Juegos Arcade online sobre mapas reales

Este proyecto implementa juegos arcade, que se desarrollan sobre mapas reales. Están hechos para poder jugar de forma online, a través de internet. La información geográfica necesaria es obtenida de la página de la fundación OpenStreetMap. Es una fundación para crear mapas libre y editables, que cuenta con la colaboración desinteresada de los usuarios de la red. Tenemos dos opciones para elegir el lugar donde se expondrá el juego. Las opciones son: bien jugar sobre unos mapas descargados previamente al realizar la aplicación por los desarroladores, o bien de forma online elegir el lugar sobre el cual queremos jugar. Para esto último nos apoyamos en aplicaciones ofertadas por esta Comunidad como puede ser el namefinder. Nuestra aplicación ha sido desarrollada bajo el lenguaje de programación Java de la empresa Sun Microsystems. Se ha usado como entorno de programación Netbeans, de la misma empresa citada con anterioridad. El proyecto se divide en dos, siguiendo la arquitectura cliente-servidor. El servidor se encarga de toda la computación y el cliente es una página web para poder jugar sobre ella. Para llevar a cabo el cliente se ha usado un applet de Java, que no es más que un programa incrustado en un documento HTML. La conexión entre las dos partes del proyecto citadas se ha realizado a través de sockets. Se ha seguido un protocolo creado por nosotros para que las comunicaciones sean correctas. Los juegos arcades disponibles en la aplicación son: el comecocos, el pilla pilla, la serpiente y el pincha globos. [ABSTRACT] This project implements arcade games, which are developed on real maps. They are made for playing online, over network. The geographic information required is got from OpenStreetMap foundation´s web page. This foundation creates free geographic data, with the unselfish collaboration of network users. We have two options for choosing the place where we will play. The options are either to play on maps downloaded by the developers previously or to choose the place when you are using this application. For the latter we use applications offered by OpenStreetMap, for example namefinder. Our application has been developed under the Java programming language of Sun Microsystems. The programming environment used has been Netbeans, of the same company previously mentioned. This project is divided into two parts, carrying on the client-server architecture. The server does all computation meanwhile and the client is a web page for playing on it. A Java applet has been used for implementing the client, which is a program incrusted in a HTML document. The connection between the two parts of the project is made using sockets. The application use a protocol defined by us for correct communications. The arcade games available in the application are: pacman, the running-running, the snake and click-balloons

Classic Kaposi’s sarcoma with multifocal gastrointestinal involvement. A case report

Although intestinal involvement occurs in more than half of the cases with KS that are HIV positive, it is uncommon in the classical form, as it occurs in approximately 10% of the patients. We present the case of a 60-year-old male patient with a one-year disease time characterized by having violaceous lesions on the feet and the hands, slightly pruritic and 2 months of epigastralgia and constipation with weight loss of approximately 12 percent of his total body weight. In the physical examination multiple violaceous papule-like lesions are shown on the hands and the feet, some coalescing to form plaques. Laboratory tests revealed a mild normocytic normocytic anemia, the serology for viral hepatitis B and C was negative, HIV negative and ELISA test too. An upper endoscopy was performed and multiple maculopapular and erythematous-violaceous lesions were observed in the esoph-agus, the stomach and the duodenum. In the colonoscopy, multiple lesions with similar characteristics in the ileum, throughout the colon and in the rectum were recognized. The biopsy result was compatible with the KS in all lesions and it was confirmed with the positive HVV-8 immunohis-tochemistry. This case highlights the likelihood of presenting GI SK in elderly patients with gastrointestinal compromise and cutaneous findings, HIV negatives as well as the need to realize an adequate discarding by performing endoscopic studies with the biopsies to optimize treatment.Revisión por pare

Estadio de madurez sexual en toros de la raza nelore

La presente investigación se planteó con el objetivo de determinar el estado de madurez sexual de toros jóvenes de la raza nelore y su relación con el perímetro escrotal y las características seminales. Se estudiaron 1985 animales con edades comprendidas entre los 19 y los 23 meses de edad, alimentados con pasturas tropicales (Brachiaria brizantha, Brachiaria decumbes y Panicum maximun) y evaluados a través de examen andrológico. Se valoraron las características físicas del eyaculado, la morfología espermática y el perímetro escrotal (PE). Tras el examen andrológico, los animales se clasificaron como aptos para la reproducción (clase andrológica 1) aptos para la reproducción en régimen de monta natural (clase 2) no aptos para la reproducción temporalmente (clase 3) y descartados (clase 5). Para comparar las medias encontradas entre las clases andrológicas se utilizaron dos pruebas: la de Tukey, con probabilidad del 5 % de error, y la de correlaciones simples de Pearson, para verificar las relaciones entre las características estudiadas. Se encontró que el 84,5 % de los toros son sexualmente maduros. El 39,75 % de los animales aptos para la reproducción presentó un PE mayor a 34 cm, y solo el 71 % de la población estudiada exhibió una circunferencia escrotal inferior a 28 cm. Se registraron correlaciones altas favorables entre PE y las características físicas del semen. Se concluye que el PE es una excelente característica para evaluar y seleccionar toros jóvenes de la raza nelore

Toenail zinc as a biomarker: Relationship with sources of environmental exposure and with genetic variability in MCC-Spain study

