6,727 research outputs found
Heavy-flavour production in Pb-Pb collisions at the LHC, measured with the ALICE detector
We present the first results from the ALICE experiment on the nuclear
modification factors for heavy-flavour hadron production in Pb-Pb collisions at
sqrt{s_NN}=2.76 TeV. Using proton-proton and lead-lead collision samples at
sqrt{s}=7 TeV and sqrt{s_NN}=2.76 TeV, respectively, nuclear modification
factors R_AA(pt) were measured for D mesons at central rapidity (via displaced
decay vertex reconstruction), and for electrons and muons, at central and
forward rapidity, respectively.Comment: 8 pages, 5 figures, plenary talk at Quark Matter 2011, Annecy, Franc
The seesaw mechanism at TeV scale in the 3-3-1 model with right-handed neutrinos
We implement the seesaw mechanism in the 3-3-1 model with right-handed
neutrinos. This is accomplished by the introduction of a scalar sextet into the
model and the spontaneous violation of the lepton number. We identify the
Majoron as a singlet under symmetry, which makes it
safe under the current bounds imposed by electroweak data. The main result of
this work is that the seesaw mechanism works already at TeV scale with the
outcome that the right-handed neutrino masses lie in the electroweak scale, in
the range from MeV to tens of GeV. This window provides a great opportunity to
test their appearance at current detectors, though when we contrast our results
with some previous analysis concerning detection sensitivity at LHC, we
conclude that further work is needed in order to validate this search.Comment: about 13 pages, no figure
Non-standard interactions versus non-unitary lepton flavor mixing at a neutrino factory
The impact of heavy mediators on neutrino oscillations is typically described
by non-standard four-fermion interactions (NSIs) or non-unitarity (NU). We
focus on leptonic dimension-six effective operators which do not produce
charged lepton flavor violation. These operators lead to particular
correlations among neutrino production, propagation, and detection non-standard
effects. We point out that these NSIs and NU phenomenologically lead, in fact,
to very similar effects for a neutrino factory, for completely different
fundamental reasons. We discuss how the parameters and probabilities are
related in this case, and compare the sensitivities. We demonstrate that the
NSIs and NU can, in principle, be distinguished for large enough effects at the
example of non-standard effects in the --sector, which basically
corresponds to differentiating between scalars and fermions as heavy mediators
as leading order effect. However, we find that a near detector at superbeams
could provide very synergistic information, since the correlation between
source and matter NSIs is broken for hadronic neutrino production, while NU is
a fundamental effect present at any experiment.Comment: 32 pages, 5 figures. Final version published in JHEP. v3: Typo in Eq.
(27) correcte
Heavy-flavour and quarkonium production in the LHC era: from proton-proton to heavy-ion collisions
This report reviews the study of open heavy-flavour and quarkonium production
in high-energy hadronic collisions, as tools to investigate fundamental aspects
of Quantum Chromodynamics, from the proton and nucleus structure at high energy
to deconfinement and the properties of the Quark-Gluon Plasma. Emphasis is
given to the lessons learnt from LHC Run 1 results, which are reviewed in a
global picture with the results from SPS and RHIC at lower energies, as well as
to the questions to be addressed in the future. The report covers heavy flavour
and quarkonium production in proton-proton, proton-nucleus and nucleus-nucleus
collisions. This includes discussion of the effects of hot and cold strongly
interacting matter, quarkonium photo-production in nucleus-nucleus collisions
and perspectives on the study of heavy flavour and quarkonium with upgrades of
existing experiments and new experiments. The report results from the activity
of the SaporeGravis network of the I3 Hadron Physics programme of the European
Union 7th Framework Programme
Towards Minimal S4 Lepton Flavor Model
We study lepton flavor models with the flavor symmetry. We construct
simple models with smaller numbers of flavon fields and free parameters, such
that we have predictions among lepton masses and mixing angles. The model with
a triplet flavon is not realistic, but we can construct realistic models
with two triplet flavons, or one triplet and one doublet flavons.Comment: 18 pages, 4 figures, references are adde
Reconstructing Neutrino Properties from Collider Experiments in a Higgs Triplet Neutrino Mass Model
We extend the minimal supersymmetric standard model with bilinear R-parity
violation to include a pair of Higgs triplet superfields. The neutral
components of the Higgs triplets develop small vacuum expectation values (VEVs)
quadratic in the bilinear R-parity breaking parameters. In this scheme the
atmospheric neutrino mass scale arises from bilinear R-parity breaking while
for reasonable values of parameters the solar neutrino mass scale is generated
from the small Higgs triplet VEVs. We calculate neutrino masses and mixing
angles in this model and show how the model can be tested at future colliders.
