Isoscalar-isovector mass splittings in excited mesons

Mass splittings between the isovector and isoscalar members of meson nonets arise in part from hadronic loop diagrams which violate the Okubo-Zweig-Iizuka rule. Using a model for these loop processes which works qualitatively well in the established nonets, I tabulate predictions for the splittings and associated isoscalar mixing angles in the remaining nonets below about 2.5 GeV, and explain some of their systematic features. The results for excited vector mesons compare favorably with experiment.Comment: 8 RevTeX pages, including 1 LaTeX figure. CMU-HEP93-23/DOE-ER-40682-4

Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II

MCoTl-I and MCoTl-II from the seeds of Momordica cochinchinensis are inhibitors of trypsin-like proteases and the only known members of the large family of squash inhibitors that are cyclic and contain an additional loop connecting the amino- and the carboxy-terminus. To investigate the contribution of macrocycle formation to biological activity, we synthesized a set of open-chain variants of MCoTl-II that lack the cyclization loop and contain various natural and non-natural amino acid substitutions in the reactive-site loop. Upon replacement of P1 lysine residue \#10 within the open-chain variant of MCoTl-II by the non-natural isosteric nucleo amino acid AlaG{[}beta-(guanin-9-yl)-L-alanine], a conformationally restricted arginine mimetic, residual inhibitory activity was detected, albeit reduced by four orders of magnitude. While the cyclic inhibitors MCoTl-I and MCoTl-II were found to be very potent trypsin inhibitors, with picomolar inhibition constants, the open-chain variants displayed an approximately 10-fold lower affinity. These data suggest that the formation of a circular backbone in the MCoTI squash inhibitors results in enhanced affinity and therefore is a determinant of biological activity

Role of prostacyclin in pulmonary hypertension

Date of Acceptance: 11/12/2014 This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY-4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.Prostacyclin is a powerful cardioprotective hormone released by the endothelium of all blood vessels. Prostacyclin exists in equilibrium with other vasoactive hormones and a disturbance in the balance of these factors leads to cardiovascular disease including pulmonary arterial hypertension. Since it’s discovery in the 1980s concerted efforts have been made to make the best therapeutic utility of prostacyclin, particularly in the treatment of pulmonary arterial hypertension. This has centred on working out the detailed pharmacology of prostacyclin and then synthesising new molecules based on its structure that are more stable or more easily tolerated. In addition, newer molecules have been developed that are not analogues of prostacyclin but that target the receptors that prostacyclin activates. Prostacyclin and related drugs have without doubt revolutionised the treatment and management of pulmonary arterial hypertension but are seriously limited by side effects within the systemic circulation. With the dawn of nanomedicine and targeted drug or stem cell delivery systems it will, in the very near future, be possible to make new formulations of prostacyclin that can evade the systemic circulation allowing for safe delivery to the pulmonary vessels. In this way, the full therapeutic potential of prostacyclin can be realised opening the possibility that pulmonary arterial hypertension will become, if not curable, a chronic manageable disease that is no longer fatal. This review discusses these and other issues relating to prostacyclin and its use in pulmonary arterial hypertensionPeer reviewedFinal Published versio

Y(2175): Distinguish Hybrid State from Higher Quarkonium

The possibility of Y(2175) as a $2{^3D_1}$ $s\bar{s}$ meson is studied. We study the decay of $2{^3D_1}$ $s\bar{s}$ from both the $^3P_0$ model and the flux tube model, and the results are similar in the two models. We show that the decay patterns of $1^{--}$ strangeonium hybrid and $2{^3D_1}$ $s\bar{s}$ are very different. The experimental search of the decay modes $KK$, $K^{*}K^{*}$, $K(1460)K$, $h_1(1380)\eta$ is suggested to distinguish the two pictures. Measuring the $K^{*}K^{*}$ partial width ratios is crucial to discriminate the $2{^3D_1}$ from the $3{^3S_1}$ $s\bar{s}$ assignment.Comment: 13 pages, 8 figure

Nonresonant Semileptonic Heavy Quark Decay

In both the large N_c limit and the valence quark model, semileptonic decays are dominated by resonant final states. Using Bjorken's sum rule in an "unquenched" version of the quark model, I demonstrate that in the heavy quark limit nonresonant final states should also be produced at a significant rate. By calculating the individual strengths of a large number of exclusive two-body nonresonant channels, I show that the total rate for such processes is highly fragmented. I also describe some very substantial duality-violating suppression factors which reduce the inclusive nonresonant rate to a few percent of the total semileptonic rate for the finite quark masses of B decay, and comment on the importance of nonresonant decays as testing grounds for very basic ideas on the structure, strength, and significance of the quark-antiquark sea and on quark-hadron duality in QCD.Comment: 51 pages, 2 Postscript figure