Background: Toenails are commonly used as biomarkers of exposure to zinc (Zn), but there is scarce information about their relationship with sources of exposure to Zn. Objectives: To investigate the main determinants of toenail Zn, including selected sources of environmental exposure to Zn and individual genetic variability in Zn metabolism. Methods: We determined toenail Zn by inductively coupled plasma mass spectrometry in 3,448 general popu-lation controls from the MultiCase-Control study MCC-Spain. We assessed dietary and supplement Zn intake using food frequency questionnaires, residential proximity to Zn-emitting industries and residential topsoil Zn levels through interpolation methods. We constructed a polygenic score of genetic variability based on 81 single nucleotide polymorphisms in genes involved in Zn metabolism. Geometric mean ratios of toenail Zn across categories of each determinant were estimated from multivariate linear regression models on log-transformed toenail Zn. Results: Geometric mean toenail Zn was 104.1 mu g/g in men and 100.3 mu g/g in women. Geometric mean toenail Zn levels were 7 % lower (95 % confidence interval 1-13 %) in men older than 69 years and those in the upper tertile of fibre intake, and 9 % higher (3-16 %) in smoking men. Women residing within 3 km from Zn-emitting industries had 4 % higher geometric mean toenail Zn levels (0-9 %). Dietary Zn intake and polygenic score were unrelated to toenail Zn. Overall, the available determinants only explained 9.3 % of toenail Zn variability in men and 4.8 % in women. Discussion: Sociodemographic factors, lifestyle, diet, and environmental exposure explained little of the indi-vidual variability of toenail Zn in the study population. The available genetic variants related to Zn metabolism were not associated with toenail Zn

Implementación de un sistema Blearning en asignaturas de grado y máster: sistema "Innovablend"

Memoria ID-0036. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2017-2018

Seminario semipresencial sobre “Metodología Cualitativa” a través de la plataforma Studium

Memoria ID12-0213. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2012-2013

Navegación segura, privacidad, riesgos en la red: un programa educativo para la adquisición de competencias digitales en alumnado de Secundaria.

Memoria ID-0109. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2013-2014

Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)

[EN] Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (<third quartile) and high consumers (≥ third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR = 1.58, 95% CI 1.05-2.41, P trend = .03) and stomach cancer (OR = 2.27 [0.99-5.44], P trend = .06). High consumption of aspartame, was associated with stomach cancer (OR = 2.04 [0.7-5.4], P trend = .05), while a lower risk was observed for breast cancer (OR = 0.28 [0.08-0.83], P trend = .03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes.SIAGAURConsejería de Salud of the Junta de AndalucíaConsejería de Sanidad de la Región de MurciaConselleria de Sanitat of the Generalitat ValencianaFundaci on Caja de Ahorros de AsturiasFundación Marqués de ValdecillaGeneralitat de CatalunyaICGC International Cancer Genome Consortium CLLJunta de Castilla y Leó

Long-Term Antipsychotic Effectiveness in First Episode of Psychosis: A 3-Year Follow-Up Randomized Clinical Trial Comparing Aripiprazole, Quetiapine, and Ziprasidone

BACKGROUND: Different effectiveness profiles among second-generation antipsychotics may be a key point to optimize treatment in patients suffering a first episode of psychosis to affect long-term outcome. The aim of this study was to compare the clinical effectiveness of aripiprazole, ziprasidone, and quetiapine in the treatment of first episode of psychosis at 3-year follow-up. METHOD: From October 2005 to January 2011, a prospective, randomized, open-label study was undertaken. Two hundred-two first-episode, drug-naïve patients were randomly assigned to aripiprazole (n=78), ziprasidone (n =62), or quetiapine (n=62) and followed-up for 3 years. The primary effectiveness measure was all cause of treatment discontinuation. In addition, an analysis based on the intention-to-treat principle was conducted in the analysis for clinical efficacy. RESULTS: The overall dropout rate at 3 years reached 19.3%. Treatment discontinuation rates were significantly different among treatment groups (aripiprazole=73.08%, ziprasidone=79.03%, and quetiapine=95.16%) (?2=11.680; P=.001). Statistically significant differences in terms of nonefficacy, nonadherence, and side effects were observed among treatment groups along the 3-year follow-up determining significant differences in time to all-cause discontinuation (log-rank=32.260; P=.001). Significant differences between treatments were found in the categories of sleepiness/sedation (?2=9.617; P=.008) and increased sleep duration (?2=6.192; P=.004). No significant differences were found in the profile of extrapyramidal symptoms. Patients on aripiprazole were more likely to be prescribed benzodiazepines. CONCLUSIONS: First-episode psychosis patients on quetiapine were more likely to discontinue treatment due to nonefficacy. Identifying different discontinuation patterns may contribute to optimize treatment selection after first episode of psychosis.This work was supported by Plan Nacional de Drogas Research (2005-Orden sco/3246/2004); SENY Fundacio (CI 2005–0308007); Fundacion Marques de Valdecilla (API07/011); and Gerencia Regional de Salud de Castilla y Leon (INT/M/04/17). The study was carried out at the Hospital Marques de Valdecilla, University of Cantabria, Santander, Spain. Unrestricted educational and research grants from AstraZeneca, Pfizer, Bristol-Myers Squibb, and Johnson & Johnson provided support for PAFIP activities. No pharmaceutical industry or institutional sponsors participated in the study design, data collection, analysis, or interpretation of the results

Una experiencia educativa con la tableta digital en el aula

Memoria ID-0076. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2014-2015.[ES]La aparición de las tabletas digitales supone un punto de inflexión en el desarrollo educativo, la forma que podemos acceder a Internet, en la portabilidad, en la conectividad sencilla, en la multifuncionalidad, en la consulta y en la generación de contenidos. Dadas sus peculiaridades, la tableta digital puede ser un elemento interesante de cara a su utilización educativa. Eso es lo que pretende averiguar el proyecto DEDOS: una experiencia educativa con la tableta digita