INTEGRATING LIDAR, AEROMAGNETIC, AND GEOLOGICAL FIELD DATA TO IDENTIFY STRUCTURAL-LITHOLOGIC ELEMENTS WITHIN THE ARCHEAN CARNEY LAKE GNEISS COMPLEX

The Archean Carney Lake Gneiss Complex (CLGC) is a suite of rocks on the southern margin of the Superior Province and within the Minnesota River Valley subprovince. It is one of many gneissic domes in Michigan, Wisconsin, and Minnesota whose complex geology is poorly understood due to a previous lack of economic interest in gneissic terranes and significant challenges to their investigation. As a consequence, the CLGC and other gneissic domes in the region are represented on geologic maps as undifferentiated masses surrounded by better defined and understood Paleoproterozoic supracrustal rocks and igneous intrusions. Within the last ten years, however, the United States has identified an urgent need to find new sources of critical minerals to sustain and grow the nation’s technology and defense industries, which has renewed interest in these very old and complex rocks. Under the Earth Mapping Resources Initiative (Earth MRI) of the U.S. Geological Survey, the CLGC and surrounding Paleoproterozoic rocks have been remapped to update geologic interpretations and to assist in identifying potential mineral systems in the region. Mapping of the CLGC was accomplished using traditional techniques combined with satellite-based phone applications and differential GPS devices to navigate in dense vegetative cover, to obtain accurate coordinates of field sites, and to collect geologic data at outcrops. As a further aid to ground mapping, high-resolution LiDAR and aeromagnetic data were analyzed to determine topographic and magnetic patterns and textures that potentially reflect structural-lithologic domains within the CLGC. Integration of the new geologic field data with features and patterns identified on LiDAR and aeromagnetic maps allows definition of three domains within the CLGC: (1) a poly-deformed, mostly felsic gneiss with folded and sheared banding; (2) a meta-igneous, plagioclase-dominated gneiss with poorly expressed banding; and (3) a meta-sedimentary gneiss with thin well-developed banding and local relict sedimentary textures. Outcrop mapping also reveals the widespread occurrence and great variety of younger felsic and mafic intrusions that were not fully appreciated by earlier mappers. Data integration has allowed better definition of geologic unit contacts around the margins of the CLGC and within some Paleoproterozoic metasedimentary units, which updates knowledge about the Sturgeon Quartzite to the northeast and the Vulcan Iron Formation to the south. Although some analytical work is ongoing, such as radiometric age dating, the integrated mapping effort has identified between five to eight tectonomagmatic events that have affected the region, plus a number of sedimentary cycles. The abundance and variety of processes that have affected the area provides multiple opportunities for concentration of mineral deposits that could be attractive for future exploration efforts. The data integration approach developed for this thesis project should be useful in identifying structural-lithologic domains within enigmatic Precambrian gneiss domes elsewhere in the region and globally

Negotiation, bargaining, and discounts:generating WoM and local tourism development at the Tabriz bazaar, Iran

This paper examines the effects of negotiation intention, bargaining propensity, and discount satisfaction on word-of-mouth (WoM) behaviours for tourists visiting Tabriz bazaar, Iran. Data from 615-survey respondents highlight that tourists are motivated to conduct WoM behaviour when they are experientially satisfied with the opportunity to negotiate and bargain, and when they are satisfied with the discount they receive. This paper makes theoretical contributions to social exchange theory and presents managerial implications for policy-makers to generate tourism development

Travelling for Umrah:destination attributes, destination image, and post-travel intentions

This paper examines the links between cosmopolitanism, self-identity, and a desire for social interaction perceived destination image and behavioural intentions. A model tested using a sample of 538 Iranian visitors to Mecca for the purpose of Umrah. The result from the structural model suggests that destination attributes influence perceived destination image. Further, such tourists are likely to revisit or recommend Islamic destinations if their experience matches their perceived image of the destination. This implies that, while the religious characteristics of the destination remain important, destination managers cannot disregard the tangential, non-religious attributes of a destination which are crucial in order to satisfy more conventional tourist desires. As such, this study suggests that those managing religious travel destinations should endeavour to foster a welcoming image, where experience, interaction and tolerance are at the forefront of the destination’s offering

Assessing anesthesiology residents’ out-of-the-operating-room (OOOR) emergent airway management

Abstract Background At many academic institutions, anesthesiology residents are responsible for managing emergent intubations outside of the operating room (OOOR), with complications estimated to be as high as 39%. In order to create an OOOR training curriculum, we evaluated residents’ familiarity with the content and correct adherence to the American Society of Anesthesiologists’ Difficult Airway Algorithm (ASA DAA). Methods Residents completed a pre-simulation multiple-choice survey measuring their understanding and use of the DAA. Residents then managed an emergent, difficult OOOR intubation in the simulation center, where two trained reviewers assessed performance using checklists. Post-simulation, the residents completed a survey rating their behaviors during the simulation. The primary outcome was comprehension and adherence to the DAA as assessed by survey responses and behavior in the simulation. Results Sixty-three residents completed both surveys and the simulation. Post-survey responses indicated a shift toward decreased self-perceived familiarity with the DAA content compared to pre-survey responses. During the simulation, 22 (35%) residents were unsuccessful with intubation. Of these, 46% placed an LMA and 46% prepared for cricothyroidotomy. Nineteen residents did not attempt intubation. Of these, only 31% considered LMA placement, and 26% initiated cricothyroidotomy. Conclusions Many anesthesiology residency training programs permit resident autonomy in managing emergent intubations OOOR. Residents self-reported familiarity with the content of and adherence to the DAA was higher than that observed during the simulation. Curriculum focused on comprehension of the DAA, as well as improving communication with higher-level physicians and specialists, may improve outcomes during OOORs.https://deepblue.lib.umich.edu/bitstream/2027.42/137699/1/12871_2017_Article_387.pd

Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders

Abstract The hypothalamic-pituitary-adrenal (HPA) axis regulates responses to internal and external stressors. Many patients diagnosed with conditions such as depression or anxiety also have hyperactivity of the HPA axis. Hyper-stimulation of the HPA axis results in sustained elevated levels of glucocorticoids which impair neuronal function and can ultimately result in a psychiatric disorder. Studies investigating Glucocorticoid Receptor (GR/NR3C1) in the brain have primarily focused on the forebrain, however in recent years, the hindbrain has become a region of interest for research into the development of anxiety and depression, though the role of GR signalling in the hindbrain remains poorly characterised. To determine the role of glucocorticoid signalling in the hindbrain we have developed a novel mouse model that specifically ablates hindbrain GR to ascertain its role in behaviour, HPA-axis regulation and adrenal structure. Our study highlights that ablation of GR in the hindbrain results in excessive barbering, obsessive compulsive digging and lack of cage exploration. These mice also develop kyphosis, elevated circulating corticosterone and severe adrenal cortex disruption. Together, this data demonstrates a role for hindbrain GR signalling in regulating stress-related behaviour and identifies a novel mouse model to allow further investigation into the pathways impacting stress and anxiety

Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men

Leucine modulates muscle protein synthesis (MPS), with potential to facilitate accrual/maintenance of muscle mass. Animal models suggest that leucine boluses shortly after meals may prolong MPS and delay onset of a “muscle-full” state. However, the effects of nutrient “top-ups” in humans, and particularly older adults where deficits exist, have not been explored. We determined the effects of a leucine top-up after essential amino acid (EAA) feeding on anabolic signaling, MPS, and muscle energy metabolism in older men. During 13C6-phenylalanine infusion, 16 men (∼70 years) consumed 15 g of EAA with (n=8, FED + LEU) or without (n=8, FED) 3 g of leucine top-up 90 min later. Repeated blood and muscle sampling permitted measurement of fasting and postprandial plasma EAA, insulin, anabolic signaling including mTOR complex 1 (mTORC1) substrates, cellular ATP and phosphorylocreatine, and MPS. Oral EAA achieved rapid insulinemia (12.5 iU·ml−1 25 min post-feed), essential aminoacidemia (3000 μM, 45–65 min post-feed), and activation of mTORC1 signaling. Leucine top-up prolonged plasma EAA (2800 μM, 135 min) and leucine availability (1050 μM, 135 min post-feed). Fasting FSRs of 0.046 and 0.056%·h-1 (FED and FED + LEU respectively) increased to 0.085 and 0.085%·h-1 90–180 min post-feed and returned to basal rates after 180 min in both groups. Phosphorylation of mTORC1 substrates returned to fasting levels 240 min post-feed in both groups. Feeding had limited effect on muscle elongation factor 2 (eEF2) phosphorylation. We demonstrate the refractoriness of muscle to nutrient-led anabolic stimulation in the postprandial period; thus, leucine supplements should be taken outside of meals, or with meals containing suboptimal protein in terms of either amount or EAA composition

Radical Response exhibition in partnership with the International Association of Design Research (IASDR) Conference

Radical Response exhibition in partnership with the International Association of Design Research (IASDR) Conferenc

Sudden cardiac death due to deficiency of the mitochondrial inorganic pyrophosphatase PPA2

We have used whole exome sequencing to identify biallelic missense mutations in the nuclearencoded mitochondrial inorganic pyrophosphatase (PPA2) in ten individuals from four unrelated pedigrees that are associated with mitochondrial disease. These individuals show a range of severity, indicating that PPA2 mutations may cause a spectrum of mitochondrial disease phenotypes. Severe symptoms include seizures, lactic acidosis and cardiac arrhythmia and death within days of birth. In the index family, presentation was milder and manifested as cardiac fibrosis and an exquisite sensitivity to alcohol, leading to sudden arrhythmic cardiac death in the second decade of life. Comparison of normal and mutated PPA2 containing mitochondria from fibroblasts showed the activity of inorganic pyrophosphatase significantly reduced in affected individuals. Recombinant PPA2 enzymes modeling hypomorphic missense mutations had decreased activity that correlated with disease severity. These findings confirm the pathogenicity of PPA2 mutations, and suggest that PPA2 is a new cardiomyopathy-associated protein, which has a greater physiological importance in mitochondrial function than previously recognized