The branching ratios of the doubly charged triplet decays are related to the
solar neutrino angle via a simple formula.Comment: 19 pages, 4 figures; one formula corrected, two author's names
corrected; some explanatory comments adde
Pathogenic variants in the human m(6)A reader YTHDC2 are associated with primary ovarian insufficiency
Primary ovarian insufficiency (POI) affects 1% of women and carries significant medical and psychosocial sequelae. Approximately 10% of POI has a defined genetic cause, with most implicated genes relating to biological processes involved in early fetal ovary development and function. Recently, Ythdc2, an RNA helicase and N6-methyladenosine reader, has emerged as a regulator of meiosis in mice. Here, we describe homozygous pathogenic variants in YTHDC2 in 3 women with early-onset POI from 2 families: C. 2567C>G, p.P856R in the helicase-associated (HA2) domain and c.1129G>T, p.E377*. We demonstrated that YTHDC2 is expressed in the developing human fetal ovary and is upregulated in meiotic germ cells, together with related meiosisassociated factors. The p.P856R variant resulted in a less flexible protein that likely disrupted downstream conformational kinetics of the HA2 domain, whereas the p.E377*variant truncated the helicase core. Taken together, our results reveal that YTHDC2 is a key regulator of meiosis in humans and pathogenic variants within this gene are associated with POI
Short-term variability in euphotic zone biogeochemistry and primary productivity at Station ALOHA : a case study of summer 2012
Author Posting. © American Geophysical Union, 2015. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Global Biogeochemical Cycles 29 (2015): 1145â1164, doi:10.1002/2015GB005141.Time-series observations are critical to understand the structure, function, and dynamics of marine ecosystems. The Hawaii Ocean Time-series program has maintained near-monthly sampling at Station ALOHA (22°45âČN, 158°00âČW) in the oligotrophic North Pacific Subtropical Gyre (NPSG) since 1988 and has identified ecosystem variability over seasonal to interannual timescales. To further extend the temporal resolution of these near-monthly time-series observations, an extensive field campaign was conducted during JulyâSeptember 2012 at Station ALOHA with near-daily sampling of upper water-column biogeochemistry, phytoplankton abundance, and activity. The resulting data set provided biogeochemical measurements at high temporal resolution and documents two important events at Station ALOHA: (1) a prolonged period of low productivity when net community production in the mixed layer shifted to a net heterotrophic state and (2) detection of a distinct sea-surface salinity minimum feature which was prominent in the upper water column (0â50 m) for a period of approximately 30 days. The shipboard observations during JulyâSeptember 2012 were supplemented with in situ measurements provided by Seagliders, profiling floats, and remote satellite observations that together revealed the extent of the low productivity and the sea-surface salinity minimum feature in the NPSG.NOAA Climate Observation Division; National Science Foundation (NSF) Center for Microbial Oceanography: Research and Education (C-MORE) Grant Numbers: EF0424599, OCE-1153656, OCE-1260164; Gordon and Betty Moore Foundation Marine Microbiology Investigator2016-02-1
Cleavage of the sarcinâricin loop of 23S rRNA differentially affects EF-G and EF-Tu binding
Ribotoxins are potent inhibitors of protein biosynthesis and inactivate ribosomes from a variety of organisms. The ribotoxin α-sarcin cleaves the large 23S ribosomal RNA (rRNA) at the universally conserved sarcinâricin loop (SRL) leading to complete inactivation of the ribosome and cellular death. The SRL interacts with translation factors that hydrolyze GTP, and it is important for their binding to the ribosome, but its precise role is not yet understood. We studied the effect of α-sarcin on defined steps of translation by the bacterial ribosome. α-Sarcin-treated ribosomes showed no defects in mRNA and tRNA binding, peptide-bond formation and sparsomycin-dependent translocation. Cleavage of SRL slightly affected binding of elongation factor Tu ternary complex (EF-TuâąGTPâątRNA) to the ribosome. In contrast, the activity of elongation factor G (EF-G) was strongly impaired in α-sarcin-treated ribosomes. Importantly, cleavage of SRL inhibited EF-G binding, and consequently GTP hydrolysis and mRNAâtRNA translocation. These results suggest that the SRL is more critical in EF-G than ternary complex binding to the ribosome implicating different requirements in this region of the ribosome during protein elongation
Constraining neutrinoless double beta decay
A class of discrete flavor-symmetry-based models predicts constrained
neutrino mass matrix schemes that lead to specific neutrino mass sum-rules
(MSR). We show how these theories may constrain the absolute scale of neutrino
mass, leading in most of the cases to a lower bound on the neutrinoless double
beta decay effective amplitude.Comment: 12 pages, 12 figure
- âŠ