatrick
- ND Lawson
- ND Lawson
- ND Lawson
- ND Wangsa-Wirawan
- NE Timmins
- Neil P. Dufton
- NN Rahbari
- NW Choi
- O Casanovas
- O Chen
- O Chen
- Ondine Cleaver
- P Allen
- P Allen
- P Au
- P Au
- P Au
- P Carmeliet
- P Carmeliet
- P Fergelot
- P Jain
- P Lovelace
- P Mistriotis
- P Nowak-Sliwinska
- P Nowak-Sliwinska
- P Nowak-Sliwinska
- P Nowak-Sliwinska
- P Nowak-Sliwinska
- P Nowak-Sliwinska
- P Nowak-Sliwinska
- P Parsons-Wingerter
- P Pedrosa
- P Rous
- P Spuul
- P Thirusangu
- P Vennemann
- P Vitorino
- P Zorzi
- PA Galie
- PA Williams
- Patrycja Nowak-Sliwinska
- Paul H. A. Quax
- PB Vermeulen
- Peter B. Vermeulen
- Peter C. Brooks
- Peter Carmeliet
- PH Burri
- Pieter Koolwijk
- PJ Dam van
- PJ Polverini
- PK Shireman
- PO Magalhaes
- PR Blackburn
- PT Jong de
- Q Chang
- QC Yu
- R Arora
- R Arora
- R Auerbach
- R Auerbach
- R Brauer
- R Cavill
- R Forough
- R Hlushchuk
- R Hlushchuk
- R Hlushchuk
- R Kalluri
- R Mazzieri
- R Medzhitov
- R Montesano
- R Nicosia
- R Noy
- R Salcedo
- R Samuel
- R Sealock
- R Swadi
- R Toro del
- R Xu
- R Zhang
- R. Hugh F. Bender
- Raghu Kalluri
- Rakesh K. Jain
- RE Conway
- RE Unger
- Reinier O. Schlingemann
- RF Nicosia
- RF Nicosia
- RF Nicosia
- RF Nicosia
- RH Berndsen
- RH Berndsen
- RJ Blatt
- RJ DeBerardinis
- RJ Medina
- RJ Melder
- RK Jain
- RK Jain
- RK Jain
- RK Jain
- RK Jain
- RK Jain
- RK Jain
- RK Jain
- RN Kaplan
- RO Schlingemann
- Robert Auerbach
- Robert J. Griffin
- Robert S. Kerbel
- Roberto F. Nicosia
- Roberto Pili
- RP Dings
- RR Ramjiawan
- RS Camplejohn
- Ruud P. M. Dings
- RZ Lin
- RZ Lin
- RZ Lin
- RZ Lin
- RZ Lin
- S Akira
- S Blacher
- S Boyden
- S Cattin
- S Comsa
- S Dymarkowski
- S Fang
- S Ferber
- S Frentzas
- S Ghaffari
- S Ghaffari
- S Goel
- S Greenberger
- S Greenberger
- S Haricharan
- S Hirakawa
- S Isogai
- S Isogai
- S Isogai
- S Javerzat
- S Kim
- S Kim
- S Lalonde
- S Lotfi
- S Mocellin
- S Nakao
- S Parangi
- S Rezzola
- S Rezzola
- S Sawamiphak
- S Schoors
- S Schulte-Merker
- S Schwartz
- S Seaman
- S Stillfried von
- S Tual-Chalot
- S Xiao
- S Yla-Herttuala
- SA Stacker
- SA Stacker
- Sarah-Maria Fendt
- SE Epstein
- Seppo Yla-Herttuala
- SH Lim
- SH Poor
- SJ Ryan
- SJ Wakelin
- SK Hobbs
- SL Bowers
- SM Ehsan
- SM Eswarappa
- SM Krishna
- SM Welten
- SM Wilson
- SO Park
- SP Crampton
- SP Williams
- SP Williams
- SR Chary
- SS Edwards
- Stefan Schulte-Merker
- Steven A. Stacker
- SV Prykhozhij
- T Asahara
- T Couffinhal
- T Donnem
- T Donnem
- T Gohongi
- T Kochi
- T Kuusk
- T Lagerweij
- T Murakami
- T Reiberger
- T Schreier
- T Wisenbaugh
- Tatiana V. Petrova
- TD Palmer
- TI Valdes
- TI Valdes
- TJ Gambino
- TO Auer
- TP Padera
- TP Padera
- TS Westvik
- TT Rissanen
- TT Rissanen
- TV Petrova
- TV Petrova
- U Sauer
- V Djonov
- V Hamburger
- V Huntosova
- V Joukov
- V Lambert
- V Muthukkaruppan
- V Perugini
- V Tchaikovski
- V Tchaikovski
- V Torres-Estay
- V Vickerman
- V Weel van
- V Weel van
- V Weel van
- Valentin Djonov
- Victor W. M. van Hinsbergh
- VL Bridgeman
- VL Thijssen
- VN Pham
- VP Chauhan
- VP Chauhan
- VS Shirure
- VS Shirure
- VV Masson
- VV Tuchin
- W Driever
- W Huang
- W Jakob
- W Jin
- W Kim
- W Koh
- W Lu
- W Lu
- W Pan
- W Song
- W Yi
- WS Kamoun
- WS Lee
- WW Kilarski
- WW Kilarski
- WW Kilarski
- WY Choi
- WY Hwang
- WY Hwang
- X Chen
- X Gu
- X Li
- X Meng
- X Wang
- X Wang
- X Wang
- XM Lopez
- XM Wijk van
- Y Adar
- Y Gazit
- Y Gazit
- Y Gong
- Y He
- Y Izumi
- Y Lei
- Y Li
- Y Lin
- Y Sato
- Y Tsuzuki
- Y Yang
- Y Yang
- Y Zhang
- Y Zhang
- Y Zheng
- Y Zheng
- Y Zhu
- Yan Gong
- YC Chen
- YH Hsu
- YK Young
- YR Cha
- Z Raval
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
- Author
- Aamir A
- Abbas J
- Abbas N
- Abbott TEF
- Abdalla M
- Abdikadir H
- Abuhussein N
- Acquaah F
- Adamson R
- Adeleye O
- Adeogun A
- Adlan A
- Aftab R
- Afzal Z
- Agarwal M
- Aglan H
- Agnew CJF
- Agrawal R
- Ahern D
- Ahluwalia J
- Ahluwalia V
- Ahmad A
- Ahmad K
- Ahmed H
- Ahmed I
- Ahmed L
- Ahmed N
- Ahmed P
- Ainger E
- Ainsworth P
- Aishwarya G
- Ajibola-Taylor O
- Akhbari M
- Akhtar A
- Akhtar R
- Akpenyi O
- Al-Ausi M
- Al-Huneidi R
- Al-Khudairi R
- Al-Masri S
- Al-Mousawi A
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- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators, Nepogodiev, D
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- Zubikarai G
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- Publication venue
- 'Wiley'
- Publication date
- 18/05/2018
- Field of study
Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
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- Zhemchugov A
- Zheng J
- Zheng K
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- Zhong D
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- Zhulanov V
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
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- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