Characterizing groundwater flow and heat transport in fractured rock using Fiber-Optic Distributed Temperature Sensing

International audienceWe show how fully distributed space-time measurements with Fiber-Optic Distributed Temperature Sensing (FO-DTS) can be used to investigate groundwater flow and heat transport in fractured media. Heat injection experiments are combined with temperature measurements along fiber-optic cables installed in boreholes. Thermal dilution tests are shown to enable detection of cross-flowing fractures and quantification of the cross flow rate. A cross borehole thermal tracer test is then analyzed to identify fracture zones that are in hydraulic connection between boreholes and to estimate spatially distributed temperature breakthrough in each fracture zone. This provides a significant improvement compared to classical tracer tests, for which concentration data are usually integrated over the whole abstraction borehole. However, despite providing some complementary results, we find that the main contributive fracture for heat transport is different to that for a solute tracer

Out of equilibrium quantum field dynamics of an initial thermal state after a change in the external field

The effects of the initial temperature in the out of equilibrium quantum field dynamics in the presence of an homogeneous external field are investigated. We consider an initial thermal state of temperature T for a constant external field J. A subsequent sign flip of the external field, J to -J, gives rise to an out of equilibrium nonperturbative quantum field dynamics. The dynamics is studied here for the symmetry broken lambda(Phi^2)^2 scalar N component field theory in the large N limit. We find a dynamical effective potential for the expectation value that helps to understand the dynamics. The dynamics presents two regimes defined by the presence or absence of a temporal trapping close to the metastable equilibrium position of the potential. The two regimes are separated by a critical value of the external field that depends on the initial temperature. The temporal trapping is shorter for larger initial temperatures or larger external fields. Parametric resonances and spinodal instabilities amplify the quantum fluctuations in the field components transverse to the external field. When there is a temporal trapping this is the main mechanism that allows the system to escape from the metastable state for large N. Subsequently backreaction stops the growth of the quantum fluctuations and the system enters a quasiperiodic regime.Comment: LaTeX, 19 pages, 12 .eps figures, improved version to appear in Phys Rev

Using pi_2(1670) -> b_1(1235) pi to Constrain Hadronic Models

We show that current analyses of experimental data indicate that the strong decay mode pi_2 -> b_1 pi is anomalously small. Non-relativistic quark models with spin-1 quark pair creation, such as ^3P_0, ^3S_1 and ^3D_1 models, as well as instanton and lowest order one-boson (in this case pi) emission models, can accommodate the analyses of experimental data, because of a quark-spin selection rule. Models and effects that violate this selection rule, such as higher order one-boson emission models, as well as mixing with other Fock states, may be constrained by the small pi_2 -> b_1 pi decay. This can provide a viability check on newly proposed decay mechanisms. We show that for mesons made up of a heavy quark and anti-quark, the selection rule is exact to all orders of Quantum Chromodynamics (QCD) perturbation theory.Comment: 11 pages, LaTeX, 3 encapsulated Postscript figures, small change

Scaling of the 3P0 strength in heavy meson strong decays

The phenomenological 3P0 decay model has been extensively applied to calculate meson strong decays. The strength \gamma\ of the decay interaction is regarded as a free flavor independent constant and is fitted to the data. We calculate through the 3P0 model the total strong decay widths of the mesons which belong to charmed, charmed-strange, hidden charm and hidden bottom sectors. The wave function of the mesons involved in the strong decays are given by a constituent quark model that describes well the meson phenomenology from the light to the heavy quark sector. A global fit of the experimental data shows that, contrarily to the usual wisdom, the \gamma\ depends on the reduced mass of the quark-antiquark pair in the decaying meson. With this scale-dependent strength \gamma, we are able to predict the decay width of orbitally excited B mesons not included in the fit.Comment: 7 pages, 5 tables, 2 figure

Managing in conflict: How actors distribute conflict in an industrial network

IMP researchers have examined conflict as a threat to established business relationships and commercial exchanges, drawing on theories and concepts developed in organization studies. We examine cases of conflict in relationships from the oil and gas industry's service sector, focusing on conflicts of interest and resources, and conflict as experienced by actors. Through a comparative case study design, we propose an explanation of how actors manage conflict and manage in conflict given that they tend to value and maintain relationships beyond episodes of exchange. We consider conflicts in relationships from a network perspective, showing that actors experienced these while adapting to changes in their business setting, modifying their roles in that network. By identifying conflict with the organizing forms of relationship and network, we show how actors formulate conflict through pursuing and combining a number of strategies, distributing the conflict across an enlarged network