289 research outputs found
Editorial: circadian rhythms and exercise in cardiometabolic health
Metabolic health: pathophysiological trajectories and therap
Interplay of Mott Transition and Ferromagnetism in the Orbitally Degenerate Hubbard Model
A slave boson representation for the degenerate Hubbard model is introduced.
The location of the metal to insulator transition that occurs at commensurate
densities is shown to depend weakly on the band degeneracy M. The relative
weights of the Hubbard sub-bands depend strongly on M, as well as the magnetic
properties. It is also shown that a sizable Hund's rule coupling is required in
order to have a ferromagnetic instability appearing. The metal to insulator
transition driven by an increase in temperature is a strong function of it.Comment: 5 pages, revtex, 5 postscript figures, submitted to Phys. Rev.
TomograPy: A Fast, Instrument-Independent, Solar Tomography Software
Solar tomography has progressed rapidly in recent years thanks to the
development of robust algorithms and the availability of more powerful
computers. It can today provide crucial insights in solving issues related to
the line-of-sight integration present in the data of solar imagers and
coronagraphs. However, there remain challenges such as the increase of the
available volume of data, the handling of the temporal evolution of the
observed structures, and the heterogeneity of the data in multi-spacecraft
studies.
We present a generic software package that can perform fast tomographic
inversions that scales linearly with the number of measurements, linearly with
the length of the reconstruction cube (and not the number of voxels) and
linearly with the number of cores and can use data from different sources and
with a variety of physical models: TomograPy
(http://nbarbey.github.com/TomograPy/), an open-source software freely
available on the Python Package Index. For performance, TomograPy uses a
parallelized-projection algorithm. It relies on the World Coordinate System
standard to manage various data sources. A variety of inversion algorithms are
provided to perform the tomographic-map estimation. A test suite is provided
along with the code to ensure software quality. Since it makes use of the
Siddon algorithm it is restricted to rectangular parallelepiped voxels but the
spherical geometry of the corona can be handled through proper use of priors.
We describe the main features of the code and show three practical examples
of multi-spacecraft tomographic inversions using STEREO/EUVI and STEREO/COR1
data. Static and smoothly varying temporal evolution models are presented.Comment: 21 pages, 6 figures, 5 table
Invariant higher-order variational problems II
Motivated by applications in computational anatomy, we consider a
second-order problem in the calculus of variations on object manifolds that are
acted upon by Lie groups of smooth invertible transformations. This problem
leads to solution curves known as Riemannian cubics on object manifolds that
are endowed with normal metrics. The prime examples of such object manifolds
are the symmetric spaces. We characterize the class of cubics on object
manifolds that can be lifted horizontally to cubics on the group of
transformations. Conversely, we show that certain types of non-horizontal
geodesics on the group of transformations project to cubics. Finally, we apply
second-order Lagrange--Poincar\'e reduction to the problem of Riemannian cubics
on the group of transformations. This leads to a reduced form of the equations
that reveals the obstruction for the projection of a cubic on a transformation
group to again be a cubic on its object manifold.Comment: 40 pages, 1 figure. First version -- comments welcome
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
RANTES/CCL5 and risk for coronary events: Results from the MONICA/KORA Augsburg case-cohort, Athero-express and CARDIoGRAM studies
Background: The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans. We hypothesised that its relevance for atherosclerosis should be reflected by associations between CCL5 gene variants, RANTES serum concentrations and protein levels in atherosclerotic plaques and risk for coronary events. Methods and Findings: We conducted a case-cohort study within the population-based MONICA/KORA Augsburg studies. Baseline RANTES serum levels were measured in 363 individuals with incident coronary events and 1,908 non-cases (mean follow-up: 10.2±
Measurement of CP observables in B± â D(â)K± and B± â D(â)ϱ decays
Measurements of CP observables in B ± âD (â) K ± and B ± âD (â) Ï Â± decays are presented, where D (â) indicates a neutral D or D â meson that is an admixture of D (â)0 and DÂŻ (â)0 states. Decays of the D â meson to the DÏ 0 and DÎł final states are partially reconstructed without inclusion of the neutral pion or photon, resulting in distinctive shapes in the B candidate invariant mass distribution. Decays of the D meson are fully reconstructed in the K ± Ï â , K + K â and Ï + Ï â final states. The analysis uses a sample of charged B mesons produced in pp collisions collected by the LHCb experiment, corresponding to an integrated luminosity of 2.0, 1.0 and 2.0 fb â1 taken at centre-of-mass energies of s=7, 8 and 13 TeV, respectively. The study of B ± âD â K ± and B ± âD â Ï Â± decays using a partial reconstruction method is the first of its kind, while the measurement of B ± âDK ± and B ± âDÏ Â± decays is an update of previous LHCb measurements. The B ± âDK ± results are the most precise to date
Casca de café em dietas para vacas em lactação: consumo, digestibilidade, produção e composição de leite
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