Search for pair production of squarks or gluinos decaying via sleptons or weak bosons in final states with two same-sign or three leptons with the ATLAS detector
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- Abbott B
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- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
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- Abusleme Hoffman AC
- Acharya BS
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- Addepalli SV
- Addison MJ
- Adelman J
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- Zhemchugov A
- Zheng K
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- Zhulanov V
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- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 15/02/2024
- Field of study
A search for pair production of squarks or gluinos decaying via sleptons or weak bosons is reported. The search targets a final state with exactly two leptons with same-sign electric charge or at least three leptons without any charge requirement. The analysed data set corresponds to an integrated luminosity of 139 fb−1 of proton-proton collisions collected at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC. Multiple signal regions are defined, targeting several SUSY simplified models yielding the desired final states. A single control region is used to constrain the normalisation of the WZ + jets background. No significant excess of events over the Standard Model expectation is observed. The results are interpreted in the context of several supersymmetric models featuring R-parity conservation or R-parity violation, yielding exclusion limits surpassing those from previous searches. In models considering gluino (squark) pair production, gluino (squark) masses up to 2.2 (1.7) TeV are excluded at 95% confidence level
Combination of searches for heavy spin-1 resonances using 139 fb−1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
- Author
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- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
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- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fb−1 of proton-proton collisions at
= 13 TeV collected during 2015–2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (τν and ττ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
Software Performance of the ATLAS Track Reconstruction for LHC Run 3
- Author
- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
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- Agullo P Martinez
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- Wu SL
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- Wuerzinger J
- Wyatt TR
- Wynne BM
- Xella S
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- Xiong A
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- Xu D
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- Yabsley B
- Yacoob S
- Yamaguchi Y
- Yamashita E
- Yamauchi H
- Yamazaki T
- Yamazaki Y
- Yan J
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- Yang HJ
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- Yao W-M
- Yap YC
- Ye H
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- Yeh Y
- Yeletskikh I
- Yeo BK
- Yexley MR
- Yildiz H Duran
- Yin P
- Yorita K
- Younas S
- Young C
- Young CJS
- Yu C
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- Yuan M
- Yuan R
- Yue L
- Zaazoua M
- Zabinski B
- Zagazeta LF Gutierrez
- Zaid E
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zang J
- Zanzi D
- Zaplatilek O
- Zeitnitz C
- Zeng H
- Zeng JC
- Zenger DT
- Zenin O
- Zenz S
- Zerradi S
- Zerwas D
- Zhai M
- Zhang B
- Zhang DF
- Zhang J
- Zhang J
- Zhang K
- Zhang L
- Zhang P
- Zhang R
- Zhang S
- Zhang T
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Z
- Zhang Z
- Zhao H
- Zhao P
- Zhao T
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
- Zhou B
- Zhou H
- Zhou N
- Zhou Y
- Zhu CG
- Zhu J
- Zhu Y
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 02/04/2024
- Field of study
Charged particle reconstruction in the presence
of many simultaneous proton–proton (pp) collisions in the
LHC is a challenging task for the ATLAS experiment’s reconstruction software due to the combinatorial complexity. This
paper describes the major changes made to adapt the software
to reconstruct high-activity collisions with an average of 50 or
more simultaneous pp interactions per bunch crossing (pileup) promptly using the available computing resources. The
performance of the key components of the track reconstruction chain and its dependence on pile-up are evaluated, and
the improvement achieved compared to the previous software
version is quantified. For events with an average of 60 pp collisions per bunch crossing, the updated track reconstruction
is twice as fast as the previous version, without significant
reduction in reconstruction efficiency and while reducing the
rate of combinatorial fake tracks by more than a factor two
- …