MUSCAT: The Mexico-UK Sub-Millimetre Camera for AsTronomy

The Mexico-UK Sub-millimetre Camera for AsTronomy (MUSCAT) is a large-format, millimetre-wave camera consisting of 1,500 background-limited lumped-element kinetic inductance detectors (LEKIDs) scheduled for deployment on the Large Millimeter Telescope (Volc\'an Sierra Negra, Mexico) in 2018. MUSCAT is designed for observing at 1.1 mm and will utilise the full 40' field of view of the LMTs upgraded 50-m primary mirror. In its primary role, MUSCAT is designed for high-resolution follow-up surveys of both galactic and extra-galactic sub-mm sources identified by Herschel. MUSCAT is also designed to be a technology demonstrator that will provide the first on-sky demonstrations of novel design concepts such as horn-coupled LEKID arrays and closed continuous cycle miniature dilution refrigeration. Here we describe some of the key design elements of the MUSCAT instrument such as the novel use of continuous sorption refrigerators and a miniature dilutor for continuous 100-mK cooling of the focal plane, broadband optical coupling to Aluminium LEKID arrays using waveguide chokes and anti-reflection coating materials as well as with the general mechanical and optical design of MUSCAT. We explain how MUSCAT is designed to be simple to upgrade and the possibilities for changing the focal plane unit that allows MUSCAT to act as a demonstrator for other novel technologies such as multi-chroic polarisation sensitive pixels and on-chip spectrometry in the future. Finally, we will report on the current status of MUSCAT's commissioning.Comment: Presented at SPIE Astronomical Telescopes + Instrumentation, 2018, Austin, Texas, United State

Design and experimental investigation of a planar metamaterial Silicon based lenslet

The next generations of ground-based cosmic microwave background experiments will require polarisation sensitive, multichroic pixels of large focal planes comprising several thousand detectors operating at the photon noise limit. One approach to achieve this goal is to couple light from the telescope to a polarisation sensitive antenna structure connected to a superconducting diplexer network where the desired frequency bands are filtered before being fed to individual ultra-sensitive detectors such as Transition Edge Sensors. Traditionally, arrays constituted of horn antennas, planar phased antennas or anti-reflection coated micro-lenses have been placed in front of planar antenna structures to achieve the gain required to couple efficiently to the telescope optics. In this paper are presented the design concept and a preliminary analysis of the measured performances of a phase-engineered metamaterial flat-lenslet. The flat lens design is inherently matched to free space, avoiding the necessity of an anti-reflection coating layer. It can be fabricated lithographically, making scaling to large format arrays relatively simple. Furthermore, this technology is compatible with the fabrication process required for the production of large-format lumped element kinetic inductance detector arrays which have already demonstrated the required sensitivity along with multiplexing ratios of order 1000 detectors/channel

Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors.

Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti-tumor effects. Here, we have identified the mechanism that limited the effect of CSF1R targeted therapy. We demonstrated that carcinoma-associated fibroblasts (CAF) are major sources of chemokines that recruit granulocytes to tumors. CSF1 produced by tumor cells caused HDAC2-mediated downregulation of granulocyte-specific chemokine expression in CAF, which limited migration of these cells to tumors. Treatment with CSF1R inhibitors disrupted this crosstalk and triggered a profound increase in granulocyte recruitment to tumors. Combining CSF1R inhibitor with a CXCR2 antagonist blocked granulocyte infiltration of tumors and showed strong anti-tumor effects

Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities.

The mammary epithelium depends on specific lineages and their stem and progenitor function to accommodate hormone-triggered physiological demands in the adult female. Perturbations of these lineages underpin breast cancer risk, yet our understanding of normal mammary cell composition is incomplete. Here, we build a multimodal resource for the adult gland through comprehensive profiling of primary cell epigenomes, transcriptomes, and proteomes. We define systems-level relationships between chromatin-DNA-RNA-protein states, identify lineage-specific DNA methylation of transcription factor binding sites, and pinpoint proteins underlying progesterone responsiveness. Comparative proteomics of estrogen and progesterone receptor-positive and -negative cell populations, extensive target validation, and drug testing lead to discovery of stem and progenitor cell vulnerabilities. Top epigenetic drugs exert cytostatic effects; prevent adult mammary cell expansion, clonogenicity, and mammopoiesis; and deplete stem cell frequency. Select drugs also abrogate human breast progenitor cell activity in normal and high-risk patient samples. This integrative computational and functional study provides fundamental insight into mammary lineage and stem cell biology

Review of the late Quaternary stratigraphy of the northern Gulf of Cadiz continental margin:New insights into controlling factors and global implications

Over the past decades, the northern Gulf of Cadiz has been the focus of a wide range of late Quaternary seismic and sequence stratigraphic studies, either addressing the slope contourite depositional system (CDS), or the development of the continental shelf. Yet, high-resolution seismic data bridging between these domains and age information have remained sparse. This study, based on new high-resolution reflection seismic profiles calibrated to IODP Expedition 339 sites U1386/U1387, now presents an updated stratigraphic framework, that integrates (for the first time) the late Quaternary records of the northern Gulf of Cadiz middle slope to shelf off the Guadiana River. Seismic stratigraphic analysis of the stacking, depocenter distribution, stratal architecture and facies of the seismic (sub-)units reveals the influence of similar to 100 kyr sea-level variations paced by Milankovitch (eccentricity) cycles, tectonics (manifesting as two pulses of uplift and margin progradation), sediment supply and bottom current activity. This work furthermore contributes to the application and understanding of high-resolution, late Quaternary sequence stratigraphy. Firstly, the proposed sequence stratigraphic interpretation shows that adaptations to the basic models are required to integrate the shelf and slope record, and to account for the presence of a significant alongslope (bottom current-controlled) component. Secondly, the results confirm that the sequences are dominantly composed of regressive deposits, whereas the preservation of transgressive to highstand deposits is more irregular. Significantly, the common assumption that successive major glacial lowstands are consistently recorded as well-marked, shelf-wide erosional unconformities, is demonstrated to be occasionally invalid, as tectonics can obliterate this one-to-one relationship

A deeper focus on the primordial universe Develoment of a metamaterial-based lenslet coupled with kinetic inductance detectors for cosmology

Modern cosmology is seeking to understand the mechanisms behind the Universe birth and evolution, dynamics at limiting cases of both high energy quantum physics and the theory of gravitation. Since the observation of the Cosmic Microwave Background, primordial light revealed at the Universe’s creation, a technological push was made towards the precise detection of its subtle variations, especially with regards to its polarisation states. Directly or not, the scientific impact resulting from this effort is strong. Radio-antennas, optical component at the base of cosmology telescopes, are commonly used for telecommunication purposes in cars, phones, computers, etc. The detectors used in instruments for Cosmic Microwave Background observations are based on superconductors, ground technology for Magnetic Resonance Imaging or quantum-computer qubits. Metamaterials, a recent artificial media tunable to shape the light as desired, enabled microscopy at nanometric scales for instance. This thesis presents efforts to prove the concept of the MetaL, a focal optics made of metamaterial surfaces. Details on the Cosmic Microwave Background current knowledge and considerations on future experiments are discussed. Compliance with the requirements dressed for Cosmic Microwave Background instrumentation is partly demonstrated through a full experimental characterisation of a prototyped device. Excellent optical performances, similar to an existing optics counterpart, are demonstrated in a warm setup. Further plans and preliminary results to prove the coupling with a detecting element cold are laid out

Assessing climate change impacts on marine ecosystems and human activities in the Arctic ocean: the european ACCESS programme (2011-2015)

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